IndraLab

Statements

"Previous studies have reported that elevated expression of MRCCAT1, ATB, and SNHG14 in KIRC were correlated with poor prognosis, and this is also the case for low expression of OTUD6B-AS1 and ADAMTS9-AS2."

32974157

➶

sparser

"The correlations between the OTUD6B-AS1 expression level and the clinicopathological features were evaluated using the Mann-Whitney test."

32256450

➶

sparser

"Overall, OTUD6B-AS1 inhibits cellular development in CRC by sponging miR-21-5p and upregulating PNRC2, providing a novel insight into the exploration on CRC treatment."

33686892

➶

sparser

"As mentioned above, we explored the mechanism by which OTUD6B-AS1 overexpression affects ccRCC by performing experiments to demonstrate that OTUD6B-AS1 decreased the activity of the Wnt/β-catenin pathway and suppressed the expression of EMT-related proteins in ccRCC cells."

30670025

➶

sparser

"As predicted by TCGA, OTUD6B-AS1 expression was markedly downregulated in CRC tissues compared with in normal tissues ( xref )."

33574932

➶

sparser

"lncRNA OTUD6B-AS1 Downregulates IDH2 Expression by Stabilizing miR-6734-5p."

32952848

➶

sparser

"We next characterized the interactions between lncRNA OTUD6B-AS1 and miR-6734-5p in evoking oxidative damage."

32952848

➶

sparser

"Notably, OTUD6B-AS1 was identified as a molecular sponge of microRNA-664b-3p (miR-664b-3p)."

32682012

➶

sparser

"Furthermore, miR-6734-5p can also inhibit development of colon cancer and acute myeloid leukemia [ xref , xref ]; however, the oxidative damage effects of lncRNA OTUD6B-AS1 and miR-6734-5p against bladder cancer have not previously been reported."

32952848

➶

sparser

"Then, we included the variables age, gender, clinical tumor grade, pathologic stage, lymph node status, metastasis status, and OTUD6B-AS1 mRNA level in a multivariate Cox regression model and found that the OTUD6B-AS1 mRNA level was an independent predictor for overall survival status in KIRC patients (HR = 0.275, 95% CI 0.081–0.930, p = 0.038; Table xref )."

30670025

OTUD6B binds AS1 and mtf1. 1 / 1

| 1

➶

sparser

"As shown in xref , the luciferase activity driven by the WT promoter sequence was markedly reduced by MTF1 knockdown, indicating that the WT sites are required for binding of MTF1 to the lncRNA OTUD6B-AS1 promoter."

32952848

OTUD6B affects VHL

| 8 16

OTUD6B binds VHL.

| 4 15

VHL binds OTUD6B. 10 / 17

| 4 13

➶

sparser

"OTUD6B interacted with pVHL tumor-derived missense mutants and reduced their ubiquitylation in cells."

35110537

➶

sparser

"Further we reveal that OTUD6B interacts with pVHL and reduces the ubiquitylation of pVHL in an enzyme‐independent manner."

32328410

➶

sparser

"The results showed that ectopic OTUD6B interacted with indicated pVHL mutants in HEK293 cells, but compared with pVHL wild type and the majority of mutants, the binding between pVHL I151T mutant with OTUD6B was markedly weakened (Fig. xref )."

35110537

➶

sparser

"Given that OTUD6B is integrated into the Cullin 2-Elongin B/C complex, it’s interesting to speculate whether it can form additional E3 complex besides pVHL to play a more general role together with Cullin 2-Elongin B/C. In addition, why does pVHL only bind with OTUD6B but not other OTU family members, such as OTUD6A? To this end, further structural study regarding the difference between the N-terminal domain (NTD) of OTUD6B and OTUD6A could provide more insights."

32323143

➶

sparser

"In addition, OTUD6B depletion reduced the inhibitory effects of ectopic pVHL missense mutants on cell migration and HIF-2α level, except for pVHL I151T. Thus, we speculated that I151 residue might be one of key sites of pVHL binding to OTUD6B. These results suggested that OTUD6B is an important regulator for the stability of pVHL missense mutants, which provides a potential therapeutic strategy for ccRCC with VHL mutations."

