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ZRANB1 activates EZH2. 4 / 4
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"Ectopic expression of ZRANB1 in both LM2 cells (XREF_FIG) and HEK293T cells (XREF_SUPPLEMENTARY) markedly upregulated endogenous EZH2 protein and increased cell proliferation, which could be reversed by knockdown of EZH2."
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"The histone methyltransferase EZH2 also appears to be a target of TRABID DUB activity , and TRABID depletion has been shown to decrease EZH2 levels ( 38 ) ."
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"Furthermore, purified His ZRANB1 could bind to purified GST-EZH2 under cell-free conditions (XREF_FIG), suggesting that ZRANB1 may directly regulate EZH2."
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"To determine whether the six EZH2 interacting DUBs affect EZH2 ubiquitination and protein levels, we transfected them individually into HEK293T cells, and we found that USP22 and ZRANB1 decreased the polyubiquitination of EZH2 (XREF_SUPPLEMENTARY); however, only ZRANB1 upregulated endogenous EZH2 protein (XREF_SUPPLEMENTARY)."
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