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"Immunofluorescence analysis of endogenous proteins showed that USP42 was present in nuclear foci that co-localized with DNA bound RNA Pol II using antibodies to detect both total and activated (phosphorylated) RNA Pol II (XREF_FIG E), and endogenous USP42 and RNA Pol II were shown to co-immunoprecipitate (XREF_FIG F)."