35110537

➶

reach

"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."

32328410

➶

sparser

"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF‐1α accumulation in HCC cells under hypoxia."

32328410

➶

sparser

"Here, we tested the interaction between OTUD6B with pVHL mutants."

35110537

➶

sparser

"Subsequently, we examined the interaction between pVHL and OTUD6B. Endogenous OTUD6B and pVHL were coimmunoprecipitated from lysates of MHCC‐LM3 cells ( Figure xref )."

32328410

➶

reach

"Indeed, further biochemical studies showed that, OTUD6B binds directly with pVHL rather than HIF-1α."

32323143

VHL binds OTUD6B and cbc. 2 / 2

| 2

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

➶

sparser

"We used gel filtration chromatography assay to analyze the CBC VHL complex binding of OTUD6B. As shown in Figure xref and Figure S5F (Supporting Information), OTUD6B was detected in the same fractions with pVHL, elongin B, and elongin C, indicating that OTUD6B might be a component of CBC VHL complex."

32328410

OTUD6B deubiquitinates VHL.

| 2

OTUD6B leads to the deubiquitination of VHL. 2 / 2

| 2

➶

reach

"Surprisingly, OTUD6B limits the ubiquitylation of pVHL independent of its deubiquitylase activity."

32328410

➶

reach

"Moreover, mutant forms of OTUD6B with deletion of OTU domain or mutating the putative catalytic active sites could still suppress the ubiquitination of pVHL, which is consistent with previous report showing that OTUD6B is incapable of cutting any di-ubiquitin in vitro (Mevissen et al., 2013)."

32323143

OTUD6B ubiquitinates VHL.

| 1

OTUD6B ubiquitinates VHL. 1 / 1

| 1

➶

sparser

"Additionally, we observed that shRNA targeting OTUD6B increased pVHL ubiquitylation (Figure xref ), and ectopic expression of OTUD6B suppressed pVHL ubiquitylation induced by WSB1 in cells (Figure xref )."

32328410

OTUD6B inhibits VHL.

| 1

OTUD6B inhibits VHL. 1 / 1

| 1

➶

reach

"In addition, OTUD6B depletion reduced the inhibitory effects of ectopic pVHL missense mutants on cell migration and HIF-2α level, except for pVHL I151T."

35110537

OTUD6B activates VHL.

| 1

OTUD6B activates VHL. 1 / 1

| 1

➶

reach

"Hence, these data suggest that as a transcriptional target gene of HIF, OTUD6B expression could be induced under the hypoxic condition to stabilize pVHL and promote the degradation of HIF-1α, thus forming a negative feedback loop in regulating HIF activity and oxygen sensing homeostasis.Taken together, this work reveals a new layer of molecular mechanism for the stability regulation of the pVHL tumor suppressor and reveals its potential clinical importance in HCC metastasis and treatment."

32323143

OTUD6B affects apoptotic process

| 1 4

OTUD6B activates apoptotic process.

| 4

OTUD6B activates apoptotic process. 4 / 4

| 4

➶

reach

"In the hormone receptor positive cell line HCC1500 (ER positive) silencing STK39 decreased survival (p = 0.03) and silencing OTUD6B increased apoptosis (p = 0.02) (XREF_FIG and XREF_FIG)."

31126858

➶

reach

"Overexpressing Otud-6B in Ba/F3 cells resulted in downregulation of proliferation and increased the frequency of apoptosis [96]."

31208841

➶

reach

"Overexpressing Otud-6B in Ba/F3 cells resulted in downregulation of proliferation and increased the frequency of apoptosis [XREF_BIBR]."

31208841

➶

reach

"In the HER2 positive cell line SKBR3, silencing all three early stage antigens decreased survival (PDHX and STK39 p < 0.0001 and OTUD6B p = 0.05) and both STK39 and OTUD6B increased apoptosis (STK39 p = 0.0002 and OTUD6B p < 0.0001)."

31126858

OTUD6B inhibits apoptotic process.

| 1

OTUD6B inhibits apoptotic process. 1 / 1

| 1

➶

eidos

"In the HER2 positive cell line SKBR3 , silencing all three early stage antigens decreased survival ( PDHX and STK39 p < 0.0001 and OTUD6B p =0 .05 ) and both STK39 and OTUD6B increased apoptosis ( STK39 p =0 .0002 and OTUD6B p < 0.0001 ) ."

