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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TSC1 binds TSC2 and proline. 1 / 1

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reach

"Perhaps the most dramatic metabolic consequence of PI3K and Akt stimulation however, is downstream activation of the cell growth regulator mechanistic target of rapamycin complex 1 (mTORC1) upon Akt mediated phosphorylation of either of two mTORC1 inhibitors : tuberous sclerosis 2 (TSC2; part of the TSC1 and TSC2 complex) or proline rich Akt substrate 40 kDa (PRAS40)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...