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YAP1 activates USP40. 3 / 3
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"The luciferase reporter assay demonstrated that YAP rather than EZH2 overexpression promoted the transcription activity of USP40 promoter in HEK293T cells (P < 0.05, Fig. 6 H)."
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"Immunoblotting results confirmed that stiffness-induced USP40 upregulation was significantly abolished by YAP knockdown in Hep3B and HUH-7 cells (P < 0.05, Supplementary Fig. 6B )."
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"Notably, we further confirmed that YAP mediated the promoting role of USP40 in HCC growth in nude mice (P < 0.05, Fig. 5 A–D)."
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