31126858

OTUD6B affects OTUB1

3 | 2

OTUB1 binds OTUD6B. 5 / 5

3 | 2

➶

biogrid

No evidence text available

22939629

➶

sparser

"Studying OTUD6B-OTUB1 Protein-Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays."

33421002

➶

biogrid

No evidence text available

19615732

➶

sparser

"We describe the GFP-Trap immunoprecipitation as a cell-based method to analyze the OTUD6B-OTUB1 interaction in the cellular context and the AlphaScreen (amplified luminescent proximity homogeneous assay) assay as a tool to detect direct interactions and to search for PPI inhibitors."

33421002

➶

biogrid

No evidence text available

26344197

OTUD6B affects cell migration

| 4

OTUD6B inhibits cell migration. 4 / 4

| 4

➶

reach

"Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma."

35110537

➶

reach

"Consistent with this mechanism, over-expression of pVHL could antagonize OTUD6B depletion-induced effects in HCC cell migration and metastasis."

32323143

➶

reach

"Correction to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma."

35650190

➶

reach

"Functionally, we revealed that OTUD6B depletion enhanced cell migration and HIF-2α level in ccRCC cells in a pVHL dependent manner."

35110537

Cbc affects OTUD6B

| 3

VHL binds OTUD6B and cbc. 2 / 2

| 2

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

➶

sparser

32328410

OTUD6B binds cbc. 1 / 1

| 1

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

OTUD6B affects cell population proliferation

| 3

OTUD6B inhibits cell population proliferation.

| 2

OTUD6B inhibits cell population proliferation. 2 / 2

| 2

➶

reach

"Further, lncRNA OTUD6B can inhibit ccRCC cell proliferation by suppressing the Wnt and beta-catenin pathway and the expressions of epithelial-to-mesenchymal transition related proteins."

33692953

➶

reach

"In normal and transformed cells, the expression of the OTUD6B isoform that represses protein synthesis and proliferation is quantitatively higher."

27864334

OTUD6B activates cell population proliferation.

| 1

OTUD6B activates cell population proliferation. 1 / 1

| 1

➶

reach

"In addition, lung cancer cell lines with OTUD6B knockdown significantly inhibited proliferation and invasion ability of lung cancer cells."

36052059

OTUD6B affects cbc

| 3

VHL binds OTUD6B and cbc. 2 / 2

| 2

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

➶

sparser

32328410

OTUD6B binds cbc. 1 / 1

| 1

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

OTUD6B affects Intellectual Disability

| 3

OTUD6B activates Intellectual Disability. 2 / 2

| 2

➶

reach

"Biallelic mutations in the OTUD6B (Ovarian tumor domain-containing 6B) gene were recently described to cause an intellectual disability syndrome characterized by seizures and dysmorphic features in six families worldwide (Santiago-Sim et al., 2017; Online Mendelian Inheritance in Men, OMIM, #617452)."

30364145

➶

reach

"Biallelic mutations in the ovarian tumor domain-containing 6B (OTUD6B) gene, coding for a deubiquitinating enzyme, were recently described to cause an intellectual disability syndrome characterized by seizures and dysmorphic features in six families worldwide."

30364145

Mutated OTUD6B activates Intellectual Disability. 1 / 1

| 1

➶

reach

"In 2017, Autosomal recessive mutations of OTUD6B were first described to cause intellectual disability associated with seizure, dysmorphic features, and congenital malformations, including distal limb abnormalities."

| PMC

OTUD6B affects IRF7

| 1 1 1

OTUD6B binds IRF7.

| 1 1

OTUD6B binds IRF3 and IRF7. 1 / 1

| 1

➶

sparser

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."

34183367

OTUD6B binds IRF7 and K63. 1 / 1

| 1

➶

reach

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."

34183367

OTUD6B ubiquitinates IRF7.

| 1

OTUD6B ubiquitinates IRF7. 1 / 1

| 1

➶

trips

"Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7."

