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CFLAR binds USP40. 7 / 7

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"GMEB1 promoted the binding of USP40 with CFLAR , conferring a role as an adaptor protein."

31046799

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"GMEB1 promoted the binding of USP40 to CFLAR L ."

31046799

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"We found the de-ubiquitination enzyme USP40 bound to CFLAR and GMEB, which enhanced the interaction between USP40 and CFLAR resulting in reduced ubiquitination and degradation of CFLAR ."

31046799

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"Data from co-IP assay in 293FT cells show that knock down of GMEB1 weakened the interaction between CFLAR and USP40; overexpression of GMEB1 enhanced the interaction (Fig. 5a and b, respectively)."

31046799

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"In addition, we found that overexpression of HA-GMEB1 (325–573), which did not interact with CFLAR , had no significant impact on the interaction between CFLAR and USP40 (Fig. 5c)."

31046799

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No evidence text available

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No evidence text available

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USP40 binds CFLAR. 3 / 3

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"Data from co-IP assay in 293FT cells show that knock down of GMEB1 weakened the interaction between CFLAR L and USP40; overexpression of GMEB1 enhanced the interaction (Fig. xref a and b, respectively)."

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"In addition, we found that overexpression of HA-GMEB1 (325–573), which did not interact with CFLAR L , had no significant impact on the interaction between CFLAR L and USP40 (Fig. xref c)."

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"GMEB1 promoted the interaction between USP40 and CFLAR L ."

31046799

USP40 deubiquitinates CFLAR.

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USP40 deubiquitinates CFLAR. 3 / 3

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"Results show that overexpression of USP40 decreased the ubiquitination of CFLAR (Fig. 4d), and knockdown USP40 increased the ubiquitination of CFLAR (Fig. 4e)."

31046799

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"Studies have shown that USP40 deubiquitinates and stabilizes CFLAR , and GMEB1 interacts with USP40 to maintain CFLAR and prevent apoptosis in NSCLC [11]."

38308285

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"In non-small cell lung cancer (NSCLC), USP40 suppresses polyubiquitination of anti-apoptotic protein CFLAR , and GMEB1 promotes CFLAR stability via USP40, followed by inhibition of CASP8 precursor activation and apoptosis [11]."

38308285

USP40-C62A deubiquitinates CFLAR. 1 / 1

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"GST pull-down assay results show mutant USP40 (C62A) did not de-ubiquitinate CFLAR (Additional file 1: Figure S4D)."

31046799

USP40 activates CFLAR.

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USP40 activates CFLAR. 4 / 4

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"These findings demonstrate USP40 promotes the stability of CFLAR at the protein level."

31046799

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"Using a reverse experiment in A549 cell lines, we showed that USP40 overexpression slightly increased CFLAR protein when GMEB1 was knocked down (Fig. 5e)."

31046799

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"We found that GMEB1 promoted the stability of CFLAR by de-ubiquitinase USP40."

31046799

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"Consequently, USP40 augmented the stability of CFLAR via its de-ubiquitinase activity."

31046799

USP40 increases the amount of CFLAR.

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USP40 increases the amount of CFLAR. 2 / 2

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"And, overexpression of USP40 increased the protein level of CFLAR though GMEB1 was knocked down."

31046799

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"Conversely, overexpression of USP40 in H1299 and A549 cell lines increased the protein level of CFLAR (Fig. 4c)."

31046799

USP40-C62A increases the amount of CFLAR. 1 / 1

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"Data show mutant USP40 (C62A) did not increase the protein level of CFLAR in A549 cell lines (Additional file 1: Figure S4B), but it still interacted with CFLAR (Additional file 1: Figure S4C)."

31046799

USP40 ubiquitinates CFLAR.

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USP40 leads to the ubiquitination of CFLAR. 2 / 2

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"We proposed that USP40 modulated the ubiquitination of CFLAR via its de-ubiquitinase activity."

31046799

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"Results show that overexpression of USP40 decreased the ubiquitination of CFLAR (Fig. 4d), and knockdown USP40 increased the ubiquitination of CFLAR (Fig. 4e)."

31046799

USP40 decreases the amount of CFLAR.

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USP40 decreases the amount of CFLAR. 2 / 2

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"USP40 knockdown did not increase CFLAR L protein level despite GMEB1 overexpression, suggesting GMEB1 promotes CFLAR L stability via USP40."

31046799

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"USP40 knockdown did not increase the protein level of CFLAR even though GMEB1 protein level was overexpressed."

31046799

USP40 affects HYCC1

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USP40 activates HYCC1.

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USP40 activates HYCC1. 10 / 17

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"USP40 overexpression dramatically accelerated HCC cell growth, migration and stemness both in vitro and in vivo."

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"USP40 is elevated in HCC and predicts poor prognosis."

38308285

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"Knockdown of USP40 inhibits HCC cell proliferation, migration and stemness."

38308285

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"In addition, USP40 knockdown inhibited HCC cell growth, migration and stemness."

38308285

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"Overall, USP40 knockdown inhibited HCC cell proliferation, migration and stemness."

38308285

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"Overexpression of USP40 promotes HCC cell proliferation, migration and stemness."

38308285

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"YAP knockdown markedly abolished USP40 overexpression-enhanced the malignant behaviors of HCC cells (P < 0.05, Fig. 4 D–F and Supplementary 4F–4H)."

38537774

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"USP40 was elevated in HCC and is an unfavorable prognostic biomarker for HCC."

38308285

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"CCK-8 and colony formation results showed that USP40 upregulation enhanced HCC cell growth (Fig. 3B, C)."

38308285

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"Furthermore, wound healing and tranwell assays confirmed that USP40 upregulation also promoted HCC cell migration (Fig. 3D, E)."

38308285

USP40 deubiquitinates HYCC1.

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USP40 deubiquitinates HYCC1. 1 / 1

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"And USP40 bind and deubiquitinate YAP facility HCC proliferation ang migration."

38537774

USP40 affects Claudin1

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USP40 deubiquitinates Claudin1.

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USP40 deubiquitinates Claudin1. 4 / 4

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"Similarly, our study confirmed that Claudin1 is degraded by the ubiquitin–proteasome system in HCC, and USP40 inhibits Claudin1 polyubiquitination to increase its stability.c-Myc is an oncogenic transcription factor participated in biological functions including cancer cell proliferation, EMT, cancer stemness, metastasis, and metabolic reprogramming [24, 25]."

