IndraLab

Statements

ZRANB1 affects EZH2
| 1 15 11
ZRANB1 binds EZH2.
| 5 10
ZRANB1 binds EZH2. 10 / 14
| 5 9
sparser
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
29669287
sparser
"Based on the result of a previous study, we found that binding of zinc finger RANBP2-type containing 1 (ZRANB1) to EZH2 led to EZH2 deubiquitination, thereby stabilizing EZH2 protein expression in breast cancer [ xref ]."
33109776
reach
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
29669287
sparser
"Deletion analysis using various truncation mutants (M1, NZFs; M2, NZFs + AnkUBD; M3, AnkUBD + OTU; xref ) demonstrated that the OTU domain not only mediated the physical interaction of ZRANB1 with EZH2 ( xref ) but also was required for the stabilization of EZH2 by ZRANB1 ( xref )."
29669287
sparser
"Moreover, CoIP assay indicated that FAM83C-AS1 depletion inhibited the association of ZRANB1 with EZH2 ( xref )."
33109776
sparser
"Previous studies have revealed that ZRANB1 binding to EZH2 resulted in EZH2 deubiquitination and thereby stabilized EZH2 protein in breast cancer [ xref ]."
33109776
sparser
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
30150556
reach
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
30150556
reach
"They demonstrated that ZRANB1 can bind, deubiquitinate, and stabilize EZH2, which enhances breast cancer tumorigenesis and metastasis."
33308321
sparser
"Furthermore, binding-domain mapping analysis showed that both the N-terminal region (EID + D1) and the CXC domain of EZH2 could interact with ZRANB1 ( xref , xref )."
29669287
SUZ12 binds ZRANB1 and EZH2. 1 / 1
| 1
sparser
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 ( xref ) and, reciprocally, the interaction of either exogenous ( xref ) or endogenous ( xref ) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
ZRANB1 activates EZH2.
| 1 3
ZRANB1 activates EZH2. 4 / 4
| 1 3
reach
"Ectopic expression of ZRANB1 in both LM2 cells (XREF_FIG) and HEK293T cells (XREF_SUPPLEMENTARY) markedly upregulated endogenous EZH2 protein and increased cell proliferation, which could be reversed by knockdown of EZH2."
29669287
eidos
"The histone methyltransferase EZH2 also appears to be a target of TRABID DUB activity , and TRABID depletion has been shown to decrease EZH2 levels ( 38 ) ."
| PMC
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"Furthermore, purified His ZRANB1 could bind to purified GST-EZH2 under cell-free conditions (XREF_FIG), suggesting that ZRANB1 may directly regulate EZH2."
29669287
reach
"To determine whether the six EZH2 interacting DUBs affect EZH2 ubiquitination and protein levels, we transfected them individually into HEK293T cells, and we found that USP22 and ZRANB1 decreased the polyubiquitination of EZH2 (XREF_SUPPLEMENTARY); however, only ZRANB1 upregulated endogenous EZH2 protein (XREF_SUPPLEMENTARY)."
29669287
ZRANB1 ubiquitinates EZH2.
| 2 1
ZRANB1 leads to the ubiquitination of EZH2. 3 / 3
| 2 1
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"More importantly, downregulation of FAM83C-AS1 or ZRANB1 in RKO and SW620 cells enhanced the EZH2 ubiquitination (XREF_FIG)."
33109776
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"To determine whether the six EZH2 interacting DUBs affect EZH2 ubiquitination and protein levels, we transfected them individually into HEK293T cells, and we found that USP22 and ZRANB1 decreased the polyubiquitination of EZH2 (XREF_SUPPLEMENTARY); however, only ZRANB1 upregulated endogenous EZH2 protein (XREF_SUPPLEMENTARY)."
29669287
sparser
"More importantly, downregulation of FAM83C-AS1 or ZRANB1 in RKO and SW620 cells enhanced the EZH2 ubiquitination ( xref )."
33109776
ZRANB1 deubiquitinates EZH2.
| 3
ZRANB1 deubiquitinates EZH2. 2 / 2
| 2
reach
"To further determine whether ZRANB1 directly deubiquitinates EZH2, we incubated purified ZRANB1 and ubiquitinated EZH2 purified from ZRANB1-knockout HEK293A cells in a cell-free system."
29669287
reach
"ZRANB1 purified from insect cells markedly decreased EZH2 polyubiquitination in vitro (XREF_FIG), suggesting that EZH2 is a substrate of ZRANB1."
29669287
Modified ZRANB1 leads to the deubiquitination of EZH2. 1 / 1
| 1
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"Indeed, overexpression of ZRANB1 in ZRANB1-knockout HEK293A cells substantially reduced EZH2 polyubiquitination (XREF_FIG, denaturing condition)."
29669287
ZRANB1 increases the amount of EZH2.
| 1
Modified ZRANB1 increases the amount of EZH2. 1 / 1
| 1
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"Conversely, silencing ZRANB1 expression in MDA-MB-231 cells by two independent small interfering RNAs (siRNAs) (2 and 5) reduced endogenous EZH2 protein levels by 70% and 60%, respectively (XREF_FIG)."
29669287
ZRANB1 decreases the amount of EZH2.
| 1
ZRANB1 decreases the amount of EZH2. 1 / 1
| 1
reach
"The histone methyltransferase EZH2 also appears to be a target of TRABID DUB activity, and TRABID depletion has been shown to decrease EZH2 levels."
| PMC
ZRANB1 affects UBC
18 |
UBC binds ZRANB1. 10 / 18
18 |
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No evidence text available
28190767
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No evidence text available
25752577
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No evidence text available
20622874
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No evidence text available
25752573
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No evidence text available
25752573
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No evidence text available
25752577
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No evidence text available
22157957
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No evidence text available
22157957
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No evidence text available
19373254
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No evidence text available
25527291
ZRANB1 affects PIK3C3
| 13 4
ZRANB1 activates PIK3C3.
| 8
ZRANB1 activates PIK3C3. 8 / 8
| 8
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"Thus, our results highlight the importance of TRABID mediated VPS34 stabilization in maintaining normal liver metabolism and uncover the contribution of TRABID downregulation to the pathogenesis of liver steatosis through VPS34 destabilization and autophagy deficiency."
33637724
reach
"TRABID knockdown decreased VPS34 protein abundance and half-life, whereas TRABID overexpression enhanced VPS34 expression and stability."
33637724
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"To interrogate the in vivo function of TRABID mediated VPS34 stabilization in liver metabolism, we set up a mouse model of nonalcoholic fatty liver disease (NAFLD) via feeding mice with a high-fat diet (HFD)."
33637724
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"We provide evidence that this switch of UBE3C localization plays a critical role for cells to cope with the stressed conditions by favoring TRABID mediated VPS34 stabilization and autophagy induction, as prevention of this switch by an enforced association of UBE3C with VPS34 impairs autophagy and compromises proteostasis, ER quality control and cell survival."
33637724
reach
"Specifically in the liver, we show that TRABID mediated VPS34 stabilization is critical for lipid metabolism and is downregulated during the pathogenesis of steatosis."
33637724
reach
"In the liver, TRABID mediated VPS34 stabilization is important for lipid metabolism and is downregulated in a mouse model of NAFLD."
33637724
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"Our findings suggest that the balance between UBE3C and TRABID on VPS34 regulation is disturbed by various ER/proteotoxic stressors to favor TRABID mediated VPS34 stabilization, thus facilitating autophagy induction."
33637724
reach
"We next investigated the functional consequence of TRABID mediated VPS34 deubiquitnation."
33637724
ZRANB1 binds PIK3C3.
| 4
ZRANB1 binds PIK3C3. 3 / 3
| 3
sparser
"Consistent with the deubiquitination effect of TRABID on VPS34, endogenous TRABID interacted with endogenous VPS34 (Fig.  xref )."
33637724
sparser
"Furthermore, baculovirally purified recombinant TRABID and VPS34 interacted in vitro (Fig.  xref )."
33637724
sparser
"The interaction of TRABID with VPS34, however, was not altered under these conditions (Supplementary Fig.  xref )."
33637724
ZRANB1 binds RUBCN and PIK3C3. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
ZRANB1 deubiquitinates PIK3C3.
| 2
ZRANB1 leads to the deubiquitination of PIK3C3 on K29. 2 / 2
| 2
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"TRABID antagonizes VPS34 K29 and K48 heterotypic ubiquitination even though it can not hydrolyze unanchored K48 diubiquitin chains 37."
33637724
reach
"TRABID reduces VPS34 K29 and K48 ubiquitination to stabilize VPS34."
33637724
ZRANB1 decreases the amount of PIK3C3.
| 2
ZRANB1 decreases the amount of PIK3C3. 2 / 2
| 2
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"TRABID knockdown decreased VPS34 protein abundance and half-life, whereas TRABID overexpression enhanced VPS34 expression and stability."
33637724
reach
"Among the subunits of VPS34 complex, TRABID overexpression reduced the ubiquitination level of transfected and endogenous VPS34, but not AMBRA1, Beclin-1, ATG14 and UVRAG."
33637724
ZRANB1 increases the amount of PIK3C3.
| 1
ZRANB1 increases the amount of PIK3C3. 1 / 1
| 1
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"In line with the latter notion, 4-week treatment of rAAV-TRABID not only restored VPS34 expression and autophagy activity, but greatly alleviated HFD induced increase of liver and body weight and lipid accumulation in the liver, which was evident by gross anatomical view of the livers as well as H&E staining and Oil Red O staining of the liver sections."
33637724
ZRANB1 affects HECTD1
4 | 5 8
ZRANB1 binds HECTD1.
4 | 3 8
ZRANB1 binds HECTD1. 10 / 14
4 | 2 8
biogrid
No evidence text available
23277359
biogrid
No evidence text available
23277359
reach
"GST pull-down was also used to further validate the interaction between TRABID and HECTD1."
| PMC
sparser
"Together, our data identify TRABID-HECTD1 as the first DUB-E3 pair regulating K29-linked polyubiquitin chains."
| PMC
sparser
"Although we attempted to validate the interaction between endogenous TRABID and endogenous HECTD1, none of the four TRABID antibodies that we tried could detect endogenous TRABID (Data not shown)."
| PMC
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
| PMC
reach
"Although we attempted to validate the interaction between endogenous TRABID and endogenous HECTD1, none of the four TRABID antibodies that we tried could detect endogenous TRABID (Data not shown)."
| PMC
biogrid
No evidence text available
19615732
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
33853758
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase which assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
33380427
ZRANB1 binds HECTD1 and APC. 1 / 1
| 1
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"Additionally, it was shown that the Trabid, Hectd1, and APC complex interacts with proteins composing the striatin interacting phosphatase and kinase (STRIPAK) complex that regulates cortical actin cytoskeleton dynamics [XREF_BIBR]."
29299163
ZRANB1 ubiquitinates HECTD1.
| 1
ZRANB1 ubiquitinates HECTD1. 1 / 1
| 1
reach
"Having established that TRABID NZF 1 to 3 is required for binding HECTD1 in cells and that catalytic dead TRABID traps polyubiquitinated HECTD1, we then validated this data in the context of HECTD1 's newly identified ubiquitin ligase activity using a pull-down approach (XREF_FIG, C and D; Fig.S3)."
| PMC
ZRANB1 increases the amount of HECTD1.
| 1
ZRANB1 increases the amount of HECTD1. 1 / 1
| 1
reach
"Importantly, this decrease in HECTD1 protein levels could be rescued by re-expression of pEGFP-TRABID WT but not pEGFP-Empty vector alone, indicating that TRABID directly regulates HECTD1 levels (XREF_FIG D)."
| PMC
EZH2 affects ZRANB1
| 7 10
EZH2 binds ZRANB1.
| 5 10
ZRANB1 binds EZH2. 10 / 14
| 5 9
sparser
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
29669287
sparser
"Based on the result of a previous study, we found that binding of zinc finger RANBP2-type containing 1 (ZRANB1) to EZH2 led to EZH2 deubiquitination, thereby stabilizing EZH2 protein expression in breast cancer [ xref ]."
33109776
reach
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
29669287
sparser
"Deletion analysis using various truncation mutants (M1, NZFs; M2, NZFs + AnkUBD; M3, AnkUBD + OTU; xref ) demonstrated that the OTU domain not only mediated the physical interaction of ZRANB1 with EZH2 ( xref ) but also was required for the stabilization of EZH2 by ZRANB1 ( xref )."
29669287
sparser
"Moreover, CoIP assay indicated that FAM83C-AS1 depletion inhibited the association of ZRANB1 with EZH2 ( xref )."
33109776
sparser
"Previous studies have revealed that ZRANB1 binding to EZH2 resulted in EZH2 deubiquitination and thereby stabilized EZH2 protein in breast cancer [ xref ]."
33109776
sparser
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
30150556
reach
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
30150556
reach
"They demonstrated that ZRANB1 can bind, deubiquitinate, and stabilize EZH2, which enhances breast cancer tumorigenesis and metastasis."
33308321
sparser
"Furthermore, binding-domain mapping analysis showed that both the N-terminal region (EID + D1) and the CXC domain of EZH2 could interact with ZRANB1 ( xref , xref )."
29669287
SUZ12 binds ZRANB1 and EZH2. 1 / 1
| 1
sparser
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 ( xref ) and, reciprocally, the interaction of either exogenous ( xref ) or endogenous ( xref ) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
EZH2 inhibits ZRANB1.
| 1
EZH2 inhibits ZRANB1. 1 / 1
| 1
reach
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED (XREF_SUPPLEMENTARY), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
EZH2 activates ZRANB1.
| 1
EZH2 activates ZRANB1. 1 / 1
| 1
reach
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED (XREF_SUPPLEMENTARY), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
HECTD1 affects ZRANB1
4 | 3 8
ZRANB1 binds HECTD1. 10 / 14
4 | 2 8
biogrid
No evidence text available
23277359
biogrid
No evidence text available
23277359
reach
"GST pull-down was also used to further validate the interaction between TRABID and HECTD1."
| PMC
sparser
"Together, our data identify TRABID-HECTD1 as the first DUB-E3 pair regulating K29-linked polyubiquitin chains."
| PMC
sparser
"Although we attempted to validate the interaction between endogenous TRABID and endogenous HECTD1, none of the four TRABID antibodies that we tried could detect endogenous TRABID (Data not shown)."
| PMC
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
| PMC
reach
"Although we attempted to validate the interaction between endogenous TRABID and endogenous HECTD1, none of the four TRABID antibodies that we tried could detect endogenous TRABID (Data not shown)."
| PMC
biogrid
No evidence text available
19615732
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
33853758
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase which assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
33380427
ZRANB1 binds HECTD1 and APC. 1 / 1
| 1
reach
"Additionally, it was shown that the Trabid, Hectd1, and APC complex interacts with proteins composing the striatin interacting phosphatase and kinase (STRIPAK) complex that regulates cortical actin cytoskeleton dynamics [XREF_BIBR]."
29299163
ZRANB1 affects APC
2 | 7 2
ZRANB1 binds APC.
2 | 4 2
ZRANB1 binds APC. 7 / 7
2 | 3 2
reach
"Trabid binds to and deubiquitylates APC."
24594309
sparser
"TRABID binds APC but rather then antagonizing the proteasomal turnover of APC TRABID inhibits APC activity through preferential deubiquitination of K63 linked ubiquitin chains."
28923280
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"However, the direct interaction between APC and TRABID was not detected [XREF_BIBR]."
22584113
sparser
"However, the direct interaction between APC and TRABID was not detected [ xref ]."
22584113
reach
"TRABID binds APC but rather then antagonizing the proteasomal turnover of APC TRABID inhibits APC activity through preferential deubiquitination of K63 linked ubiquitin chains."
28923280
biogrid
No evidence text available
18281465
biogrid
No evidence text available
18281465
ZRANB1 binds HECTD1 and APC. 1 / 1
| 1
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"Additionally, it was shown that the Trabid, Hectd1, and APC complex interacts with proteins composing the striatin interacting phosphatase and kinase (STRIPAK) complex that regulates cortical actin cytoskeleton dynamics [XREF_BIBR]."
29299163
ZRANB1 deubiquitinates APC.
| 2
ZRANB1 deubiquitinates APC. 2 / 2
| 2
reach
"Trabid binds to and deubiquitylates APC."