34183367

OTUD6B affects HIF1A

| 1 2

OTUD6B binds HIF1A.

| 2

OTUD6B binds HIF1A. 2 / 2

| 2

➶

sparser

"Through luciferase reporter assay and chromatin immunoprecipitation assay, the authors found that HIF-1α binds with the promoter of OTUD6B . Hence, these data suggest that as a transcriptional target gene of HIF, OTUD6B expression could be induced under the hypoxic condition to stabilize pVHL and promote the degradation of HIF-1α, thus forming a negative feedback loop in regulating HIF activity and oxygen sensing homeostasis."

32323143

➶

sparser

"However, OTUD6B did not bind to HIF-1α but instead directly bound to pVHL."

34201062

OTUD6B activates HIF1A.

| 1

OTUD6B bound to VHL activates HIF1A. 1 / 1

| 1

➶

reach

"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."

32328410

Valproic acid affects OTUD6B

2 |

Valproic acid increases the amount of OTUD6B. 2 / 2

2 |

➶

ctd

No evidence text available

23179753

➶

ctd

No evidence text available

29154799

Cbc affects VHL

| 2

VHL binds OTUD6B and cbc. 2 / 2

| 2

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

➶

sparser

32328410

Bisphenol A affects OTUD6B

2 |

Bisphenol A decreases the amount of OTUD6B. 2 / 2

2 |

➶

ctd

No evidence text available

25181051

➶

ctd

No evidence text available

30816183

VHL affects cbc

| 2

VHL binds OTUD6B and cbc. 2 / 2

| 2

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

➶

sparser

32328410

SMURF1 affects OTUD6B

1 1 |

SMURF1 ubiquitinates OTUD6B.

1 |

SMURF1 ubiquitinates OTUD6B. 1 / 1

1 |

➶

ubibrowser

No evidence text available

SMURF1 binds OTUD6B.

1 |

SMURF1 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

20804422

PTK2 affects OTUD6B

1 | 1

OTUD6B binds PTK2. 2 / 2

1 | 1

➶

biogrid

No evidence text available

26344197

➶

sparser

"It is possible that some of the OTUD6B-related features are partly a result of defective interaction between the OTUD6B and PTK2 genes."

| PMC

OTUD6B affects pathway

| 2

OTUD6B inhibits pathway.

| 1

OTUD6B inhibits pathway. 1 / 1

| 1

➶

sparser

"Mechanistically, OTUD6B-AS1 inactivates the Wnt/β-catenin pathway and suppresses the expression of epithelial-to-mesenchymal transition-related proteins, including E-cadherin, N-cadherin and Snail in RCC cells [ xref ]."

33593347

OTUD6B activates pathway.

| 1

OTUD6B activates pathway. 1 / 1

| 1

➶

sparser

"Interestingly, the RNA‐seq data suggested that depletion of OTUD6B remarkably activated HIF pathway in HCC cells (Figure S2C,D, Supporting Information)."

32328410

OTUD6B affects acetohydroxamic acid

| 2

OTUD6B activates acetohydroxamic acid. 2 / 2

| 2

➶

reach

"Additionally, OTUD6B depletion increased AHA incorporation in H1734 and H1437 cells, and in transformed or primary cells other than NSCLC, specifically the mesothelioma cell line ME16, HaCaT immortalized human keratinocytes, and primary lung fibroblasts WI38 (XREF_FIG)."

27864334

➶

reach

"Furthermore, NSCLC exposure to Torin-1 (an mTOR inhibitor, which target the mTOR catalytic site) abolished OTUD6B depletion enhanced AHA incorporation in these cells (XREF_FIG)."

27864334

OTUD6B affects VHL, and cbc

| 2

VHL binds OTUD6B and cbc. 2 / 2

| 2

➶

sparser

"In this proposed model, OTUD6B is a direct transcriptional target of HIF‐1α, and HIF‐1α is a direct ubiquitylation and degradation target of OTUD6B‐CBC VHL complex."