38308285

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"Our study reveals that USP40 enhances HCC malignant development by deubiquitinating and stabilizing Claudin1, suggesting that targeting USP40 may be a novel approach for HCC therapy."

38308285

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"USP40 could interact with Claudin1 and deubiquitinates Claudin1 to stabilize its protein level."

38308285

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"Ubiquitination assay revealed that USP40 knockdown increased the polyubiquitination of Claudin1, whereas USP40 overexpression reduced the polyubiquitination of Claudin1 (Fig. 5G, H)."

38308285

USP40 binds Claudin1.

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USP40 binds Claudin1. 4 / 4

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"USP40 could interact with Claudin1 and deubiquitinates Claudin1 to stabilize its protein level."

38308285

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"The interaction between USP40 and Claudin1 was identified by immunofluorescence, co-immunoprecipitation and ubiquitination assays."

38308285

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"As a DUB, USP40 could interact with and stabilize Claudin1 in HCC."

38308285

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"Then we transfected HA-USP40 and Claudin1 plasmids into HCC cells, Co-IP findings demonstrated the interactions between USP40 and Claudin1 (Fig. 4F), which was consistent with the immunofluorescence staining results."

38308285

USP40 ubiquitinates Claudin1.

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USP40 leads to the ubiquitination of Claudin1. 2 / 2

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"Ubiquitination assay revealed that USP40 knockdown increased the polyubiquitination of Claudin1, whereas USP40 overexpression reduced the polyubiquitination of Claudin1 (Fig. 5G, H)."

38308285

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"Mechanistic experiments revealed that USP40 interacted with Claudin1 and increased protein stability by inhibiting polyubiquitination of Claudin1 in HCC cells (Fig. 8)."

38308285

USP40 increases the amount of Claudin1.

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USP40 increases the amount of Claudin1. 2 / 2

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"MHCC97H cells with stable knockdown of USP40 were transfected with Claudin1 plasmid or vector, and western blotting showed that USP40 silencing reduced Claudin1 protein levels, which could be restored by overexpressing Claudin1 (Fig. 6A)."

38308285

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"Western blotting analysis of tumor tissues suggested that USP40 knockdown suppressed Claudin1 expression, and USP40 overexpression promoted Claudin1 expression (Fig. 7D, H), which was in accordance with the findings of in vitro experiments."

38308285

USP40 activates Claudin1.

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USP40 activates Claudin1. 2 / 2

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"USP40 promotes HCC progression by regulating Claudin1."

38308285

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"We observed that Claudin1 protein level in the USP40 knockdown group decreased faster compared to the control group, while USP40 overexpression enhanced the protein stability of Claudin1 (Fig. 5B, D, E, F)."

38308285

USP40 decreases the amount of Claudin1.

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USP40 decreases the amount of Claudin1. 1 / 1

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38308285

USP40 affects YAP1

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USP40 activates YAP1.

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USP40 activates YAP1. 5 / 5

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"USP40 overexpression increased the half-life of YAP in HCCLM3 and PLC/PRF/5 cells (P < 0.05, Supplementary Fig. 2A )."

38537774

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"Moreover, USP40 knockdown prominently attenuated stiffness-induced YAP accumulation in HCC cells (P < 0.05, Supplementary Fig. 6C )."

38537774

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"Notably, ECM stiffness signals activated USP40 transcription by YAP and stiffness-induced YAP accumulation was attenuated by USP40 knockdown in HCC cells."

38537774

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"USP40 overexpression prominently increased YAP protein but did not impact mRNA expression in HCC cells (P < 0.05, Fig. 1 D and E and Supplementary Fig. 1C )."

38537774

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"Thus, our data suggest that USP40 positively regulates YAP abundance in HCC cells.Next, we demonstrated that endogenous USP40 interacted with YAP in HUH-7 and HepG2 cells ( Fig. 2 A)."

38537774

USP40 binds YAP1.

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USP40 binds YAP1. 3 / 3

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"The binding of USP40 to YAP was weak as suggested by an in vitro pulldown assay with purified recombinant proteins (data was not shown)."

38537774

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"This may be because the purified YAP protein does not undergo ubiquitination modification, or the binding of USP40 to YAP protein requires the participation of other proteins."

38537774

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"FLAG-USP40 and HA-YAP vectors were co-transfected into HEK293T cells and the interaction between exogenous USP40 and YAP was confirmed by co-IP assay ( Fig. 2 B)."

38537774

USP40 ubiquitinates YAP1.

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USP40 leads to the ubiquitination of YAP1. 1 / 1

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"Moreover, USP40 knockdown increased but USP40 overexpression decreased the ubiquitination of YAP ( Fig. 3 C and D)."

38537774

USP40 inhibits YAP1.

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USP40 inhibits YAP1. 1 / 1

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"The proteasomal inhibitor MG132 abolished USP40 knockdown-induced YAP downregulation in HCC cells (P < 0.05, Fig. 3 B and Supplementary Fig. 2B )."

38537774

USP40 deubiquitinates YAP1.

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USP40 leads to the deubiquitination of YAP1. 1 / 1

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"We mutated two lysine sites (K252R and K315R) and found that the K252 mutation totally reduced and the K315 mutation partially attenuated the ubiquitination of YAP increased by USP40 knockdown ( Fig. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

38537774

USP40 affects HSP90

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USP40 deubiquitinates HSP90.

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USP40 deubiquitinates HSP90. 7 / 7

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"USP40 overexpression increased lysine acetylation of HSP90β (Fig. 6i, j), suggesting that USP40 deubiquitinates HSP90β, resulting in an increase in lysine acetylation of HSP90β, thereby leading to inactivation of HSP90β and preservation of EC integrity."

38307937

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"We revealed that USP40 preserves EC function by deubiquitinating and inactivating HSP90β."

38307937

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"USP40 deubiquitinates HSP90β, resulting in the inactivation of HSP90β in ECs, suggesting that USP40 protects EC integrity by blocking HSP90β-mediated EC dysfunction."

38307937

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"Taken together with findings showing that USP40 deubiquitinates HSP90β, these data suggest that USP40 inactivates HSP90β by modulating its ubiquitination and acetylation.The detrimental effect of HSP90 activity in ECs has been well reported ."

38307937

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"This is the first report to reveal that USP40 deubiquitinates and inactivates HSP90."

