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TBC1D7 binds TSC1 and TSC2. 33 / 34
1 | 13 20
sparser
"When the TSC1-TSC2-TBC1D7 (TSC-TBC) complex is formed, it inhibits mTORC1 activity by means of its GTPase-activating protein (GAP) domain [ xref , xref ]."
26937223
sparser
"One of the interacting proteins named TBC1D7 and TSC1/2 heterodimer bind together to form the TSC1-TSC2-TBC1D7 complex (TSC-TBC) [ xref ], which regulates the mammalian target of the rapamycin (mTOR) signaling pathway in response to upstream signals such as growth factor stimulation and hypoxia."
33628792
sparser
"TSC1, TSC2, and TBC1D7 form a heteromeric complex that can bind to and stimulate the GTPase Ras homolog enriched in brain Rheb ( xref ; xref ; xref ; xref ) (for reviews see ( xref ; xref ) ( xref )."
23485365
reach
"Insulin activates mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1, TSC2, and TBC1D7 complex (the TSC complex) to turn on Rheb, an essential activator of mTORC1."
24529379
sparser
"Active AKT decreases interaction between PRAS40 and mTORC1 and deactivates the tuberous sclerosis complex (TSC) formed by TSC1, TSC2 and TBC1D7 [ xref ]."
25592035
sparser
"The proteins encoded by the TSC1 and TSC2 genes, hamartin and tuberin, respectively, interact with TBC1 domain family member 7 (TBC1D7) to form an active complex that regulates the mTORC1 activation state [ xref – xref ]."
26872016
sparser
"Active PKB/Akt phosphorylates TSC2 ( T uberosis S clerosis C omplex 2), and thereby destabilizes the complex formed by TSC1, TSC2 and TBC1D7 ( TBC1 D omain family member 7) ( xref ; xref ; xref )."
32982690
sparser
"This suggests that the TSC1-TSC2-TBC1D7 interaction may also be conserved."
24714658
sparser
"The overall architecture of TSC1–TSC2 and TSC1–TBC1D7 interactions together allows one TBC1D7 to be assembled into TSC complex and this subunit stoichiometry is consistent with previous structural and biochemical analyses xref , xref ."
33436626
sparser
"Tumor suppressors hamartin ( TSC1 ) and tuberin ( TSC2 ) can form an intracellular complex with TBC1 domain family member 7 (TBC1D7) that exerts GTPase-activating protein (GAP) activity towards the small GTPase Ras homolog enriched in brain 1 (RHEB1) (Dibble et al. xref ; Inoki et al. xref )."
34709498
sparser
"This parallel dimerization of TSC1 leads to an asymmetric formation of TSC1–TSC2 tetramer and recruitment of a single TBC1D7 molecule, generating a unique and characteristic modular organization (Fig.  xref and Supplementary Fig.  xref )."
33436626
sparser
"Along with TBC1D7, TSC1 and TSC2 form a physical complex that supports the GTPase-activating protein (GAP) activity of TSC2 towards the small GTPase, RHEB, a direct and positive regulator of MTOR (specifically, MTOR complex I or MTORC1) xref ."
28643795
sparser
"The interaction of TBC7 with the TSC1–TSC2 complex was, however, not altered by the growth factor stimuli such as insulin, epidermal growth factor, and serum (data not shown)."
17658474
sparser
"Additional immunoprecipitations with antibodies that only recognize TSC2 phosphorylated by Akt on either S939 or T1462, confirmed that TSC1 and TBC1D7 readily associate with phosphorylated TSC2 and remain stably bound even after an hour of insulin stimulation ( xref )."
24529379
reach
"The TSC1, TSC2, and TBC1D7 complex is the critical negative regulator of mTORC1 signalling with respect to most of its upstream regulators, such as growth factors, insulin and energy levels [XREF_BIBR]."
