IndraLab

Statements

USP40 activates YAP1. 5 / 5
| 5
reach
"USP40 overexpression increased the half-life of YAP in HCCLM3 and PLC/PRF/5 cells (P < 0.05, Supplementary Fig. 2A )."
38537774
reach
"Moreover, USP40 knockdown prominently attenuated stiffness-induced YAP accumulation in HCC cells (P < 0.05, Supplementary Fig. 6C )."
38537774
reach
"Notably, ECM stiffness signals activated USP40 transcription by YAP and stiffness-induced YAP accumulation was attenuated by USP40 knockdown in HCC cells."
38537774
reach
"USP40 overexpression prominently increased YAP protein but did not impact mRNA expression in HCC cells (P < 0.05, Fig. 1 D and E and Supplementary Fig. 1C )."
38537774
reach
"Thus, our data suggest that USP40 positively regulates YAP abundance in HCC cells.Next, we demonstrated that endogenous USP40 interacted with YAP in HUH-7 and HepG2 cells ( Fig. 2 A)."
38537774