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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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TSC binds TSC1, TSC2, and TBC1D7. 3 / 3

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"TSC1, TSC2, and TBC1D7 assemble the TSC complex with a 2:2:1 stoichiometry, generating an asymmetric modular organization."

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"This interaction is inhibited by the Rheb-GTPase activating protein (GAP) activity of the tuberous sclerosis protein complex (TSC) that is formed by the TSC1, TSC2 and TBC1D7 proteins [ xref ]."

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"The TSC heteromeric complex formed by TSC1, TSC2 and TBC1D7 acts as a GTPase activating protein (GAP) for the small Ras-related GTPase Rheb, which, in active GTP-bound form, binds and activates mTOR."

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Statements

TSC binds TSC1, TSC2, and TBC1D7. 3 / 3

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