24594309
reach
"For example, Trabid and Cezanne, both deubiquitinating (DUB) enzymes, antagonize the ubiquitination of APC, resulting in activation of beta-catenin and TCF-mediated transcription."
21118991
ZRANB1 inhibits APC.
| 1
ZRANB1 bound to APC inhibits APC. 1 / 1
| 1
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"TRABID binds APC but rather then antagonizing the proteasomal turnover of APC TRABID inhibits APC activity through preferential deubiquitination of K63 linked ubiquitin chains."
28923280
ZRANB1 affects TWIST1
| 10
ZRANB1 binds TWIST1.
| 8
TWIST1 binds ZRANB1. 7 / 7
| 7
sparser
"It was observed that GST-full-length (FL) Trabid and Trabid (1–354) strongly interacted with Twist1, whereas GST-Trabid (355–708) showed no interaction (Fig.  xref ), indicating that the N-terminal of Trabid should contain a primary interaction domain for Twist1."
29748601
sparser
"Mechanistically, Trabid forms a complex with Twist1 and specifically cleaves RNF8-induced K63-linked poly-ubiquitin chains from Twist1, which enhances the association of Twist1 with β-TrCP1 and allows for subsequent K48-linked ubiquitination of Twist1."
29748601
sparser
"Chromatin immunoprecipitation (ChIP) further confirmed that Twist1 directly binds to the Trabid promoter in HCC cells (Fig.  xref ) and clinical HCC tissues (Fig.  xref )."
29748601
sparser
"It suggests that Trabid-Twist1 inverse regulation in HCC was associated with reduced survival, and that Trabid downregulation in combination with RNF8 or Twist1 overexpression is a stronger predictor of poor survival than Trabid alone (Fig.  xref )."
29748601
sparser
"Thus, we concluded that Trabid directly interacts with Twist1."
29748601
sparser
"To elucidate the mechanisms by which Trabid suppresses Twist1, we firstly examined the interaction between Trabid and Twist1."
29748601
sparser
"We demonstrate the following: (1) Trabid expression is significantly downregulated in HCC cell lines and two independent cohorts of HCC patients’ tissues; (2) Trabid expression is negatively correlated with pathological grading, recurrence, and poor survival; (3) Reintroduction of Trabid in HCC cells significantly decreases HCC growth and pulmonary metastasis; (4) The inhibitory effect of Trabid on HCC development occurs at least partially through regulation of Twist1 activity; (5) Trabid forms a complex with Twist1 and specifically cleaves RNF8-induced K63-linked poly-ubiquitin chains from Twist1, which enhances the association of Twist1 with β-TrCP1 and allows for subsequent K48-linked ubiquitination of Twist1; (6) AKT-mediated phosphorylation at Ser78/Thr117 is essential for the role of Trabid in negatively regulating Twist1 signaling; and (7) Twist1 negatively regulates the promoter activity of Trabid, indicating a double-negative feedback loop."
29748601
GST binds TWIST1 and ZRANB1. 1 / 1
| 1
sparser
"We also demonstrated that Trabid mainly interacted with the FL and the 169–202 amino acid fragment (Twist1 box domain) of GST-Twist1, but not with other Twist1 fragments and GST alone (Fig.  xref )."
29748601
ZRANB1 inhibits TWIST1.
| 2
ZRANB1 inhibits TWIST1. 2 / 2
| 2
sparser
"Trabid inactivates Twist1 by cleaving RNF8-mediated Twist1 K63-linked ubiquitination."
29748601
sparser
"Taken together, Trabid inactivates Twist1 by cleaving RNF8-mediated Twist1 K63-linked ubiquitination, facilitating the complex formation of β-TrCP1 with Twist1, whereby enhancing K48-linked ubiquitination of Twist1 by β-TrCP1."
29748601
ZRANB1 affects IL12
| 9
ZRANB1 activates IL12.
| 6
ZRANB1 activates IL12. 6 / 6
| 6
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"Our data further suggested that Trabid mediated IL-12 and IL-23 induction plays an important role in mediating inflammatory T cell responses and the pathogenesis of EAE, an animal model of the autoimmune neuroinflammatory disease multiple sclerosis."
26808229
reach
"DC-conditional deletion of Trabid impairs IL-12 and IL-23 production in DCs and the generation of Th1 and Th17 subsets of inflammatory T cells, rendering mice refractory to the induction of EAE 180."
27012466
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"To elucidate the molecular mechanism by which Trabid mediates induction of IL-12 family of cytokines, we examined the role of Trabid in regulating TLR mediated activation of MAP kinases (MAPKs), IkappaB kinase (IKK) and downstream transcription factors known to regulate Il12 and Il23 gene induction XREF_BIBR, XREF_BIBR, XREF_BIBR."
26808229
reach
"Conditional deletion of Zranb1 in dendritic cells impairs IL-12 and IL-23 production and the generation of T 1 and T 17 subsets of inflammatory T cells, rendering mice refractory to the induction of experimental autoimmune encephalomyelitis (EAE) ."
28959952
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"Conditional deletion of Zranb1 in dendritic cells impairs IL-12 and IL-23 production and the generation of T H 1 and T H 17 subsets of inflammatory T cells, rendering mice refractory to the induction of experimental autoimmune encephalomyelitis (EAE) 191 ."
28959952
reach
"Collectively, these results suggest that Trabid mediates induction of IL-12 and IL-23, thereby promoting T H 1 and T H 17 differentiation."
26808229
ZRANB1 inhibits IL12.
| 2
ZRANB1 inhibits IL12. 2 / 2
| 2
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"Moreover ZRANB1 deficiency in macrophages and dendritic cells impairs the induction of IL-12 and IL-23 by the regulation of histone modifications at the IL-12 promoter, indicating a role of ZRANB1 in mediating inflammatory responses 18 and macrophage activation 19."
| PMC
reach
"By employing a gene targeting approach, we show that Trabid deficiency in DCs and macrophages impaired the induction of Il12 and Il23 genes without affecting the induction of many other cytokine genes."
26808229
ZRANB1 increases the amount of IL12.
| 1
ZRANB1 increases the amount of IL12. 1 / 1
| 1
reach
"Deletion of Zranb1 (which encodes Trabid) in dendritic cells inhibited induction of the expression of Il12 and Il23 by Toll like receptors (TLRs), which impaired the differentiation of inflammatory T cells and protected mice from autoimmune inflammation."
26808229
TWIST1 affects ZRANB1
| 1 8
TWIST1 binds ZRANB1.
| 8
TWIST1 binds ZRANB1. 7 / 7
| 7
sparser
"It was observed that GST-full-length (FL) Trabid and Trabid (1–354) strongly interacted with Twist1, whereas GST-Trabid (355–708) showed no interaction (Fig.  xref ), indicating that the N-terminal of Trabid should contain a primary interaction domain for Twist1."
29748601
sparser
"Mechanistically, Trabid forms a complex with Twist1 and specifically cleaves RNF8-induced K63-linked poly-ubiquitin chains from Twist1, which enhances the association of Twist1 with β-TrCP1 and allows for subsequent K48-linked ubiquitination of Twist1."
29748601
sparser
"Chromatin immunoprecipitation (ChIP) further confirmed that Twist1 directly binds to the Trabid promoter in HCC cells (Fig.  xref ) and clinical HCC tissues (Fig.  xref )."
29748601
sparser
"It suggests that Trabid-Twist1 inverse regulation in HCC was associated with reduced survival, and that Trabid downregulation in combination with RNF8 or Twist1 overexpression is a stronger predictor of poor survival than Trabid alone (Fig.  xref )."
29748601
sparser
"Thus, we concluded that Trabid directly interacts with Twist1."
29748601
sparser
"To elucidate the mechanisms by which Trabid suppresses Twist1, we firstly examined the interaction between Trabid and Twist1."
29748601
sparser
"We demonstrate the following: (1) Trabid expression is significantly downregulated in HCC cell lines and two independent cohorts of HCC patients’ tissues; (2) Trabid expression is negatively correlated with pathological grading, recurrence, and poor survival; (3) Reintroduction of Trabid in HCC cells significantly decreases HCC growth and pulmonary metastasis; (4) The inhibitory effect of Trabid on HCC development occurs at least partially through regulation of Twist1 activity; (5) Trabid forms a complex with Twist1 and specifically cleaves RNF8-induced K63-linked poly-ubiquitin chains from Twist1, which enhances the association of Twist1 with β-TrCP1 and allows for subsequent K48-linked ubiquitination of Twist1; (6) AKT-mediated phosphorylation at Ser78/Thr117 is essential for the role of Trabid in negatively regulating Twist1 signaling; and (7) Twist1 negatively regulates the promoter activity of Trabid, indicating a double-negative feedback loop."
29748601
GST binds TWIST1 and ZRANB1. 1 / 1
| 1
sparser
"We also demonstrated that Trabid mainly interacted with the FL and the 169–202 amino acid fragment (Twist1 box domain) of GST-Twist1, but not with other Twist1 fragments and GST alone (Fig.  xref )."
29748601
TWIST1 inhibits ZRANB1.
| 1
TWIST1 inhibits ZRANB1. 1 / 1
| 1
reach
"Interestingly, Twist1 negatively regulates the promoter activity of Trabid, indicating that a double negative feedback loop exists."
29748601
MIB2 affects ZRANB1
| 5 4
MIB2 binds ZRANB1.
| 4 3
ZRANB1 binds MIB2. 4 / 4
| 4
reach
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF dependent substrate ubiquitylation."
24714733
reach
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
reach
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
MIB2 ubiquitinates ZRANB1.
| 1 1
MIB2 ubiquitinates ZRANB1. 2 / 2
| 1 1
reach
"Both Mib and Mib2 can ubiquitylate Trabid and Fih-1, indicating a potential regulating role of Mib and Mib2 on Trabid and Fih-1 and, furthermore, the possible involvement of Notch signaling in hypoxia regulated differentiation, tumorigenesis and NF-kappaB pathway."
24714733
sparser
"Both Mib and Mib2 facilitated Fih-1 and Trabid C ubiquitylation ( xref , lanes 2, 4), while the E3 ligase-inactivated Mib ta52b or Mib2RF12m failed to do so ( xref , lanes 3, 5)."
24714733
APC affects ZRANB1
2 | 5 2
APC binds ZRANB1.
2 | 4 2
ZRANB1 binds APC. 7 / 7
2 | 3 2
reach
"Trabid binds to and deubiquitylates APC."
24594309
sparser
"TRABID binds APC but rather then antagonizing the proteasomal turnover of APC TRABID inhibits APC activity through preferential deubiquitination of K63 linked ubiquitin chains."
28923280
reach
"However, the direct interaction between APC and TRABID was not detected [XREF_BIBR]."
22584113
sparser
"However, the direct interaction between APC and TRABID was not detected [ xref ]."
22584113
reach
"TRABID binds APC but rather then antagonizing the proteasomal turnover of APC TRABID inhibits APC activity through preferential deubiquitination of K63 linked ubiquitin chains."
28923280
biogrid
No evidence text available
18281465
biogrid
No evidence text available
18281465
ZRANB1 binds HECTD1 and APC. 1 / 1
| 1
reach
"Additionally, it was shown that the Trabid, Hectd1, and APC complex interacts with proteins composing the striatin interacting phosphatase and kinase (STRIPAK) complex that regulates cortical actin cytoskeleton dynamics [XREF_BIBR]."
29299163
APC activates ZRANB1.
| 1
APC activates ZRANB1. 1 / 1
| 1
reach
"Although it is not clear if APC is the sole target of Trabid, this finding is consistent with the suggestion that K63 linked ubiquitination of APC antagonizes Wnt signaling, presumably by potentiating APC activity."
23256519
ZRANB1 affects MIB2
| 4 3
ZRANB1 binds MIB2. 4 / 4
| 4
reach
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF dependent substrate ubiquitylation."
24714733
reach
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
reach
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
Gag affects ZRANB1
| 6
ZRANB1 binds gag. 2 / 2
| 2
sparser
"To understand the structural basis of selective interaction between TRABID NZF1 and K29 chains, we determined the structure of TRABID NZF1 in complex with K29-linked diUb."
25752573
sparser
"K29 is in close proximity to the tail of the distal Ub, and it is conceivable that K29-linked polymers interact with TRABID NZF1 in a similar manner and can form similar filaments."
25752577
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
ZRANB1 binds UBD and gag. 1 / 1
| 1
sparser
"We found that the TRABID N terminus, which contains three Npl4-type zinc finger (NZF) UBDs, specifically binds K29- and K33-linked diUb, and specificity can be attributed to the first NZF domain (NZF1)."
25752577
ZRANB1 binds pol and gag. 1 / 1
| 1
sparser
"Indeed, mutation of T14, Y15, or M26 to alanine is sufficient to disrupt the binding of TRABID NZF1 to K29 and K33 chains ( xref E)."
25752573
ZRANB1 affects Wnt
| 5
ZRANB1 activates Wnt.
| 3
ZRANB1 activates Wnt. 3 / 3
| 3
reach
"Although Trabid was first reported to activate the Wnt pathway by cleavage of the K63 linked chains, it was recently demonstrated to be 40-fold more active toward the K29 linked chains."
21118991
reach
"TRABID, one of K63 specific DUB enzymes, became an attractive candidate to achieve this task since it has been reported to regulate Wnt signal positively [XREF_BIBR], as inhibition of TRABID presumably decreases Wnt signaling activity."
22584113
reach
"However, in this study, we failed to confirm the notion that TRABID positively regulates canonical Wnt signaling based on several lines of evidence."
22584113
ZRANB1 inhibits Wnt.
| 1
ZRANB1 inhibits Wnt. 1 / 1
| 1
reach
"Knockdown of TRABID with RNAi resulted in downregulated expression of canonical Wnt target genes and decreased Wnt transcription activity, whereas its knockdown does not affect TNF-2 pathway [XREF_BIBR]."
22584113
ZRANB1 decreases the amount of Wnt.
| 1
ZRANB1 decreases the amount of Wnt. 1 / 1
| 1
reach
"Secondly, the TRABID shRNAs failed to downregulate Wnt and beta-catenin-mediated transcription activity or endogenous Wnt target gene Axin2 mRNA levels in these tumor cells."
22584113
ZRANB1 affects Ubiquitin
| 1 4
Ubiquitin binds ZRANB1. 3 / 3
| 1 2
sparser
"Although TRABID NZF1 interacts with both proximal and distal Ub, it does not directly recognize the K29-linked isopeptide bond of the diUb."
25752573
reach
"The proximal Ub is bound by TRABID NZF1 in an unusual way, at a binding site involving the start of the Ub alpha helix and two nearby loop regions (XREF_FIG A)."
25752577
sparser
"Thus in the NZF1 of TRABID, residues T14, Y15, and M26 interact with the distal Ub, and these residues are conserved in evolution ( xref D)."
25752573
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
Ubiquitin binds ZRANB1 and ANK. 1 / 1
| 1
sparser
"This confirmed that the Ank domain of TRABID interacts with Ub."
22157957
ZRANB1 affects USP9X
| 1 4
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP9X binds ZRANB1. 1 / 1
| 1
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP1 binds USP9X and ZRANB1. 1 / 1
| 1
sparser
"In this study, we demonstrated that Usp1, Usp9 and Trabid are interacting proteins of Mib and Mib2 by yeast two-hybrid and immunoprecipitation."
24714733
ZRANB1 affects USP1
| 1 4
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP1 binds ZRANB1. 1 / 1
| 1
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X and ZRANB1. 1 / 1
| 1
sparser
"In this study, we demonstrated that Usp1, Usp9 and Trabid are interacting proteins of Mib and Mib2 by yeast two-hybrid and immunoprecipitation."
24714733
ZRANB1 affects TRAF6
2 1 | 1
TRAF6 binds ZRANB1. 3 / 4
2 1 |
biogrid
No evidence text available
11463333
hprd
No evidence text available
11463333
biogrid
No evidence text available
20622874
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
ZRANB1 affects KDM4D
| 5
ZRANB1 deubiquitinates KDM4D.
| 2
ZRANB1 leads to the deubiquitination of KDM4D. 2 / 2
| 2
reach
"When transfected into HEK293 cells, wild-type Trabid, but not C443A Trabid, inhibited Jmjd2d ubiquitination (XREF_FIG), and the transfected Jmjd2d was abundantly conjugated with both K11- and K29 linked polyubiquitin chains (XREF_FIG)."
