IndraLab

Statements

USP42 activates cell population proliferation. 7 / 7
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"USP42 promotes the proliferation and invasion of gastric cancer cells by affecting matrix metalloproteinases (MMPs) and epithelial-mesenchymal transition (EMT)43."
34405018
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"Our in vitro findings showed that silencing of USP42 inhibited cell proliferation via inducing G0/G1 arrest and suppressed cell invasion via MMPs and EMT regulators."
27030989
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"To further explore the cellular mechanism underlying USP42 induced cell proliferation, the protein levels of cell cycle proteins were assessed."
27030989
eidos
"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size , TNM staging , lymph node metastasis , and OS rate of GC patients , while inhibition of USP42 can induce G0 / G1 block and suppress cell proliferation and invasion ( Hou et al ., 2016 ) ."
33791299
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"Moreover, USP42 silencing in two GC cell lines, AGS and MKN-45, notably inhibited cell proliferation, but stimulated G1 phase arrest."
27030989
eidos
"USP42 depletion hinders cell proliferation and alters nuclear speckle morphology After comparing different methodologies to deplete USP42 expression , we achieved the best efficiency using CRISPR / Cas9 although without complete knockout , instead obtaining reduction to ~ 50 % , likely due to one allele disruption ( Fig. 6A ) ."
33731873
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"USP42 is highly expressed in GC tissue and conspicuously associated with the tumor size, TNM staging, lymph node metastasis, and OS rate of GC patients, while inhibition of USP42 can induce G0/G1 block and suppress cell proliferation and invasion."
33791299