IndraLab
Statements
eidos
"Regardless of the mechanism that TRABID reduces K48 linkages from the substrate , the partially overlapping chain type specificity of UBE3C and TRABID , as well as their opposite roles in regulating VPS34 , suggest that they function as an E3 ligase-DUB pair to govern the K29 / K48 ubiquitination status and the stability of a set of cellular proteins ."