IndraLab

"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals including Dox [ xref ].."

24143256

➶

biogrid

No evidence text available

22085928

➶

sparser

"USP42 forms a direct complex with p53 and controls level of ubiquitination during the early phase of the response to a range of stress signals."

22085928

➶

sparser

"Usp42 forms a direct complex with p53 and controls its activation in response to cellular stress; as a result it regulates p53-dependent transcription and cell cycle arrest."

25962961

➶

biogrid

No evidence text available

22085928

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

TP53 binds USP10, USP7, and USP42. 1 / 1

| 1

➶

sparser

"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."

31745110

USP42 deubiquitinates TP53.

1 | 6

USP42 deubiquitinates TP53. 7 / 7

1 | 6

➶

reach

"It has been reported that USP42 interacts with and deubiquitinates p53."

24143256

➶

reach

"In the initial phases of a stress response, USP42 deubiquitinates p53 by forming a direct complex with p53."

29479529

➶

reach

"During the early phase of response to a stress signal, USP42 preferentially makes up a complex with and deubiquitinates p53, leading to the rapid activation of p53 for cell cycle arrest and p53-dependent transcription [55]."

| PMC

➶

ubibrowser

"Review"

28801249

➶

reach

"P53 can be directly deubiquitinated by Usp42 which reverses its ubiquitination by MDM2 [XREF_BIBR]."

25962961

➶

reach

"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."

31745110

➶

reach

"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."

28208785

USP42 activates TP53.

| 3 1

USP42 activates TP53. 4 / 4

| 3 1

➶

reach

"Our previous work showed that USP42 can target p53 for deubiquitylation, with depletion of USP42 resulting in delays in stabilization of p53 and recruitment of p53 to target gene promoters."

25336640

➶

sparser

"Importantly though, USP42-dependent activation of p53 does not lead to apoptosis, suggesting that its main function is to contribute to the repair and recovery of cells from mild or transient damage."

32201366

➶

reach

"USP42 itself was reported to increase the stability of p53 [XREF_BIBR]."

24646765

➶

reach

"Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent cell-cycle arrest in response to stress."

22085928

USP42 affects Histone_H2B

| 6 2

USP42 binds Histone_H2B.

| 1 2

Histone_H2B binds USP42. 3 / 5

| 1 2

➶

sparser

"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."

25336640

➶

sparser

"This was of particular interest because a proteomic analysis of USP42-binding proteins had shown association of USP42 with histone H2B and other components of the transcriptional machinery (not shown)."

25336640

➶

reach

"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."

25336640

USP42 ubiquitinates Histone_H2B.

| 2

USP42 leads to the ubiquitination of Histone_H2B. 2 / 2

| 2

➶

reach

"Depletion of USP42 increased H2B ubiquitylation at a model promoter and decreased both basal and induced transcription from a number of promoters."

25336640

➶

reach

"These results suggest that USP42 can specifically modulate the levels of H2B ubiquitylation in the first nucleosomes of the p21 coding sequences in response to p53 activation."

25336640

USP42 deubiquitinates Histone_H2B.

| 2

USP42 deubiquitinates Histone_H2B. 2 / 2

| 2

➶

reach

"Interestingly, USP42 was also proposed to regulate transcription by deubiquitylating histone H2B [56]."

33731873

➶

reach

"Indeed, in vitro analysis showed that USP42 is able to efficiently deubiquitylate histone H2B (XREF_FIG, E and F)."

25336640

USP42 activates Histone_H2B.

| 1

USP42 activates Histone_H2B. 1 / 1

| 1

➶

reach

"Results : USP42 targets histone H2B at promoters, leading to decreased ubiquitylation."

25336640

USP42 affects cell population proliferation

| 2 5 1

USP42 activates cell population proliferation.

| 2 5

USP42 activates cell population proliferation. 7 / 7

| 2 5

➶

reach

"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."

34405018

➶

reach

"Our in vitro findings showed that silencing of USP42 inhibited cell proliferation via inducing G0/G1 arrest and suppressed cell invasion via MMPs and EMT regulators."

27030989

➶

reach

"To further explore the cellular mechanism underlying USP42 induced cell proliferation, the protein levels of cell cycle proteins were assessed."

27030989

➶

eidos

"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size , TNM staging , lymph node metastasis , and OS rate of GC patients , while inhibition of USP42 can induce G0 / G1 block and suppress cell proliferation and invasion ( Hou et al ., 2016 ) ."

33791299

➶

reach

"Moreover, USP42 silencing in two GC cell lines, AGS and MKN-45, notably inhibited cell proliferation, but stimulated G1 phase arrest."

27030989

➶

eidos

"USP42 depletion hinders cell proliferation and alters nuclear speckle morphology After comparing different methodologies to deplete USP42 expression , we achieved the best efficiency using CRISPR / Cas9 although without complete knockout , instead obtaining reduction to ~ 50 % , likely due to one allele disruption ( Fig. 6A ) ."

33731873

➶

reach

"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."

33791299

USP42 inhibits cell population proliferation.

| 1

USP42 inhibits cell population proliferation. 1 / 2

| 1

➶

sparser

"Our in vitro findings showed that silencing of USP42 inhibited cell proliferation via inducing G0/G1 arrest and suppressed cell invasion via MMPs and EMT regulators."

27030989

USP42 affects homologous recombination

| 6

USP42 activates homologous recombination.

| 5

USP42 activates homologous recombination. 4 / 4

| 4

➶

reach

"Altogether, these results indicated that USP42 promoted HR and cellular viability by facilitating DNA-end resection."

32541651

➶

reach

"To understand how USP42 promotes HR, the effects of USP42 depletion with siRNAs on various aspects of HR were investigated."

32541651

➶

reach

"USP42 promotes HR by facilitating DNA-end resection."

32541651

➶

reach

"Depleting USP42 resulted in significantly reduced RAD51 foci formation, suggesting that USP42 functions upstream of RAD51 recruitment to DSB sites and promotes HR."

32541651

USP42 activates homologous recombination. 1 / 1

| 1

➶

reach

"USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9."

32541651

USP42 inhibits homologous recombination.

| 1

USP42 inhibits homologous recombination. 1 / 1

| 1

➶

reach

"We have also performed a DR-GFP assay to investigate whether DHX9 over-expression can rescue the HR defect caused by USP42 depletion (Fig. S5E)."

32541651

USP42 affects DHX9

| 3 3

USP42 binds DHX9.

| 2 3

USP42 binds DHX9. 5 / 5

| 2 3

➶

reach

"Furthermore, we established that USP42 interacts with DHX9, which possesses DNA-RNA helicase activity, and is required for efficient resolution of DSB induced R-loop."

32541651

➶

sparser

"Firstly, we confirmed that USP42 interacted with DHX9 in a reciprocal manner by coimmunoprecipitation (Fig. xref )."

32541651

➶

sparser

"It is worth noting that the interaction between USP42 and DHX9 was independent of RNA and DNA, since immunoprecipitation was carried out in the presence of Benzonase (also see section “Materials and methods”)."

32541651

➶

reach

32541651

➶

sparser

"Furthermore, we established that USP42 interacts with DHX9, which possesses DNA–RNA helicase activity, and is required for efficient resolution of DSB-induced R-loop."

