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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP42 leads to the ubiquitination of FZD. 1 / 1

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reach

"In this way USP42 antagonizes RSPOs by protecting ZNRF3/RNF43 from RSPO- and ubiquitin-dependent internalization, thereby increasing the ubiquitylation and turnover of FZD and LRP6 receptors, and inhibiting WNT signaling."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...