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TSC1 binds TSC2 and MTOR. 10 / 10
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"TSC1 and TSC2 gene products—hamartin and tuberin, respectively—are components of a complex that negatively regulates mTOR signaling and, correspondingly, inactivation of TSC1 or TSC2 is associated wit[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
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"Here we explored the hypothesis that mutations in MTOR , TSC1 or TSC2 are associated with response to rapalog therapy."
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"For example, mutations in MTOR, TSC1 , or TSC2 were associated with response to mTOR inhibitors, 21% in responders versus 11% in non-responders ( xref )."
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"Interaction of hamartin with tuberin forms a heterodimer that inhibits signaling by the mammalian target of rapamycin to its downstream targets: eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)."
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"Mutations of either tuberous sclerosis 1 (TSC1) or TSC2 are associated with aberrant activation of mammalian target of rapamycin (mTOR) pathway, which increases the risk of RCC ( xref , xref )."
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"Tuberous sclerosis (TSC) is a monogenic disease resulting from defects of the TSC1 or TSC2 genes, which encode the proteins forming hamartin-tuberin tumor suppressor complex, the mammalian target of rapamycin complex (mTOR)."
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"This is achieved via directly phosphorylation of Ser 1345 and Thr 1227 on the tumour suppressor protein tuberous sclerosis 2 (TSC2), which forms an mTOR complex 1 (mTORC1)-inhibitory complex with TSC1 [ xref ]."
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"The genes code for the proteins hamartin (TSC1) and tuberin (TSC2) which form a complex that regulates the mTOR cell signalling pathway, responsible for important aspects of cell growth and differentiation [ xref ]."
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"These results suggest that the identified TSC1 and TSC2 mutations are closely associated with both aberrant mTOR activation and dysregulation of neuronal growth in individuals with FCDII."
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"In addition, TSC1 and TSC2 , which form a complex that negatively regulates mTOR activity, demonstrate decreased mRNA and protein levels in GBMs compared to grade II tumors and non-tumor brain."