26808229
reach
"DC-cKO BMDCs had markedly more abundant Jmjd2d ubiquitination than the wild-type BMDCs (XREF_FIG), suggesting that Trabid negatively regulated Jmjd2d ubiquitination."
26808229
ZRANB1 ubiquitinates KDM4D.
| 1
ZRANB1-C443A leads to the ubiquitination of KDM4D. 1 / 1
| 1
reach
"When transfected into HEK293 cells, wild-type Trabid, but not C443A Trabid, inhibited Jmjd2d ubiquitination (XREF_FIG), and the transfected Jmjd2d was abundantly conjugated with both K11- and K29 linked polyubiquitin chains (XREF_FIG)."
26808229
ZRANB1 binds KDM4D.
| 1
ZRANB1-C443A binds KDM4D. 1 / 1
| 1
reach
"Furthermore, both wild-type and C443A Trabid physically associated with endogenous Jmjd2d in reconstituted KO MEFs (XREF_FIG and XREF_SUPPLEMENTARY)."
26808229
ZRANB1 activates KDM4D.
| 1
ZRANB1 activates KDM4D. 1 / 1
| 1
reach
"TRABID promotes experimental autoimmune encephalitis (EAE) by stabilizing JMJD2D at the Il12 promoter, enhancing IL-12 production and immunopathology (91)."
31214161
Ubiquitin affects ZRANB1
| 1 4
Ubiquitin binds ZRANB1. 3 / 3
| 1 2
sparser
"Although TRABID NZF1 interacts with both proximal and distal Ub, it does not directly recognize the K29-linked isopeptide bond of the diUb."
25752573
reach
"The proximal Ub is bound by TRABID NZF1 in an unusual way, at a binding site involving the start of the Ub alpha helix and two nearby loop regions (XREF_FIG A)."
25752577
sparser
"Thus in the NZF1 of TRABID, residues T14, Y15, and M26 interact with the distal Ub, and these residues are conserved in evolution ( xref D)."
25752573
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
Ubiquitin binds ZRANB1 and ANK. 1 / 1
| 1
sparser
"This confirmed that the Ank domain of TRABID interacts with Ub."
22157957
USP9X affects ZRANB1
| 1 4
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP9X binds ZRANB1. 1 / 1
| 1
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP1 binds USP9X and ZRANB1. 1 / 1
| 1
sparser
"In this study, we demonstrated that Usp1, Usp9 and Trabid are interacting proteins of Mib and Mib2 by yeast two-hybrid and immunoprecipitation."
24714733
USP1 affects ZRANB1
| 1 4
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP1 binds ZRANB1. 1 / 1
| 1
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X and ZRANB1. 1 / 1
| 1
sparser
"In this study, we demonstrated that Usp1, Usp9 and Trabid are interacting proteins of Mib and Mib2 by yeast two-hybrid and immunoprecipitation."
24714733
TRAF6 affects ZRANB1
2 1 | 1
TRAF6 binds ZRANB1. 3 / 4
2 1 |
biogrid
No evidence text available
11463333
hprd
No evidence text available
11463333
biogrid
No evidence text available
20622874
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
Pol affects ZRANB1
| 4
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
ZRANB1 binds pol and gag. 1 / 1
| 1
sparser
"Indeed, mutation of T14, Y15, or M26 to alanine is sufficient to disrupt the binding of TRABID NZF1 to K29 and K33 chains ( xref E)."
25752573
ZRANB1 binds pol. 1 / 1
| 1
sparser
"Validation of the TRABID-K33 Chain Interaction."
25752577
reach
"However, non TNBC cell lines, T47D (ER+HER 2-), ZR75-1 (ER+HER 2+), SKBR3 (ER-HER2+), and MCF7 (ER+HER 2-), showed variable responses : knockdown of ZRANB1 inhibited the proliferation of SKBR3 and MCF7 cells, but not T47D and ZR75-1 cells, even though EZH2 was downregulated (XREF_SUPPLEMENTARY)."
29669287
reach
"Ectopic expression of ZRANB1 in both LM2 cells (XREF_FIG) and HEK293T cells (XREF_SUPPLEMENTARY) markedly upregulated endogenous EZH2 protein and increased cell proliferation, which could be reversed by knockdown of EZH2."
29669287
reach
"TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells."
35944360
ZRANB1 inhibits cell population proliferation. 1 / 1
| 1
reach
"In contrast, depletion of ZRANB1 in TNBC cells markedly suppressed cell proliferation and migration and induced apoptosis, and systemic delivery of nanoliposome encapsulated ZRANB1 siRNA led to pronounced anticancer effects in xenograft models of TNBC, suggesting that ZRANB1 could be a novel therapeutic target."
29669287
ZRANB1 affects UVRAG
1 | 2 1
ZRANB1 binds UVRAG.
| 1 1
UVRAG binds ZRANB1 and ATG14. 1 / 1
| 1
sparser
"Immunoprecipitation analysis revealed the association of TRABID with both ATG14 and UVRAG, along with the common subunits of VPS34 complex, in cells cultured in DMEM or EBSS (Supplementary Fig.  xref )."
33637724
UVRAG binds ZRANB1. 1 / 1
| 1
reach
"Furthermore, GFP-ATG14 and GFP-UVRAG interacted with endogenous TRABID in transfected cells and these associations were not affected by starvation."
33637724
ZRANB1 inhibits UVRAG.
| 1
ZRANB1 inhibits UVRAG. 1 / 1
| 1
reach
"Among the subunits of VPS34 complex, TRABID overexpression reduced the ubiquitination level of transfected and endogenous VPS34, but not AMBRA1, Beclin-1, ATG14 and UVRAG."
33637724
ZRANB1 deubiquitinates UVRAG.
1 |
ZRANB1 deubiquitinates UVRAG. 1 / 1
1 |
ubibrowser
"However, the deubiquitinase ZRANB1 specifically cleaves SMURF1-induced K29 and K33-linked polyubiquitin chains from UVRAG, thereby increasing the binding of UVRAG to RUBCN and inhibiting autophagy flux."
30686098
ZRANB1 affects PHF20
| 4
PHF20 binds ZRANB1. 2 / 2
| 2
sparser
"The NZF domains however provide increased affinity for longer TRABID substrates that can bind simultaneously to AnkOTU and NZF domains ( xref )."
22157957
sparser
"The NZF domain of TRABID interacts with the I44-centered hydrophobic patch on the distal Ub ( xref B and 4C)."
25752573
PHF20 binds TAB2 and ZRANB1. 1 / 1
| 1
sparser
"For example, NZF domains of TAB2 (TAK1 binding protein 2) or TRABID (TRAF binding domain) preferentially bind to Lys63- over Lys48-linked ubiquitin chains xref ."
19773779
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
ZRANB1 affects Neoplasm Metastasis
| 1 3
ZRANB1 activates Neoplasm Metastasis.
| 1 2
eidos
"We also demonstrated that ZRANB1 knockdown downregulated the expression of LOXL2 and suppressed HCC growth and metastasis in vitro and in vivo ."
34765294
reach
"More importantly, ZRANB1 regulated LOXL2 through specificity protein 1 (SP1) and SP1 overexpression rescued the suppression of HCC growth and metastasis induced by ZRANB1 knockdown."
34765294
ZRANB1 bound to EZH2 activates Neoplasm Metastasis. 1 / 1
| 1
reach
"They demonstrated that ZRANB1 can bind, deubiquitinate, and stabilize EZH2, which enhances breast cancer tumorigenesis and metastasis."
33308321
ZRANB1 inhibits Neoplasm Metastasis.
| 1
ZRANB1 inhibits Neoplasm Metastasis. 1 / 1
| 1
reach
"The reintroduction of Trabid expression in tumor cells significantly decreases HCC progression as well as pulmonary metastasis."
29748601
ZRANB1 affects IL23A
| 4
ZRANB1 activates IL23A.
| 3
ZRANB1 activates IL23A. 2 / 2
| 2
reach
"DC-conditional deletion of Trabid impairs IL-12 and IL-23 production in DCs and the generation of Th1 and Th17 subsets of inflammatory T cells, rendering mice refractory to the induction of EAE 180."
27012466
reach
"Collectively, these results suggest that Trabid mediates induction of IL-12 and IL-23, thereby promoting T H 1 and T H 17 differentiation."
26808229
ZRANB1-C443A activates IL23A. 1 / 1
| 1
reach
"In similar experiments using BMDCs, reconstitution of DC-cKO BMDCs with wild-type Trabid, but not C443A Trabid, rescued the induction of Il12a, Il12b, and Il23a genes (XREF_FIG)."
26808229
ZRANB1 increases the amount of IL23A.
| 1
ZRANB1 increases the amount of IL23A. 1 / 1
| 1
reach
"Deletion of Zranb1, the gene encoding Trabid, in dendritic cells inhibited the induction of IL-12 and IL-23 expression by Toll like receptors (TLR), impairing the differentiation of inflammatory T cells and protecting mice from autoimmune inflammation."
26808229
ZRANB1 affects HIF1AN
| 1 3
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
HIF1AN binds ZRANB1. 1 / 1
| 1
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
ZRANB1 affects GST
| 4
GST binds ZRANB1. 3 / 3
| 3
sparser
"Polyubiquitinated His 6 -HECTD1 CD , generated in vitro , could be efficiently enriched for by GST-TRABID NZF 1 to 3 pull-down but not GST alone ( xref D , lane 14 versus 9)."
| PMC
sparser
"GST-TRABID NZF 1 to 3 pull-down showed a faint signal for HERC2 further suggestive of a very weak interaction ( xref A )."
| PMC
sparser
"GST-TRABID NZF 1 to 3, but not its ubiquitin binding deficient mutant GST-TRABID NZF 1 to 3 TY>LV nor GST alone, could enrich for high-molecular-weight ubiquitin chains as well as endogenous HECTD1 ( xref A , lane 3)."
| PMC
GST binds TWIST1 and ZRANB1. 1 / 1
| 1
sparser
"We also demonstrated that Trabid mainly interacted with the FL and the 169–202 amino acid fragment (Twist1 box domain) of GST-Twist1, but not with other Twist1 fragments and GST alone (Fig.  xref )."
29748601
ZRANB1 affects DDB2
| 2 2
ZRANB1 binds DDB2.
| 1 2
ZRANB1 binds DDB2. 2 / 2
| 2
sparser
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
sparser
"Thus, our data revealed a critical role of the TRABID-DDB2 axis in the proliferation of hepatocellular carcinoma cells."
35944360
ZRANB1 binds DDB2 and OTU domain. 1 / 1
| 1
reach
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
ZRANB1 deubiquitinates DDB2.
| 1
ZRANB1 deubiquitinates DDB2. 1 / 1
| 1
reach
"Furthermore, TRABID deubiquitinates DDB2, and this deubiquitination effect of TRABID depends on its active site."
35944360
ZRANB1 affects ATG14
| 3 1
ZRANB1 binds ATG14.
| 1 1
UVRAG binds ZRANB1 and ATG14. 1 / 1
| 1
sparser
"Immunoprecipitation analysis revealed the association of TRABID with both ATG14 and UVRAG, along with the common subunits of VPS34 complex, in cells cultured in DMEM or EBSS (Supplementary Fig.  xref )."
33637724
ZRANB1 binds ATG14. 1 / 1
| 1
reach
"Furthermore, GFP-ATG14 and GFP-UVRAG interacted with endogenous TRABID in transfected cells and these associations were not affected by starvation."
33637724
ZRANB1 inhibits ATG14.
| 1
ZRANB1 inhibits ATG14. 1 / 1
| 1
reach
"Among the subunits of VPS34 complex, TRABID overexpression reduced the ubiquitination level of transfected and endogenous VPS34, but not AMBRA1, Beclin-1, ATG14 and UVRAG."
33637724
ZRANB1 activates ATG14.
| 1
ZRANB1 activates ATG14. 1 / 1
| 1
reach
"However, TRABID knockdown diminished DFCP1 puncta, ATG16 puncta, and ATG14 puncta."
33637724
USP9X affects USP1
| 4
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP1 binds USP9X and ZRANB1. 1 / 1
| 1
sparser
"In this study, we demonstrated that Usp1, Usp9 and Trabid are interacting proteins of Mib and Mib2 by yeast two-hybrid and immunoprecipitation."
24714733
PIK3C3 affects ZRANB1
| 4
ZRANB1 binds PIK3C3. 3 / 3
| 3
sparser
"Consistent with the deubiquitination effect of TRABID on VPS34, endogenous TRABID interacted with endogenous VPS34 (Fig.  xref )."
33637724
sparser
"Furthermore, baculovirally purified recombinant TRABID and VPS34 interacted in vitro (Fig.  xref )."
33637724
sparser
"The interaction of TRABID with VPS34, however, was not altered under these conditions (Supplementary Fig.  xref )."
33637724
ZRANB1 binds RUBCN and PIK3C3. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
PIEZO1 affects ZRANB1
| 4
PIEZO1 binds ZRANB1.
| 3
ZRANB1 binds PIEZO1. 3 / 3
| 3
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
reach
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
reach
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF dependent substrate ubiquitylation."
24714733
PIEZO1 ubiquitinates ZRANB1.
| 1
PIEZO1 ubiquitinates ZRANB1. 1 / 1
| 1
reach
"Both Mib and Mib2 can ubiquitylate Trabid and Fih-1, indicating a potential regulating role of Mib and Mib2 on Trabid and Fih-1 and, furthermore, the possible involvement of Notch signaling in hypoxia regulated differentiation, tumorigenesis and NF-kappaB pathway."
24714733
PHF20 affects ZRANB1
| 4
PHF20 binds ZRANB1. 2 / 2
| 2
sparser
"The NZF domains however provide increased affinity for longer TRABID substrates that can bind simultaneously to AnkOTU and NZF domains ( xref )."
22157957
sparser
"The NZF domain of TRABID interacts with the I44-centered hydrophobic patch on the distal Ub ( xref B and 4C)."
25752573
PHF20 binds TAB2 and ZRANB1. 1 / 1
| 1
sparser
"For example, NZF domains of TAB2 (TAK1 binding protein 2) or TRABID (TRAF binding domain) preferentially bind to Lys63- over Lys48-linked ubiquitin chains xref ."
19773779
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
ZRANB1 is modified
| 4
ZRANB1 is phosphorylated.
| 3
ZRANB1 is phosphorylated on S78. 1 / 1
| 1
sparser
"Notably, the stimulating effect of AKT on the activity of Trabid was substantially inhibited by S78A/T117A mutation (Fig.  xref ), suggesting that the phosphorylation of Trabid at S78 and T117 is an important regulatory mechanism for its activity."
29748601
ZRANB1 is phosphorylated on T117. 1 / 1
| 1
sparser
"Notably, the stimulating effect of AKT on the activity of Trabid was substantially inhibited by S78A/T117A mutation (Fig.  xref ), suggesting that the phosphorylation of Trabid at S78 and T117 is an important regulatory mechanism for its activity."
29748601
ZRANB1 is phosphorylated. 1 / 1
| 1
sparser
"In vitro kinase assay clearly demonstrated that co-incubation of recombinant Trabid and activated AKT led to Trabid phosphorylation (Fig.  xref )."
29748601
ZRANB1 is ubiquitinated.
| 1
ZRANB1 is ubiquitinated. 1 / 1
| 1
sparser
"Both Mib and Mib2 can ubiquitylate Trabid and Fih-1, indicating a potential regulating role of Mib and Mib2 on Trabid and Fih-1 and, furthermore, the possible involvement of Notch signaling in hypoxia-regulated differentiation, tumorigenesis and NF-κB pathway."
