IndraLab

Statements

USP42 activates TP53. 4 / 4
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"Our previous work showed that USP42 can target p53 for deubiquitylation, with depletion of USP42 resulting in delays in stabilization of p53 and recruitment of p53 to target gene promoters."
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"Importantly though, USP42-dependent activation of p53 does not lead to apoptosis, suggesting that its main function is to contribute to the repair and recovery of cells from mild or transient damage."
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"USP42 itself was reported to increase the stability of p53 [XREF_BIBR]."
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"Although we do not find a clear role for USP42 in controlling either the basal or fully activated levels of p53, the function of USP42 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent cell-cycle arrest in response to stress."
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