38307937

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"Taken together, this study shows that USP40 deubiquitinates HSP90β, thereby inhibiting its activity by increasing its acetylation (Fig. 7g)."

38307937

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"Furthermore, our data reveal that USP40 deubiquitinates HSP90, thereby increasing its acetylation and reducing its activation."

38307937

USP40 acetylates HSP90.

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USP40 leads to the acetylation of HSP90 on lysine. 2 / 2

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"We found that USP40 reduced the polyubiquitination and increased the lysine acetylation of HSP90β (Fig. 6f)."

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38307937

USP40 ubiquitinates HSP90.

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USP40 leads to the ubiquitination of HSP90. 1 / 1

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"Our observations are the first to reveal that USP40 reduces the severity of acute lung injury by reducing HSP90 ubiquitination, thereby attenuating the activation of RhoA and NF-κB, EC permeability, and inflammation."

38307937

CFLAR affects USP40

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CFLAR binds USP40. 7 / 7

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"GMEB1 promoted the binding of USP40 with CFLAR , conferring a role as an adaptor protein."

31046799

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"GMEB1 promoted the binding of USP40 to CFLAR L ."

31046799

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"We found the de-ubiquitination enzyme USP40 bound to CFLAR and GMEB, which enhanced the interaction between USP40 and CFLAR resulting in reduced ubiquitination and degradation of CFLAR ."

31046799

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"Data from co-IP assay in 293FT cells show that knock down of GMEB1 weakened the interaction between CFLAR and USP40; overexpression of GMEB1 enhanced the interaction (Fig. 5a and b, respectively)."

31046799

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"In addition, we found that overexpression of HA-GMEB1 (325–573), which did not interact with CFLAR , had no significant impact on the interaction between CFLAR and USP40 (Fig. 5c)."

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No evidence text available

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USP40 binds CFLAR. 3 / 3

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"In addition, we found that overexpression of HA-GMEB1 (325–573), which did not interact with CFLAR L , had no significant impact on the interaction between CFLAR L and USP40 (Fig. xref c)."

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"GMEB1 promoted the interaction between USP40 and CFLAR L ."

31046799

YAP1 affects USP40

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YAP1 increases the amount of USP40.

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YAP1 increases the amount of USP40. 3 / 3

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"YAP mediated the tumor-promoting role of USP40 and transcriptionally activated USP40 expression in HCC."

38537774

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"Next, we confirmed that YAP overexpression increased USP40 expression in HCCLM3 and PLC/PRF/5 cells (P < 0.05, Fig. 6 A and B and Supplementary Fig. 5A )."

38537774

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"Otherwise, YAP-TEAD inhibitor (Verteporfin) and YAP knockdown consistently reduced USP40 level in HCC cells (P < 0.05, Fig. 6 C–F and Supplementary Fig. 5B )."

38537774

YAP1 binds USP40.

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USP40 binds YAP1. 3 / 3

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"The binding of USP40 to YAP was weak as suggested by an in vitro pulldown assay with purified recombinant proteins (data was not shown)."

38537774

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"This may be because the purified YAP protein does not undergo ubiquitination modification, or the binding of USP40 to YAP protein requires the participation of other proteins."

38537774

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"FLAG-USP40 and HA-YAP vectors were co-transfected into HEK293T cells and the interaction between exogenous USP40 and YAP was confirmed by co-IP assay ( Fig. 2 B)."

38537774

YAP1 activates USP40.

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YAP1 activates USP40. 3 / 3

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"The luciferase reporter assay demonstrated that YAP rather than EZH2 overexpression promoted the transcription activity of USP40 promoter in HEK293T cells (P < 0.05, Fig. 6 H)."

38537774

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"Immunoblotting results confirmed that stiffness-induced USP40 upregulation was significantly abolished by YAP knockdown in Hep3B and HUH-7 cells (P < 0.05, Supplementary Fig. 6B )."

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"Notably, we further confirmed that YAP mediated the promoting role of USP40 in HCC growth in nude mice (P < 0.05, Fig. 5 A–D)."

38537774

USP40 affects cell population proliferation

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USP40 activates cell population proliferation. 7 / 7

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"Then, we transfected siClaudin1 or siNC to MHCC97H cells stably overexpressed USP40 (Fig. 6F), CCK-8 and colony formation showed that the impact of USP40 upregulation on promoting cell proliferation could be limited by Claudin1 suppression (Fig. 6G, H)."

38308285

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"Knockdown of USP40 inhibits HCC cell proliferation, migration and stemness."

38308285

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"Overall, USP40 knockdown inhibited HCC cell proliferation, migration and stemness."

38308285

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"Overexpression of USP40 promotes HCC cell proliferation, migration and stemness."

38308285

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"In general, our findings suggest that USP40 upregulation can enhance HCC cell proliferation, migration and stemness."

38308285

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"USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1."

38308285

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"USP40 knockdown inhibits HCC cell proliferation, migration and stemness, whereas USP40 overexpression shows the opposite impact."

38308285

USP40 affects HINT1

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USP40 binds HINT1.

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HINT1 binds USP40. 4 / 4

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No evidence text available

35605301

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No evidence text available

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"Binding of USP40 and HINT1 was confirmed by immunoprecipitation using HEK-USP40 cells transfected with Myc 6 -tagged HINT1 ( Fig. 3 A and B)."

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No evidence text available

35605301

USP40 activates HINT1.

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USP40 activates HINT1. 2 / 2

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"Cultured podocytes with USP40 knockdown decreased HINT1 and p53 [39]."

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"It was apparent that reduction of USP40 decreased HINT1 and p53 ( Fig. 3 D and E)."

35605301

USP40 deubiquitinates HINT1.

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USP40 deubiquitinates HINT1. 1 / 1

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"In addition, USP40 was involved in the process of glomerulosclerosis by deubiquitinating HINT1 and stabilizing p53 leading to podocyte hypertrophy [9]."

38308285

Bisphenol A affects USP40

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Bisphenol A decreases the amount of USP40.

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Bisphenol A decreases the amount of USP40. 4 / 4

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Bisphenol A increases the amount of USP40.

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Bisphenol A increases the amount of USP40. 1 / 1

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No evidence text available

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USP40 affects NES

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USP40 increases the amount of NES.

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USP40 increases the amount of NES. 2 / 2

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"USP40 gene knockdown disrupts glomerular barrier integrity by reducing the expression of nestin, a filament protein ."