24714733
HIF1AN affects ZRANB1
| 1 3
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
HIF1AN binds ZRANB1. 1 / 1
| 1
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
GST affects ZRANB1
| 4
GST binds ZRANB1. 3 / 3
| 3
sparser
"Polyubiquitinated His 6 -HECTD1 CD , generated in vitro , could be efficiently enriched for by GST-TRABID NZF 1 to 3 pull-down but not GST alone ( xref D , lane 14 versus 9)."
| PMC
sparser
"GST-TRABID NZF 1 to 3 pull-down showed a faint signal for HERC2 further suggestive of a very weak interaction ( xref A )."
| PMC
sparser
"GST-TRABID NZF 1 to 3, but not its ubiquitin binding deficient mutant GST-TRABID NZF 1 to 3 TY>LV nor GST alone, could enrich for high-molecular-weight ubiquitin chains as well as endogenous HECTD1 ( xref A , lane 3)."
| PMC
GST binds TWIST1 and ZRANB1. 1 / 1
| 1
sparser
"We also demonstrated that Trabid mainly interacted with the FL and the 169–202 amino acid fragment (Twist1 box domain) of GST-Twist1, but not with other Twist1 fragments and GST alone (Fig.  xref )."
29748601
FAM83C-AS1 affects ZRANB1
| 4
FAM83C-AS1 binds ZRANB1.
| 3
ZRANB1 binds FAM83C-AS1. 3 / 3
| 3
reach
"Based on molecular mechanism related assays, we concluded that FAM83C-AS1 binding to ZRANB1 promoted EZH2 deubiquitination and thereby inhibited EZH2 downregulation, which led to the enhanced protein stability of EZH2 in CRC tumor cells."
33109776
reach
"Our data thus demonstrate that FAM83C-AS1 binds to ZRANB1 and stabilizes EZH2 protein in CRCs."
33109776
reach
"Subsequent RIP assays further validated that FAM83C-AS1 bound to ZRANB1 in RKO and SW620 cells (XREF_FIG)."
33109776
FAM83C-AS1 inhibits ZRANB1.
| 1
FAM83C-AS1 inhibits ZRANB1. 1 / 1
| 1
reach
"Moreover, CoIP assay indicated that FAM83C-AS1 depletion inhibited the association of ZRANB1 with EZH2 (XREF_FIG)."
33109776
CSNK1A1 affects ZRANB1
| 2 2
CSNK1A1 phosphorylates ZRANB1 on S209. 2 / 2
| 1 1
reach
"Interestingly, ZRANB1 is phosphorylated at Thr35, and Ser209 residues by CSNK1A1, and this phosphorylation activates its deubiquitinating activity."
30686098
sparser
"Interestingly, ZRANB1 is phosphorylated at Thr35, and Ser209 residues by CSNK1A1, and this phosphorylation activates its deubiquitinating activity."
30686098
CSNK1A1 phosphorylates ZRANB1 on T35. 2 / 2
| 1 1
reach
"Interestingly, ZRANB1 is phosphorylated at Thr35, and Ser209 residues by CSNK1A1, and this phosphorylation activates its deubiquitinating activity."
30686098
sparser
"Interestingly, ZRANB1 is phosphorylated at Thr35, and Ser209 residues by CSNK1A1, and this phosphorylation activates its deubiquitinating activity."
30686098
Valproic acid affects ZRANB1
3 |
Valproic acid decreases the amount of ZRANB1.
2 |
Valproic acid decreases the amount of ZRANB1. 2 / 2
2 |
ctd
No evidence text available
28001369
ctd
No evidence text available
23179753
Valproic acid increases the amount of ZRANB1.
1 |
Valproic acid increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
29154799
Pol affects gag
| 3
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
ZRANB1 binds pol and gag. 1 / 1
| 1
sparser
"Indeed, mutation of T14, Y15, or M26 to alanine is sufficient to disrupt the binding of TRABID NZF1 to K29 and K33 chains ( xref E)."
25752573
eidos
"TRABID diminishes the K29 / K48 ubiquitination on VPS34 and promotes autophagosome maturation ."
33637724
eidos
"Thus , besides autophagosome formation , TRABID promotes autophagosome maturation ."
33637724
eidos
"We found that TRABID knockdown decreased autophagosome maturation into autolysosome , whereas TRABID overexpression enhanced it ( Fig. 2n , o and Supplementary Fig. 2j , k ) ."
33637724
ZRANB1 activates apoptotic process.
| 2
ZRANB1 activates apoptotic process. 2 / 2
| 2
reach
"In contrast, depletion of ZRANB1 in TNBC cells markedly suppressed cell proliferation and migration and induced apoptosis, and systemic delivery of nanoliposome encapsulated ZRANB1 siRNA led to pronounced anticancer effects in xenograft models of TNBC, suggesting that ZRANB1 could be a novel therapeutic target."
29669287
reach
"Moreover, ZRANB1 knockdown reduced glaucoma induced RGC apoptosis."
29748605
ZRANB1 inhibits apoptotic process.
| 1
reach
"In addition, knockdown of ZRANB1 in MDA-MB-231 cells increased early apoptosis and late apoptosis (cell death) by 3-fold and 9-fold, respectively (XREF_SUPPLEMENTARY)."
29669287
ZRANB1 affects SUZ12
| 1 2
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
SUZ12 binds ZRANB1. 1 / 1
| 1
reach
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 (XREF_SUPPLEMENTARY) and, reciprocally, the interaction of either exogenous (XREF_SUPPLEMENTARY) or endogenous (XREF_FIG) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
SUZ12 binds ZRANB1 and EZH2. 1 / 1
| 1
sparser
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 ( xref ) and, reciprocally, the interaction of either exogenous ( xref ) or endogenous ( xref ) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
ZRANB1 affects STRN4
3 |
STRN4 binds ZRANB1. 3 / 3
3 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
ZRANB1 affects STRN
3 |
STRN binds ZRANB1. 3 / 3
3 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
ZRANB1 affects PIEZO1
| 3
ZRANB1 binds PIEZO1. 3 / 3
| 3
reach
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib and Mib2 were confirmed by immunoprecipitation."
24714733
reach
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
reach
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF dependent substrate ubiquitylation."
24714733
ZRANB1 affects NZF1
| 3
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
ZRANB1 binds NZF1. 1 / 1
| 1
sparser
"Interestingly, these short vOTU-resistant chains stayed bound to the Halo-TRABID NZF1 bead fraction, while the supernatant contained only monoUb ( xref D and xref B)."
25752573
ZRANB1 affects MAP1LC3
| 3
ZRANB1 activates MAP1LC3. 3 / 3
| 3
reach
"Remarkably, UBE3C depletion induced upregulation of VPS34 expression, LC3 puncta and LC3 lipidation in cells cultured in DMEM or EBSS were all reversed by TRABID knockdown."
33637724
reach
"Accordingly, LC3 lipidation was also enhanced by TRABID overexpression in DMEM- or EBSS cultured cells treated with bafilomycin A1."
33637724
reach
"Furthermore, in cells treated with bafilomycin A1 to block autophagic turnover, TRABID knockdown still reduced LC3 lipidation but did not alter p62 level, indicating a promoting role of TRABID in autophagosome formation."
33637724
ZRANB1 affects FAM83C-AS1
| 3
ZRANB1 binds FAM83C-AS1. 3 / 3
| 3
reach
"Based on molecular mechanism related assays, we concluded that FAM83C-AS1 binding to ZRANB1 promoted EZH2 deubiquitination and thereby inhibited EZH2 downregulation, which led to the enhanced protein stability of EZH2 in CRC tumor cells."
33109776
reach
"Our data thus demonstrate that FAM83C-AS1 binds to ZRANB1 and stabilizes EZH2 protein in CRCs."
33109776
reach
"Subsequent RIP assays further validated that FAM83C-AS1 bound to ZRANB1 in RKO and SW620 cells (XREF_FIG)."
33109776
TFAP4 affects ZRANB1
3 |
TFAP4 decreases the amount of ZRANB1. 3 / 3
3 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
SUZ12 affects ZRANB1
| 1 2
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
SUZ12 binds ZRANB1. 1 / 1
| 1
reach
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 (XREF_SUPPLEMENTARY) and, reciprocally, the interaction of either exogenous (XREF_SUPPLEMENTARY) or endogenous (XREF_FIG) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
SUZ12 binds ZRANB1 and EZH2. 1 / 1
| 1
sparser
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 ( xref ) and, reciprocally, the interaction of either exogenous ( xref ) or endogenous ( xref ) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
STRN4 affects ZRANB1
3 |
STRN4 binds ZRANB1. 3 / 3
3 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
STRN affects ZRANB1
3 |
STRN binds ZRANB1. 3 / 3
3 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
NZF1 affects ZRANB1
| 3
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
ZRANB1 binds NZF1. 1 / 1
| 1
sparser
"Interestingly, these short vOTU-resistant chains stayed bound to the Halo-TRABID NZF1 bead fraction, while the supernatant contained only monoUb ( xref D and xref B)."
25752573
DDB2 affects ZRANB1
| 1 2
ZRANB1 binds DDB2. 2 / 2
| 2
sparser
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
sparser
"Thus, our data revealed a critical role of the TRABID-DDB2 axis in the proliferation of hepatocellular carcinoma cells."
35944360
ZRANB1 binds DDB2 and OTU domain. 1 / 1
| 1
reach
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
AKT affects ZRANB1
| 3
AKT phosphorylates ZRANB1. 3 / 3
| 3
sparser
"An AKT phosphorylation motif (R × × S/T) antibody further confirmed the phosphorylation of Trabid by AKT, while lambda phosphatase eliminated the reactivity of Trabid with this antibody (Fig.  xref )."
29748601
sparser
"Here, our observation that phosphorylation of Trabid by AKT is required for β-TrCP1-mediated Twist1 ubiquitination and degradation, maybe provide an explanation about how AKT inhibits EMT."
29748601
sparser
"Then we studied whether phosphorylation of Trabid by AKT was required for its DUB activity toward K63 ubiquitination of Twist1."
29748601
Succimer affects ZRANB1
2 |
Succimer decreases the amount of ZRANB1. 2 / 2
2 |
ctd
No evidence text available
21641980
ctd
No evidence text available
26378955
Pol affects NZF1
| 2
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
Magnetite nanoparticle decreases the amount of ZRANB1. 2 / 2
2 |
ctd
No evidence text available
26378955
ctd
No evidence text available
21641980
Hsa-miR-933 affects ZRANB1
2 |
Hsa-miR-933 decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-892a affects ZRANB1
2 |
Hsa-miR-892a decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-6867-5p affects ZRANB1
2 |
Hsa-miR-6867-5p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-574-5p affects ZRANB1
2 |
Hsa-miR-574-5p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-548x-3p affects ZRANB1
2 |
Hsa-miR-548x-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548j-3p affects ZRANB1
2 |
Hsa-miR-548j-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548g-3p affects ZRANB1
2 |
Hsa-miR-548g-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548f-3p affects ZRANB1
2 |
Hsa-miR-548f-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-548e-3p affects ZRANB1
2 |
Hsa-miR-548e-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548az-3p affects ZRANB1
2 |
Hsa-miR-548az-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548ar-3p affects ZRANB1
2 |
Hsa-miR-548ar-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-548aq-3p affects ZRANB1
2 |
Hsa-miR-548aq-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548am-3p affects ZRANB1
2 |
Hsa-miR-548am-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-548aj-3p affects ZRANB1
2 |
Hsa-miR-548aj-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-548ah-3p affects ZRANB1
2 |
Hsa-miR-548ah-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
27418678
biopax:mirtarbase
No evidence text available
24906430
Hsa-miR-548ae-3p affects ZRANB1
2 |
Hsa-miR-548ae-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-548a-3p affects ZRANB1
2 |
Hsa-miR-548a-3p decreases the amount of ZRANB1. 2 / 2
2 |
biopax:mirtarbase
No evidence text available
24906430
biopax:mirtarbase
No evidence text available
27418678
Gag affects NZF1
| 2
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
ZRANB1 activates interleukin-23 production. 2 / 2
| 2
reach
"Conditional deletion of Zranb1 in dendritic cells impairs IL-12 and IL-23 production and the generation of T 1 and T 17 subsets of inflammatory T cells, rendering mice refractory to the induction of experimental autoimmune encephalomyelitis (EAE) ."
28959952
reach
"Conditional deletion of Zranb1 in dendritic cells impairs IL-12 and IL-23 production and the generation of T H 1 and T H 17 subsets of inflammatory T cells, rendering mice refractory to the induction of experimental autoimmune encephalomyelitis (EAE) 191 ."
28959952
ZRANB1 affects immune response
| 2
reach
"Genetic or pharmacological inhibition of TRABID promotes anti-tumor immune surveillance and sensitizes tumors to anti-PD-1 therapy in preclinical cancer models in male mice."
37237031
reach
"TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation."
37237031
ZRANB1 affects cell growth
| 1 1
ZRANB1 inhibits cell growth.
| 1
ZRANB1 inhibits cell growth. 1 / 1
| 1
sparser
"The observation that the TRABID inhibitors were able to inhibit cell growth suggests that TRABID may have a role in cell growth regulation."
22584113
ZRANB1 activates cell growth.
| 1
ZRANB1 activates cell growth. 1 / 1
| 1
reach
"Nevertheless, inhibition of TRABID may inhibit cell growth."
22584113
ZRANB1 affects USP39
| 1 1
ZRANB1 binds USP39. 2 / 2
| 1 1
reach
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article shows instead the interaction between ZRANB1 and USP39."
23118479
sparser
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article ( xref ) shows instead the interaction between ZRANB1 and USP39."
23118479
ZRANB1 affects TUMOR-SUPPRESSOR-PROTEIN
| 2
ZRANB1 deubiquitinates TUMOR-SUPPRESSOR-PROTEIN.
| 1
ZRANB1 deubiquitinates TUMOR-SUPPRESSOR-PROTEIN. 1 / 1
| 1
trips
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription."
18281465
ZRANB1 binds TUMOR-SUPPRESSOR-PROTEIN.
| 1
ZRANB1 binds TUMOR-SUPPRESSOR-PROTEIN. 1 / 1
| 1
trips
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription."
18281465
ZRANB1 affects TRAF
| 2
ZRANB1 binds TRAF. 2 / 2
| 2
reach
"Structural and biochemical analysis suggests a novel architecture of the catalytic triad, which might be present in a subset of OTU domains including Cezanne and TRABID (TRAF binding domain)."
17961127
reach
"We report two novel genes, Cezanne (cellular zinc finger anti-NF-kappa B) and TRABID (TRAF binding domain), with sequence similarity to A20."
11463333
ZRANB1 affects TAB2
| 2
PHF20 binds TAB2 and ZRANB1. 1 / 1
| 1
sparser
"For example, NZF domains of TAB2 (TAK1 binding protein 2) or TRABID (TRAF binding domain) preferentially bind to Lys63- over Lys48-linked ubiquitin chains xref ."
19773779
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
ZRANB1 affects STRN3
2 |
STRN3 binds ZRANB1. 2 / 2
2 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
ZRANB1 affects STRIP1
2 |
ZRANB1 binds STRIP1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
ZRANB1 affects SP1
| 1 1
SP1 binds ZRANB1. 2 / 2
| 1 1
sparser
"Mechanistically, ZRANB1 bound with SP1 directly and stabilized the SP1 protein by deubiquitinating it."
34765294
reach
"Mechanistically, ZRANB1 bound with SP1 directly and stabilized the SP1 protein by deubiquitinating it."
34765294
ZRANB1 affects SLMAP
2 |
SLMAP binds ZRANB1. 2 / 2
2 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
ZRANB1 affects RUBCN
| 2
ZRANB1 binds RUBCN and PIK3C3. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
ZRANB1 binds RUBCN. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
ZRANB1 affects PBLD
2 |
ZRANB1 binds PBLD. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
ZRANB1 affects OTU domain
| 2
ZRANB1 binds DDB2 and OTU domain. 1 / 1
| 1
reach
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
ZRANB1 binds NSC267309 and OTU domain. 1 / 1
| 1
reach
"The molecular modeling of the bindings of NSC112200, NSC267309 and NSC60650 to TRABID OTU domain suggests that while all three compounds can form electrostatic interactions with the side chain of E522 and the backbone NH of T556, both NSC112200 and NSC267309 can form an additional hydrogen bond with the side chain of S491."
22584113
ZRANB1 affects MITF
| 1 1
ZRANB1 ubiquitinates MITF.
| 1
ZRANB1 leads to the ubiquitination of MITF. 1 / 1
| 1
reach
"However, the deubiquitinase ZRANB1 rescued MITF ubiquitination and degradation."
