IndraLab

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USP40 leads to the acetylation of HSP90 on lysine. 2 / 2
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"We found that USP40 reduced the polyubiquitination and increased the lysine acetylation of HSP90β (Fig. 6f)."

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"USP40 overexpression increased lysine acetylation of HSP90β (Fig. 6i, j), suggesting that USP40 deubiquitinates HSP90β, resulting in an increase in lysine acetylation of HSP90β, thereby leading to inactivation of HSP90β and preservation of EC integrity."