32541651

USP42 activates DHX9.

| 1

USP42 activates DHX9. 1 / 1

| 1

➶

reach

"Similarly, the deubiquitinase USP42 promotes DHX9 activity towards R-loops at DSBs and is needed to recruit BRCA1 to break sites (Matsui et al., 2020)."

35508167

Histone_H2B affects USP42

| 2 2

Histone_H2B binds USP42.

| 1 2

Histone_H2B binds USP42. 3 / 5

| 1 2

➶

sparser

"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."

25336640

➶

sparser

25336640

➶

reach

"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."

25336640

Histone_H2B activates USP42.

| 1

Histone_H2B activates USP42. 1 / 1

| 1

➶

reach

"Results : USP42 targets histone H2B at promoters, leading to decreased ubiquitylation."

25336640

Valproic acid affects USP42

5 |

Valproic acid decreases the amount of USP42.

4 |

Valproic acid decreases the amount of USP42. 4 / 4

4 |

➶

ctd

No evidence text available

23179753

➶

ctd

No evidence text available

26272509

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

28001369

Valproic acid methylates USP42.

1 |

Valproic acid methylates USP42. 1 / 1

1 |

➶

ctd

No evidence text available

29154799

USP42 affects Wnt

| 3 2

USP42 inhibits Wnt. 5 / 5

| 3 2

➶

eidos

"Accordingly , USP42 increases the turnover of LRP6 and Frizzled ( FZD ) receptors and inhibits Wnt signalling ."

33786993

➶

reach

"USP42 protects ZNRF3 and RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling."

33786993

➶

reach

"Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling."

33786993

➶

eidos

"USP42 protects ZNRF3 / RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling ."

33786993

➶

eidos

"We conclude that USP42 inhibits Wnt signalling in HCT116 cells by destabilising the Wnt receptors , independently of its roles in p53 response to genotoxic stress ."

33786993

USP42 affects RUNX1

| 5

RUNX1 binds USP42. 5 / 5

| 5

➶

sparser

"Of note, del(5q) occurs as a secondary abnormality in at least two subtypes of AML with cryptic abnormalities: t(5;11)(q35;p15)/ NUP98-NSD1 and the rare t(7;21)(p22;q22)/ RUNX1-USP42 , thus emphasizing the need for a complete cytogenetic and molecular screening of such cases [ xref , xref , xref ]."

34204358

➶

sparser

"Today, t(7;21)(p22;q22)/ RUNX1-USP42 is considered a rare nonrandom genomic aberration of myeloid malignancies which is frequently seen together with del(5q) [ xref – xref ]."

29672642

➶

sparser

"Recently, it was suggested that AML with diploidy/tetraploidy and/or 5q alterations may be associated with the cryptic translocation, t(7;21)(p22;q22) resulting in RUNX1-USP42 gene fusion and this association may have been underestimated."

34974291

➶

sparser

"The t(7;21)(p22;q22) which generates the RUNX1-USP42 fusion gene was originally found in a 7-year-old boy with AML-M0 [ xref ]."

29672642

➶

sparser

"Whole-genome sequencing identified cytogenetically cryptic structural variants in 13 patients, including complex or cryptic chromosomal translocations involving the inv(16)(p13.1q22) fusion gene CBFB–MYH11 in 2 patients, the t(7;21) (p22;q22) fusion gene USP42–RUNX1 in 1 patient, and 10 rearrangements involving KMT2A , all of which were verified with the use of orthogonal methods ( xref and xref , xref , and xref in the xref )."

33704937

DHX9 affects USP42

| 2 3

USP42 binds DHX9. 5 / 5

| 2 3

➶

reach

"Furthermore, we established that USP42 interacts with DHX9, which possesses DNA-RNA helicase activity, and is required for efficient resolution of DSB induced R-loop."

32541651

➶

sparser

"Firstly, we confirmed that USP42 interacted with DHX9 in a reciprocal manner by coimmunoprecipitation (Fig. xref )."

32541651

➶

sparser

32541651

➶

reach

32541651

➶

sparser

"Furthermore, we established that USP42 interacts with DHX9, which possesses DNA–RNA helicase activity, and is required for efficient resolution of DSB-induced R-loop."

32541651

USP42 affects transcription, DNA-templated

| 4

USP42 inhibits transcription, DNA-templated.

| 2

USP42 inhibits transcription, DNA-templated. 2 / 2

| 2

➶

reach

"USP42 depletion decreased the transcription of most of these target genes, although some (CASP1, PUMA, BAX, PIDD, and WIP1) were not affected (XREF_FIG G)."

25336640

➶

reach

"To assess how the knockdown of USP42 induces a change in transcription from an endogenous promoter, we investigated the influence of USP42 reduction on the p21 promoter."

25336640

USP42 activates transcription, DNA-templated.

| 2

USP42 activates transcription, DNA-templated. 2 / 2

| 2

➶

reach

"Again, we found three examples of genes that were not significantly affected by USP42 depletion (TAp73, FOXM1, and CCNE1), indicating that the requirement for USP42 to promote transcription is not universal."

25336640

➶

reach

22085928

USP42 affects PLRG1

1 | 1 2

USP42 inhibits PLRG1.

| 1

USP42 inhibits PLRG1. 1 / 1

| 1

➶

eidos

"Nevertheless , USP42 downregulation did not lead to significant changes in the expression levels of PLRG1 ( Supplementary Fig. 5C ) ."

33731873

USP42 increases the amount of PLRG1.

| 1

USP42 increases the amount of PLRG1. 1 / 1

| 1

➶

reach

"Nevertheless, USP42 downregulation did not lead to significant changes in the expression levels of PLRG1 (Supplementary Fig. 5C)."

33731873

USP42 binds PLRG1.

1 |

USP42 binds PLRG1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 activates PLRG1.

| 1

USP42 activates PLRG1. 1 / 1

| 1

➶

reach

"Notably, USP42 directs the integration of the spliceosome component PLRG1 into nuclear speckles, and its depletion interferes with the conformation of SC35 foci."

33731873

USP42 affects Neoplasm Invasiveness

| 1 3

USP42 activates Neoplasm Invasiveness.

| 1 2

USP42 activates Neoplasm Invasiveness. 3 / 3

| 1 2

➶

eidos

33791299

➶

reach

"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."

34405018

➶

reach

"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."

33791299

USP42 inhibits Neoplasm Invasiveness.

| 1

USP42 inhibits Neoplasm Invasiveness. 1 / 1

| 1

➶

reach

"The USP42 suppressed cells exhibited significantly less invasive potential than the siNC transfected cells (P < 0.01), suggesting that high expression of USP42 enhanced tumor invasiveness."

27030989

USP42 affects DVL

| 4

DVL binds USP42. 4 / 4

| 4

➶

sparser

"USP42 binds to the Dishevelled interacting region (DIR) of ZNRF3 and stalls the R‐spondin‐LGR4‐ZNRF3 ternary complex by deubiquitinating ZNRF3."

33786993

➶

sparser

"We also found that USP42 interacts with the Dishevelled interacting region (DIR) of ZNRF3."

33786993

➶

sparser

"Cytoplasmic USP42 binds the Dishevelled interacting region of ZNRF3."

33786993

➶

sparser

"Mechanistically, USP42 interacts with the Dishevelled interacting region (DIR) of ZNRF3 and stalls the ZNRF3/LGR/RSPO complex."