38307937

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"It has been reported that USP40 knockdown disrupts the permeability of glomerular endothelial cells in zebrafish by reducing the nestin level ."

38307937

USP40 binds NES.

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USP40 binds NES. 2 / 2

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"Protein binding of endogenous USP40 to Nestin in cultured podocytes was assayed using anti -USP40 antibody as previously described [ 8 ]."

35605301

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"In glomerular endothelial cells, immunoprecipitation confirmed actual protein protein binding of USP40 with nestin, and USP40-small-interfering RNA transfection revealed significant reduction of nestin."

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USP40 decreases the amount of NES.

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USP40 decreases the amount of NES. 1 / 1

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"Depletion of USP40 further elevated LPS-induced ICAM1 expression in the lungs without altering nestin expression (Fig. 2g and Supplementary Fig. 2a)."

38307937

Claudin1 affects USP40

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Claudin1 binds USP40.

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USP40 binds Claudin1. 4 / 4

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"USP40 could interact with Claudin1 and deubiquitinates Claudin1 to stabilize its protein level."

38308285

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"The interaction between USP40 and Claudin1 was identified by immunofluorescence, co-immunoprecipitation and ubiquitination assays."

38308285

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"As a DUB, USP40 could interact with and stabilize Claudin1 in HCC."

38308285

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38308285

Claudin1 activates USP40.

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Claudin1 activates USP40. 1 / 1

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"Furthermore, wound healing and transwell experiments revealed that USP40 silencing mediated cell migration suppression was partly restored by overexpressing Claudin1 (Fig. 6D, E)."

38308285

USP40 affects cell growth

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USP40 activates cell growth. 4 / 4

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"CCK-8 test displayed that USP40 depletion dramatically suppressed HCC cell growth, and Claudin1 overexpression partially reversed this growth (Fig. 6B), which was also verified by colony formation assay (Fig. 6C)."

38308285

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"USP40 overexpression dramatically accelerated HCC cell growth, migration and stemness both in vitro and in vivo."

38308285

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"CCK-8 and colony formation results showed that USP40 upregulation enhanced HCC cell growth (Fig. 3B, C)."

38308285

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"In addition, USP40 knockdown inhibited HCC cell growth, migration and stemness."

38308285

USP40 affects ICAM1

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USP40 decreases the amount of ICAM1.

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USP40 decreases the amount of ICAM1. 3 / 3

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"Depletion of USP40 further elevated LPS-induced ICAM1 expression in the lungs without altering nestin expression (Fig. 2g and Supplementary Fig. 2a)."

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"Downregulation of USP40 increased TNFα-induced ICAM1 expression (Fig. 2a), while overexpression of wild-type USP40 but not an enzyme active site mutant of USP40 (USP40 ) attenuated TNFα-induced ICAM1 expression in HLMVECs (Fig. 2b)."

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"Depletion of USP40 (USP40 and USP40 ) significantly increased ICAM1 expression in endothelial cells and neutrophil infiltration in the lungs of mice treated with LPS (i.t."

38307937

USP40 increases the amount of ICAM1.

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USP40 increases the amount of ICAM1. 1 / 1

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38307937

USP40 affects GMEB1

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USP40 binds GMEB1.

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USP40 binds GMEB1. 3 / 3

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"We then examined the interaction between GMEB1 and USP40 using Co-IP assay and found that tagged GMEB1 directly interacted with tagged USP40, which was confirmed by a reverse experiment (Additional file 1: Figure S3A and B)."

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No evidence text available

31046799

USP40 activates GMEB1.

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USP40 activates GMEB1. 1 / 1

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"We found that GMEB1 promoted the stability of CFLAR by de-ubiquitinase USP40."

31046799

USP40 affects ACSF2

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USP40 binds ACSF2.

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USP40 binds ACSF2. 3 / 3

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"Apoc1 overexpression inhibited ACSF2 binding to USP40."

39041949

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"M2-Exos-derived Apoc1 promoted ferroptosis resistance by inhibiting USP40 binding to ACSF2 and promoting ACSF2 ubiquitination and degradation, thus enhancing OS development."

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No evidence text available

35605301

USP40 ubiquitinates ACSF2.

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USP40 leads to the ubiquitination of ACSF2. 1 / 1

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"Apoc1 overexpression increased ACSF2 ubiquitination, promoting its degradation, whereas USP40 overexpression inhibited ACSF2 ubiquitination and promoted its expression."

39041949

HINT1 affects USP40

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HINT1 binds USP40. 4 / 4

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No evidence text available

35605301

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No evidence text available

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"Binding of USP40 and HINT1 was confirmed by immunoprecipitation using HEK-USP40 cells transfected with Myc 6 -tagged HINT1 ( Fig. 3 A and B)."

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No evidence text available

35605301

USP40 affects Endothelial Cells

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USP40 activates Endothelial Cells.

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USP40 activates Endothelial Cells. 2 / 2

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"These contrasting findings indicate that the molecular mechanism of USP40-mediated EC biological functions differs across species."

38307937

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"In this study, we report that USP40, a poorly characterized DUB, prevents EC barrier disruption through reductions in the activation of RhoA and phosphorylation of myosin light chain (MLC) and cofilin."

38307937

USP40 inhibits Endothelial Cells.

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USP40 inhibits Endothelial Cells. 1 / 1

| 1

➶

reach

"Furthermore, USP40 reduces EC inflammation through the attenuation of NF-kB activation, ICAM1 expression, and leukocyte-EC adhesion."

38307937

NES affects USP40

| 3

NES binds USP40.

| 2

USP40 binds NES. 2 / 2

| 2

➶

reach

"Protein binding of endogenous USP40 to Nestin in cultured podocytes was assayed using anti -USP40 antibody as previously described [ 8 ]."

35605301

➶

reach

28148530

NES activates USP40.

| 1

NES activates USP40. 1 / 1

| 1

➶

reach

"Because Nestin could support USP40 function as a scaffold, upregulation of Nestin might occur due to the increased demand responding to USP40 upregulation."

35605301

GMEB1 affects USP40

2 | 1

USP40 binds GMEB1. 3 / 3

2 | 1

➶

reach

31046799

➶

biogrid

No evidence text available

31046799

➶

biogrid

No evidence text available

31046799

ACSF2 affects USP40

1 | 2

USP40 binds ACSF2. 3 / 3

1 | 2

➶

reach

"Apoc1 overexpression inhibited ACSF2 binding to USP40."

