IndraLab

Statements

ZRANB1 binds HECTD1. 14 / 14
4 | 2 8
biogrid
No evidence text available
23277359
biogrid
No evidence text available
23277359
reach
"GST pull-down was also used to further validate the interaction between TRABID and HECTD1."
| PMC
sparser
"Together, our data identify TRABID-HECTD1 as the first DUB-E3 pair regulating K29-linked polyubiquitin chains."
| PMC
sparser
"Although we attempted to validate the interaction between endogenous TRABID and endogenous HECTD1, none of the four TRABID antibodies that we tried could detect endogenous TRABID (Data not shown)."
| PMC
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
| PMC
reach
"Although we attempted to validate the interaction between endogenous TRABID and endogenous HECTD1, none of the four TRABID antibodies that we tried could detect endogenous TRABID (Data not shown)."
| PMC
biogrid
No evidence text available
19615732
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase that assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
33853758
sparser
"Thus, this study identifies HECTD1 as a mammalian E3 ligase which assembles branched K29/K48 chains and also establishes TRABID-HECTD1 as a DUB/E3 pair regulating K29 linkages."
33380427
sparser
"Therefore, we further explored the TRABID-HECTD1 interaction in order to reconcile and also expand on these observations."
| PMC
sparser
"Therefore, we further explored the molecular basis for the TRABID-HECTD1 interaction and hypothesized that HECTD1 could assemble ubiquitin chains that are subject to TRABID DUB activity."
| PMC
biogrid
No evidence text available
23277359
sparser
"Transient and genetic loss-of-function/rescue assays in mammalian cells showed that TRABID-HECTD1 is a functional DUB-E3 pair, with TRABID required to maintain HECTD1 stability."
| PMC