32328410

➶

sparser

32328410

OTUD6B affects Syndrome

| 2

OTUD6B activates Syndrome. 2 / 2

| 2

➶

reach

30364145

➶

reach

30364145

OTUD6B affects PTK2

1 | 1

OTUD6B binds PTK2. 2 / 2

1 | 1

➶

biogrid

No evidence text available

26344197

➶

sparser

"It is possible that some of the OTUD6B-related features are partly a result of defective interaction between the OTUD6B and PTK2 genes."

| PMC

OTUD6B affects Neoplasm Metastasis

| 2

OTUD6B inhibits Neoplasm Metastasis. 2 / 2

| 2

➶

reach

"Consistent with this mechanism, over-expression of pVHL could antagonize OTUD6B depletion-induced effects in HCC cell migration and metastasis."

32323143

➶

reach

"Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis."

32328410

OTUD6B affects LIMCH1

2 |

OTUD6B binds LIMCH1. 2 / 2

2 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

26186194

OTUD6B affects IRF3

| 1 1

OTUD6B ubiquitinates IRF3.

| 1

OTUD6B ubiquitinates IRF3. 1 / 1

| 1

➶

trips

"Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7."

34183367

OTUD6B binds IRF3.

| 1

OTUD6B binds IRF3 and IRF7. 1 / 1

| 1

➶

sparser

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."

34183367

OTUD6B affects GALC

2 |

OTUD6B binds GALC. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

OTUD6B affects BTBD1

2 |

BTBD1 binds OTUD6B. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

LIMCH1 affects OTUD6B

2 |

OTUD6B binds LIMCH1. 2 / 2

2 |

➶

biogrid

No evidence text available

28514442

➶

biogrid

No evidence text available

26186194

IRF7 affects OTUD6B

| 1 1

OTUD6B binds IRF3 and IRF7. 1 / 1

| 1

➶

sparser

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."

34183367

OTUD6B binds IRF7 and K63. 1 / 1

| 1

➶

reach

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."

34183367

HIF1A affects OTUD6B

| 2

OTUD6B binds HIF1A. 2 / 2

| 2

➶

sparser

32323143

➶

sparser

"However, OTUD6B did not bind to HIF-1α but instead directly bound to pVHL."

34201062

GALC affects OTUD6B

2 |

OTUD6B binds GALC. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

BTBD1 affects OTUD6B

2 |

BTBD1 binds OTUD6B. 2 / 2

2 |

➶

biogrid

No evidence text available

26186194

➶

biogrid

No evidence text available

28514442

Urethane affects OTUD6B

1 |

Urethane decreases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

28818685

Trimellitic anhydride affects OTUD6B

1 |

Trimellitic anhydride increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

19042947

Titanium dioxide affects OTUD6B

1 |

Titanium dioxide decreases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

29264374

Thioacetamide affects OTUD6B

1 |

Thioacetamide increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

23411599

Thimerosal affects OTUD6B

1 |

Thimerosal increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Tetrachloromethane affects OTUD6B

1 |

Tetrachloromethane increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Schizandrin B affects OTUD6B

1 |

Schizandrin B increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Retinoic acid affects OTUD6B

| 1

Retinoic acid activates OTUD6B. 1 / 1

| 1

➶

reach

"Importantly, all-trans retinoic acid (ATRA) is found to promote OTUD6B translation and thus suppress ESCC tumor growth and enhance the response of ESCC tumors to anti-PD-1 immunotherapies."

37038094

Quercetin affects OTUD6B

1 |

Quercetin decreases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

21632981

Pirinixic acid affects OTUD6B

1 |

Pirinixic acid increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

23811191

Phorbol 13-acetate 12-myristate affects OTUD6B

1 |

Phorbol 13-acetate 12-myristate increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

PVHL affects OTUD6B

| 1

OTUD6B binds pVHL. 1 / 1

| 1

➶

isi

"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."

32328410

Omacetaxine mepesuccinate affects OTUD6B

| 1

Omacetaxine mepesuccinate activates OTUD6B. 1 / 1

| 1

➶

reach

"siRNAs to OTUD6B were unable to modify AHA incorporation when cells were treated with cycloheximide or homoharringtonine (XREF_FIG, left)."

