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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ZRANB1 inhibits IL12. 2 / 2

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"Moreover ZRANB1 deficiency in macrophages and dendritic cells impairs the induction of IL-12 and IL-23 by the regulation of histone modifications at the IL-12 promoter, indicating a role of ZRANB1 in mediating inflammatory responses 18 and macrophage activation 19."

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"By employing a gene targeting approach, we show that Trabid deficiency in DCs and macrophages impaired the induction of Il12 and Il23 genes without affecting the induction of many other cytokine genes."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...