A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

GAP binds TSC1 and TSC2. 2 / 2
| 2
sparser
"This is accomplished by AKT-1 phosphorylation and inactivation of TSC2 [ xref - xref ], which forms a TSC1–TSC2 protein complex that is a GAP for the RHEB G-protein."
sparser
"The C-terminal domain of TSC2 contains a small region of homology with GTPase-activating proteins (GAPs), and TSC1 and TSC2 interact to form a complex that acts as a GAP for the small G-protein RHEB, accelerating the conversion of RHEB from its active GTP-bound state to its inactive GDP-bound form xref ."