33786993

Hsa-miR-7157-5p affects USP42

3 |

Hsa-miR-7157-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-6838-5p affects USP42

3 |

Hsa-miR-6838-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-6792-5p affects USP42

3 |

Hsa-miR-6792-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-6731-3p affects USP42

3 |

Hsa-miR-6731-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-6088 affects USP42

3 |

Hsa-miR-6088 decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-497-5p affects USP42

3 |

Hsa-miR-497-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-4770 affects USP42

3 |

Hsa-miR-4770 decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-4708-5p affects USP42

3 |

Hsa-miR-4708-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-4503 affects USP42

3 |

Hsa-miR-4503 decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-4482-3p affects USP42

3 |

Hsa-miR-4482-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-4310 affects USP42

3 |

Hsa-miR-4310 decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-424-5p affects USP42

3 |

Hsa-miR-424-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-3686 affects USP42

3 |

Hsa-miR-3686 decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-3607-3p affects USP42

3 |

Hsa-miR-3607-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-26a-2-3p affects USP42

3 |

Hsa-miR-26a-2-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-26a-1-3p affects USP42

3 |

Hsa-miR-26a-1-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-195-5p affects USP42

3 |

Hsa-miR-195-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-16-5p affects USP42

3 |

Hsa-miR-16-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-15b-5p affects USP42

3 |

Hsa-miR-15b-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-15a-5p affects USP42

3 |

Hsa-miR-15a-5p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-143-3p affects USP42

3 |

Hsa-miR-143-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

Hsa-miR-1273f affects USP42

3 |

Hsa-miR-1273f decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-107 affects USP42

3 |

Hsa-miR-107 decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

23446348

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

20371350

Hsa-miR-103a-3p affects USP42

3 |

Hsa-miR-103a-3p decreases the amount of USP42. 3 / 3

3 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

20371350

➶

biopax:mirtarbase

No evidence text available

23446348

USP42 affects paracrine Wnt

| 3

USP42 inhibits paracrine Wnt. 3 / 3

| 3

➶

eidos

"Taken together we concluded that Usp42 inhibits paracrine Wnt signalling in mouse small intestinal organoids ."

33786993

➶

eidos

"USP42 inhibits paracrine Wnt signalling in colorectal cancer cells A B C D E , F qPCR analysis of USP42 , LGR5 and AXIN2 expression levels in HCT116 cells ."

33786993

➶

eidos

"USP42 inhibits paracrine Wnt signalling in RKO cells A B C D Immunofluorescence microscopy showing endogenous E-cadherin levels in RKO cells upon transfection with siUSP42 ."

33786993

USP42 affects cell growth

| 1 2

USP42 activates cell growth. 3 / 3

| 1 2

➶

eidos

"Depletion of USP42 leads to a reduced number of nuclear speckles and attenuated cell growth ."

33731873

➶

reach

"Depletion of USP42 leads to a reduced number of nuclear speckles and attenuated cell growth."

33731873

➶

reach

"Functionally, USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth, which is consistent with the impact of PLRG1 repression."

33731873

USP42 affects MMP

| 3

USP42 increases the amount of MMP.

| 1

USP42 increases the amount of MMP. 1 / 1

| 1

➶

reach

"In gastric cancer cells, USP42 is regarded as an invasion promotor since the evidence showed that silencing of USP42 upregulated the expression of the E-cadherin, and downregulated the expression of MMPs, beta-catenin, Twist, and Snail1."

28279784

USP42 decreases the amount of MMP.

| 1

USP42 decreases the amount of MMP. 1 / 1

| 1

➶

reach

28279784

USP42 activates MMP.

| 1

USP42 activates MMP. 1 / 1

| 1

➶

reach

"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."

34405018

USP42 affects LRP6

| 3

USP42 ubiquitinates LRP6.

| 1

USP42 leads to the ubiquitination of LRP6. 1 / 1

| 1

➶

reach

"In this way USP42 antagonizes RSPOs by protecting ZNRF3/RNF43 from RSPO- and ubiquitin-dependent internalization, thereby increasing the ubiquitylation and turnover of FZD and LRP6 receptors, and inhibiting WNT signaling."

35817504

USP42 inhibits LRP6.

| 1

USP42 inhibits LRP6. 1 / 1

| 1

➶

reach

"Consequently, USP42 increases the turnover of Frizzled and LRP6 and diminishes WNT signaling in CRC cells and mouse intestinal organoids [73]."

34071313

USP42 activates LRP6.

| 1

USP42 activates LRP6. 1 / 1

| 1

➶

reach

"Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling."

33786993

Trichostatin A affects USP42

2 |

Trichostatin A decreases the amount of USP42. 2 / 2

2 |

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

26272509

Hsa-miR-924 affects USP42

2 |

Hsa-miR-924 decreases the amount of USP42. 2 / 2

2 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Hsa-miR-627-5p affects USP42

2 |

Hsa-miR-627-5p decreases the amount of USP42. 2 / 2

2 |

➶

biopax:mirtarbase

No evidence text available

21572407

➶

biopax:mirtarbase

No evidence text available

23446348

Cyclosporin A affects USP42

2 |

Cyclosporin A increases the amount of USP42. 2 / 2

2 |

➶

ctd

No evidence text available

20106945

➶

ctd

No evidence text available

25562108

USP7 affects USP42

| 2

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

TP53 binds USP10, USP7, and USP42. 1 / 1

| 1

➶

sparser

"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."

31745110

USP42 affects epithelial to mesenchymal transition

| 1 1

USP42 inhibits epithelial to mesenchymal transition.

| 1

USP42 inhibits epithelial to mesenchymal transition. 1 / 1

| 1

➶

eidos

"We conclude that USP42 prevents EMT in HCT116 cells by inhibiting paracrine Wnt signalling ."

33786993

USP42 activates epithelial to mesenchymal transition.

| 1

USP42 activates epithelial to mesenchymal transition. 1 / 1

| 1

➶

reach

"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."

34405018

USP42 affects USP7

| 2

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

TP53 binds USP10, USP7, and USP42. 1 / 1

| 1

➶

sparser

"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."

31745110

USP42 affects MMP9

1 | 1

USP42 increases the amount of MMP9.

| 1

USP42 increases the amount of MMP9. 1 / 1

| 1

➶

reach

"As shown in XREF_FIG, silencing of USP42 downregulated the expression of MMP-2 and MMP-9."

27030989

USP42 deubiquitinates MMP9.

1 |

USP42 deubiquitinates MMP9. 1 / 1

1 |

➶

ubibrowser

"Review"

28279784

USP42 affects Histone

| 1 1

USP42 binds Histone.

| 1

Histone binds USP42. 1 / 1

| 1

➶

sparser

"A previous proteomic analysis of the DUB interactome described an association of USP42 with histones, but also with a large number of other proteins, including other DUBs ( xref )."

25336640

USP42 activates Histone.

| 1

USP42 activates Histone. 1 / 1

| 1

➶

reach

"The binding of USP42 to histone H2B suggested that USP42 may target histones for deubiquitylation."

25336640

USP42 affects Group I intron splicing

| 2

USP42 inhibits Group I intron splicing.

| 1

USP42 inhibits Group I intron splicing. 1 / 1

| 1

➶

reach

"Functionally, USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth, which is consistent with the impact of PLRG1 repression."

