IndraLab

Statements

MTORC2 binds TSC1 and TSC2. 5 / 5
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sparser
"Most surprising was the finding that the TSC1-TSC2 complex can physically associate with components of mTORC2, but not those unique to mTORC1."
19602587
sparser
"In a previous study, we found that the TSC1-TSC2 complex can physically associate with mTORC2, but not mTORC1, and that the mTORC2 associated with the TSC1-TSC2 complex was catalytically active ( xref )."
19602587
sparser
"The N-terminal region of TSC2 and C-terminal region of Rictor mediate the interaction between the TSC1-TSC2 complex and mTORC2."
19602587
sparser
"To avoid co-purification of endogenous mTORC2, we washed the immunoprecipitates with a high salt wash buffer found previously to disrupt binding of mTORC2 to the TSC1-TSC2 complex ( xref )."
19602587
sparser
"Finally, we find that the TSC1-TSC2 complex can physically associate with mTORC2 but not mTORC1."
18411301