IndraLab

Statements


OTUD6B affects AS1
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sparser
"Previous studies have reported that elevated expression of MRCCAT1, ATB, and SNHG14 in KIRC were correlated with poor prognosis, and this is also the case for low expression of OTUD6B-AS1 and ADAMTS9-AS2."

sparser
"To further interrogate the molecular mechanism by which lncRNA OTUD6B-AS1 exacerbates As 2 O 3 -induced oxidative damage, we investigated the downstream targets of lncRNA OTUD6B-AS1 by bioinformatic analysis."

sparser
"Overall, OTUD6B-AS1 inhibits cellular development in CRC by sponging miR-21-5p and upregulating PNRC2, providing a novel insight into the exploration on CRC treatment."

sparser
"As predicted by TCGA, OTUD6B-AS1 expression was markedly downregulated in CRC tissues compared with in normal tissues ( xref )."

sparser
"OTUD6B-AS1."

sparser
"After constructing the overexpression plasmid of OTUD6B-AS1, transfection efficiency was verified by RT-qPCR, and it was demonstrated that OTUD6B-AS1 expression was significantly upregulated in the Oe-OTUD6B-AS1 group compared with the Oe-NC group ( xref )."

sparser
"lncRNA OTUD6B-AS1 Downregulates IDH2 Expression by Stabilizing miR-6734-5p."

sparser
"We next characterized the interactions between lncRNA OTUD6B-AS1 and miR-6734-5p in evoking oxidative damage."

sparser
"Notably, OTUD6B-AS1 was identified as a molecular sponge of microRNA-664b-3p (miR-664b-3p)."

sparser
"The aim of the present study was to investigate the role of ovarian tumor domain containing 6B antisense RNA1 (OTUD6B-AS1) in CRC and its underlying mechanisms."
OTUD6B binds AS1 and mtf1. 1 / 1
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sparser
"As shown in xref , the luciferase activity driven by the WT promoter sequence was markedly reduced by MTF1 knockdown, indicating that the WT sites are required for binding of MTF1 to the lncRNA OTUD6B-AS1 promoter."
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"In the hormone receptor positive cell line HCC1500 (ER positive) silencing STK39 decreased survival (p = 0.03) and silencing OTUD6B increased apoptosis (p = 0.02) (XREF_FIG and XREF_FIG)."

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"Overexpressing Otud-6B in Ba/F3 cells resulted in downregulation of proliferation and increased the frequency of apoptosis [96]."

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"Overexpressing Otud-6B in Ba/F3 cells resulted in downregulation of proliferation and increased the frequency of apoptosis [XREF_BIBR]."

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"In the HER2 positive cell line SKBR3, silencing all three early stage antigens decreased survival (PDHX and STK39 p < 0.0001 and OTUD6B p = 0.05) and both STK39 and OTUD6B increased apoptosis (STK39 p = 0.0002 and OTUD6B p < 0.0001)."
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eidos
"In the HER2 positive cell line SKBR3 , silencing all three early stage antigens decreased survival ( PDHX and STK39 p < 0.0001 and OTUD6B p =0 .05 ) and both STK39 and OTUD6B increased apoptosis ( STK39 p =0 .0002 and OTUD6B p < 0.0001 ) ."
OTUD6B affects OTUB1
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No evidence text available

sparser
"Studying OTUD6B-OTUB1 Protein-Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays."

No evidence text available

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sparser
"We describe the GFP-Trap immunoprecipitation as a cell-based method to analyze the OTUD6B-OTUB1 interaction in the cellular context and the AlphaScreen (amplified luminescent proximity homogeneous assay) assay as a tool to detect direct interactions and to search for PPI inhibitors."
OTUD6B affects VHL
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OTUD6B binds VHL.
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sparser
"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1α accumulation in HCC cells under hypoxia."

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"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."
OTUD6B deubiquitinates VHL.
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OTUD6B leads to the deubiquitination of VHL. 1 / 1
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"Surprisingly, OTUD6B limits the ubiquitylation of pVHL independent of its deubiquitylase activity."
OTUD6B affects IRF7
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OTUD6B binds IRF7.
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OTUD6B binds IRF3 and IRF7. 1 / 1
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sparser
"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."
OTUD6B binds IRF7 and K63. 1 / 1
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"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."
OTUD6B ubiquitinates IRF7.
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OTUD6B ubiquitinates IRF7. 1 / 1
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trips
"Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7."
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Valproic acid increases the amount of OTUD6B. 2 / 2
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No evidence text available

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Bisphenol A decreases the amount of OTUD6B. 2 / 2
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VHL affects OTUD6B
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sparser
"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1α accumulation in HCC cells under hypoxia."

