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Statements

AMPK binds TSC1 and TSC2. 4 / 4
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"In the present study, the activation of AMPK by Met in DLD1 cells with mutated KRAS resulted in an increase in the interaction between TSC2, TSC1, and AMPK (Fig. xref f)."
| PMC
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"Sestrin 1 and 2 have been shown to interact with AMPK, TSC1, and TSC2 to inhibit mTOR signaling in response to genotoxic stress xref ."
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"For instance, SESN2 (up-regulated by ~ 3.1-fold) which is stress inducible and regulated by p53 inhibits mTORC1 by activating AMPK via forming AMPK-TSC1:TSC2 complex xref – xref ."
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"Co-immunoprecipitation and gel filtration analyses revealed an interaction between Sesn2 and AMPKα, suggesting that Sestrins are engaged in formation of a large protein complex containing AMPK and TSC1:TSC2."
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