33731873

USP42 activates Group I intron splicing.

| 1

USP42 activates Group I intron splicing. 1 / 1

| 1

➶

reach

"One example is the human USP42, which drives nuclear speckle phase separation dependent on its de-ubiquitinating activity, thus governing mRNA splicing events (Liu et al., 2021)."

34291086

USP42 affects FZD

| 2

USP42 ubiquitinates FZD.

| 1

USP42 leads to the ubiquitination of FZD. 1 / 1

| 1

➶

reach

35817504

USP42 activates FZD.

| 1

USP42 activates FZD. 1 / 1

| 1

➶

reach

"Accordingly, USP42 increases the turnover of LRP6 and Frizzled (FZD) receptors and inhibits Wnt signalling."

33786993

USP42 affects EGFR

| 2

USP42 binds EGFR. 1 / 1

| 1

➶

sparser

"EGFR fusions are rare genomic events in NSCLC, and a total of nine types have been previously reported in lung adenocarcinoma: EGFR-RAD51, EGFR-PURB, EGFR-ANXA2, EGFR-ZNF713, EGFR-YAP1, USP42-EGFR, EGFR-SEPTIN14, EGFR-TNS3 and EGFR-ZCCHC6."

34342091

YAP1 binds USP42 and EGFR. 1 / 1

| 1

➶

sparser

34342091

USP42 affects CDH1

| 2

USP42 decreases the amount of CDH1. 2 / 2

| 2

➶

reach

"Inhibition of miR-21-5p or knockdown of USP42 inhibited cell proliferation and cell migration, upregulated the level of E-cadherin, and downregulated the level of vimentin, fibronectin and N-cadherin."

37187452

➶

reach

28279784

USP10 affects USP7

| 2

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

TP53 binds USP10, USP7, and USP42. 1 / 1

| 1

➶

sparser

"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."

31745110

EGFR affects USP42

| 2

USP42 binds EGFR. 1 / 1

| 1

➶

sparser

34342091

YAP1 binds USP42 and EGFR. 1 / 1

| 1

➶

sparser

34342091

2,3,7,8-tetrachlorodibenzodioxine affects USP42

2 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP42. 2 / 2

2 |

➶

ctd

No evidence text available

17942748

➶

ctd

No evidence text available

25270620

17alpha-ethynylestradiol affects USP42

2 |

17alpha-ethynylestradiol increases the amount of USP42.

1 |

17alpha-ethynylestradiol increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

17942748

17alpha-ethynylestradiol decreases the amount of USP42.

1 |

17alpha-ethynylestradiol decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

23129252

Urethane affects USP42

1 |

Urethane increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

28818685

Tungsten affects USP42

1 |

Tungsten decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

30912803

Triphenyl phosphate affects USP42

1 |

Triphenyl phosphate decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

30864794

Torcetrapib affects USP42

1 |

Torcetrapib increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

23228038

Thiram affects USP42

1 |

Thiram decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

20530235

Sodium arsenite affects USP42

1 |

Sodium arsenite decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

21297353

Pirinixic acid affects USP42

1 |

Pirinixic acid decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

21318169

Phorbol 13-acetate 12-myristate affects USP42

1 |

Phorbol 13-acetate 12-myristate increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Pentachlorophenol affects USP42

1 |

Pentachlorophenol increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

23892564

Paracetamol affects USP42

1 |

Paracetamol decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

21420995

MiR-590 affects USP42

| 1

USP42 binds miR-590. 1 / 1

| 1

➶

reach

"DENV propagation, MiRNA overexpression, miRNA knockdown, transfection, RT-PCR, luciferase assay, and western blotting have been used in this study to establish the interaction of miR-590 and USP42."

32123831

MiR-21-5p affects USP42

| 1

MiR-21-5p inhibits USP42. 1 / 1

| 1

➶

reach

"Overexpression of miR-21-5p reversed the knockdown of USP42."

37187452

Methyl methanesulfonate affects USP42

1 |

Methyl methanesulfonate increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

26011545

Let-7b affects USP42

| 1

Let-7b activates USP42. 1 / 1

| 1

➶

reach

"Specifically, let-7b is predicted to target USP44, USP42 and ATXN7L3 [XREF_FIG]."

28604753

Lead diacetate affects USP42

1 |

Lead diacetate increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

20542052

Ionomycin affects USP42

1 |

Ionomycin increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Indometacin affects USP42

1 |

Indometacin decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Hsa-miR-320a affects USP42

1 |

Hsa-miR-320a decreases the amount of USP42. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Homologous recombination affects USP42

| 1

Homologous recombination inhibits USP42. 1 / 1

| 1

➶

reach

"HR efficiency that was reduced by knocking down endogenous USP42 was not significantly reverted by transient over-expression of mCherry-fused DHX9, although a trend was seen in that HR efficiency was increased."

32541651

Formaldehyde affects USP42

1 |

Formaldehyde decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

20655997

Experimental process affects USP42

| 1

Experimental process activates USP42. 1 / 1

| 1

➶

eidos

"We also established through various in vitro and in vivo experiments that increased USP42 can maintain a higher cellular level of both TRIM21 as well as OAS1 ."

35779335

Doxorubicin affects USP42

1 |

Doxorubicin decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

29803840

Dorsomorphin affects USP42

1 |

Dorsomorphin decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Disulfiram affects USP42

1 |

Disulfiram decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

20530235

Different methodologies affects USP42

| 1

Different methodologies inhibits USP42. 1 / 1

| 1

➶

eidos

33731873

Dexamethasone affects USP42

1 |

Dexamethasone decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Copper(II) sulfate affects USP42

1 |

Copper(II) sulfate increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

19549813

Cisplatin affects USP42

1 |

Cisplatin decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

27594783

Bisphenol A affects USP42

1 |

Bisphenol A increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

30816183

Acrylamide affects USP42

1 |

Acrylamide decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

28959563

ZEB1 affects USP42

1 |

ZEB1 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

29119051

YWHAQ affects USP42

1 |

YWHAQ binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

20618440

YTHDC2 affects USP42

1 |

USP42 binds YTHDC2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

YAP1 affects USP42

| 1

YAP1 binds USP42 and EGFR. 1 / 1

| 1

➶

sparser

34342091

Water Pollutants, Chemical affects USP42

1 |

Water Pollutants, Chemical decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

20526952

WDR18 affects USP42

1 |

WDR18 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Virus Diseases affects USP42

| 1

Virus Diseases activates USP42. 1 / 1

| 1

➶

reach

"Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia."

35779335

USP7 affects USP4

| 1

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

USP42 affects ubiquitination clearance

| 1

USP42 inhibits ubiquitination clearance. 1 / 1

| 1

➶

eidos

"We found that USP42 blocks ubiquitination and clearance of ZNRF3 / RNF43 by R-spondin ."

33786993

USP42 affects ubiquitination ZNRF3 RNF43

| 1

USP42 inhibits ubiquitination ZNRF3 RNF43. 1 / 1

| 1

➶

eidos

"Expression of USP42 reduced the ubiquitination of ZNRF3 and RNF43 at the plasma membrane ( Fig 3A , 2nd IP , lanes 3-4 and lanes 7-8 , respectively ) ."