27864334

Mtf1 affects OTUD6B

| 1

OTUD6B binds AS1 and mtf1. 1 / 1

| 1

➶

sparser

32952848

LinC affects OTUD6B

| 1

OTUD6B binds Delta-actitoxin-Avd1a and linC. 1 / 1

| 1

➶

sparser

"Further multifactorial analysis showed that a total of 11 lncRNAs, including SEMA3B-AS1, ST7-AS1, AL136295.7, AC090912.1, LINC01871, AL136531.1, AC024361.1, OTUD6B-AS1, LINC01786, AL122010.1, and MAPT-AS1 , were prognostically independent influencers of BRCA."

35282059

Ionomycin affects OTUD6B

1 |

Ionomycin increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Enzyme inhibitor affects OTUD6B

1 |

Enzyme inhibitor inhibits OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

23301498

Dicrotophos affects OTUD6B

1 |

Dicrotophos decreases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

28302478

Cyclosporin A affects OTUD6B

1 |

Cyclosporin A increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

20106945

Clothianidin affects OTUD6B

1 |

Clothianidin increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

29044138

Carbon nanotube affects OTUD6B

1 |

Carbon nanotube increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

25620056

Cadmium dichloride affects OTUD6B

1 |

Cadmium dichloride demethylates OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

22457795

Benzo[a]pyrene affects OTUD6B

1 |

Benzo[a]pyrene increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

22228805

Benzo[a]pyrene diol epoxide I affects OTUD6B

1 |

Benzo[a]pyrene diol epoxide I decreases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

19150397

All-trans-retinoic acid affects OTUD6B

| 1

All-trans-retinoic acid activates OTUD6B. 1 / 1

| 1

➶

reach

"Importantly, all-trans retinoic acid (ATRA) is found to promote OTUD6B translation and thus suppress ESCC tumor growth and enhance the response of ESCC tumors to anti-PD-1 immunotherapies."

37038094

Aflatoxin B1 affects OTUD6B

1 |

Aflatoxin B1 increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

23630614

TNFSF13B affects OTUD6B

| 1

TNFSF13B increases the amount of OTUD6B. 1 / 1

| 1

➶

reach

"BAFF, a B cell activating factor of the TNF family, could also induce Otud-6b expression on mouse B cells after 4 hours stimulation XREF_BIBR."

21267069

SWAP70 affects OTUD6B

1 |

SWAP70 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

SPC24 affects OTUD6B

1 |

OTUD6B binds SPC24. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

SEC24C affects OTUD6B

1 |

SEC24C binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

RPF2 affects OTUD6B

1 |

RPF2 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RP23-15I21.5 affects OTUD6B

1 |

OTUD6B binds RP23-15I21.5. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

RP23-121M7.1 affects OTUD6B

1 |

OTUD6B binds RP23-121M7.1. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

PARVA affects OTUD6B

1 |

PARVA binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD7A affects OTUD6B

| 1

OTUD7A binds OTUD6B. 1 / 1

| 1

➶

reach

"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."

34060252

OTUD6B affects ubiquitination pVHL

| 1

OTUD6B inhibits ubiquitination pVHL. 1 / 1

| 1

➶

eidos

"More interestingly , OTU deubiquitinase 6B ( OTUD6B ) as the first reported deubiquitination enzyme is capable of inhibiting pVHL ubiquitination , and the deubiquitination regulation of OTUD6B on pVHL did not depend on its enzyme activity , but via interaction with pVHL to enhance the stability of CBCVHL ubiquitin ligase complex , and reduce the ubiquitination degradation of pVHL by Trp-Asp repeat and suppressors of cytokine signaling box-containing protein 1 ( WSB1 ) and E2-EPF ubiquitin carrier protein ( UCP ) ."

33109235

OTUD6B affects translation

| 1

OTUD6B activates translation. 1 / 1

| 1

➶

reach

"OTUD6B depletion caused an increased rate of cap dependent translation."

27864334

OTUD6B affects traf6-mediated K63-linked polyubiquitination irf3 irf7

| 1

OTUD6B inhibits traf6-mediated K63-linked polyubiquitination irf3 irf7. 1 / 1

| 1

➶

eidos

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7 ."

