IndraLab
Statements
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"The C-terminal domain of TSC2 contains a small region of homology with GTPase-activating proteins (GAPs), and TSC1 and TSC2 interact to form a complex that acts as a GAP for the small G-protein RHEB, accelerating the conversion of RHEB from its active GTP-bound state to its inactive GDP-bound form xref ."
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"The regulation of mTORC1 is dependent on tuberous sclerosis 1 and 2 proteins (TSC1 and TSC2), which form a stable heterodimer (TSC1:TSC2 complex), of which the TSC2 subunit acts as a GTPase-activating protein for the small GTPase Rheb, which negatively controls Rheb and activates mTOR [ xref , xref ]."
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"While in our experiments relatively acute mTORC1 activation (< 24 hrs) did not alter postsynaptic function directly, there is evidence to suggest that longer, chronic hyperactivation of neuronal mTORC1, via knockdown of TSC1 or TSC2, is associated with morphological and functional changes in the postsynaptic compartment ( xref ; xref )."
AMPK binds TSC1, TSC2, and sestrin family. 2 / 2
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"The complex of hamartin (TSC1) and tuberin (TSC2) interact with AMPK and mTOR, and mutations in TSC1 or TSC2 lead to uncontrolled cell growth. xref TSC is associated with characteristic neoplasms such as neurofibromas in the skin, angiomyolipoma in the kidney and LAM in the lung."
TSC1 binds TSC2 and Autosomal dominant inheritance. 2 / 2
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"Most TSC patients present with mutations in the TSC1 or TSC2 genes, which encode proteins that form the TSC1-TSC2 complex that serves to antagonize the signaling pathway downstream of mammalian target of rapamycin (mTOR) by promoting the activation of the small GTPase Rheb and thereby inhibiting cellular growth and proliferation."
TSC1 binds TSC2 and tumour suppressor. 2 / 2
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"While a very small amount of Flag-TSC2 was associated with the PEX19-TSC1 complex ( xref ), this association was abrogated with the TSC2-G294E mutant (a TSC1 binding-deficient mutant xref ), indicating the little TSC2 detected in this complex was likely associated with TSC1, rather than directly bound to PEX19 ( xref )."
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"This allows the formation of an active TSC1-TSC2 dimer that inhibits the phosphorylation of Ribosomal Protein S6 Kinase B1 (RPS6KB1) by the mTOR protein complex, which in turn inhibits the phosphorylation of Ribosomal Protein S6 (RPS6), part of the 40S ribosomal subunit required for initiation [ xref ]."
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"To gain insights into the molecular mechanism of CIB2-mediated mTORC1 modulation, we assessed direct interactions between CIB2 and TSC1, TSC2, mTORC1-specific subunit Raptor, mTOR kinase, and Rheb, using a previously reported nanoscale pulldown 2.0 (NanoSPD) quantitative interaction assay xref ."
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"Loss of the TSC1 or TSC2 gene has been associated with increased production of vascular endothelial growth factor (VEGF), and inhibitors of mTOR have been shown to have an inhibitory effect on production of VEGF, tumor growth, and angiogenesis, both in vitro and in vivo. xref , xref "
reach
"Perhaps the most dramatic metabolic consequence of PI3K and Akt stimulation however, is downstream activation of the cell growth regulator mechanistic target of rapamycin complex 1 (mTORC1) upon Akt mediated phosphorylation of either of two mTORC1 inhibitors : tuberous sclerosis 2 (TSC2; part of the TSC1 and TSC2 complex) or proline rich Akt substrate 40 kDa (PRAS40)."
E3_Ub_ligase binds TSC1 and TSC2. 1 / 1
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TSC1 binds TSC2, MYC, and Hemagglutinins. 1 / 1
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E3_Ub_ligase affects TSC2
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D1 affects TSC2
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sparser
"To gain insights into the molecular mechanism of CIB2-mediated mTORC1 modulation, we assessed direct interactions between CIB2 and TSC1, TSC2, mTORC1-specific subunit Raptor, mTOR kinase, and Rheb, using a previously reported nanoscale pulldown 2.0 (NanoSPD) quantitative interaction assay xref ."
sparser
"This allows the formation of an active TSC1-TSC2 dimer that inhibits the phosphorylation of Ribosomal Protein S6 Kinase B1 (RPS6KB1) by the mTOR protein complex, which in turn inhibits the phosphorylation of Ribosomal Protein S6 (RPS6), part of the 40S ribosomal subunit required for initiation [ xref ]."
293T affects TSC2
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