33786993

USP42 affects turnover Wnt receptors

| 1

USP42 activates turnover Wnt receptors. 1 / 1

| 1

➶

eidos

"Accordingly , USP42 promotes the turnover of the Wnt receptors LRP6 and FZD and inhibits Wnt / beta-catenin signalling ."

33786993

USP42 affects turnover LRP6 Frizzled FZD

| 1

USP42 activates turnover LRP6 Frizzled FZD. 1 / 1

| 1

➶

eidos

"Accordingly , USP42 increases the turnover of LRP6 and Frizzled ( FZD ) receptors and inhibits Wnt signalling ."

33786993

USP42 affects survival HCT116 cells

| 1

USP42 inhibits survival HCT116 cells. 1 / 1

| 1

➶

eidos

"Loss of USP42 promotes Wnt-dependent EMT , survival and proliferation in HCT116 cells A-C D , E F , G Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ."

33786993

USP42 affects stabilize TRIM21 OAS1 neuroinflammatory anti-viral response human microglia

| 1

USP42 activates stabilize TRIM21 OAS1 neuroinflammatory anti-viral response human microglia. 1 / 1

| 1

➶

eidos

"Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia ."

35779335

USP42 affects spheroid growth

| 1

USP42 activates spheroid growth. 1 / 1

| 1

➶

eidos

"As in the case of HCT116 cells , knockdown of USP42 in RKO promoted spheroid growth and colony formation , which was blocked by PORCN inhibitors ( Fig EV5A-C ) ."

33786993

USP42 affects rich domain

| 1

Mutated USP42 activates rich domain. 1 / 1

| 1

➶

reach

"Expression of USP42 mutants targeting the linker domain and the C-terminal lysine rich domain (XREF_FIG B) showed that although the DUB-inactive USP42 C120A mutant retained the ability to bind histone H2B, this interaction was reduced with the DeltaKK mutant and lost with the Deltalinker mutant (XREF_FIG C)."

25336640

USP42 affects repair

| 1

USP42 activates repair. 1 / 1

| 1

➶

eidos

"This fact has also been demonstrated by others , since , it has been recently shown , that USP42 and DHX9 promote DSB repair , through R-loop resolution and have a role in DNA resection , as well ( Matsui et al ., 2020 ) ."

34691154

USP42 affects recombinational repair

| 1

USP42 activates recombinational repair. 1 / 1

| 1

➶

eidos

"USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9 ."

32541651

USP42 affects poly-ubiquitination Fig 1I

| 1

USP42 inhibits poly-ubiquitination Fig 1I. 1 / 1

| 1

➶

eidos

"We immunoprecipitated ZNRF3 under denaturing conditions and found that knockdown of USP42 increased its poly-ubiquitination ( Fig 1I ) ."

33786993

USP42 affects p53-dependent genotoxic response

| 1

USP42 activates p53-dependent genotoxic response. 1 / 1

| 1

➶

eidos

"USP42 also promotes p53-dependent genotoxic response ( Hock et al , 2011 ) ( Fig EV2 ) ."

33786993

USP42 affects nuclear speckles marked SC35

| 1

USP42 activates nuclear speckles marked SC35. 1 / 1

| 1

➶

eidos

"Interestingly , a decrease in USP42 expression led to a significantly reduced number of nuclear speckles marked with SC35 ( Fig. 6E ; Supplementary Fig. 5B ) ."

33731873

USP42 affects nuclear speck

| 1

USP42 activates nuclear speck. 1 / 1

| 1

➶

eidos

"Depletion of USP42 leads to a reduced number of nuclear speckles and attenuated cell growth ."

33731873

USP42 affects mouse intestinal organoids

| 1

USP42 inhibits mouse intestinal organoids. 1 / 1

| 1

➶

eidos

"Taken together we concluded that Usp42 inhibits paracrine Wnt signalling in mouse small intestinal organoids ."

33786993

USP42 affects most included intestinal stem cell signature

| 1

USP42 inhibits most included intestinal stem cell signature. 1 / 1

| 1

➶

eidos

"Notably , knockdown of USP42 upregulated most of the 45 genes included in the intestinal stem cell proliferation signature ( Merlos-Suarez et al , 2011 ) ( Fig 5B and Dataset EV1F ) ."

33786993

USP42 affects morphological HCT116 cells including shift cobblestone-like elongated cell-cell contact

| 1

USP42 activates morphological HCT116 cells including shift cobblestone-like elongated cell-cell contact. 1 / 1

| 1

➶

eidos

"In agreement with our RNA-sequencing results ( Fig 5C ) , knockdown of USP42 induced morphological changes in HCT116 cells , including a shift from cobblestone-like to elongated phenotype and loss of cell-cell contact ( Fig 5D ) , which are characteristics of EMT ( Thiery & Sleeman , 2006 ; Roger et al , 2010 ; Nieto et al , 2016 ) ."

33786993

USP42 affects miR-590

| 1

USP42 binds miR-590. 1 / 1

| 1

➶

reach

"DENV propagation, MiRNA overexpression, miRNA knockdown, transfection, RT-PCR, luciferase assay, and western blotting have been used in this study to establish the interaction of miR-590 and USP42."

32123831

USP42 affects miR-21-5p inhibitor

| 1

USP42 inhibits miR-21-5p inhibitor. 1 / 1

| 1

➶

reach

"The tumor size in the miR-21-5p inhibitor group was smaller, and Ki-67 and LC3 in tumor tissue were reduced, while the overexpression of USP42 reversed the effect of the miR-21-5p inhibitor."

37187452

USP42 affects mRNA splicing events

| 1

USP42 activates mRNA splicing events. 1 / 1

| 1

➶

eidos

"Functionally , USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth , which is consistent with the impact of PLRG1 repression ."

33731873

USP42 affects histone H2B .

| 1

USP42 deubiquitinates histone H2B .. 1 / 1

| 1

➶

reach

"USP42 was suggested to enhance transcription by deubiquitylating histone H2B ."

32541651

USP42 affects epithelial

| 1

USP42 activates epithelial. 1 / 1

| 1

➶

eidos

"In addition , knockdown of USP42 downregulated epithelial genes and upregulated mesenchymal genes from the EMT gene signature in cancer ( N = 171 genes ) ( Rokavec et al , 2017 ) ( Fig 5C and Dataset EV1G ) ."

33786993

USP42 affects endogenous LRP6 protein

| 1

USP42 inhibits endogenous LRP6 protein. 1 / 1

| 1

➶

eidos

"Finally , knockdown of USP42 in HEK293T increased endogenous LRP6 protein levels , both in basal conditions and upon RSPO3 treatment ( Fig 3H ) ."

33786993

USP42 affects doxycycline

| 1

USP42 decreases the amount of doxycycline. 1 / 1

| 1

➶

reach

"Interestingly, depletion of USP42 also slightly reduced the basal expression of doxycycline driven GFP and substantially decreased the induced levels of GFP expression following doxycycline treatment of the cells (XREF_FIG, C and D)."

25336640

USP42 affects deterred cancer cell growth

| 1

USP42 inhibits deterred cancer cell growth. 1 / 1

| 1

➶

eidos

"Functionally , USP42 downregulation deregulates multiple mRNA splicing events and leads to deterred cancer cell growth , which is consistent with the impact of PLRG1 repression ."

