IndraLab

Statements

ZRANB1 activates Wnt. 4 / 4
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"TRABID, one of K63 specific DUB enzymes, became an attractive candidate to achieve this task since it has been reported to regulate Wnt signal positively [XREF_BIBR], as inhibition of TRABID presumably decreases Wnt signaling activity."
22584113
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"Although Trabid was first reported to activate the Wnt pathway by cleavage of the K63 linked chains, it was recently demonstrated to be 40-fold more active toward the K29 linked chains."
21118991
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"However, in this study, we failed to confirm the notion that TRABID positively regulates canonical Wnt signaling based on several lines of evidence."
22584113
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"ZRANB1 has been shown to increase the stability of β-catenin and induce the activation of the Wnt signaling in CRC cells [11] ."
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