IndraLab

Statements

ZRANB1 increases the amount of LOXL2. 3 / 3
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"We also demonstrated that ZRANB1 knockdown downregulated the expression of LOXL2 and suppressed HCC growth and metastasis in vitro and in vivo ."
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"In addition, it has also been reported that deubiquitinase (DUB) zinc finger RANBP2-type containing 1 (ZRANB1) can upregulate the transcription of LOXL2 and promote the proliferation and migration of HCC cells by deubiquitination of specificity protein 1 (SP1) [74]."
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"ZRANB1, as a deubiquitinate, is involved in the increasing progression and malignancy of HCC and, to this end, increases LOXL2 expression to promote tumor metastasis [68]."
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