33731873

USP42 affects colorectal cancer cells B C D E

| 1

USP42 inhibits colorectal cancer cells B C D E. 1 / 1

| 1

➶

eidos

"USP42 inhibits paracrine Wnt signalling in colorectal cancer cells A B C D E , F qPCR analysis of USP42 , LGR5 and AXIN2 expression levels in HCT116 cells ."

33786993

USP42 affects colony

| 1

USP42 activates colony. 1 / 1

| 1

➶

eidos

"As in the case of HCT116 cells , knockdown of USP42 in RKO promoted spheroid growth and colony formation , which was blocked by PORCN inhibitors ( Fig EV5A-C ) ."

33786993

USP42 affects colony HCT116 cells

| 1

USP42 inhibits colony HCT116 cells. 1 / 1

| 1

➶

eidos

"Conversely , knockdown of USP42 increased colony formation in HCT116 cells ( Fig EV4D and E ) ."

33786993

USP42 affects cell

| 1

USP42 inhibits cell. 1 / 1

| 1

➶

eidos

"To investigate whether USP42 inhibits Wnt-driven cell proliferation , we performed spheroid assays , which are more representative for the in vivo growth conditions than 2D cultures , as they recapitulate tumour cell clusters ( Timmins et al , 2004 ) ."

33786993

USP42 affects biological role

| 1

USP42 activates biological role. 1 / 1

| 1

➶

eidos

"Given the wide range of functions of ZNRF3 / RNF43 in embryogenesis ( Chang et al , 2020 ; Lee et al , 2020 ) , limb development ( Szenker-Ravi et al , 2018 ) , liver zonation ( Planas-Paz et al , 2016 ) , intestinal tract and adrenal gland homeostasis ( Koo et al , 2012 ; Basham et al , 2019 ) and sex determination ( Harris et al , 2018 ) , it would be important to explore whether USP42 also contributes to these biological functions ."

33786993

USP42 affects basic induced transcription many promoters

| 1

USP42 activates basic induced transcription many promoters. 1 / 1

| 1

➶

eidos

"The decrease in USP42 expression regulates the ubiquitination of H2B and inhibits the basic and induced transcription of many promoters ( Hock et al ., 2014 ) ."

34456895

USP42 affects alternative splicing cancer-related

| 1

USP42 activates alternative splicing cancer-related. 1 / 1

| 1

➶

eidos

"USP42 modulates alternative splicing of cancer-related genes through regulating PLRG1 ."

33731873

USP42 affects ZNRF3 RNF43 residence

| 1

USP42 activates ZNRF3 RNF43 residence. 1 / 1

| 1

➶

eidos

"Accordingly , USP42 strongly increased ZNRF3 and RNF43 residence at the plasma membrane ( Fig 3A , 1st IP , lanes 3-4 and lanes 7-8 , respectively ) ."

33786993

USP42 affects ZEB1

1 |

ZEB1 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

29119051

USP42 affects YWHAQ

1 |

YWHAQ binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

20618440

USP42 affects YTHDC2

1 |

USP42 binds YTHDC2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects YAP1

| 1

YAP1 binds USP42 and EGFR. 1 / 1

| 1

➶

sparser

34342091

USP42 affects Wnt-dependent

| 1

USP42 inhibits Wnt-dependent. 1 / 1

| 1

➶

eidos

"Loss of USP42 leads to Wnt-dependent proliferation and EMT A B , C D E , H I-L Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ( I-K ) or electroporation with eSpCas9 empty plasmid ( non-edited ) or eSpCas9-USP42 gRNAs ( L ) ."

33786993

USP42 affects Wnt signalling Abstract tumour

| 1

USP42 inhibits Wnt signalling Abstract tumour. 1 / 1

| 1

➶

eidos

"USP42 protects ZNRF3 / RNF43 from R-spondin-dependent clearance and inhibits Wnt signalling Nicole Giebel et al Abstract The tumour suppressors RNF43 and ZNRF3 play a central role in development and tissue homeostasis by promoting the turnover of the Wnt receptors LRP6 and Frizzled ( FZD ) ."

33786993

USP42 affects Wnt reporter

| 1

USP42 inhibits Wnt reporter. 1 / 1

| 1

➶

eidos

"Critically , knockdown of USP42 did not upregulate Wnt reporter activity in ZNRF3 / RNF43 double knockout HEK293T cells ( Fig 1F ) , indicating a requirement of the E3 ligases for USP42 activity in Wnt signalling ."

33786993

USP42 affects Wnt functions including stabilisation proteins

| 1

USP42 activates Wnt functions including stabilisation proteins. 1 / 1

| 1

➶

eidos

"As such , it would be interesting to explore whether USP42 also contributes to other Wnt functions including stabilisation of proteins ( Wnt / STOP ) ( Taelman et al , 2010 ; Acebron et al , 2014 ) , activation of macropinocytosis ( Tejeda-Munoz et al , 2019 ) and modulation of Wnt / Jun and Wnt / Ca +2 ( Tsukiyama et al , 2015 ) ."

33786993

USP42 affects Wnt beta-catenin signalling

| 1

USP42 inhibits Wnt beta-catenin signalling. 1 / 1

| 1

➶

eidos

"Accordingly , USP42 promotes the turnover of the Wnt receptors LRP6 and FZD and inhibits Wnt / beta-catenin signalling ."

33786993

USP42 affects Wnt beta-catenin signalling A B C D E-H

| 1

USP42 inhibits Wnt beta-catenin signalling A B C D E-H. 1 / 1

| 1

➶

eidos

"USP42 deubiquitinates ZNRF3 and inhibits Wnt / beta-catenin signalling A B C D E-H I , J K L , M TOPflash reporter assays in HEK293T cells stimulated with either control , Wnt3a , Wnt3a and RSPO1-4 conditioned media , or by transfection with the indicated constructs ."

33786993

USP42 affects WDR18

1 |

WDR18 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects VIM

| 1

USP42 increases the amount of VIM. 1 / 1

| 1

➶

reach

37187452

USP42 affects USP42

| 1

USP42 decreases the amount of USP42. 1 / 1

| 1

➶

reach

"USP42 siRNA suppressed USP42 expression."

27030989

USP42 affects USP4

| 1

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

USP42 affects TWIST1

| 1

USP42 decreases the amount of TWIST1. 1 / 1

| 1

➶

reach

"Transfection of USP42 siRNA significantly reduced the expression levels of beta-catenin, Twist and Snail1, while increasing E-cadherin."

27030989

USP42 affects TP53BP1

| 1

USP42 inhibits TP53BP1. 1 / 1

| 1

➶

reach

"Of note, loss of other R-loop resolution factors, such as DDX1 or EXOSC10, augmented NHEJ efficiency at the cost of HR efficiency, and loss of USP42/DHX9 increased 53BP1 foci (Domingo-Prim et al., 2019; Li et al., 2016; Matsui et al., 2020)."

35508167

USP42 affects TEX10

1 |

USP42 binds TEX10. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects Stomach Neoplasms

| 1

USP42 binds Stomach Neoplasms. 1 / 1

| 1

➶

sparser

"Further clinical characteristics analysis showed that expression level of USP42 was associated with overall survival of GC patients."