35092699
ZRANB1 binds MITF.
| 1
ZRANB1 binds MITF. 1 / 1
| 1
sparser
"Significantly, WT‐CLK4 disrupted the interaction between ZRANB1 and MITF (Figure  xref )."
35092699
ZRANB1 affects MAP3K7
| 2
ZRANB1 deubiquitinates MAP3K7.
| 1
ZRANB1 leads to the deubiquitination of MAP3K7. 1 / 1
| 1
reach
"Trabid has also been shown to interact with and inhibits K63 ubiquitination of Drosophila TAK1, reducing the expression of downstream genes encoding antimicrobial peptides in flies 42."
26808229
ZRANB1 binds MAP3K7.
| 1
ZRANB1 binds MAP3K7. 1 / 1
| 1
reach
"The deubiquitinase Trabid interacted with TAK1, reducing immune signalling output and K63 linked ubiquitination."
24586180
ZRANB1 affects LOXL2
| 1 1
ZRANB1 increases the amount of LOXL2.
| 1
ZRANB1 increases the amount of LOXL2. 1 / 1
| 1
reach
"We also demonstrated that ZRANB1 knockdown downregulated the expression of LOXL2 and suppressed HCC growth and metastasis in vitro and in vivo ."
34765294
ZRANB1 activates LOXL2.
| 1
ZRANB1 activates LOXL2. 1 / 1
| 1
eidos
"We also demonstrated that ZRANB1 knockdown downregulated the expression of LOXL2 and suppressed HCC growth and metastasis in vitro and in vivo ."
34765294
ZRANB1 affects K33
| 2
ZRANB1 binds K29- and K33. 2 / 2
| 2
reach
"We found that the TRABID N terminus, which contains three Npl4-type zinc finger (NZF) UBDs, specifically binds K29- and K33 linked diUb, and specificity can be attributed to the first NZF domain (NZF1)."
25752577
reach
"TRABID NZF1 Specifically Binds K29- and K33 Linked Chains."
25752577
ZRANB1 affects Il23
| 2
ZRANB1 inhibits Il23.
| 1
ZRANB1 inhibits Il23. 1 / 1
| 1
reach
"By employing a gene targeting approach, we show that Trabid deficiency in DCs and macrophages impaired the induction of Il12 and Il23 genes without affecting the induction of many other cytokine genes."
26808229
ZRANB1 increases the amount of Il23.
| 1
ZRANB1 increases the amount of Il23. 1 / 1
| 1
reach
"Deletion of Zranb1 (which encodes Trabid) in dendritic cells inhibited induction of the expression of Il12 and Il23 by Toll like receptors (TLRs), which impaired the differentiation of inflammatory T cells and protected mice from autoimmune inflammation."
26808229
ZRANB1 affects IL12B
| 2
ZRANB1-C443A activates IL12B. 2 / 2
| 2
reach
"In similar experiments using BMDCs, reconstitution of DC-cKO BMDCs with wild-type Trabid, but not C443A Trabid, rescued the induction of Il12a, Il12b, and Il23a genes (XREF_FIG)."
26808229
reach
"Consistently, reconstitution of KO MEFs with wild-type Trabid, but not C443A Trabid, greatly promoted poly (I : C)-induced Il12b, Il12a and Il23a mRNA expression in these cells (XREF_FIG) but had no effect on the induction of the control gene Il6 (XREF_FIG)."
26808229
ZRANB1 affects FAM83C
| 2
FAM83C binds ZRANB1 and AS1. 2 / 2
| 2
sparser
"Our data thus demonstrate that FAM83C-AS1 binds to ZRANB1 and stabilizes EZH2 protein in CRCs."
33109776
sparser
"Subsequent RIP assays further validated that FAM83C-AS1 bound to ZRANB1 in RKO and SW620 cells ( xref )."
33109776
ZRANB1 affects Circulin-C
| 2
sparser
"The expression of circ-ZRANB1 was significantly upregulated in the aqueous humor of a rat model of glaucoma."
33816552
sparser
"Circ-ZRANB1 is mainly derived from Müller cells, which can bind to miR-271 to regulate the expression of RUNX2."
33816552
reach
"Functionally, we showed that TRABID-mediated hepatocellular carcinoma cell proliferation is attenuated by DDB2 knockdown."
35944360
ZRANB1 activates Carcinoma, Hepatocellular. 1 / 1
| 1
reach
"TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells."
35944360
ZRANB1 affects Carcinogenesis
| 1 1
ZRANB1 activates Carcinogenesis. 2 / 2
| 1 1
eidos
"The upregulation of ZRANB1 promoted tumorigenesis in vivo ."
34798260
reach
"The upregulation of ZRANB1 promoted tumorigenesis in vivo."
34798260
ZRANB1 affects CTTNBP2NL
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
ZRANB1 affects CTTNBP2
2 |
CTTNBP2 binds ZRANB1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
ZRANB1 affects AS1
| 2
FAM83C binds ZRANB1 and AS1. 2 / 2
| 2
sparser
"Our data thus demonstrate that FAM83C-AS1 binds to ZRANB1 and stabilizes EZH2 protein in CRCs."
33109776
sparser
"Subsequent RIP assays further validated that FAM83C-AS1 bound to ZRANB1 in RKO and SW620 cells ( xref )."
33109776
ZRANB1 affects APC tumor suppressor protein
| 2
ZRANB1 deubiquitinates APC tumor suppressor protein.
| 1
ZRANB1 deubiquitinates APC tumor suppressor protein. 1 / 1
| 1
reach
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt mediated transcription."
18281465
ZRANB1 binds APC tumor suppressor protein.
| 1
ZRANB1 binds APC tumor suppressor protein. 1 / 1
| 1
reach
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt mediated transcription."
18281465
UVRAG affects ZRANB1
| 1 1
UVRAG binds ZRANB1 and ATG14. 1 / 1
| 1
sparser
"Immunoprecipitation analysis revealed the association of TRABID with both ATG14 and UVRAG, along with the common subunits of VPS34 complex, in cells cultured in DMEM or EBSS (Supplementary Fig.  xref )."
33637724
UVRAG binds ZRANB1. 1 / 1
| 1
reach
"Furthermore, GFP-ATG14 and GFP-UVRAG interacted with endogenous TRABID in transfected cells and these associations were not affected by starvation."
33637724
USP9X affects MIB2
| 2
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP9X affects HIF1AN
| 2
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP39 affects ZRANB1
| 1 1
ZRANB1 binds USP39. 2 / 2
| 1 1
reach
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article shows instead the interaction between ZRANB1 and USP39."
23118479
sparser
"For example, the interaction between ZRANB2 and USP39, annotated by IntAct and BioGRID, is not correct because the cited article ( xref ) shows instead the interaction between ZRANB1 and USP39."
23118479
USP1 affects MIB2
| 2
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
USP1 affects HIF1AN
| 2
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
TRAF affects ZRANB1
| 2
ZRANB1 binds TRAF. 2 / 2
| 2
reach
"Structural and biochemical analysis suggests a novel architecture of the catalytic triad, which might be present in a subset of OTU domains including Cezanne and TRABID (TRAF binding domain)."
17961127
reach
"We report two novel genes, Cezanne (cellular zinc finger anti-NF-kappa B) and TRABID (TRAF binding domain), with sequence similarity to A20."
11463333
TAB2 affects ZRANB1
| 2
PHF20 binds TAB2 and ZRANB1. 1 / 1
| 1
sparser
"For example, NZF domains of TAB2 (TAK1 binding protein 2) or TRABID (TRAF binding domain) preferentially bind to Lys63- over Lys48-linked ubiquitin chains xref ."
19773779
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
STRN3 affects ZRANB1
2 |
STRN3 binds ZRANB1. 2 / 2
2 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
STRIP1 affects ZRANB1
2 |
ZRANB1 binds STRIP1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
SP1 affects ZRANB1
| 1 1
SP1 binds ZRANB1. 2 / 2
| 1 1
sparser
"Mechanistically, ZRANB1 bound with SP1 directly and stabilized the SP1 protein by deubiquitinating it."
34765294
reach
"Mechanistically, ZRANB1 bound with SP1 directly and stabilized the SP1 protein by deubiquitinating it."
34765294
SLMAP affects ZRANB1
2 |
SLMAP binds ZRANB1. 2 / 2
2 |
biogrid
No evidence text available
23277359
biogrid
No evidence text available
19615732
SF1 affects ZRANB1
2 |
SF1 decreases the amount of ZRANB1. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
S1 affects ZRANB1
| 2
S1 inhibits ZRANB1. 2 / 2
| 2
reach
"Table S1) inhibition of TRABID DUB activity."
22584113
reach
"Table S1, which share similar chemical structures to NSC112200 and NSC267309, did not inhibit TRABID DUB activity, suggesting that the two hydroxyl groups and their locations on the benzene ring may be important for the inhibitory activity."
22584113
RUBCN affects ZRANB1
| 2
ZRANB1 binds RUBCN and PIK3C3. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
ZRANB1 binds RUBCN. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
PHF20 affects TAB2
| 2
PHF20 binds TAB2 and ZRANB1. 1 / 1
| 1
sparser
"For example, NZF domains of TAB2 (TAK1 binding protein 2) or TRABID (TRAF binding domain) preferentially bind to Lys63- over Lys48-linked ubiquitin chains xref ."
19773779
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
PBLD affects ZRANB1
2 |
ZRANB1 binds PBLD. 2 / 2
2 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
OTU domain affects ZRANB1
| 2
ZRANB1 binds DDB2 and OTU domain. 1 / 1
| 1
reach
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
ZRANB1 binds NSC267309 and OTU domain. 1 / 1
| 1
reach
"The molecular modeling of the bindings of NSC112200, NSC267309 and NSC60650 to TRABID OTU domain suggests that while all three compounds can form electrostatic interactions with the side chain of E522 and the backbone NH of T556, both NSC112200 and NSC267309 can form an additional hydrogen bond with the side chain of S491."
22584113
NZF1 affects pol
| 2
ZRANB1 binds pol, gag, and NZF1. 2 / 2
| 2
sparser
"Although mutation of T25 to alanine does not affect TRABID-NZF1 binding to K29 or K33 chains ( xref F), the corresponding residue in TAB2 (E685) interacts with the proximal Ub and is important for binding K63 chains ( xref )."
25752573
sparser
"We have established a method to investigate K29 chains in cells that relies on TRABID-NZF1 binding to K29 and K33 chains and subsequent cleavage with a DUB that does not hydrolyze K29 linkages ( xref A)."
25752573
NSC112200 affects ZRANB1
| 2
NSC112200 inhibits ZRANB1. 2 / 2
| 2
reach
"We also found that NSC112200 inhibited the deubiquitinase activity of ZRANB1, but not another OTU family member, A20 (XREF_SUPPLEMENTARY)."
29669287
reach
"In an in vitro deubiquitination assay using ubiquitin chains as substrates, we found that ZRANB1 cleaved K33 linked di-ubiquitin; this cleavage was blocked by NSC112200, but not by the control compound NSC60650 (1,5-dichloro-2,4-dihydroxybenzene) (XREF_FIG)."
29669287
MYOD1 affects ZRANB1
2 |
MYOD1 decreases the amount of ZRANB1. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
MIB2 affects USP9X
| 2
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
MIB2 affects HIF1AN
| 2
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
K33 affects ZRANB1
| 2
ZRANB1 binds K29- and K33. 2 / 2
| 2
reach
"We found that the TRABID N terminus, which contains three Npl4-type zinc finger (NZF) UBDs, specifically binds K29- and K33 linked diUb, and specificity can be attributed to the first NZF domain (NZF1)."
25752577
reach
"TRABID NZF1 Specifically Binds K29- and K33 Linked Chains."
25752577
HIF1AN affects USP9X
| 2
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
HIF1AN affects MIB2
| 2
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
FAM83C affects ZRANB1
| 2
FAM83C binds ZRANB1 and AS1. 2 / 2
| 2
sparser
"Our data thus demonstrate that FAM83C-AS1 binds to ZRANB1 and stabilizes EZH2 protein in CRCs."
33109776
sparser
"Subsequent RIP assays further validated that FAM83C-AS1 bound to ZRANB1 in RKO and SW620 cells ( xref )."
33109776
ESRRA affects ZRANB1
2 |
ESRRA decreases the amount of ZRANB1. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
Circulin-C affects ZRANB1
| 2
sparser
"The expression of circ-ZRANB1 was significantly upregulated in the aqueous humor of a rat model of glaucoma."
33816552
sparser
"Circ-ZRANB1 is mainly derived from Müller cells, which can bind to miR-271 to regulate the expression of RUNX2."
33816552
CTTNBP2NL affects ZRANB1
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
CTTNBP2 affects ZRANB1
2 |
CTTNBP2 binds ZRANB1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
23277359
ATG14 affects ZRANB1
| 1 1
UVRAG binds ZRANB1 and ATG14. 1 / 1
| 1
sparser
"Immunoprecipitation analysis revealed the association of TRABID with both ATG14 and UVRAG, along with the common subunits of VPS34 complex, in cells cultured in DMEM or EBSS (Supplementary Fig.  xref )."
33637724
ZRANB1 binds ATG14. 1 / 1
| 1
reach
"Furthermore, GFP-ATG14 and GFP-UVRAG interacted with endogenous TRABID in transfected cells and these associations were not affected by starvation."
33637724
AS1 affects ZRANB1
| 2
FAM83C binds ZRANB1 and AS1. 2 / 2
| 2
sparser
"Our data thus demonstrate that FAM83C-AS1 binds to ZRANB1 and stabilizes EZH2 protein in CRCs."
33109776
sparser
"Subsequent RIP assays further validated that FAM83C-AS1 bound to ZRANB1 in RKO and SW620 cells ( xref )."
33109776
AKT1 affects ZRANB1
2 |
AKT1 phosphorylates ZRANB1 on S78. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
AKT1 phosphorylates ZRANB1 on T117. 1 / 1
1 |
biopax:phosphositeplus
No evidence text available
Urethane affects ZRANB1
1 |
Urethane increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
28818685
Troglitazone affects ZRANB1
1 |
Troglitazone decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
28973697
Titanium dioxide affects ZRANB1
1 |
Titanium dioxide increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
23409001
Sunitinib affects ZRANB1
1 |
Sunitinib increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
31533062
Sodium arsenate affects ZRANB1
1 |
Sodium arsenate increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
21795629
Progesterone affects ZRANB1
1 |
Progesterone increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
23012394
Polyubiquitin affects ZRANB1
| 1
ZRANB1 binds polyubiquitin. 1 / 1
| 1
sparser
"TRABID preferentially binds to lysine 63-linked polyubiquitin chains (K63 chains), but not K48-linked polyubiquitin chains (K48 chains), and specifically cleaves K63 chains [ xref ]."
22584113
Pirinixic acid affects ZRANB1
1 |
Pirinixic acid increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
17426115
Pentanal affects ZRANB1
1 |
Pentanal decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
26079696
Oleic acid affects ZRANB1
| 1
Oleic acid activates ZRANB1. 1 / 1
| 1
reach
"HFD also decreased the expression of Trabid mRNA and TRABID downregulation was further detected in mouse hepatocyte cell line AML12 treated with oleic acid, but not tunicamycin."