39041949

➶

reach

"M2-Exos-derived Apoc1 promoted ferroptosis resistance by inhibiting USP40 binding to ACSF2 and promoting ACSF2 ubiquitination and degradation, thus enhancing OS development."

39041949

➶

biogrid

No evidence text available

35605301

Titanium dioxide affects USP40

2 |

Titanium dioxide methylates USP40.

1 |

Titanium dioxide methylates USP40. 1 / 1

1 |

➶

ctd

No evidence text available

35295148

Titanium dioxide demethylates USP40.

1 |

Titanium dioxide demethylates USP40. 1 / 1

1 |

➶

ctd

No evidence text available

35295148

Pirinixic acid affects USP40

2 |

Pirinixic acid increases the amount of USP40. 2 / 2

2 |

➶

ctd

No evidence text available

18301758

➶

ctd

No evidence text available

21318169

Paracetamol affects USP40

2 |

Paracetamol decreases the amount of USP40. 2 / 2

2 |

➶

ctd

No evidence text available

33387578

➶

ctd

No evidence text available

21420995

Ozone affects USP40

2 |

Ozone increases the amount of USP40.

1 |

Ozone increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32699268

Ozone decreases the amount of USP40.

1 |

Ozone decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32845096

Methacrylaldehyde affects USP40

2 |

Methacrylaldehyde increases the amount of USP40.

1 |

Methacrylaldehyde increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32699268

Methacrylaldehyde decreases the amount of USP40.

1 |

Methacrylaldehyde decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32845096

Dioxygen affects USP40

2 |

Dioxygen increases the amount of USP40.

1 |

Dioxygen increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

22629407

Dioxygen decreases the amount of USP40.

1 |

Dioxygen decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

22629407

Acrolein affects USP40

2 |

Acrolein increases the amount of USP40.

1 |

Acrolein increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32699268

Acrolein decreases the amount of USP40.

1 |

Acrolein decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32845096

USP40 affects cell migration

| 2

USP40 activates cell migration. 2 / 2

| 2

➶

reach

"Furthermore, wound healing and tranwell assays confirmed that USP40 upregulation also promoted HCC cell migration (Fig. 3D, E)."

38308285

➶

reach

"Furthermore, wound healing and transwell experiments revealed that USP40 silencing mediated cell migration suppression was partly restored by overexpressing Claudin1 (Fig. 6D, E)."

38308285

USP40 affects UBC

2 |

UBC binds USP40. 2 / 2

2 |

➶

biogrid

No evidence text available

29576527

➶

biogrid

No evidence text available

28190767

USP40 affects TP53

| 2

USP40 activates TP53. 2 / 2

| 2

➶

reach

"Cultured podocytes with USP40 knockdown decreased HINT1 and p53 [39]."

37509442

➶

reach

"It was apparent that reduction of USP40 decreased HINT1 and p53 ( Fig. 3 D and E)."

35605301

USP40 affects Parkinson Disease

| 2

USP40 ubiquitinates Parkinson Disease.

| 1

USP40 leads to the ubiquitination of Parkinson Disease. 1 / 1

| 1

➶

reach

"Variants in USP24 and USP40 are implicated in the risk for late-onset Parkinson’s disease (PD), supporting the proposed role of ubiquitination pathways in PD pathogenesis (25)."

39998882

USP40 inhibits Parkinson Disease.

| 1

USP40 inhibits Parkinson Disease. 1 / 1

| 1

➶

reach

"Interestingly, it has been reported that some polymorphisms of USP24 and USP40 significantly decrease the risk of developing PD [22,23]."

26797011

USP40 affects Neoplasms

| 2

USP40 activates Neoplasms. 2 / 2

| 2

➶

reach

"USP40 promotes tumor growth in vivo."

38308285

➶

reach

"Through TCGA and UALCAN databases, we discovered that USP40 mRNA was elevated in tumor compared to normal tissues and correlated with tumor stage (Fig. 1A, B)."

38308285

USP40 affects MYL

| 2

USP40 leads to the dephosphorylation of MYL. 2 / 2

| 2

➶

reach

"Among the overexpressed DUBs, only USP40 attenuated thrombin-induced phosphorylation of MLC (Supplementary Fig. 1a)."

38307937

➶

reach

"LPS treatment of HLMVECs increased the phosphorylation of MLC, while it was reduced by USP40-V5 overexpression (Fig. 1f), suggesting that USP40 negatively regulates the phosphorylation of MLC."

38307937

USP40 affects MYC

| 2

USP40 increases the amount of MYC.

| 1

USP40 increases the amount of MYC. 1 / 1

| 1

➶

reach

"We confirmed that silencing USP40 limited the sphere-forming capacity of HCC cells and decreased c-Myc and KLF4 expression."

38308285

USP40 activates MYC.

| 1

USP40 activates MYC. 1 / 1

| 1

➶

reach

"Meanwhile, overexpression of USP40 elevated the levels of stemness-related proteins, including c-Myc and KLF4 (Fig. 3G)."

38308285

USP40 affects KLF4

| 2

USP40 increases the amount of KLF4.

| 1

USP40 increases the amount of KLF4. 1 / 1

| 1

➶

reach

"We confirmed that silencing USP40 limited the sphere-forming capacity of HCC cells and decreased c-Myc and KLF4 expression."

38308285

USP40 activates KLF4.

| 1

USP40 activates KLF4. 1 / 1

| 1

➶

reach

"Meanwhile, overexpression of USP40 elevated the levels of stemness-related proteins, including c-Myc and KLF4 (Fig. 3G)."

38308285

USP40 affects CLDN1

| 2

USP40 deubiquitinates CLDN1.

| 1

USP40 deubiquitinates CLDN1. 1 / 1

| 1

➶

reach

"Our recently published paper reports that USP40 deubiquitinates and stabilizes Claudin 1 to facilitate HCC cell proliferation, migration and stemness [ 31 ]."

38537774

USP40 activates CLDN1.

| 1

USP40 activates CLDN1. 1 / 1

| 1

➶

reach

"Our recently published paper also shows that USP40 contributes to HCC progression by stabilizing Claudin 1 [ 31 ]."

