IndraLab

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ZRANB1 deubiquitinates EZH2. 3 / 4
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"To further determine whether ZRANB1 directly deubiquitinates EZH2, we incubated purified ZRANB1 and ubiquitinated EZH2 purified from ZRANB1-knockout HEK293A cells in a cell-free system."
29669287
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"ZRANB1 purified from insect cells markedly decreased EZH2 polyubiquitination in vitro (XREF_FIG), suggesting that EZH2 is a substrate of ZRANB1."
29669287
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"When recruited by lncRNA FAM83C-AS1, ZRANB1 de-ubiquitinates and stabilizes histone methyltransferase EZH2 to downregulate the expression of the metastasis suppressor SEMA3F and increase CRC cell stemness, proliferative, and metastatic capabilities [183]."
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