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CFLAR binds USP40. 5 / 5
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"In addition, we found that overexpression of HA-GMEB1 (325–573), which did not interact with CFLAR , had no significant impact on the interaction between CFLAR and USP40 (Fig. 5c)."
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"GMEB1 promoted the binding of USP40 with CFLAR , conferring a role as an adaptor protein."
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"Data from co-IP assay in 293FT cells show that knock down of GMEB1 weakened the interaction between CFLAR and USP40; overexpression of GMEB1 enhanced the interaction (Fig. 5a and b, respectively)."
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"We found the de-ubiquitination enzyme USP40 bound to CFLAR and GMEB, which enhanced the interaction between USP40 and CFLAR resulting in reduced ubiquitination and degradation of CFLAR ."
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"GMEB1 promoted the binding of USP40 to CFLAR L ."
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