IndraLab
Statements
reach
"One of the interacting proteins named TBC1D7 and TSC1/2 heterodimer bind together to form the TSC1, TSC2, and TBC1D7 complex (TSC-TBC) [XREF_BIBR], which regulates the mammalian target of the rapamycin (mTOR) signaling pathway in response to upstream signals such as growth factor stimulation and hypoxia."
sparser
"AMPK inactivates mTORC1 by at least two mechanisms, i.e. inhibitory phosphorylation of the Raptor subunit that targets the complex to downstream targets and to the lysosome where it is activated, and activatory phosphorylation of TSC2, which forms a key part of the TSC1:TSC2:TBC1D7 complex."
sparser
"These two proteins function together with TBC1D7 to form a tuberin‐hamartin‐TBC1D7 complex by coiled‐coil to restrain mammalian target of rapamycin (mTOR)‐mediated signaling pathway and insulin signaling pathway, thus, playing a role in the regulation of both cell growth, proliferation and differentiation (Dibble et al., xref ; Rosner, Hofer, Kubista, & Hengstschläger, xref ; Tee et al., xref ; Van Slegtenhorst et al., xref )."
sparser
"Tumor suppressors hamartin ( TSC1 ) and tuberin ( TSC2 ) can form an intracellular complex with TBC1 domain family member 7 (TBC1D7) that exerts GTPase-activating protein (GAP) activity towards the small GTPase Ras homolog enriched in brain 1 (RHEB1) (Dibble et al. xref ; Inoki et al. xref )."
sparser
"Signals including growth factors, cellular stresses and energy levels act on the disruption the formation of tuberous sclerosis complex (TSC) complex, comprised of TSC1, TSC2 and TBC1D7, which leads to the translocation and activation of Rheb on the lysosome membrane (Dibble et al., xref )."
sparser
"One of the interacting proteins named TBC1D7 and TSC1/2 heterodimer bind together to form the TSC1-TSC2-TBC1D7 complex (TSC-TBC) [ xref ], which regulates the mammalian target of the rapamycin (mTOR) signaling pathway in response to upstream signals such as growth factor stimulation and hypoxia."