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"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."
SMURF1 affects OTUD6B
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SMURF1 ubiquitinates OTUD6B.
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SMURF1 ubiquitinates OTUD6B. 1 / 1
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No evidence text available
SMURF1 binds OTUD6B.
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No evidence text available
PTK2 affects OTUD6B
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No evidence text available

sparser
"It is possible that some of the OTUD6B-related features are partly a result of defective interaction between the OTUD6B and PTK2 genes."
| PMC

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"Further, lncRNA OTUD6B can inhibit ccRCC cell proliferation by suppressing the Wnt and beta-catenin pathway and the expressions of epithelial-to-mesenchymal transition related proteins."

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"In normal and transformed cells, the expression of the OTUD6B isoform that represses protein synthesis and proliferation is quantitatively higher."

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"Additionally, OTUD6B depletion increased AHA incorporation in H1734 and H1437 cells, and in transformed or primary cells other than NSCLC, specifically the mesothelioma cell line ME16, HaCaT immortalized human keratinocytes, and primary lung fibroblasts WI38 (XREF_FIG)."

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"Furthermore, NSCLC exposure to Torin-1 (an mTOR inhibitor, which target the mTOR catalytic site) abolished OTUD6B depletion enhanced AHA incorporation in these cells (XREF_FIG)."
OTUD6B affects PTK2
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No evidence text available

sparser
"It is possible that some of the OTUD6B-related features are partly a result of defective interaction between the OTUD6B and PTK2 genes."
| PMC
OTUD6B affects LIMCH1
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No evidence text available

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OTUD6B affects IRF3
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OTUD6B ubiquitinates IRF3.
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OTUD6B ubiquitinates IRF3. 1 / 1
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trips
"Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7."
OTUD6B binds IRF3.
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OTUD6B binds IRF3 and IRF7. 1 / 1
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sparser
"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."
OTUD6B affects GALC
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OTUD6B affects BTBD1
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LIMCH1 affects OTUD6B
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IRF7 affects OTUD6B
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OTUD6B binds IRF3 and IRF7. 1 / 1
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sparser
"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."
OTUD6B binds IRF7 and K63. 1 / 1
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"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."
GALC affects OTUD6B
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BTBD1 affects OTUD6B
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Urethane affects OTUD6B
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Urethane decreases the amount of OTUD6B. 1 / 1
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No evidence text available
Trimellitic anhydride increases the amount of OTUD6B. 1 / 1
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No evidence text available
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Titanium dioxide decreases the amount of OTUD6B. 1 / 1
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No evidence text available
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Thioacetamide increases the amount of OTUD6B. 1 / 1
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No evidence text available
Thimerosal affects OTUD6B
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Thimerosal increases the amount of OTUD6B. 1 / 1
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No evidence text available
Tetrachloromethane increases the amount of OTUD6B. 1 / 1
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No evidence text available
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Schizandrin B increases the amount of OTUD6B. 1 / 1
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No evidence text available
Quercetin affects OTUD6B
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Quercetin decreases the amount of OTUD6B. 1 / 1
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No evidence text available
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Pirinixic acid increases the amount of OTUD6B. 1 / 1
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No evidence text available
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No evidence text available
PVHL affects OTUD6B
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OTUD6B binds pVHL. 1 / 1
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isi
"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."