38537774

UBC affects USP40

2 |

UBC binds USP40. 2 / 2

2 |

➶

biogrid

No evidence text available

29576527

➶

biogrid

No evidence text available

28190767

HSP90 affects USP40

| 2

HSP90 inhibits USP40.

| 1

HSP90 inhibits USP40. 1 / 1

| 1

➶

reach

"Furthermore, expression of HSP90 significantly reduced the monoubiquitination of HSP90β (Fig. 7e), possibly due to the high binding affinity of this mutant for USP40."

38307937

HSP90 activates USP40.

| 1

HSP90 activates USP40. 1 / 1

| 1

➶

reach

"Consistent with findings indicating that inhibition of HSP90 diminishes EC inflammation and barrier dysfunction, USP40 protects lung ECs against inflammatory stimulus-induced inflammatory responses and barrier disruption in vitro and in vivo."

38307937

2,3,7,8-tetrachlorodibenzodioxine affects USP40

2 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP40.

1 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

34747641

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP40.

1 |

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33387578

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone affects USP40

2 |

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone increases the amount of USP40.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone decreases the amount of USP40.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine affects USP40

2 |

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine increases the amount of USP40.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine decreases the amount of USP40.

1 |

N-(1,3-dimethylbutyl)-N'-phenyl-1,4-phenylenediamine decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

38574660

Vinclozolin affects USP40

1 |

Vinclozolin increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

23034163

Verteporfin affects USP40

| 1

Verteporfin increases the amount of USP40. 1 / 1

| 1

➶

reach

"Otherwise, YAP-TEAD inhibitor (Verteporfin) and YAP knockdown consistently reduced USP40 level in HCC cells (P < 0.05, Fig. 6 C–F and Supplementary Fig. 5B )."

38537774

Valproic acid affects USP40

1 |

Valproic acid increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

17183730

Urethane affects USP40

1 |

Urethane decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

28818685

Trichloroethene affects USP40

1 |

Trichloroethene decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33387578

Thioacetamide affects USP40

1 |

Thioacetamide decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

34492290

Thiabendazole affects USP40

1 |

Thiabendazole increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33854195

Tetrachloromethane affects USP40

1 |

Tetrachloromethane decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Sunitinib affects USP40

1 |

Sunitinib increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Sorafenib affects USP40

1 |

Sorafenib decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

39786591

SiNC affects USP40

| 1

SiNC activates USP40. 1 / 1

| 1

➶

reach

38308285

SiClaudin1 affects USP40

| 1

SiClaudin1 activates USP40. 1 / 1

| 1

➶

reach

38308285

Schizandrin B affects USP40

1 |

Schizandrin B increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Polybromodiphenyl ether affects USP40

1 |

Polybromodiphenyl ether decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

23948077

Phorbol 13-acetate 12-myristate affects USP40

1 |

Phorbol 13-acetate 12-myristate decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Okadaic acid affects USP40

1 |

Okadaic acid decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

38832940

Leflunomide affects USP40

1 |

Leflunomide decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

28988120

Lead diacetate affects USP40

1 |

Lead diacetate increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

20542052

Lead atom affects USP40

1 |

Lead atom decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

19921347

Ketoconazole affects USP40

1 |

Ketoconazole decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

36621641

Iron dichloride affects USP40

1 |

Iron dichloride decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

35984750

Ionomycin affects USP40

1 |

Ionomycin decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Indometacin affects USP40

1 |

Indometacin decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Hydralazine affects USP40

1 |

Hydralazine increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

17183730

Hexabromocyclododecane affects USP40

1 |

Hexabromocyclododecane increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

29177809

Glycidamide affects USP40

1 |

Glycidamide increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

17822822

Dibutyl phthalate affects USP40

1 |

Dibutyl phthalate decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

21266533

Dexamethasone affects USP40

1 |

Dexamethasone decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Deltamethrin affects USP40

1 |

Deltamethrin decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

37019170

Cyclosporin A affects USP40

1 |

Cyclosporin A decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

25562108

Coumestrol affects USP40

1 |

Coumestrol decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

19167446

Chlorpyrifos affects USP40

1 |

Chlorpyrifos increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33854195

Calcitriol affects USP40

1 |

Calcitriol increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

16002434

Caffeine affects USP40

1 |

Caffeine dephosphorylates USP40. 1 / 1

1 |

➶

ctd

No evidence text available

35688186

Butanal affects USP40

1 |

Butanal decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

26079696

Bisphenol F affects USP40

1 |

Bisphenol F decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

28628672

Azoxystrobin affects USP40

1 |

Azoxystrobin increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33854195

Aristolochic acid A affects USP40

1 |

Aristolochic acid A decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33212167

Antirheumatic drug affects USP40

1 |

Antirheumatic drug increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

24449571

Alpha-pinene affects USP40

1 |

Alpha-pinene increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32699268

Aflatoxin B1 affects USP40

1 |

Aflatoxin B1 increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

19770486

ZRANB1 affects USP40

1 |

ZRANB1 binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

35944360

YAP-TEAD inhibitor affects USP40

| 1

YAP-TEAD inhibitor increases the amount of USP40. 1 / 1

| 1

➶

reach

"Otherwise, YAP-TEAD inhibitor (Verteporfin) and YAP knockdown consistently reduced USP40 level in HCC cells (P < 0.05, Fig. 6 C–F and Supplementary Fig. 5B )."

38537774

VAPA affects USP40

1 |

USP40 binds VAPA. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects inflammatory response

| 1

USP40 inhibits inflammatory response. 1 / 1

| 1

➶

reach

"Furthermore, USP40 reduces EC inflammation through the attenuation of NF-kB activation, ICAM1 expression, and leukocyte-EC adhesion."

38307937

USP40 affects apoptotic process

| 1

USP40 inhibits apoptotic process. 1 / 1

| 1

➶

reach

"USP40 is up-regulated in non-small cell lung cancer and inhibits lung cancer cell apoptosis through deubiquitination and stabilization of CFLARL protein [ 30 ]."

38537774

USP40 affects ZRANB1

1 |

ZRANB1 binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

35944360

USP40 affects VAPA

1 |

USP40 binds VAPA. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects USP40

| 1

USP40 activates USP40. 1 / 1

| 1

➶

reach

"Overexpression of USP40 also reduced thrombin-induced phosphorylation of cofilin 1 (Supplementary Fig. 1e), suggesting an inhibitory role of USP40 in stress fiber stabilization."

