IndraLab

Statements

ZRANB1 activates MAP1LC3. 3 / 3
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"Remarkably, UBE3C depletion induced upregulation of VPS34 expression, LC3 puncta and LC3 lipidation in cells cultured in DMEM or EBSS were all reversed by TRABID knockdown."
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"Accordingly, LC3 lipidation was also enhanced by TRABID overexpression in DMEM- or EBSS cultured cells treated with bafilomycin A1."
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"Furthermore, in cells treated with bafilomycin A1 to block autophagic turnover, TRABID knockdown still reduced LC3 lipidation but did not alter p62 level, indicating a promoting role of TRABID in autophagosome formation."
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