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Different methodologies inhibits USP42. 1 / 1
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eidos
"USP42 depletion hinders cell proliferation and alters nuclear speckle morphology After comparing different methodologies to deplete USP42 expression , we achieved the best efficiency using CRISPR / Cas9 although without complete knockout , instead obtaining reduction to ~ 50 % , likely due to one allele disruption ( Fig. 6A ) ."