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"siRNAs to OTUD6B were unable to modify AHA incorporation when cells were treated with cycloheximide or homoharringtonine (XREF_FIG, left)."
Mtf1 affects OTUD6B
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OTUD6B binds AS1 and mtf1. 1 / 1
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sparser
"As shown in xref , the luciferase activity driven by the WT promoter sequence was markedly reduced by MTF1 knockdown, indicating that the WT sites are required for binding of MTF1 to the lncRNA OTUD6B-AS1 promoter."
Ionomycin affects OTUD6B
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Ionomycin increases the amount of OTUD6B. 1 / 1
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No evidence text available
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No evidence text available
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Dicrotophos decreases the amount of OTUD6B. 1 / 1
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No evidence text available
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Cyclosporin A increases the amount of OTUD6B. 1 / 1
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No evidence text available
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Clothianidin increases the amount of OTUD6B. 1 / 1
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No evidence text available
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Carbon nanotube increases the amount of OTUD6B. 1 / 1
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Benzo[a]pyrene increases the amount of OTUD6B. 1 / 1
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No evidence text available
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No evidence text available
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Aflatoxin B1 increases the amount of OTUD6B. 1 / 1
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No evidence text available
TNFSF13B affects OTUD6B
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TNFSF13B increases the amount of OTUD6B. 1 / 1
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"BAFF, a B cell activating factor of the TNF family, could also induce Otud-6b expression on mouse B cells after 4 hours stimulation XREF_BIBR."
SWAP70 affects OTUD6B
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No evidence text available
SPC24 affects OTUD6B
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No evidence text available
SEC24C affects OTUD6B
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No evidence text available
RPF2 affects OTUD6B
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No evidence text available
RP23-15I21.5 affects OTUD6B
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OTUD6B binds RP23-15I21.5. 1 / 1
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No evidence text available
RP23-121M7.1 affects OTUD6B
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OTUD6B binds RP23-121M7.1. 1 / 1
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No evidence text available
PARVA affects OTUD6B
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No evidence text available
OTUD6B affects ubiquitination pVHL
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OTUD6B inhibits ubiquitination pVHL. 1 / 1
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eidos
"More interestingly , OTU deubiquitinase 6B ( OTUD6B ) as the first reported deubiquitination enzyme is capable of inhibiting pVHL ubiquitination , and the deubiquitination regulation of OTUD6B on pVHL did not depend on its enzyme activity , but via interaction with pVHL to enhance the stability of CBCVHL ubiquitin ligase complex , and reduce the ubiquitination degradation of pVHL by Trp-Asp repeat and suppressors of cytokine signaling box-containing protein 1 ( WSB1 ) and E2-EPF ubiquitin carrier protein ( UCP ) ."
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"OTUD6B depletion caused an increased rate of cap dependent translation."
OTUD6B affects traf6-mediated K63-linked polyubiquitination irf3 irf7
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OTUD6B inhibits traf6-mediated K63-linked polyubiquitination irf3 irf7. 1 / 1
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eidos
"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7 ."
OTUD6B affects tbk1 bind irf3 irf7 resulting irf3 irf7 phosphorylation
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OTUD6B inhibits tbk1 bind irf3 irf7 resulting irf3 irf7 phosphorylation. 1 / 1
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eidos
"Moreover , otud6b also attenuates tbk1 to bind to irf3 and irf7 , resulting in the impairment of irf3 and irf7 phosphorylation ."
OTUD6B affects pathway
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OTUD6B inhibits pathway. 1 / 1
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sparser
"Mechanistically, OTUD6B-AS1 inactivates the Wnt/β-catenin pathway and suppresses the expression of epithelial-to-mesenchymal transition-related proteins, including E-cadherin, N-cadherin and Snail in RCC cells [ xref ]."
OTUD6B affects pVHL
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OTUD6B binds pVHL. 1 / 1
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isi
"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."
OTUD6B affects mtf1
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OTUD6B binds AS1 and mtf1. 1 / 1
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sparser
"As shown in xref , the luciferase activity driven by the WT promoter sequence was markedly reduced by MTF1 knockdown, indicating that the WT sites are required for binding of MTF1 to the lncRNA OTUD6B-AS1 promoter."
OTUD6B affects growth
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OTUD6B inhibits growth. 1 / 1
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sparser
"When TgMMTV-neu mice (n=5/group) were vaccinated with the individual antigens, vaccination with Pdhx inhibited tumor growth by 62.1%, Otud6B inhibited tumor growth by 23.5%, and Stk39 inhibited tumor growth by 50.3% as compared to empty vector vaccinated control at 27 weeks (p<0.001 for each individual antigen as compared to empty vector)."
| PMC
OTUD6B affects cell renal cell carcinoma
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OTUD6B inhibits cell renal cell carcinoma. 1 / 1
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eidos
"OTUD6B was found to inhibit clear cell renal cell carcinoma by regulating the Wnt / beta-catenin pathway and suppressing EMT-related protein expression ( 31 ) ."
OTUD6B affects cell cycle
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"However, the rapid down-regulation of Otud-6b is probably required to maintain a normal cell cycle as enforced Otud-6b expression can cause cell cycle arrest in Ba/F3 cells."
OTUD6B affects Wnt
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OTUD6B activates Wnt. 1 / 1
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"Further, lncRNA OTUD6B can inhibit ccRCC cell proliferation by suppressing the Wnt and beta-catenin pathway and the expressions of epithelial-to-mesenchymal transition related proteins."
OTUD6B affects TRAF6
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OTUD6B bound to IRF3 inhibits TRAF6. 1 / 1
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"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."
OTUD6B affects TBK1
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OTUD6B inhibits TBK1. 1 / 1
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"Moreover, otud6b also attenuates tbk1 to bind to irf3 and irf7, resulting in the impairment of irf3 and irf7 phosphorylation."
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eidos
"Disruption of otud6b in zebrafish increases the survival rate upon spring viremia of carp virus and grass carp reovirus exposure ."
OTUD6B affects SWAP70
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No evidence text available
OTUD6B affects SPC24
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No evidence text available
OTUD6B affects SMURF1
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No evidence text available
OTUD6B affects SEC24C
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No evidence text available
OTUD6B affects RPF2
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No evidence text available
OTUD6B affects RP23-15I21.5
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OTUD6B binds RP23-15I21.5. 1 / 1
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No evidence text available
OTUD6B affects RP23-121M7.1
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OTUD6B binds RP23-121M7.1. 1 / 1
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No evidence text available

