IndraLab

Statements

TSC1 binds TSC2 and MTOR. 13 / 13
| 13
sparser
"Interaction of hamartin with tuberin forms a heterodimer that inhibits signaling by the mammalian target of rapamycin to its downstream targets: eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)."
12867426
sparser
"These results suggest that the identified TSC1 and TSC2 mutations are closely associated with both aberrant mTOR activation and dysregulation of neuronal growth in individuals with FCDII."
28215400
sparser
"Hamartin and tuberin proteins form a complex which would further downregulate the activity of mammalian target of rapamycin (mTOR) activity."
33897168
sparser
"This is achieved via directly phosphorylation of Ser 1345 and Thr 1227 on the tumour suppressor protein tuberous sclerosis 2 (TSC2), which forms an mTOR complex 1 (mTORC1)-inhibitory complex with TSC1 [ xref ]."
26475449
sparser
"The genes code for the proteins hamartin (TSC1) and tuberin (TSC2) which form a complex that regulates the mTOR cell signalling pathway, responsible for important aspects of cell growth and differentiation [ xref ]."
28270230
sparser
"However, due to the limitations of this method, it does not allow us to conclude in which part of the GA, (i.e., cis-, medial-, or trans-) mTOR and TSC1-TSC2 complex exert their effects on cargo transport."
34006213
sparser
"Here we explored the hypothesis that mutations in MTOR , TSC1 or TSC2 are associated with response to rapalog therapy."
26831717
sparser
"Mutations of either tuberous sclerosis 1 (TSC1) or TSC2 are associated with aberrant activation of mammalian target of rapamycin (mTOR) pathway, which increases the risk of RCC ( xref , xref )."
27347102
sparser
"In addition, TSC1 and TSC2 , which form a complex that negatively regulates mTOR activity, demonstrate decreased mRNA and protein levels in GBMs compared to grade II tumors and non-tumor brain."
18759130
sparser
"TSC1 and TSC2 gene products—hamartin and tuberin, respectively—are components of a complex that negatively regulates mTOR signaling and, correspondingly, inactivation of TSC1 or TSC2 is associated wit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15261145
sparser
"RV infection causes significant downregulation of let-7g to stabilize the TSC1-TSC2, that resulting in the inhibition of mTOR activity."
30718795
sparser
"For example, mutations in MTOR, TSC1 , or TSC2 were associated with response to mTOR inhibitors, 21% in responders versus 11% in non-responders ( xref )."
29479523
sparser
"Tuberous sclerosis (TSC) is a monogenic disease resulting from defects of the TSC1 or TSC2 genes, which encode the proteins forming hamartin-tuberin tumor suppressor complex, the mammalian target of rapamycin complex (mTOR)."
27680012