33637724
Methylmercury chloride decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
28001369
Hsa-miR-93-5p affects ZRANB1
1 |
Hsa-miR-93-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-875-5p affects ZRANB1
1 |
Hsa-miR-875-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-770-5p affects ZRANB1
1 |
Hsa-miR-770-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-6859-3p affects ZRANB1
1 |
Hsa-miR-6859-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6846-3p affects ZRANB1
1 |
Hsa-miR-6846-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-6083 affects ZRANB1
1 |
Hsa-miR-6083 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-5591-3p affects ZRANB1
1 |
Hsa-miR-5591-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-519d-3p affects ZRANB1
1 |
Hsa-miR-519d-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-513c-3p affects ZRANB1
1 |
Hsa-miR-513c-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-513a-3p affects ZRANB1
1 |
Hsa-miR-513a-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-5011-5p affects ZRANB1
1 |
Hsa-miR-5011-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-4783-5p affects ZRANB1
1 |
Hsa-miR-4783-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
27418678
Hsa-miR-4482-5p affects ZRANB1
1 |
Hsa-miR-4482-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-410-3p affects ZRANB1
1 |
Hsa-miR-410-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3606-3p affects ZRANB1
1 |
Hsa-miR-3606-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3144-3p affects ZRANB1
1 |
Hsa-miR-3144-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-3130-5p affects ZRANB1
1 |
Hsa-miR-3130-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-2681-5p affects ZRANB1
1 |
Hsa-miR-2681-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-21-5p affects ZRANB1
1 |
Hsa-miR-21-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
18591254
Hsa-miR-20b-5p affects ZRANB1
1 |
Hsa-miR-20b-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-20a-5p affects ZRANB1
1 |
Hsa-miR-20a-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-1912 affects ZRANB1
1 |
Hsa-miR-1912 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-190a-3p affects ZRANB1
1 |
Hsa-miR-190a-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-17-5p affects ZRANB1
1 |
Hsa-miR-17-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-16-5p affects ZRANB1
1 |
Hsa-miR-16-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-16-1-3p affects ZRANB1
1 |
Hsa-miR-16-1-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-136-3p affects ZRANB1
1 |
Hsa-miR-136-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
24374217
Hsa-miR-1295b-5p affects ZRANB1
1 |
Hsa-miR-1295b-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-1277-5p affects ZRANB1
1 |
Hsa-miR-1277-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Hsa-miR-106b-5p affects ZRANB1
1 |
Hsa-miR-106b-5p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
22473208
Hsa-miR-103a-3p affects ZRANB1
1 |
Hsa-miR-103a-3p decreases the amount of ZRANB1. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
20371350
Gag affects UBD
| 1
ZRANB1 binds UBD and gag. 1 / 1
| 1
sparser
"We found that the TRABID N terminus, which contains three Npl4-type zinc finger (NZF) UBDs, specifically binds K29- and K33-linked diUb, and specificity can be attributed to the first NZF domain (NZF1)."
25752577
Formaldehyde affects ZRANB1
1 |
Formaldehyde decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
20655997
Fluoranthene affects ZRANB1
1 |
Fluoranthene increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
28329830
Diarsenic trioxide increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
20458559
DIKKγ affects ZRANB1
| 1
ZRANB1 binds dIKKγ. 1 / 1
| 1
reach
"Trabid and Cylindromatosis (CYLD) deubiquitinases bind to dTAK1 and dIKKγ (key) , respectively and modulate K63-linked polyubiquitination of their respective target."
34330981
Cyclosporin A affects ZRANB1
1 |
Cyclosporin A decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
19770486
Copper(II) sulfate increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
19549813
Carbon nanotube affects ZRANB1
1 |
Carbon nanotube decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
25554681
Cadmium dichloride increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
21457566
Butanal affects ZRANB1
1 |
Butanal decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
26079696
Bisphenol A affects ZRANB1
1 |
Bisphenol A demethylates ZRANB1. 1 / 1
1 |
ctd
No evidence text available
27312807
Bafilomycin A1 affects ZRANB1
| 1
reach
"Accordingly, LC3 lipidation was also enhanced by TRABID overexpression in DMEM- or EBSS cultured cells treated with bafilomycin A1."
33637724
All-trans-retinoic acid increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
23724009
Aflatoxin B1 affects ZRANB1
1 |
Aflatoxin B1 increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
19770486
ZRANB1 inhibits transcription, DNA-templated. 1 / 1
| 1
reach
"Knockdown of TRABID with RNAi resulted in downregulated expression of canonical Wnt target genes and decreased Wnt transcription activity, whereas its knockdown does not affect TNF-2 pathway [XREF_BIBR]."
22584113
ZRANB1 affects stem-cell-like features
| 1
ZRANB1 activates stem-cell-like features. 1 / 1
| 1
eidos
"ZRANB1 enhances stem-cell-like features and accelerates tumor progression by regulating Sox9-mediated USP22 / Wnt / beta-catenin pathway in colorectal cancer ."
34798260
ZRANB1 affects stem-cell-like features cells
| 1
ZRANB1 activates stem-cell-like features cells. 1 / 1
| 1
eidos
"Moreover , ZRANB1 enhances stem-cell-like features of CRC cells and activated the Wnt / beta-catenin pathway through USP22 ."
34798260
ZRANB1 affects stability Sox9 cells
| 1
ZRANB1 activates stability Sox9 cells. 1 / 1
| 1
eidos
"ZRANB1 increased the stability of Sox9 in CRC cells by decelerating its ubiquitination ."
34798260
ZRANB1 affects span
| 1
ZRANB1 activates span. 1 / 1
| 1
reach
"Loss of Trabid, a new negative regulator of the drosophila immune-deficiency pathway at the level of TAK1, reduces life span."
24586180
ZRANB1 affects recruitment p62 K33-associated protein aggregates
| 1
ZRANB1 inhibits recruitment p62 K33-associated protein aggregates. 1 / 1
| 1
eidos
"Knockdown of ZRANB1 enhances the recruitment of p62 to K33-associated protein aggregates , suggesting that ZRANB1 is a negative regulator of aggrephagy ; yet , the physiological function of K33-linked ubiquitin chains and the role of ZRANB1 are not entirely understood [ 94 ] ."
30126257
ZRANB1 affects polyubiquitin
| 1
ZRANB1 binds polyubiquitin. 1 / 1
| 1
sparser
"TRABID preferentially binds to lysine 63-linked polyubiquitin chains (K63 chains), but not K48-linked polyubiquitin chains (K48 chains), and specifically cleaves K63 chains [ xref ]."
22584113
ZRANB1 affects isopeptidase
| 1
ZRANB1 activates isopeptidase. 1 / 1
| 1
reach
"However, as TRABID has been shown to mediate efficient isopeptidase activity toward Ub polymers, it would appear that it has the potential to confer dual chemical substrate specificity within cells."
33479176
ZRANB1 affects interleukin-12
| 1
ZRANB1 decreases the amount of interleukin-12. 1 / 1
| 1
reach
"Additionally, recent work has shown that the cellular DUB, Trabid, negatively regulates expression of interleukin-12 (IL-12) and IL-23 via the modification of ubiquitinated histones."
28096485
ZRANB1 activates interleukin-12 production. 1 / 1
| 1
reach
"TRABID promotes experimental autoimmune encephalitis (EAE) by stabilizing JMJD2D at the Il12 promoter, enhancing IL-12 production and immunopathology (91)."
31214161
ZRANB1 affects growth
| 1
ZRANB1 inhibits growth. 1 / 1
| 1
sparser
"Collectively, these functional studies demonstrate that Trabid inhibits HCC growth."
29748601
ZRANB1 affects gag, and pol
| 1
ZRANB1 binds pol and gag. 1 / 1
| 1
sparser
"Indeed, mutation of T14, Y15, or M26 to alanine is sufficient to disrupt the binding of TRABID NZF1 to K29 and K33 chains ( xref E)."
25752573
ZRANB1 affects development novel therapies efficacy
| 1
ZRANB1 activates development novel therapies efficacy. 1 / 1
| 1
eidos
"Our results highlighted the role of ZRANB1 as a molecular target for CRC treatment , which may contribute to the development of novel therapies with better efficacy ."
34798260
ZRANB1 affects depends active site
| 1
ZRANB1 activates depends active site. 1 / 1
| 1
eidos
"Furthermore , TRABID deubiquitinates DDB2 , and this deubiquitination effect of TRABID depends on its active site ."
35944360
ZRANB1 affects dIKKγ
| 1
ZRANB1 binds dIKKγ. 1 / 1
| 1
reach
"Trabid and Cylindromatosis (CYLD) deubiquitinases bind to dTAK1 and dIKKγ (key) , respectively and modulate K63-linked polyubiquitination of their respective target."
34330981
ZRANB1 affects cleavage
| 1
ZRANB1 inhibits cleavage. 1 / 1
| 1
eidos
"Moreover , some candidate compounds of TRABID inhibitor have demonstrated their ability in inhibiting the cleavage of hexa-K63 ubiquitin by TRABID [ 29 ] ."
32781716
ZRANB1 affects cancer development
| 1
ZRANB1 activates cancer development. 1 / 1
| 1
eidos
"Taken together , these reports suggest that ZRANB1 , USP7 , USP1 and USP36 can promote cancer development via the stabilization of EZH2 by deubiquitination ."
33308321
ZRANB1 affects autophagy
| 1
ZRANB1 activates autophagy. 1 / 1
| 1
reach
"Future study will be aimed to determine the mechanism of TRABID downregulation in NAFLD and the impact of TRABID stimulated autophagy activity on HCC suppression."
33637724
ZRANB1 affects autophagosome maturation VPS34
| 1
ZRANB1 activates autophagosome maturation VPS34. 1 / 1
| 1
eidos
"TRABID promotes autophagosome maturation VPS34 is present in different complexes ."
33637724
ZRANB1 affects autophagosome biogenesis
| 1
ZRANB1 activates autophagosome biogenesis. 1 / 1
| 1
eidos
"TRABID promotes autophagosome biogenesis ."
33637724
ZRANB1 affects autophagosome LC3 lipidation cells cultured modified medium
| 1
ZRANB1 activates autophagosome LC3 lipidation cells cultured modified medium. 1 / 1
| 1
eidos
"Validation experiment showed that TRABID knockdown reduced autophagosome numbers and LC3 lipidation in cells cultured in Dulbecco 's modified Eagle 's medium ( DMEM ; for measuring basal autophagy activity ) or Earle 's Balanced Salt Solution ( EBSS ) ( for measuring starvation-induced autophagy activity ) ( Fig. 1a , b ) ."
33637724
ZRANB1 affects activity
| 1
ZRANB1 inhibits activity. 1 / 1
| 1
sparser
"TRABID binds APC but rather then antagonizing the proteasomal turnover of APC TRABID inhibits APC activity through preferential deubiquitination of K63 linked ubiquitin chains."
28923280
ZRANB1 affects accumulation autophagic cargo p62
| 1
ZRANB1 inhibits accumulation autophagic cargo p62. 1 / 1
| 1
eidos
"TRABID knockdown also caused the accumulation of autophagic cargo p62 in both conditions ( Fig. 1b ) ."
33637724
ZRANB1 affects ZRANB1
| 1
ZRANB1 inhibits ZRANB1. 1 / 1
| 1
reach
"Importantly, re-expression of ZRANB1 rescued the inhibitory effect of ZRANB1 siRNA (XREF_SUPPLEMENTARY) and ZRANB1 gRNA (XREF_FIG) on EZH2 protein level and cell proliferation."
29669287
ZRANB1 affects ZNF414
1 |
ZRANB1 binds ZNF414. 1 / 1
1 |
biogrid
No evidence text available
28514442
ZRANB1 affects ZFYVE1
| 1
ZRANB1 activates ZFYVE1. 1 / 1
| 1
reach
"However, TRABID knockdown diminished DFCP1 puncta, ATG16 puncta, and ATG14 puncta."
33637724
ZRANB1 affects Wnt5a/β-Catenin
| 1
ZRANB1 activates Wnt5a/β-Catenin. 1 / 1
| 1
reach
"Downregulated circular RNA zRANB1 mediates Wnt5a/β-Catenin Signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models."
32777532
ZRANB1 affects Wnt5a beta-Catenin Signaling
| 1
ZRANB1 inhibits Wnt5a beta-Catenin Signaling. 1 / 1
| 1
eidos
"Downregulated circular RNA zRANB1 mediates Wnt5a / beta-Catenin Signaling to promote neuropathic pain via miR-24-3p / LPAR3 axis in CCI rat models ."
32777532
ZRANB1 affects Wnt/β-catenin
| 1
ZRANB1 activates Wnt/β-catenin. 1 / 1
| 1
reach
"Moreover, ZRANB1 enhances stem-cell-like features of CRC cells and activated the Wnt/β-catenin pathway through USP22."
34798260
ZRANB1 affects Wnt-induced transcription
| 1
ZRANB1 activates Wnt-induced transcription. 1 / 1
| 1
eidos
"Cezanne has a negative effect on NF-kappaB activation , whereas TRABID activates Wnt-induced transcription [ 32 ] ."
| PMC
ZRANB1 affects Wnt beta-catenin pathway
| 1
ZRANB1 activates Wnt beta-catenin pathway. 1 / 1
| 1
eidos
"Moreover , ZRANB1 enhances stem-cell-like features of CRC cells and activated the Wnt / beta-catenin pathway through USP22 ."
34798260
ZRANB1 affects WIPI1
| 1
ZRANB1 binds WIPI1. 1 / 1
| 1
sparser
"Inactive TRABID forms puncta enriched in atypical polyUb."
22157957
ZRANB1 affects VPS34 protein abundance
| 1
ZRANB1 activates VPS34 protein abundance. 1 / 1
| 1
eidos
"TRABID knockdown decreased VPS34 protein abundance and half-life , whereas TRABID overexpression enhanced VPS34 expression and stability ( Fig. 2i-l ) ."
33637724
ZRANB1 affects VPS34 K29
| 1
ZRANB1 inhibits VPS34 K29. 1 / 1
| 1
eidos
"TRABID reduces VPS34 K29 / K48 ubiquitination to stabilize VPS34 Next , we defined the functional position of TRABID in the autophagosome biogenesis process ."
33637724
ZRANB1 affects UBI4
| 1
ZRANB1 binds UBI4. 1 / 1
| 1
sparser
"We focused on the NZF1 of TRABID, which binds to K29 and K33 polyUb and pulls down small amounts of M1 and K63 chains ( xref D)."
25752573
ZRANB1 affects UBE3C depletion-induced VPS34
| 1
ZRANB1 activates UBE3C depletion-induced VPS34. 1 / 1
| 1
eidos
"Remarkably , UBE3C depletion-induced upregulation of VPS34 expression , LC3 puncta and LC3 lipidation in cells cultured in DMEM or EBSS were all reversed by TRABID knockdown ( Fig. 4e-g ) ."
33637724
ZRANB1 affects UBE2S
1 |
UBE2S binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
20622874
ZRANB1 affects UBD
| 1
ZRANB1 binds UBD and gag. 1 / 1
| 1
sparser
"We found that the TRABID N terminus, which contains three Npl4-type zinc finger (NZF) UBDs, specifically binds K29- and K33-linked diUb, and specificity can be attributed to the first NZF domain (NZF1)."
25752577
ZRANB1 affects Th17
| 1
ZRANB1 activates Th17. 1 / 1
| 1
reach
"DC-conditional deletion of Trabid impairs IL-12 and IL-23 production in DCs and the generation of Th1 and Th17 subsets of inflammatory T cells, rendering mice refractory to the induction of EAE 180."
27012466
ZRANB1 affects TP53BP1
| 1
reach
"Here, we demonstrate that TRABID deubiquitinase binds to 53BP1 at endogenous level and regulates 53BP1 retention at DSB sites."
37002234
ZRANB1 affects TCHP
| 1
ZRANB1 inhibits TCHP. 1 / 1
| 1
sparser
"Firstly, although Trabid indeed inactivated the APC tumor suppressor protein [ xref ], the previous study did not provide in vivo data to confirm this alleged oncogenic role of Trabid in CRC."
29748601
ZRANB1 affects TAB3
| 1
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
ZRANB1 affects Span
| 1
ZRANB1 activates Span. 1 / 1
| 1
reach
"Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span."
24586180
ZRANB1 affects STRIPAK
| 1
ZRANB1 binds STRIPAK. 1 / 1
| 1
reach
"Although this kinase and phosphatase complex had already been identified in the original full-length TRABID WT interactome, our data now show that the interaction between STRIPAK and TRABID is primarily mediated by the catalytic OTU domain rather than the ubiquitin binding properties of TRABID NZF (XREF_FIG, B and C)."
| PMC
ZRANB1 affects STRIP2
1 |
ZRANB1 binds STRIP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects RBBP4
| 1
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
ZRANB1 affects PRC2_complex
| 1
PRC2_complex binds ZRANB1. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
ZRANB1 affects PPP2R1B
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects PMF1
1 |
ZRANB1 binds PMF1. 1 / 1
1 |
biogrid
No evidence text available
26186194
ZRANB1 affects PGAM5
1 |
ZRANB1 binds PGAM5. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects PARP inhibitor
| 1
ZRANB1 inhibits PARP inhibitor. 1 / 1
| 1
reach
"TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks."