sparser
"More interestingly, another major finding was that the molecular mechanism involved lncRNA OTUD6B-AS1 inhibition of IDH2 expression through stabilization of miR-6734-5p ( xref )."
OTUD6B affects PARVA
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No evidence text available

reach
"Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis."
OTUD6B affects MYH9
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No evidence text available
OTUD6B affects MYH14
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No evidence text available
OTUD6B affects MTDH
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No evidence text available
OTUD6B affects METAP2
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No evidence text available
OTUD6B affects MCTS1
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No evidence text available
OTUD6B affects K63
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OTUD6B binds IRF7 and K63. 1 / 1
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"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."
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"In 2017, Autosomal recessive mutations of OTUD6B were first described to cause intellectual disability associated with seizure, dysmorphic features, and congenital malformations, including distal limb abnormalities."
| PMC
OTUD6B affects IFN-1 activation K63-linked polyubiquitination irf3 irf7
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OTUD6B inhibits IFN-1 activation K63-linked polyubiquitination irf3 irf7. 1 / 1
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eidos
"In addition , the OTU domain is required for otud6b to repress IFN-1 activation and K63-linked polyubiquitination of irf3 and irf7 ."
OTUD6B affects ID1
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sparser
"Because OTUD6B is associated with autosomal recessive ID, with characteristic phenotypes that matched our patient’s manifestations, we believed that there could be another OTUD6B mutation in compound with the 8q21.3 microdeletion that is responsible for the patient’s phenotypes."
| PMC
OTUD6B affects HIF1A
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OTUD6B bound to VHL activates HIF1A. 1 / 1
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"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."
OTUD6B affects HDDC2
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No evidence text available
OTUD6B affects First Spanish case
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OTUD6B activates First Spanish case. 1 / 1
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"[First Spanish case of syndromic intellectual disability with dysmorphic facies, seizures, and distal limb anomalies caused by balletic mutations in the OTUD6B gene]."
OTUD6B affects ELAVL1
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No evidence text available

