IndraLab

Statements

ZRANB1 binds EZH2. 14 / 14
| 5 9
sparser
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
29669287
sparser
"Based on the result of a previous study, we found that binding of zinc finger RANBP2-type containing 1 (ZRANB1) to EZH2 led to EZH2 deubiquitination, thereby stabilizing EZH2 protein expression in breast cancer [ xref ]."
33109776
reach
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
29669287
sparser
"Deletion analysis using various truncation mutants (M1, NZFs; M2, NZFs + AnkUBD; M3, AnkUBD + OTU; xref ) demonstrated that the OTU domain not only mediated the physical interaction of ZRANB1 with EZH2 ( xref ) but also was required for the stabilization of EZH2 by ZRANB1 ( xref )."
29669287
sparser
"Moreover, CoIP assay indicated that FAM83C-AS1 depletion inhibited the association of ZRANB1 with EZH2 ( xref )."
33109776
sparser
"Previous studies have revealed that ZRANB1 binding to EZH2 resulted in EZH2 deubiquitination and thereby stabilized EZH2 protein in breast cancer [ xref ]."
33109776
sparser
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
30150556
reach
"ZRANB1 binds, deubiquitinates, and stabilizes EZH2."
30150556
reach
"They demonstrated that ZRANB1 can bind, deubiquitinate, and stabilize EZH2, which enhances breast cancer tumorigenesis and metastasis."
33308321
sparser
"Furthermore, binding-domain mapping analysis showed that both the N-terminal region (EID + D1) and the CXC domain of EZH2 could interact with ZRANB1 ( xref , xref )."
29669287
sparser
"They demonstrated that ZRANB1 can bind, deubiquitinate, and stabilize EZH2, which enhances breast cancer tumorigenesis and metastasis."
33308321
reach
"Previous studies have revealed that ZRANB1 binding to EZH2 resulted in EZH2 deubiquitination and thereby stabilized EZH2 protein in breast cancer [XREF_BIBR]."
33109776
sparser
"It should be noted that all three truncation mutants of ZRANB1 were also localized in both the nucleus and the cytoplasm ( xref ), suggesting that the M1 and M2 mutants of ZRANB1 did not interact with EZH2 because they lack the OTU domain, not because they were not localized in the nucleus."
29669287
reach
"Furthermore, we observed the interaction of ZRANB1 with endogenous EZH2 and SUZ12 (XREF_SUPPLEMENTARY) and, reciprocally, the interaction of either exogenous (XREF_SUPPLEMENTARY) or endogenous (XREF_FIG) EZH2 with endogenous ZRANB1, SUZ12, and EED, suggesting that ZRANB1 may regulate EZH2 that is present in the PRC2."
29669287