34183367

OTUD6B affects tbk1 bind irf3 irf7 resulting irf3 irf7 phosphorylation

| 1

OTUD6B inhibits tbk1 bind irf3 irf7 resulting irf3 irf7 phosphorylation. 1 / 1

| 1

➶

eidos

"Moreover , otud6b also attenuates tbk1 to bind to irf3 and irf7 , resulting in the impairment of irf3 and irf7 phosphorylation ."

34183367

OTUD6B affects phosphorylation IRFs molecules

| 1

OTUD6B inhibits phosphorylation IRFs molecules. 1 / 1

| 1

➶

eidos

"Besides , OTUD6B can also inhibit the binding of TBK1 to IRF3 and IRF7 and damage the phosphorylation of IRFs molecules ."

34966378

OTUD6B affects pVHL

| 1

OTUD6B binds pVHL. 1 / 1

| 1

➶

isi

"OTUD6B directly interacts with pVHL, decreases its ubiquitylation and proteasomal degradation to reduce HIF-1alpha accumulation in HCC cells under hypoxia."

32328410

OTUD6B affects mtf1

| 1

OTUD6B binds AS1 and mtf1. 1 / 1

| 1

➶

sparser

32952848

OTUD6B affects linC

| 1

OTUD6B binds Delta-actitoxin-Avd1a and linC. 1 / 1

| 1

➶

sparser

35282059

OTUD6B affects growth

| 1

OTUD6B inhibits growth. 1 / 1

| 1

➶

sparser

"When TgMMTV-neu mice (n=5/group) were vaccinated with the individual antigens, vaccination with Pdhx inhibited tumor growth by 62.1%, Otud6B inhibited tumor growth by 23.5%, and Stk39 inhibited tumor growth by 50.3% as compared to empty vector vaccinated control at 27 weeks (p<0.001 for each individual antigen as compared to empty vector)."

| PMC

OTUD6B affects dissociation Cullin 2VHL complex pVHL known upstream E3 ligases

| 1

OTUD6B activates dissociation Cullin 2VHL complex pVHL known upstream E3 ligases. 1 / 1

| 1

➶

eidos

"On the other hand , depletion of OTUD6B results in the dissociation of Cullin 2VHL complex and the degradation of pVHL presumably by known upstream E3 ligases such as WSB1 ( Kim et al ., 2015 ) or E2-EPF-UCP ( Jung et al ., 2006 ) ."

32323143

OTUD6B affects cells migration

| 1

OTUD6B inhibits cells migration. 1 / 1

| 1

➶

eidos

"Using siRNA-based targeted screening , the authors found that OTUD6B , but not other OTU family members , could significantly suppress HCC cells migration and metastasis ."

32323143

OTUD6B affects cell renal cell carcinoma

| 1

OTUD6B inhibits cell renal cell carcinoma. 1 / 1

| 1

➶

eidos

"OTUD6B was found to inhibit clear cell renal cell carcinoma by regulating the Wnt / beta-catenin pathway and suppressing EMT-related protein expression ( 31 ) ."

33000250

OTUD6B affects cell cycle

| 1

OTUD6B activates cell cycle. 1 / 1

| 1

➶

reach

"However, the rapid down-regulation of Otud-6b is probably required to maintain a normal cell cycle as enforced Otud-6b expression can cause cell cycle arrest in Ba/F3 cells."

21267069

OTUD6B affects binding TBK1 IRF3 IRF7

| 1

OTUD6B inhibits binding TBK1 IRF3 IRF7. 1 / 1

| 1

➶

eidos

"Besides , OTUD6B can also inhibit the binding of TBK1 to IRF3 and IRF7 and damage the phosphorylation of IRFs molecules ."

34966378

OTUD6B affects Wnt

| 1

OTUD6B activates Wnt. 1 / 1

| 1

➶

reach

"Further, lncRNA OTUD6B can inhibit ccRCC cell proliferation by suppressing the Wnt and beta-catenin pathway and the expressions of epithelial-to-mesenchymal transition related proteins."

33692953

OTUD6B affects TRAF6-induced K63-linked polyubiquitination IRF3 IRF7

| 1

OTUD6B inhibits TRAF6-induced K63-linked polyubiquitination IRF3 IRF7. 1 / 1

| 1

➶

eidos

"OTUD6B , another member of the OTUD family , was found to inhibit TRAF6-induced K63-linked polyubiquitination of IRF3 and IRF7 in zebrafish , depending on the role of the OTU domain ."