38307937

USP40 affects TRAPPC8

1 |

USP40 binds TRAPPC8. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects TPT1

1 |

USP40 binds TPT1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects TOP3B

1 |

TOP3B binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

35748872

USP40 affects TOMM20

1 |

USP40 binds TOMM20. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects TCF25

1 |

USP40 binds TCF25. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects STT3A

1 |

USP40 binds STT3A. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects SRSF2

1 |

USP40 binds SRSF2. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects SLC2A5

1 |

USP40 binds SLC2A5. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects SLC12A1

1 |

USP40 binds SLC12A1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects RPS3A

1 |

USP40 binds RPS3A. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects RPS20

1 |

USP40 binds RPS20. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects RPS18

1 |

USP40 binds RPS18. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects RPL30

1 |

USP40 binds RPL30. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects RNF7

1 |

USP40 binds RNF7. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects RIGI

1 |

RIGI binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

32513696

USP40 affects RACK1

1 |

USP40 binds RACK1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects PSTK

1 |

USP40 binds PSTK. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects PMS2P1

1 |

USP40 binds PMS2P1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects OS9

1 |

USP40 binds OS9. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects OCLN

1 |

USP40 binds OCLN. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects NORAD

1 |

USP40 binds NORAD. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects NFkappaB

| 1

USP40 inhibits NFkappaB. 1 / 1

| 1

➶

reach

"USP40 negatively regulates the NF-kappaB pathway in HLMVECs."

38307937

USP40 affects MTRNR2L1

1 |

USP40 binds MTRNR2L1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects MT2A

1 |

USP40 binds MT2A. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects MITF

| 1

USP40 inhibits MITF. 1 / 1

| 1

➶

reach

"Regardless, the changes driven by Socs6 and Baiap2 warrant further study.Interestingly, a small number of transcripts, including Usp40, Pkd1l1, Pdgfc, and Cpne4, have significantly decreased relative expression (lrt q<0.05, FC < -1) in Mitf B cells compared to wild type."

38444862

USP40 affects Lung Injury

| 1

USP40 activates Lung Injury. 1 / 1

| 1

➶

reach

"Global depletion of USP40 and EC-targeted USP40 depletion in mice exacerbated experimental lung injury, whereas lentiviral gene transfer of USP40 protected against endotoxin-induced lung injury."

38307937

USP40 affects LRP2

1 |

USP40 binds LRP2. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects LDHB

1 |

USP40 binds LDHB. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects ITGA6

1 |

USP40 binds ITGA6. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects IRF6

| 1

USP40 inhibits IRF6. 1 / 1

| 1

➶

reach

"Through an unbiased screening approach, we found that USP40 attenuates LPS- or thrombin-induced human lung microvascular endothelial cell (HLMVEC) barrier disruption and LPS-induced EC inflammatory responses, such as ICAM1 expression and neutrophil-EC interactions."

38307937

USP40 affects IL11RA

1 |

USP40 binds IL11RA. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects IL10

| 1

USP40 activates IL10. 1 / 1

| 1

➶

reach

"Knockdown of USP40 significantly decreased ManLAM and Pam3CSK4 induced IL-10 production by WT B cells, whereas IL-10 production by USP40 silenced TLR2 -/- B cells was not reduced compared with scramble RNA treated TLR2 -/- B cells upon stimulation with ManLAM (XREF_FIG C, 5D, and XREF_SUPPLEMENTARY F)."

30572206

USP40 affects HSPA8

1 |

USP40 binds HSPA8. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects HSP90beta

| 1

USP40 deubiquitinates HSP90beta. 1 / 1

| 1

➶

reach

"USP40 deubiquitinates and inactivates HSP90beta."

38307937

USP40 affects HNRNPL

1 |

HNRNPL binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

28611215

USP40 affects HEBP2

1 |

USP40 binds HEBP2. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects HCG11

1 |

USP40 binds HCG11. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects GMEB

| 1

USP40 binds GMEB. 1 / 1

| 1

➶

reach

"We found the de-ubiquitination enzyme USP40 bound to CFLAR and GMEB, which enhanced the interaction between USP40 and CFLAR resulting in reduced ubiquitination and degradation of CFLAR ."

31046799

USP40 affects F2

| 1

USP40 inhibits F2. 1 / 1

| 1

➶

reach

38307937

USP40 affects EPB41L1

1 |

USP40 binds EPB41L1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects EEF1D

1 |

USP40 binds EEF1D. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects EEF1A1

1 |

USP40 binds EEF1A1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects DDB2

1 |

USP40 binds DDB2. 1 / 1

1 |

➶

hprd

No evidence text available

11673459

USP40 affects DDB1

1 |

DDB1 binds USP40. 1 / 1

1 |

➶

hprd

No evidence text available

11673459

USP40 affects Carcinoma, Hepatocellular

| 1

USP40 activates Carcinoma, Hepatocellular. 1 / 1

| 1

➶

reach

"USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1."

38308285

USP40 affects CUL7

1 |

CUL7 binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

31343991

USP40 affects COMMD6

1 |

USP40 binds COMMD6. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects CLN8

1 |

USP40 binds CLN8. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects CFL1

| 1

USP40 leads to the dephosphorylation of CFL1. 1 / 1

| 1

➶

reach

"Overexpression of USP40 also reduced thrombin-induced phosphorylation of cofilin 1 (Supplementary Fig. 1e), suggesting an inhibitory role of USP40 in stress fiber stabilization."

38307937

USP40 affects CCN2

| 1

USP40 increases the amount of CCN2. 1 / 1

| 1

➶

reach

"We found that USP40 knockdown down-regulated while USP40 overexpression up-regulated CTGF and CYR61 levels in HCC cells (P < 0.05, Fig. 1 F and G and Supplementary Figs."

38537774

USP40 affects CCN1

| 1

USP40 increases the amount of CCN1. 1 / 1

| 1

➶

reach

"We found that USP40 knockdown down-regulated while USP40 overexpression up-regulated CTGF and CYR61 levels in HCC cells (P < 0.05, Fig. 1 F and G and Supplementary Figs."