23216249
reach
"Thus, it is exciting to see the observations of Yang et al., which provide new insights into how nutrients and growth factors, via the RAG GTPase, coordinately affect the recruitment dynamics of the T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33171106
sparser
"The TSC complex, formed by the subunits TSC1, TSC2, and TBC1D7, is responsible for relaying most growth factor signaling pathways to mTORC1 (Ben‐Sahra & Manning, xref )."
29210103
reach
"One of the interacting proteins named TBC1D7 and TSC1/2 heterodimer bind together to form the TSC1, TSC2, and TBC1D7 complex (TSC-TBC) [XREF_BIBR], which regulates the mammalian target of the rapamycin (mTOR) signaling pathway in response to upstream signals such as growth factor stimulation and hypoxia."
33628792
reach
"However, the simple model that nutrient-derived signals uniquely converge upon the RAGs while growth-factor-derived signals uniquely converge on RHEB has recently been challenged with the observation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33171106
reach
"Complete loss of either TSC1 or TSC2 inactivates the TSC1, TSC2, and TBC1D7 complex leading to constitutive high-level activation of mTORC1 in TSC tumors."
23386687
sparser
"Signals including growth factors, cellular stresses and energy levels act on the disruption the formation of tuberous sclerosis complex (TSC) complex, comprised of TSC1, TSC2 and TBC1D7, which leads to the translocation and activation of Rheb on the lysosome membrane (Dibble et al., xref )."
31134526
reach
"Remarkably, TSC2 protein, a critical component of the TSC1-TSC2-TBC1D7 complex that negatively regulates mTOR(C1) signaling [88,89] , proved to be induced in response of WM-266-4 melanoma cells to bot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29180045
sparser
"TSC2 forms a protein complex with TSC1 and the recently discovered protein TBC1D7 [ xref ]."
26937223
sparser
"AMPK inactivates mTORC1 by at least two mechanisms, i.e. inhibitory phosphorylation of the Raptor subunit that targets the complex to downstream targets and to the lysosome where it is activated, and activatory phosphorylation of TSC2, which forms a key part of the TSC1:TSC2:TBC1D7 complex."
31288625
reach
"Insulin thus activates mTORC1 through the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 complex that functions as a repressor of the mTORC1 activator Rheb."
29186685
reach
"The TSC1, TSC2, and TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues."
24714658
sparser
"TSC2 forms a complex with TSC1 and TBC1 domain family member 7 (TSC complex) and acts as a negative regulator of mTORC1 signaling xref , xref , xref ."
26918392
reach
"TSC1 is an essential component of the TSC1, TSC2, and TBC1D7 complex."
24714658
sparser
"These two proteins function together with TBC1D7 to form a tuberin‐hamartin‐TBC1D7 complex by coiled‐coil to restrain mammalian target of rapamycin (mTOR)‐mediated signaling pathway and insulin signaling pathway, thus, playing a role in the regulation of both cell growth, proliferation and differentiation (Dibble et al., xref ; Rosner, Hofer, Kubista, & Hengstschläger, xref ; Tee et al., xref ; Van Slegtenhorst et al., xref )."
32735081
reach
"Our work gives more detailed insight into the structural and functional relationships between TSC1 and TBC1D7, and provides useful information for further studies aimed at unravelling the molecular structure of the TSC1, TSC2, and TBC1D7 complex."
24714658
reach
"The TSC1, TSC2, and TBC1D7 complex negatively regulates this axis by inhibiting the activation of mTORC1 through a small GTPase protein RHEB XREF_BIBR, XREF_BIBR."
33833339
reach
"Hence, exogenous expression of TSC1, as effected here by infection with a gene therapy vector can serve to rescue normal levels of the TSC1, TSC2, and TBC1D7 complex."
26019056
sparser
"Tre2-Bub2-Cdc16 (TBC) 1 domain family, member 7 (TBC1D7) is one of the interacting proteins, which stably binds to the TSC1/2 heterodimer to form the TSC1-TSC2-TBC1D7 (TSC–TBC) complex ( xref )."
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