IndraLab

Statements

TSC binds TSC1 and TSC2. 10 / 10
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"In mouse models of TSC, loss of Tsc1 or Tsc2 is associated with abnormal neuronal connectivity – specifically neuronal polarity, axon formation and guidance [ xref – xref ]."
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"In addition, the TSC complex, which is formed by TSC1 and TSC2, can activate mTORC2 in an independent Rheb manner [ xref ]."
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"TSC gene products TSC1 and TSC2 form a functional complex and inhibit cell growth."
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"Hence, loss of the TSC protein complex, either TSC1 or TSC2, leads to high levels of RHEB-GTP, and constitutive activation of mTORC1 [ xref ]."
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"Two tumor suppressor genes, TSC1 and TSC2 , are associated with the development of TSC, and mutations in either gene are responsible for both the familial and sporadic forms of TSC ( Young and Pove[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The two genes associated with TSC, TSC1 and TSC2 , were discovered by linkage analysis of large TSC families conducted by multinational consortia in 1997 and 1993, respectively."
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"TSC1 and TSC2 together form the upstream negative regulator TSC complex for mTORC1."
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"Activated AKT inhibits the formation of the tuberous sclerosis proteins TSC1 and TSC2, thus allowing activation of MTOR."
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"TSC is associated with mutations in 2 genes, TSC1 and TSC2, which encode hamartin and tuberin, respectively."
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"The overactivated mammalian target of rapamycin (mTOR) complex 1 (mTORC1) in TSC is associated with loss of function mutation in TSC1 and TSC2 genes ( xref , xref )."
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