37002234
ZRANB1 affects OTUD7B
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
ZRANB1 affects OTUB1
| 1
ZRANB1 binds OTUB1. 1 / 1
| 1
sparser
"Crystal structures of the human OTUB1, OTUB2, TRABID, A20, and yeast Otu1 enzymes have revealed the conserved catalytic OTU domain which contains the S1 site, and N-terminal residues in TRABID and OTUB1 that form the S1’ site [ xref - xref , xref - xref ] (see xref S1/S1’ nomenclature)."
23845989
ZRANB1 affects O41957
1 |
ZRANB1 binds O41957. 1 / 1
1 |
virhostnet
No evidence text available
22028648
ZRANB1 increases the amount of Neoplastic Stem Cells. 1 / 1
| 1
reach
"The overexpression of ZRANB1 also induced the expression of CSC markers in CRC cells."
34798260
ZRANB1 affects Neoplasms
| 1
ZRANB1 activates Neoplasms. 1 / 1
| 1
eidos
"ZRANB1 enhances stem-cell-like features and accelerates tumor progression by regulating Sox9-mediated USP22 / Wnt / beta-catenin pathway in colorectal cancer ."
34798260
ZRANB1 affects NXF1
1 |
ZRANB1 binds NXF1. 1 / 1
1 |
biogrid
No evidence text available
22658674
ZRANB1 affects NSC267309
| 1
ZRANB1 binds NSC267309 and OTU domain. 1 / 1
| 1
reach
"The molecular modeling of the bindings of NSC112200, NSC267309 and NSC60650 to TRABID OTU domain suggests that while all three compounds can form electrostatic interactions with the side chain of E522 and the backbone NH of T556, both NSC112200 and NSC267309 can form an additional hydrogen bond with the side chain of S491."
22584113
ZRANB1 affects NSC112200
| 1
ZRANB1 activates NSC112200. 1 / 1
| 1
reach
"Moreover, we assessed the viability of NSC112200 treated ZRANB1-knockout HEK293A cells, and we found that they were much more resistant to NSC112200 than isogenic ZRANB1 wild-type cells; re-expression of ZRANB1 in these ZRANB1-knockout cells restored their sensitivity to NSC112200 (XREF_FIG)."
29669287
ZRANB1 affects NELFCD
| 1
ZRANB1 activates NELFCD. 1 / 1
| 1
reach
"DC-conditional deletion of Trabid impairs IL-12 and IL-23 production in DCs and the generation of Th1 and Th17 subsets of inflammatory T cells, rendering mice refractory to the induction of EAE 180."
27012466
ZRANB1 inhibits N,N-diisopropyltryptamine. 1 / 1
| 1
reach
"Finally, concomitant loss of pirk and trabid led to a 5-fold induction of dipt over and above wild type activation levels (XREF_FIG)."
24586180
ZRANB1 affects Mice
| 1
ZRANB1 activates Mice. 1 / 1
| 1
reach
"Conditional deletion of Zranb1 in dendritic cells impairs IL-12 and IL-23 production and the generation of T 1 and T 17 subsets of inflammatory T cells, rendering mice refractory to the induction of experimental autoimmune encephalomyelitis (EAE) ."
28959952
ZRANB1 affects MOV10
1 |
ZRANB1 binds MOV10. 1 / 1
1 |
biogrid
No evidence text available
22658674
ZRANB1 affects MOB4
1 |
MOB4 binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects MAP4K4
1 |
ZRANB1 binds MAP4K4. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects LC3 puncta
| 1
ZRANB1 activates LC3 puncta. 1 / 1
| 1
reach
"Remarkably, UBE3C depletion induced upregulation of VPS34 expression, LC3 puncta and LC3 lipidation in cells cultured in DMEM or EBSS were all reversed by TRABID knockdown."
33637724
ZRANB1 affects LC3 lipidation
| 1
ZRANB1 activates LC3 lipidation. 1 / 1
| 1
eidos
"Furthermore , in cells treated with bafilomycin A1 to block autophagic turnover , TRABID knockdown still reduced LC3 lipidation but did not alter p62 level ( Fig. 1c ) , indicating a promoting role of TRABID in autophagosome formation ."
33637724
ZRANB1 affects KEAP1
1 |
ZRANB1 binds KEAP1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects K48
| 1
ZRANB1 inhibits K48. 1 / 1
| 1
eidos
"Regardless of the mechanism that TRABID reduces K48 linkages from the substrate , the partially overlapping chain type specificity of UBE3C and TRABID , as well as their opposite roles in regulating VPS34 , suggest that they function as an E3 ligase-DUB pair to govern the K29 / K48 ubiquitination status and the stability of a set of cellular proteins ."
33637724
ZRANB1 affects K29
| 1
ZRANB1 inhibits K29. 1 / 1
| 1
eidos
"TRABID diminishes the K29 / K48 ubiquitination on VPS34 and promotes autophagosome maturation ."
33637724
ZRANB1 affects IL23
| 1
ZRANB1 inhibits IL23. 1 / 1
| 1
reach
"Moreover ZRANB1 deficiency in macrophages and dendritic cells impairs the induction of IL-12 and IL-23 by the regulation of histone modifications at the IL-12 promoter, indicating a role of ZRANB1 in mediating inflammatory responses 18 and macrophage activation 19."
| PMC
ZRANB1 affects IL12A
| 1
ZRANB1-C443A activates IL12A. 1 / 1
| 1
reach
"In similar experiments using BMDCs, reconstitution of DC-cKO BMDCs with wild-type Trabid, but not C443A Trabid, rescued the induction of Il12a, Il12b, and Il23a genes (XREF_FIG)."
26808229
ZRANB1 affects Histone
| 1
ZRANB1 activates Histone. 1 / 1
| 1
reach
"To assess the functional role of Trabid mediated histone modifications at the Il12 promoters, we determined the binding level of RNA polymerase II (Pol II) preinitiation complex components, including Pol II, serine 5 phosphorylated Pol II (Pol II pS5) and the general transcription factor subunits TFIIB and TFIID, in the Il12 and Il23 promoters."
26808229
ZRANB1 affects Half-Life
| 1
ZRANB1 activates Half-Life. 1 / 1
| 1
eidos
"TRABID knockdown decreased VPS34 protein abundance and half-life , whereas TRABID overexpression enhanced VPS34 expression and stability ( Fig. 2i-l ) ."
33637724
ZRANB1 affects HERC2
1 |
ZRANB1 binds HERC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects H3K27me3
| 1
ZRANB1 inhibits H3K27me3. 1 / 1
| 1
reach
"Moreover, ablation of ZRANB1 abrogated H3K27me3, but not H3K27me1 or H3K27me2 (XREF_FIG)."
29669287
ZRANB1 affects H3K27me2
| 1
ZRANB1 inhibits H3K27me2. 1 / 1
| 1
reach
"Moreover, ablation of ZRANB1 abrogated H3K27me3, but not H3K27me1 or H3K27me2 (XREF_FIG)."
29669287
ZRANB1 affects H3K27me1
| 1
ZRANB1 inhibits H3K27me1. 1 / 1
| 1
reach
"Moreover, ablation of ZRANB1 abrogated H3K27me3, but not H3K27me1 or H3K27me2 (XREF_FIG)."
29669287
ZRANB1 affects GCC2
1 |
ZRANB1 binds GCC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects FGFR1OP2
1 |
ZRANB1 binds FGFR1OP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects FBXW11
1 |
FBXW11 binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects FAM126A
| 1
ZRANB1 inhibits FAM126A. 1 / 1
| 1
reach
"More importantly, ZRANB1 regulated LOXL2 through specificity protein 1 (SP1) and SP1 overexpression rescued the suppression of HCC growth and metastasis induced by ZRANB1 knockdown."
34765294
ZRANB1 affects Encephalitis
| 1
ZRANB1 activates Encephalitis. 1 / 1
| 1
reach
"TRABID promotes experimental autoimmune encephalitis (EAE) by stabilizing JMJD2D at the Il12 promoter, enhancing IL-12 production and immunopathology (91)."
31214161
ZRANB1 affects EED
| 1
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
ZRANB1 affects Dendritic Cells
| 1
ZRANB1 activates Dendritic Cells. 1 / 1
| 1
reach
"We next analyzed the effect of Trabid deficiency on TLR stimulated DC activation and cytokine expression in vitro."
26808229
ZRANB1 affects DFCP1 puncta
| 1
ZRANB1 activates DFCP1 puncta. 1 / 1
| 1
eidos
"However , TRABID knockdown diminished DFCP1 puncta , ATG16 puncta , and ATG14 puncta ( Fig. 1f , g and Supplementary Fig. 1d ) ."
33637724
ZRANB1 affects DAB2IP
| 1
ZRANB1 decreases the amount of DAB2IP. 1 / 1
| 1
reach
"We then examined the expression of 10 previously reported PRC2 target genes, and we found that ADRB2 and DAB2IP were significantly upregulated by knockdown of EZH2 in MDA-MB-231 cells (XREF_SUPPLEMENTARY); consistently, knockdown of ZRANB1 in MDA-MB-231 cells also increased ADRB2 and DAB2IP mRNA levels (XREF_SUPPLEMENTARY)."
29669287
ZRANB1 activates Chromosomal Instability. 1 / 1
| 1
eidos
"TRABID deubiquitinates K29-linked polyubiquitination of 53BP1 mediated by E3 ubiquitin ligase SPOP and prevents 53BP1 dissociation from DSBs , consequently inducing HR defects and chromosomal instability ."
37002234
ZRANB1 affects Cell Viability
| 1
ZRANB1 inhibits Cell Viability. 1 / 1
| 1
sparser
"A ZRANB1 Inhibitor Destabilizes EZH2 and Inhibits Cell Viability through ZRANB1."
29669287
ZRANB1 affects Cell Survival
| 1
ZRANB1 inhibits Cell Survival. 1 / 1
| 1
reach
"A ZRANB1 Inhibitor Destabilizes EZH2 and Inhibits Cell Viability through ZRANB1."
29669287
ZRANB1 affects Casp14
| 1
ZRANB1 activates Casp14. 1 / 1
| 1
reach
"Conditional deletion of Zranb1 in dendritic cells impairs IL-12 and IL-23 production and the generation of T H 1 and T H 17 subsets of inflammatory T cells, rendering mice refractory to the induction of experimental autoimmune encephalomyelitis (EAE) 191 ."
28959952
ZRANB1 affects CXXC1
| 1
ZRANB1 binds CXXC1. 1 / 1
| 1
sparser
"We further show that the N-terminal Npl4-like zinc finger (NZF1) domain of the K29/K33-specific deubiquitinase TRABID specifically binds K29/K33-linked diUb, and a crystal structure of this complex explains TRABID specificity and suggests a model for chain binding by TRABID."
25752577
ZRANB1 affects CORO7
1 |
ZRANB1 binds CORO7. 1 / 1
1 |
biogrid
No evidence text available
24768539
ZRANB1 affects CGAS
| 1
ZRANB1 inhibits CGAS. 1 / 1
| 1
eidos
"TRABID inhibition causes micronuclei through a combinatory defect in mitosis and autophagy and protects cGAS from autophagic degradation , thereby activating the cGAS / STING innate immunity pathway ."
37237031
ZRANB1 affects CACYBP
1 |
ZRANB1 binds CACYBP. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects BICD2
1 |
BICD2 binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects BECN1
| 1
ZRANB1 inhibits BECN1. 1 / 1
| 1
reach
"Among the subunits of VPS34 complex, TRABID overexpression reduced the ubiquitination level of transfected and endogenous VPS34, but not AMBRA1, Beclin-1, ATG14 and UVRAG."
33637724
ZRANB1 affects AXIN2
| 1
ZRANB1 decreases the amount of AXIN2. 1 / 1
| 1
reach
"Secondly, the TRABID shRNAs failed to downregulate Wnt and beta-catenin-mediated transcription activity or endogenous Wnt target gene Axin2 mRNA levels in these tumor cells."
22584113
ZRANB1 affects ATG16
| 1
ZRANB1 activates ATG16. 1 / 1
| 1
reach
"However, TRABID knockdown diminished DFCP1 puncta, ATG16 puncta, and ATG14 puncta."
33637724
ZRANB1 affects ATG16 puncta
| 1
ZRANB1 activates ATG16 puncta. 1 / 1
| 1
eidos
"However , TRABID knockdown diminished DFCP1 puncta , ATG16 puncta , and ATG14 puncta ( Fig. 1f , g and Supplementary Fig. 1d ) ."
33637724
ZRANB1 affects ATG14 puncta
| 1
ZRANB1 activates ATG14 puncta. 1 / 1
| 1
eidos
"However , TRABID knockdown diminished DFCP1 puncta , ATG16 puncta , and ATG14 puncta ( Fig. 1f , g and Supplementary Fig. 1d ) ."
33637724
ZRANB1 affects ANK1
| 1
ZRANB1 binds ANK1. 1 / 1
| 1
reach
"Indeed, these residues are reminiscent of the TPLH motif that is characteristic for internal Ank repeats XREF_BIBR, and it is possible that other Ank repeat containing proteins may bind Ub in a similar fashion to TRABID."
22157957
ZRANB1 affects ANK
| 1
Ubiquitin binds ZRANB1 and ANK. 1 / 1
| 1
sparser
"This confirmed that the Ank domain of TRABID interacts with Ub."
22157957
ZRANB1 affects AMBRA1
| 1
ZRANB1 inhibits AMBRA1. 1 / 1
| 1
reach
"Among the subunits of VPS34 complex, TRABID overexpression reduced the ubiquitination level of transfected and endogenous VPS34, but not AMBRA1, Beclin-1, ATG14 and UVRAG."
33637724
ZRANB1 affects ALDH18A1
1 |
biogrid
No evidence text available
19615732
ZRANB1 affects ADRB2
| 1
ZRANB1 decreases the amount of ADRB2. 1 / 1
| 1
reach
"We then examined the expression of 10 previously reported PRC2 target genes, and we found that ADRB2 and DAB2IP were significantly upregulated by knockdown of EZH2 in MDA-MB-231 cells (XREF_SUPPLEMENTARY); consistently, knockdown of ZRANB1 in MDA-MB-231 cells also increased ADRB2 and DAB2IP mRNA levels (XREF_SUPPLEMENTARY)."
29669287
ZNF414 affects ZRANB1
1 |
ZRANB1 binds ZNF414. 1 / 1
1 |
biogrid
No evidence text available
28514442
WIPI1 affects ZRANB1
| 1
ZRANB1 binds WIPI1. 1 / 1
| 1
sparser
"Inactive TRABID forms puncta enriched in atypical polyUb."
22157957
ctd
No evidence text available
25560391
Ubiquitin affects TAB3
| 1
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
Ubiquitin affects ANK
| 1
Ubiquitin binds ZRANB1 and ANK. 1 / 1
| 1
sparser
"This confirmed that the Ank domain of TRABID interacts with Ub."
22157957
Ub binding fold affects ZRANB1
| 1
Ub binding fold inhibits ZRANB1. 1 / 1
| 1
reach
"A novel Ub binding fold, the AnkUBD, further restricts the linkage specificity of the TRABID OTU domain and makes TRABID most efficient for Lys29- and Lys33-linkages."
22157957
UVRAG affects ATG14
| 1
UVRAG binds ZRANB1 and ATG14. 1 / 1
| 1
sparser
"Immunoprecipitation analysis revealed the association of TRABID with both ATG14 and UVRAG, along with the common subunits of VPS34 complex, in cells cultured in DMEM or EBSS (Supplementary Fig.  xref )."
33637724
USP1 affects USP9X, and ZRANB1
| 1
USP1 binds USP9X and ZRANB1. 1 / 1
| 1
sparser
"In this study, we demonstrated that Usp1, Usp9 and Trabid are interacting proteins of Mib and Mib2 by yeast two-hybrid and immunoprecipitation."