27030989

USP42 affects Snail1

| 1

USP42 decreases the amount of Snail1. 1 / 1

| 1

➶

reach

"Transfection of USP42 siRNA significantly reduced the expression levels of beta-catenin, Twist and Snail1, while increasing E-cadherin."

27030989

USP42 affects SRRM2

1 |

SRRM2 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects SPP1

1 |

SPP1 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

22779921

USP42 affects RPA2

| 1

USP42 leads to the phosphorylation of RPA2. 1 / 1

| 1

➶

reach

"Although exogenously expressed GFP-USP42 (FL) restored CPT-induced phosphorylation of RPA2, cells expressing truncated mutants of USP42 that lost nuclear speckle localization failed to rescue this phenotype, suggesting that nuclear speckle localization of USP42 is indispensable for proper HR progression."

32541651

USP42 affects RP23-446O17.1

1 |

USP42 binds RP23-446O17.1. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP42 affects RP23-139J21.8

1 |

USP42 binds RP23-139J21.8. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP42 affects RNF43

| 1

RNF43 binds USP42. 1 / 1

| 1

➶

sparser

"Additional co‐IP experiments revealed that USP42 also interacted with RNF43 (Fig xref )."

33786993

USP42 affects RNA Pol II

| 1

USP42 binds RNA Pol II. 1 / 1

| 1

➶

reach

"Immunofluorescence analysis of endogenous proteins showed that USP42 was present in nuclear foci that co-localized with DNA bound RNA Pol II using antibodies to detect both total and activated (phosphorylated) RNA Pol II (XREF_FIG E), and endogenous USP42 and RNA Pol II were shown to co-immunoprecipitate (XREF_FIG F)."

25336640

USP42 affects RKO cells B C D Immunofluorescence microscopy showing endogenous RKO cells

| 1

USP42 inhibits RKO cells B C D Immunofluorescence microscopy showing endogenous RKO cells. 1 / 1

| 1

➶

eidos

"USP42 inhibits paracrine Wnt signalling in RKO cells A B C D Immunofluorescence microscopy showing endogenous E-cadherin levels in RKO cells upon transfection with siUSP42 ."

33786993

USP42 affects RIOX1

1 |

USP42 binds RIOX1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects RANBP9

1 |

RANBP9 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects RAD50

1 |

USP42 binds RAD50. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects R Z autoubiquitination

| 1

USP42 inhibits R Z autoubiquitination. 1 / 1

| 1

➶

eidos

"Interestingly , R / Z autoubiquitination is also a dynamic process and is reversed by Usp42 , a deubiquitinase that stabilizes R / Z levels at the plasma membrane , counteracting Rspo / Lgr4-mediated clearance and promoting Wnt inhibition125 ,126 ."

36117218

USP42 affects PROGNOSIS

| 1

USP42 binds PROGNOSIS. 1 / 1

| 1

➶

trips

"circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis."

32938310

USP42 affects POU5F1

1 |

USP42 binds POU5F1. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP42 affects PCGF1

1 |

PCGF1 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP42 affects Neoplasms

| 1

USP42 activates Neoplasms. 1 / 1

| 1

➶

eidos

"USP42 was reported to stabilize TP53 , but USP42 knockdown inhibits cancer formation , implying that other unknown factors related to cancer formation may exist [ 53 ] ."

31133011

USP42 affects Neoplasm Metastasis

| 1

USP42 activates Neoplasm Metastasis. 1 / 1

| 1

➶

reach

"Thus, our data indicated that elevated expression of USP42 in GC may promote tumor metastasis and is associated with the clinical outcome of GC patients."

27030989

USP42 affects NPPA

| 1

USP42 binds NPPA. 1 / 1

| 1

➶

sparser

"According to the values established in the USP42-NF 37, all the batches of co-processed excipients showed excellent flow with values of 24–32°."

| PMC

USP42 affects NANOG

1 |

USP42 binds NANOG. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP42 affects MRPS35

1 |

MRPS35 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects MRPS34

1 |

MRPS34 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects MRPS31

1 |

MRPS31 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects MRPS26

1 |

MRPS26 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects MRPS21

1 |

MRPS21 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects MRPS14

1 |

MRPS14 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects MMP2

| 1

USP42 increases the amount of MMP2. 1 / 1

| 1

➶

reach

"As shown in XREF_FIG, silencing of USP42 downregulated the expression of MMP-2 and MMP-9."

27030989

USP42 affects MDM2

1 |

USP42 binds MDM2. 1 / 1

1 |

➶

biogrid

No evidence text available

22085928

USP42 affects LRRC47

1 |

USP42 binds LRRC47. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects LRP6 receptors

| 1

USP42 leads to the ubiquitination of LRP6 receptors. 1 / 1

| 1

➶

reach

35817504

USP42 affects KPNA3

1 |

USP42 binds KPNA3. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects JMJD6

1 |

JMJD6 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP42 affects HERC2

1 |

USP42 binds HERC2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects HCT116 cells A-C D

| 1

USP42 inhibits HCT116 cells A-C D. 1 / 1

| 1

➶

eidos

"Loss of USP42 promotes Wnt-dependent EMT , survival and proliferation in HCT116 cells A-C D , E F , G Spheroid formation experiments with HCT116 cells upon transfection with siUSP42 ."

33786993

USP42 affects HCT116 Cells

| 1

USP42 inhibits HCT116 Cells. 1 / 1

| 1

➶

eidos

"We conclude that USP42 inhibits Wnt signalling in HCT116 cells by destabilising the Wnt receptors , independently of its roles in p53 response to genotoxic stress ."

33786993

USP42 affects H2BC21

1 |

USP42 binds H2BC21. 1 / 1

1 |

➶

biogrid

No evidence text available

25336640

USP42 affects H2BC10

1 |

USP42 deubiquitinates H2BC10. 1 / 1

1 |

➶

ubibrowser

"Depletion of USP42 increased H2B ubiquitylation at a model promoter and decreased both basal and induced transcription from a number of promoters."

25336640

USP42 affects G0/G1 block

| 1

USP42 activates G0/G1 block. 1 / 1

| 1

➶

reach

"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."

33791299

USP42 affects G0 G1

| 1

USP42 activates G0 G1. 1 / 1

| 1

➶

eidos

33791299

USP42 affects FN1

| 1

USP42 increases the amount of FN1. 1 / 1

| 1

➶

reach

37187452

USP42 affects FECH

1 |

USP42 binds FECH. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects ENOPH1

| 1

USP42 increases the amount of ENOPH1. 1 / 1

| 1

➶

reach

"USP42 knockdown significantly reduced the expression of Cyclin D1, Cyclin E1 and PCNA (XREF_FIG)."

27030989

USP42 affects EMT A B

| 1

USP42 inhibits EMT A B. 1 / 1

| 1

➶

eidos

33786993

USP42 affects DPPA4

1 |

DPPA4 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP42 affects DIMT1

1 |

USP42 binds DIMT1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects Cyclin

| 1

USP42 increases the amount of Cyclin. 1 / 1

| 1

➶

reach

"USP42 knockdown significantly reduced the expression of Cyclin D1, Cyclin E1 and PCNA (XREF_FIG)."