38537774

USP40 affects C1QA

1 |

USP40 binds C1QA. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects Adenocarcinoma of Lung

| 1

Mutated USP40 activates Adenocarcinoma of Lung. 1 / 1

| 1

➶

reach

"Through whole exon sequencing, Xu et al. reported a case of lung adenocarcinoma caused by USP40 mutations, indicating that the gene plays a crucial driving role [22]."

38308285

USP40 affects Acute Lung Injury

| 1

USP40 activates Acute Lung Injury. 1 / 1

| 1

➶

reach

"To investigate whether overexpression of USP40 mitigates LPS-induced acute lung injury, a lentiviral vector containing the USP40 gene was administered to mice."

38307937

USP40 affects AURKA

1 |

USP40 binds AURKA. 1 / 1

1 |

➶

biogrid

No evidence text available

33669244

USP40 affects ATPase

| 1

USP40 inhibits ATPase. 1 / 1

| 1

➶

reach

"Furthermore, USP40 reduced HSP90β ATPase activity (Fig. 6h)."

38307937

USP40 affects APOM

1 |

USP40 binds APOM. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects ALDOB

1 |

USP40 binds ALDOB. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects AHSA1

1 |

USP40 binds AHSA1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects ADH5

1 |

USP40 binds ADH5. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects A2M

1 |

USP40 binds A2M. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

USP40 affects 2-hydroxy-17beta-estradiol

| 1

USP40 activates 2-hydroxy-17beta-estradiol. 1 / 1

| 1

➶

reach

"We also investigated whether nestin plays a role in USP40-mediated biological functions of lung ECs and found that nestin expression was not reduced in HLMVECs with USP40 downregulation or the lungs of USP40 mice (Fig. 2g and Supplementary Fig. 2a)."

38307937

Triptolide affects USP40

1 |

Triptolide increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

32519852

TRAPPC8 affects USP40

1 |

USP40 binds TRAPPC8. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

TPT1 affects USP40

1 |

USP40 binds TPT1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

TOP3B affects USP40

1 |

TOP3B binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

35748872

TOMM20 affects USP40

1 |

USP40 binds TOMM20. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

TLR2 affects USP40

| 1

TLR2 bound to ManLAM activates USP40. 1 / 1

| 1

➶

reach

"Molecular mechanism analysis reveals that the interaction of ManLAM and TLR2 induces IL-10 production by B cells mainly via the TLR2/MyD88/PI3K/AKT/AP -1 and NEMO K63 ubiquitination NF-kappaB signaling pathways, and increased USP40."

30572206

TCF25 affects USP40

1 |

USP40 binds TCF25. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

STT3A affects USP40

1 |

USP40 binds STT3A. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

STAT6 affects USP40

1 |

STAT6 decreases the amount of USP40. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

STAT5A affects USP40

1 |

STAT5A decreases the amount of USP40. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SRSF2 affects USP40

1 |

USP40 binds SRSF2. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

SLC2A5 affects USP40

1 |

USP40 binds SLC2A5. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

SLC12A1 affects USP40

1 |

USP40 binds SLC12A1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

RPS3A affects USP40

1 |

USP40 binds RPS3A. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

RPS20 affects USP40

1 |

USP40 binds RPS20. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

RPS18 affects USP40

1 |

USP40 binds RPS18. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

RPL30 affects USP40

1 |

USP40 binds RPL30. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

RNF7 affects USP40

1 |

USP40 binds RNF7. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

RIGI affects USP40

1 |

RIGI binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

32513696

RACK1 affects USP40

1 |

USP40 binds RACK1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

Phthalic Acids affects USP40

1 |

Phthalic Acids decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

21061450

PSTK affects USP40

1 |

USP40 binds PSTK. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

PMS2P1 affects USP40

1 |

USP40 binds PMS2P1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

OS9 affects USP40

1 |

USP40 binds OS9. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

OCLN affects USP40

1 |

USP40 binds OCLN. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

NORAD affects USP40

1 |

USP40 binds NORAD. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

ManLAM-TLR2 affects USP40

| 1

ManLAM-TLR2 activates USP40. 1 / 1

| 1

➶

reach

"ManLAM-TLR2 induces USP40 increase, which positively regulated the IL-10 production in B cells (XREF_FIG B-5D and XREF_SUPPLEMENTARY C-S5F)."

30572206

MTRNR2L1 affects USP40

1 |

USP40 binds MTRNR2L1. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

MT2A affects USP40

1 |

USP40 binds MT2A. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

MIR7-3HG affects USP40

| 1

MIR7-3HG activates USP40. 1 / 1

| 1

➶

reach

"To further confirm the function of USP40 in HCC, Huh7 and MHCC97H cell lines stably overexpressed USP40 were constructed by lentivirus transfection."

38308285

MIR484 affects USP40

1 |

MIR484 decreases the amount of USP40. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

LRP2 affects USP40

1 |

USP40 binds LRP2. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

LDHB affects USP40

1 |

USP40 binds LDHB. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

ITGA6 affects USP40

1 |

USP40 binds ITGA6. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

IL11RA affects USP40

1 |

USP40 binds IL11RA. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

HSPA8 affects USP40

1 |

USP40 binds HSPA8. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

HNRNPL affects USP40

1 |

HNRNPL binds USP40. 1 / 1

1 |

➶

biogrid

No evidence text available

28611215

HLMVECs affects USP40

| 1

HLMVECs inhibits USP40. 1 / 1

| 1

➶

reach

"LPS increased ICAM1 and VCAM1 expression, and these effects were attenuated in USP40-overexpressing HLMVECs (Fig. 2c, d)."

38307937

HEBP2 affects USP40

1 |

USP40 binds HEBP2. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

HCG11 affects USP40

1 |

USP40 binds HCG11. 1 / 1

1 |

➶

biogrid

No evidence text available

35605301

Glyphosate affects USP40

1 |

Glyphosate increases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

33854195

GSK-J4 affects USP40

1 |

GSK-J4 decreases the amount of USP40. 1 / 1

1 |

➶

ctd

No evidence text available

29301935

GMEB affects USP40

| 1

USP40 binds GMEB. 1 / 1

| 1

➶

reach

"We found the de-ubiquitination enzyme USP40 bound to CFLAR and GMEB, which enhanced the interaction between USP40 and CFLAR resulting in reduced ubiquitination and degradation of CFLAR ."

31046799