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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TSC1 binds TSC2 and Thr1462. 1 / 1

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reach

"AKT is a key activator of the Mammalian target of rapamycin (mTOR) signaling cascade by directly phosphorylating Ser 2448 of mTOR and by inhibiting of the TSC1/TSC2 complex via catalyzing Thr1462 phosphorylation of TSC2."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...