sparser
"In addition, the differential expression levels of lncRNAs included TSIX, NRIR, ncRNA00201, OTUD6B-AS, CTBP1-AS2, AGAP2-AS1, and HIFA-AS1, which can target mRNAs and might also involve pathogenesis and pathological changes in patients with SSc."
| PMC
OTUD6B affects Cyclin
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OTUD6B activates Cyclin. 1 / 1
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"Nevertheless, OTUD-6B probably could directly affect either the synthesis or the degradation process of cyclin D2 as overexpressing OTUD-6B in Hela cells could also cause cyclin D2 expression level down-regulation even without affecting cell cycle (XREF_SUPPLEMENTARY)."
OTUD6B affects CTNNB1
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OTUD6B activates CTNNB1. 1 / 1
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"Further, lncRNA OTUD6B can inhibit ccRCC cell proliferation by suppressing the Wnt and beta-catenin pathway and the expressions of epithelial-to-mesenchymal transition related proteins."
OTUD6B affects CTBP1
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sparser
"In addition, the differential expression levels of lncRNAs included TSIX, NRIR, ncRNA00201, OTUD6B-AS, CTBP1-AS2, AGAP2-AS1, and HIFA-AS1, which can target mRNAs and might also involve pathogenesis and pathological changes in patients with SSc."
| PMC
OTUD6B affects CRMP1
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No evidence text available
OTUD6B affects CORO1B
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No evidence text available
OTUD6B affects CHD3
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No evidence text available
OTUD6B affects CD3
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OTUD6B inhibits CD3. 1 / 1
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"For mice vaccinated with Pdhx, Stk39, and Otud6B depletion of CD3 + T cells increased tumor growth (p < 0.0001 compared to empty vector control for all targets)."
OTUD6B affects BASP1
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No evidence text available
OTUD6B affects ASCC3
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No evidence text available
OTUD6B affects AS
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sparser
"In addition, the differential expression levels of lncRNAs included TSIX, NRIR, ncRNA00201, OTUD6B-AS, CTBP1-AS2, AGAP2-AS1, and HIFA-AS1, which can target mRNAs and might also involve pathogenesis and pathological changes in patients with SSc."
| PMC
OTUD6B affects APEX1
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No evidence text available
OTUD6B affects AP2M1
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No evidence text available
OTUD6B affects AKAP5
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No evidence text available
NRF1 affects OTUD6B
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NRF1 decreases the amount of OTUD6B. 1 / 1
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No evidence text available
MYH9 affects OTUD6B
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No evidence text available
MYH14 affects OTUD6B
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No evidence text available
MTDH affects OTUD6B
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No evidence text available
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MT19c compound increases the amount of OTUD6B. 1 / 1
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No evidence text available
METAP2 affects OTUD6B
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No evidence text available
MCTS1 affects OTUD6B
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No evidence text available
K63 affects OTUD6B
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OTUD6B binds IRF7 and K63. 1 / 1
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reach
"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."
IRF7 affects IRF3
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OTUD6B binds IRF3 and IRF7. 1 / 1
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sparser
"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."
IL4 affects OTUD6B
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IL4 activates OTUD6B. 1 / 1
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"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."
IL3 affects OTUD6B
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IL3 activates OTUD6B. 1 / 1
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"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."
IL2 affects OTUD6B
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IL2 increases the amount of OTUD6B. 1 / 1
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"On the other hand, IL-2 could not induce Otud-6b expression in Ba/F3 cells (XREF_SUPPLEMENTARY)."
IL13 affects OTUD6B
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IL13 activates OTUD6B. 1 / 1
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"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."
ID1 affects OTUD6B
| 1
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sparser
"Because OTUD6B is associated with autosomal recessive ID, with characteristic phenotypes that matched our patient’s manifestations, we believed that there could be another OTUD6B mutation in compound with the 8q21.3 microdeletion that is responsible for the patient’s phenotypes."
| PMC
HDDC2 affects OTUD6B
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No evidence text available
ELAVL1 affects OTUD6B
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No evidence text available

sparser
"In addition, the differential expression levels of lncRNAs included TSIX, NRIR, ncRNA00201, OTUD6B-AS, CTBP1-AS2, AGAP2-AS1, and HIFA-AS1, which can target mRNAs and might also involve pathogenesis and pathological changes in patients with SSc."
| PMC
CSF3 affects OTUD6B
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CSF3 decreases the amount of OTUD6B. 1 / 1
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"However, granulocyte colony stimulating factor (G-CSF) could effectively down-regulate OTUD-6B expression when human leukocytes were stimulated for 16 hours XREF_BIBR."
CSF2 affects OTUD6B
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CSF2 activates OTUD6B. 1 / 1
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"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."
CRMP1 affects OTUD6B
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No evidence text available
CORO1B affects OTUD6B
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No evidence text available
CHD3 affects OTUD6B
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No evidence text available
BASP1 affects OTUD6B
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No evidence text available
ASCC3 affects OTUD6B
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No evidence text available
AS1 affects mtf1
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OTUD6B binds AS1 and mtf1. 1 / 1
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sparser
"As shown in xref , the luciferase activity driven by the WT promoter sequence was markedly reduced by MTF1 knockdown, indicating that the WT sites are required for binding of MTF1 to the lncRNA OTUD6B-AS1 promoter."
AS affects OTUD6B
| 1

sparser
"In addition, the differential expression levels of lncRNAs included TSIX, NRIR, ncRNA00201, OTUD6B-AS, CTBP1-AS2, AGAP2-AS1, and HIFA-AS1, which can target mRNAs and might also involve pathogenesis and pathological changes in patients with SSc."
| PMC
APEX1 affects OTUD6B