IndraLab

Statements

USP40 activates HYCC1. 17 / 17
| 17
reach
"USP40 overexpression dramatically accelerated HCC cell growth, migration and stemness both in vitro and in vivo."
38308285
reach
"USP40 is elevated in HCC and predicts poor prognosis."
38308285
reach
"Knockdown of USP40 inhibits HCC cell proliferation, migration and stemness."
38308285
reach
"In addition, USP40 knockdown inhibited HCC cell growth, migration and stemness."
38308285
reach
"Overall, USP40 knockdown inhibited HCC cell proliferation, migration and stemness."
38308285
reach
"Overexpression of USP40 promotes HCC cell proliferation, migration and stemness."
38308285
reach
"YAP knockdown markedly abolished USP40 overexpression-enhanced the malignant behaviors of HCC cells (P < 0.05, Fig. 4 D–F and Supplementary 4F–4H)."
38537774
reach
"USP40 was elevated in HCC and is an unfavorable prognostic biomarker for HCC."
38308285
reach
"CCK-8 and colony formation results showed that USP40 upregulation enhanced HCC cell growth (Fig. 3B, C)."
38308285
reach
"Furthermore, wound healing and tranwell assays confirmed that USP40 upregulation also promoted HCC cell migration (Fig. 3D, E)."
38308285
reach
"In general, our findings suggest that USP40 upregulation can enhance HCC cell proliferation, migration and stemness."
38308285
reach
"Moreover, USP40 knockdown prominently attenuated stiffness-induced YAP accumulation in HCC cells (P < 0.05, Supplementary Fig. 6C )."
38537774
reach
"Both in vivo and in vitro experiments suggested that USP40 promoted HCC progression in a YAP-dependent manner."
38537774
reach
"USP40 promotes HCC progression by regulating Claudin1."
38308285
reach
"To investigate whether Claudin1 is participated in USP40-mediated HCC cell growth and migration, several rescue experiments were conducted."
38308285
reach
"USP40 knockdown inhibits HCC cell proliferation, migration and stemness, whereas USP40 overexpression shows the opposite impact."
38308285
reach
"CCK-8 test displayed that USP40 depletion dramatically suppressed HCC cell growth, and Claudin1 overexpression partially reversed this growth (Fig. 6B), which was also verified by colony formation assay (Fig. 6C)."
38308285