IndraLab

Statements


USP42 deubiquitinates TP53. 6 / 6
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"It has been reported that USP42 interacts with and deubiquitinates p53."

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"In the initial phases of a stress response, USP42 deubiquitinates p53 by forming a direct complex with p53."

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"During the early phase of response to a stress signal, USP42 preferentially makes up a complex with and deubiquitinates p53, leading to the rapid activation of p53 for cell cycle arrest and p53-dependent transcription [55]."
| PMC

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"P53 can be directly deubiquitinated by Usp42 which reverses its ubiquitination by MDM2 [XREF_BIBR]."

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"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."