27030989

USP42 affects CTNNB1

| 1

USP42 decreases the amount of CTNNB1. 1 / 1

| 1

➶

reach

"Transfection of USP42 siRNA significantly reduced the expression levels of beta-catenin, Twist and Snail1, while increasing E-cadherin."

27030989

USP42 affects CPNE3

1 |

USP42 binds CPNE3. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects CEP192

1 |

USP42 binds CEP192. 1 / 1

1 |

➶

biogrid

No evidence text available

24613305

USP42 affects CDKN1A

| 1

USP42 increases the amount of CDKN1A. 1 / 1

| 1

➶

reach

"As we had demonstrated before, USP42 knockdown lowers p21 transcription at the early time points of p53 induction as a reflection of the reduced levels of p53."

25336640

USP42 affects CDH2

| 1

USP42 increases the amount of CDH2. 1 / 1

| 1

➶

reach

37187452

USP42 affects CA2

1 |

CA2 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects BRCA1

| 1

USP42 activates BRCA1. 1 / 1

| 1

➶

reach

"Based on these results, we propose a model in which USP42 and DHX9 promote BRCA1 loading to DSB sites near nuclear speckles, which facilitates DSB-induced R-loop resolution and preferential DSB repair by HR."

32541651

USP42 affects BMS1

1 |

USP42 binds BMS1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects BCOR

1 |

USP42 binds BCOR. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

USP42 affects AVPR2

| 1

USP42 binds AVPR2. 1 / 1

| 1

➶

sparser

"We conclude that cytoplasmic and catalytically active USP42 interacts with the ZNRF3 DIR (Fig xref ), which is emerging as a key modulatory domain of the E3 ligase (Jiang et al, xref ; Chang et al, xref ; Spit et al, xref ; Tsukiyama et al, xref )."

33786993

USP42 affects AMOT

1 |

AMOT binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP42 affects AHCYL1

1 |

USP42 binds AHCYL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP4 affects USP7

| 1

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

Tobacco Smoke Pollution affects USP42

1 |

Tobacco Smoke Pollution increases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

28065790

TRIM21 affects USP42

| 1

TRIM21 increases the amount of USP42. 1 / 1

| 1

➶

reach

"This study also suggests that TRIM21, independently of its RING domain, can increase USP42 level in a positive feedback loop and induces the cellular OAS1 levels in human microglial cells."

35779335

TRIM21 RING domain affects USP42

| 1

TRIM21 RING domain activates USP42. 1 / 1

| 1

➶

eidos

"This study also suggests that TRIM21 , independently of its RING domain , can increase USP42 level in a positive feedback loop and induces the cellular OAS1 levels in human microglial cells ."

35779335

TP53 affects USP4

| 1

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

TP53 affects USP10, USP42, and USP7

| 1

TP53 binds USP10, USP7, and USP42. 1 / 1

| 1

➶

sparser

"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation xref – xref ."

31745110

TP53 affects USP10, USP4, USP42, and USP7

| 1

TP53 binds USP10, USP4, USP7, and USP42. 1 / 1

| 1

➶

sparser

"For example, the cell cycle-related protein p53 can bind USP4, USP7, USP10 and USP42, and then be deubiquitinated by these deubiquitinases [ xref , xref – xref ]."

30497519

TEX10 affects USP42

1 |

USP42 binds TEX10. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Stomach Neoplasms affects USP42

| 1

USP42 binds Stomach Neoplasms. 1 / 1

| 1

➶

sparser

"Further clinical characteristics analysis showed that expression level of USP42 was associated with overall survival of GC patients."

27030989

SRRM2 affects USP42

1 |

SRRM2 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SPP1 affects USP42

1 |

SPP1 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

22779921

RP23-446O17.1 affects USP42

1 |

USP42 binds RP23-446O17.1. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

RP23-139J21.8 affects USP42

1 |

USP42 binds RP23-139J21.8. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

RNF43 affects USP42

| 1

RNF43 binds USP42. 1 / 1

| 1

➶

sparser

"Additional co‐IP experiments revealed that USP42 also interacted with RNF43 (Fig xref )."

33786993

RNA Pol II affects USP42

| 1

USP42 binds RNA Pol II. 1 / 1

| 1

➶

reach

25336640

RIOX1 affects USP42

1 |

USP42 binds RIOX1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RANBP9 affects USP42

1 |

RANBP9 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RAD50 affects USP42

1 |

USP42 binds RAD50. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PROGNOSIS affects USP42

| 1

USP42 binds PROGNOSIS. 1 / 1

| 1

➶

trips

"circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis."

32938310

POU5F1 affects USP42

1 |

USP42 binds POU5F1. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

PLRG1 affects USP42

1 |

USP42 binds PLRG1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PCGF1 affects USP42

1 |

PCGF1 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

Organic Chemicals affects USP42

1 |

Organic Chemicals decreases the amount of USP42. 1 / 1

1 |

➶

ctd

No evidence text available

20526952

NUP214 affects USP42

| 1

NUP214 increases the amount of USP42. 1 / 1

| 1

➶

reach

"These findings establish that DENV-NS5 protein can potentially modulate the host deubiquitinase protein USP42 expression via altering cellular miR-590 levels in human microglial cells."

32123831

NPPA affects USP42

| 1

USP42 binds NPPA. 1 / 1

| 1

➶

sparser

"According to the values established in the USP42-NF 37, all the batches of co-processed excipients showed excellent flow with values of 24–32°."

| PMC

NANOG affects USP42

1 |

USP42 binds NANOG. 1 / 1

1 |

➶

biogrid

No evidence text available

26687479

Microglia affects USP42

| 1

Microglia inhibits USP42. 1 / 1

| 1

➶

eidos

"34 In this study , we have demonstrated , how DENV NS5 protein alters the host cellular microRNA , miR-590-3p , in microglial cells which in turn downregulate USP42 ( a deubiquitinase ) ."

32123831

MRPS35 affects USP42

1 |

MRPS35 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MRPS34 affects USP42

1 |

MRPS34 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MRPS31 affects USP42

1 |

MRPS31 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MRPS26 affects USP42

1 |

MRPS26 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MRPS21 affects USP42

1 |

MRPS21 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MRPS14 affects USP42

1 |

MRPS14 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MDM2 affects USP42

1 |

USP42 binds MDM2. 1 / 1

1 |

➶

biogrid

No evidence text available

22085928

LRRC47 affects USP42

1 |

USP42 binds LRRC47. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

KPNA3 affects USP42

1 |

USP42 binds KPNA3. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Japanese infection affects USP42

| 1

Japanese infection activates USP42. 1 / 1

| 1

➶

eidos

"Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia ."

35779335

JMJD6 affects USP42

1 |

JMJD6 binds USP42. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

Histone affects USP42

| 1

Histone binds USP42. 1 / 1

| 1

➶

sparser

"A previous proteomic analysis of the DUB interactome described an association of USP42 with histones, but also with a large number of other proteins, including other DUBs ( xref )."

25336640

HERC2 affects USP42

1 |

USP42 binds HERC2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

H2BC21 affects USP42

1 |

USP42 binds H2BC21. 1 / 1

1 |

➶

biogrid

No evidence text available

25336640

FECH affects USP42

1 |

USP42 binds FECH. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Encephalitis, Japanese affects USP42

| 1

Encephalitis, Japanese activates USP42. 1 / 1

| 1

➶

reach

"Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia."

35779335