IndraLab

Statements

USP42 activates homologous recombination. 5 / 5
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"USP42 promotes HR by facilitating DNA-end resection."
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"To understand how USP42 promotes HR, the effects of USP42 depletion with siRNAs on various aspects of HR were investigated."
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"Depleting USP42 resulted in significantly reduced RAD51 foci formation, suggesting that USP42 functions upstream of RAD51 recruitment to DSB sites and promotes HR."
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"Furthermore, the deubiquitylation enzyme USP42, another component of nuclear speckle, also promotes HR [ 82 ]."
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"Altogether, these results indicated that USP42 promoted HR and cellular viability by facilitating DNA-end resection."
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