24714733
UCHL3 affects ZRANB1
| 1
UCHL3 activates ZRANB1. 1 / 1
| 1
reach
"Structure of a USP20 inhibitor from GSK.Figure 29 Structure of a USP30 inhibitor.Structures of UCHL1 inhibitors.VAE(OMe)-FMK Structure of a weak tripeptide FMK UCHL1 inhibitor.Figure 33 Structures of UCHL3 inhibitors.Structures of TRABID and RPN11 inhibitors."
26852935
UBP1 affects ZRANB1
1 |
UBP1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
UBI4 affects ZRANB1
| 1
ZRANB1 binds UBI4. 1 / 1
| 1
sparser
"We focused on the NZF1 of TRABID, which binds to K29 and K33 polyUb and pulls down small amounts of M1 and K63 chains ( xref D)."
25752573
UBE2S affects ZRANB1
1 |
UBE2S binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
20622874
UBD affects gag
| 1
ZRANB1 binds UBD and gag. 1 / 1
| 1
sparser
"We found that the TRABID N terminus, which contains three Npl4-type zinc finger (NZF) UBDs, specifically binds K29- and K33-linked diUb, and specificity can be attributed to the first NZF domain (NZF1)."
25752577
TWIST1 affects GST
| 1
GST binds TWIST1 and ZRANB1. 1 / 1
| 1
sparser
"We also demonstrated that Trabid mainly interacted with the FL and the 169–202 amino acid fragment (Twist1 box domain) of GST-Twist1, but not with other Twist1 fragments and GST alone (Fig.  xref )."
29748601
TUMOR-SUPPRESSOR-PROTEIN affects ZRANB1
| 1
ZRANB1 binds TUMOR-SUPPRESSOR-PROTEIN. 1 / 1
| 1
trips
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt-mediated transcription."
18281465
TRAF6 affects OTUD7B
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
TP53BP1 affects ZRANB1
| 1
reach
"Here, we demonstrate that TRABID deubiquitinase binds to 53BP1 at endogenous level and regulates 53BP1 retention at DSB sites."
37002234
TCF12 affects ZRANB1
1 |
TCF12 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
TAB3 affects ZRANB1
| 1
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
SUZ12 affects RBBP4
| 1
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
SUZ12 affects EZH2
| 1
SUZ12 binds ZRANB1 and EZH2. 1 / 1
| 1
sparser
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 ( xref ) and, reciprocally, the interaction of either exogenous ( xref ) or endogenous ( xref ) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
SUZ12 affects EED
| 1
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
STRIPAK affects ZRANB1
| 1
ZRANB1 binds STRIPAK. 1 / 1
| 1
reach
"Although this kinase and phosphatase complex had already been identified in the original full-length TRABID WT interactome, our data now show that the interaction between STRIPAK and TRABID is primarily mediated by the catalytic OTU domain rather than the ubiquitin binding properties of TRABID NZF (XREF_FIG, B and C)."
| PMC
STRIP2 affects ZRANB1
1 |
ZRANB1 binds STRIP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
STAT6 affects ZRANB1
1 |
STAT6 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
SPZ1 affects ZRANB1
1 |
SPZ1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
SMAD3 affects ZRANB1
1 |
SMAD3 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
RUBCN affects PIK3C3
| 1
ZRANB1 binds RUBCN and PIK3C3. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
RORA affects ZRANB1
1 |
RORA decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
RFX1 affects ZRANB1
1 |
RFX1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
REPIN1 affects ZRANB1
1 |
REPIN1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
RBBP4 affects ZRANB1
| 1
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
PRC2_complex affects ZRANB1
| 1
PRC2_complex binds ZRANB1. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
PPP2R1B affects ZRANB1
1 |
biogrid
No evidence text available
19615732
POU2F1 affects ZRANB1
1 |
POU2F1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
PMF1 affects ZRANB1
1 |
ZRANB1 binds PMF1. 1 / 1
1 |
biogrid
No evidence text available
26186194
PIK3C3 affects RUBCN, and ZRANB1
| 1
ZRANB1 binds RUBCN and PIK3C3. 1 / 1
| 1
sparser
"However, no association of TRABID with Rubicon, which forms a VPS34 complex with autophagy-inhibitory function xref , could be detected (Supplementary Fig.  xref )."
33637724
PHF20 affects Ubiquitin
| 1
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
PHF20 affects TAB2, and ZRANB1
| 1
PHF20 binds TAB2 and ZRANB1. 1 / 1
| 1
sparser
"For example, NZF domains of TAB2 (TAK1 binding protein 2) or TRABID (TRAF binding domain) preferentially bind to Lys63- over Lys48-linked ubiquitin chains xref ."
19773779
PHF20 affects TAB2, TAB3, Ubiquitin, and ZRANB1
| 1
Ubiquitin binds PHF20, TAB2, ZRANB1, and TAB3. 1 / 1
| 1
sparser
"Whereas the NZF motif of TAB2, TAB3 and ZRANB1 binds ubiquitin though a conserved TY/F motif (T674, F675 in TAB2), the NZF motif of RANBP2 does not associate with ubiquitin, due to the divergence of the TY/F motif to LV (L1489, V1490) ( xref , blue box) ( xref )."
22704558
PGAM5 affects ZRANB1
1 |
ZRANB1 binds PGAM5. 1 / 1
1 |
biogrid
No evidence text available
19615732
OTUD7B affects ZRANB1
| 1
TRAF6 binds OTUD7B and ZRANB1. 1 / 1
| 1
sparser
"Co-immunoprecipitation studies indicated that TRAF6 was able to interact with both Cezanne and TRABID."
11463333
OTUB1 affects ZRANB1
| 1
ZRANB1 binds OTUB1. 1 / 1
| 1
sparser
"Crystal structures of the human OTUB1, OTUB2, TRABID, A20, and yeast Otu1 enzymes have revealed the conserved catalytic OTU domain which contains the S1 site, and N-terminal residues in TRABID and OTUB1 that form the S1’ site [ xref - xref , xref - xref ] (see xref S1/S1’ nomenclature)."
23845989
OTU domain affects NSC267309
| 1
ZRANB1 binds NSC267309 and OTU domain. 1 / 1
| 1
reach
"The molecular modeling of the bindings of NSC112200, NSC267309 and NSC60650 to TRABID OTU domain suggests that while all three compounds can form electrostatic interactions with the side chain of E522 and the backbone NH of T556, both NSC112200 and NSC267309 can form an additional hydrogen bond with the side chain of S491."
22584113
OTU domain affects DDB2
| 1
ZRANB1 binds DDB2 and OTU domain. 1 / 1
| 1
reach
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
O41957 affects ZRANB1
1 |
ZRANB1 binds O41957. 1 / 1
1 |
virhostnet
No evidence text available
22028648
NXF1 affects ZRANB1
1 |
ZRANB1 binds NXF1. 1 / 1
1 |
biogrid
No evidence text available
22658674
NSC267309 affects ZRANB1
| 1
ZRANB1 binds NSC267309 and OTU domain. 1 / 1
| 1
reach
"The molecular modeling of the bindings of NSC112200, NSC267309 and NSC60650 to TRABID OTU domain suggests that while all three compounds can form electrostatic interactions with the side chain of E522 and the backbone NH of T556, both NSC112200 and NSC267309 can form an additional hydrogen bond with the side chain of S491."
22584113
NSC1122002 affects ZRANB1
| 1
NSC1122002 inhibits ZRANB1. 1 / 1
| 1
reach
"NSC1122002 is a novel inhibitor of TRABID, and this study aimed to examine the effects of NSC1122002 on the expression of IL-12 and IL-23 both in vitro and in vivo in the context of collagen-induced arthritis, consequently to evaluate its potential as a drug candidate for treating inflammatory disease."
34936549
Menthol affects ZRANB1
1 |
Menthol decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
26760959
MOV10 affects ZRANB1
1 |
ZRANB1 binds MOV10. 1 / 1
1 |
biogrid
No evidence text available
22658674
MOB4 affects ZRANB1
1 |
MOB4 binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
MITF affects ZRANB1
| 1
ZRANB1 binds MITF. 1 / 1
| 1
sparser
"Significantly, WT‐CLK4 disrupted the interaction between ZRANB1 and MITF (Figure  xref )."
35092699
MIB2 affects USP1, USP9X, and ZRANB1
| 1
USP1 binds USP9X, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Mib and Mib2 interact with deubiquitylases Usp1, Usp9 and Trabid."
24714733
MECOM affects ZRANB1
1 |
MECOM decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
MAP4K4 affects ZRANB1
1 |
ZRANB1 binds MAP4K4. 1 / 1
1 |
biogrid
No evidence text available
19615732
MAP3K7 affects ZRANB1
| 1
ZRANB1 binds MAP3K7. 1 / 1
| 1
reach
"The deubiquitinase Trabid interacted with TAK1, reducing immune signalling output and K63 linked ubiquitination."
24586180
LMO2 affects ZRANB1
1 |
LMO2 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
KEAP1 affects ZRANB1
1 |
ZRANB1 binds KEAP1. 1 / 1
1 |
biogrid
No evidence text available
19615732
KDM4D affects ZRANB1
| 1
ZRANB1-C443A binds KDM4D. 1 / 1
| 1
reach
"Furthermore, both wild-type and C443A Trabid physically associated with endogenous Jmjd2d in reconstituted KO MEFs (XREF_FIG and XREF_SUPPLEMENTARY)."
26808229
K 7174 affects ZRANB1
1 |
K 7174 increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
24086573
IRF1 affects ZRANB1
1 |
IRF1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
HIF1AN affects USP1, USP9X, and ZRANB1
| 1
USP1 binds USP9X, HIF1AN, and ZRANB1. 1 / 1
| 1
sparser
"The interaction of Usp1, Usp9, Trabid, Fih-1 and Mib/Mib2 were confirmed by immunoprecipitation."
24714733
HIF1AN affects MIB2, and ZRANB1
| 1
HIF1AN binds ZRANB1 and MIB2. 1 / 1
| 1
sparser
"Since both Mib and Mib2 can bind to Fih-1 and Trabid, we next asked whether Mib and Mib2 could promote the most C-terminal RF-dependent substrate ubiquitylation."
24714733
HIF1AN affects MIB2, USP1, USP9X, and ZRANB1
| 1
USP1 binds USP9X, HIF1AN, ZRANB1, and MIB2. 1 / 1
| 1
sparser
"Usp1, Usp9, Trabid and Fih-1 also bound to zebrafish Mib2, a Mib homolog with similar structural domains and functions."
24714733
HERC2 affects ZRANB1
1 |
ZRANB1 binds HERC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
HECTD1 affects APC
| 1
ZRANB1 binds HECTD1 and APC. 1 / 1
| 1
reach
"Additionally, it was shown that the Trabid, Hectd1, and APC complex interacts with proteins composing the striatin interacting phosphatase and kinase (STRIPAK) complex that regulates cortical actin cytoskeleton dynamics [XREF_BIBR]."
29299163
GST affects TWIST1, and ZRANB1
| 1
GST binds TWIST1 and ZRANB1. 1 / 1
| 1
sparser
"We also demonstrated that Trabid mainly interacted with the FL and the 169–202 amino acid fragment (Twist1 box domain) of GST-Twist1, but not with other Twist1 fragments and GST alone (Fig.  xref )."
29748601
GFI1 affects ZRANB1
1 |
GFI1 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
GCC2 affects ZRANB1
1 |
ZRANB1 binds GCC2. 1 / 1
1 |
biogrid
No evidence text available
19615732
FOXF2 affects ZRANB1
1 |
FOXF2 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
FGFR1OP2 affects ZRANB1
1 |
ZRANB1 binds FGFR1OP2. 1 / 1
1 |
biogrid
No evidence text available
19615732
FBXW11 affects ZRANB1
1 |
FBXW11 binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
EZH2 affects SUZ12, and ZRANB1
| 1
SUZ12 binds ZRANB1 and EZH2. 1 / 1
| 1
sparser
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 ( xref ) and, reciprocally, the interaction of either exogenous ( xref ) or endogenous ( xref ) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287
ETV4 affects ZRANB1
1 |
ETV4 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
EED affects ZRANB1
| 1
SUZ12 binds ZRANB1, EED, and RBBP4. 1 / 1
| 1
sparser
"Interestingly, knockdown of EZH2 impaired but did not abolish the interaction of ZRANB1 with SUZ12, RBBP4, and EED ( xref ), indicating that EZH2 partially mediates the association of ZRANB1 with the PRC2."
29669287
DDB2 affects OTU domain, and ZRANB1
| 1
ZRANB1 binds DDB2 and OTU domain. 1 / 1
| 1
reach
"Immunoprecipitation assay showed that the interaction of TRABID and DDB2 is mediated by their OTU domain and N-terminal region, respectively."
35944360
D-glucopyranose affects ZRANB1
1 |
D-glucopyranose decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
22634610
Carcinoma, Hepatocellular activates ZRANB1. 1 / 1
| 1
reach
"Deubiquitinase ZRANB1 drives hepatocellular carcinoma progression through SP1-LOXL2 axis."
34765294
CXXC1 affects ZRANB1
| 1
ZRANB1 binds CXXC1. 1 / 1
| 1
sparser
"We further show that the N-terminal Npl4-like zinc finger (NZF1) domain of the K29/K33-specific deubiquitinase TRABID specifically binds K29/K33-linked diUb, and a crystal structure of this complex explains TRABID specificity and suggests a model for chain binding by TRABID."
25752577
CORO7 affects ZRANB1
1 |
ZRANB1 binds CORO7. 1 / 1
1 |
biogrid
No evidence text available
24768539
CDX2 affects ZRANB1
1 |
CDX2 decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
CACYBP affects ZRANB1
1 |
ZRANB1 binds CACYBP. 1 / 1
1 |
biogrid
No evidence text available
19615732
BICD2 affects ZRANB1
1 |
BICD2 binds ZRANB1. 1 / 1
1 |
biogrid
No evidence text available
19615732
Antirheumatic Agents increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
24449571
AZM551248 affects ZRANB1
1 |
AZM551248 decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
22323515
ATP12A affects ZRANB1
1 |
ATP12A decreases the amount of ZRANB1. 1 / 1
1 |
biopax:msigdb
No evidence text available
ATG14 affects UVRAG, and ZRANB1
| 1
UVRAG binds ZRANB1 and ATG14. 1 / 1
| 1
sparser
"Immunoprecipitation analysis revealed the association of TRABID with both ATG14 and UVRAG, along with the common subunits of VPS34 complex, in cells cultured in DMEM or EBSS (Supplementary Fig.  xref )."
33637724
APC affects HECTD1, and ZRANB1
| 1
ZRANB1 binds HECTD1 and APC. 1 / 1
| 1
reach
"Additionally, it was shown that the Trabid, Hectd1, and APC complex interacts with proteins composing the striatin interacting phosphatase and kinase (STRIPAK) complex that regulates cortical actin cytoskeleton dynamics [XREF_BIBR]."
29299163
APC tumor suppressor protein affects ZRANB1
| 1
ZRANB1 binds APC tumor suppressor protein. 1 / 1
| 1
reach
"We further show that Trabid can bind to and deubiquitylate the APC tumor suppressor protein, a negative regulator of Wnt mediated transcription."
18281465
ANK1 affects ZRANB1
| 1
ZRANB1 binds ANK1. 1 / 1
| 1
reach
"Indeed, these residues are reminiscent of the TPLH motif that is characteristic for internal Ank repeats XREF_BIBR, and it is possible that other Ank repeat containing proteins may bind Ub in a similar fashion to TRABID."
22157957
ANK affects ZRANB1
| 1
Ubiquitin binds ZRANB1 and ANK. 1 / 1
| 1
sparser
"This confirmed that the Ank domain of TRABID interacts with Ub."
22157957
ALDH18A1 affects ZRANB1
1 |
biogrid
No evidence text available
19615732
2-hydroxypropanoic acid decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
30851411
1-methylanthracene increases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
28329830
reach
"Bioluminescent imaging of live animals revealed the consistent reduction of lung metastases in mice treated with DOPC encapsulated ZRANB1 siRNA, but not in mice treated with DOPC encapsulated scramble RNA oligonucleotides (XREF_FIG)."
29669287
4,4'-diaminodiphenylmethane decreases the amount of ZRANB1. 1 / 1
1 |
ctd
No evidence text available
30723492