34966378

OTUD6B affects TRAF6

| 1

OTUD6B bound to IRF3 inhibits TRAF6. 1 / 1

| 1

➶

reach

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."

34183367

OTUD6B affects TBK1

| 1

OTUD6B inhibits TBK1. 1 / 1

| 1

➶

reach

"Moreover, otud6b also attenuates tbk1 to bind to irf3 and irf7, resulting in the impairment of irf3 and irf7 phosphorylation."

34183367

OTUD6B affects Survival Rate

| 1

OTUD6B inhibits Survival Rate. 1 / 1

| 1

➶

eidos

"Disruption of otud6b in zebrafish increases the survival rate upon spring viremia of carp virus and grass carp reovirus exposure ."

34183367

OTUD6B affects SWAP70

1 |

SWAP70 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects SPC24

1 |

OTUD6B binds SPC24. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects SMURF1

1 |

SMURF1 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

20804422

OTUD6B affects SEC24C

1 |

SEC24C binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects RPF2

1 |

RPF2 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

OTUD6B affects RP23-15I21.5

1 |

OTUD6B binds RP23-15I21.5. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

OTUD6B affects RP23-121M7.1

1 |

OTUD6B binds RP23-121M7.1. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

OTUD6B affects RNA, Long Noncoding

| 1

OTUD6B inhibits RNA, Long Noncoding. 1 / 1

| 1

➶

sparser

"More interestingly, another major finding was that the molecular mechanism involved lncRNA OTUD6B-AS1 inhibition of IDH2 expression through stabilization of miR-6734-5p ( xref )."

32952848

OTUD6B affects PARVA

1 |

PARVA binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects OTUD7A

| 1

OTUD7A binds OTUD6B. 1 / 1

| 1

➶

reach

"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."

34060252

OTUD6B affects OTUD4

| 1

OTUD6B binds OTUD4. 1 / 1

| 1

➶

reach

"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."

34060252

OTUD6B affects OTUD3

| 1

OTUD6B binds OTUD3. 1 / 1

| 1

➶

reach

"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."

34060252

OTUD6B affects Neoplasm Invasiveness

| 1

OTUD6B activates Neoplasm Invasiveness. 1 / 1

| 1

➶

reach

"In addition, lung cancer cell lines with OTUD6B knockdown significantly inhibited proliferation and invasion ability of lung cancer cells."

36052059

OTUD6B affects MYH9

1 |

OTUD6B binds MYH9. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects MYH14

1 |

MYH14 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects MTDH

1 |

OTUD6B binds MTDH. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

OTUD6B affects METAP2

1 |

METAP2 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26186194

OTUD6B affects MCTS1

1 |

MCTS1 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

OTUD6B affects LIN28B

| 1

OTUD6B binds LIN28B. 1 / 1

| 1

➶

sparser

"Thus, we link proteolytic ubiquitylation with post-transcriptional regulation and nominate OTUD6B as a potential mediator of the MGUS-multiple myeloma transition, a central regulator of MYC, and an actionable vulnerability in multiple myeloma and other tumors with an activated OTUD6B-LIN28B axis."

36059274

OTUD6B affects K63

| 1

OTUD6B binds IRF7 and K63. 1 / 1

| 1

➶

reach

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."

34183367

OTUD6B affects IFN-1 activation K63-linked polyubiquitination irf3 irf7

| 1

OTUD6B inhibits IFN-1 activation K63-linked polyubiquitination irf3 irf7. 1 / 1

| 1

➶

eidos

"In addition , the OTU domain is required for otud6b to repress IFN-1 activation and K63-linked polyubiquitination of irf3 and irf7 ."

34183367

OTUD6B affects IDDFSDA

| 1

OTUD6B activates IDDFSDA. 1 / 1

| 1

➶

reach

"Recently, biallelic variants in OTUD6B have been reported to cause IDDFSDA, characterized by a wide clinical spectrum (Santiago-Sim et al., 2017)."

35430327

OTUD6B affects ID1

| 1

OTUD6B binds ID1. 1 / 1

| 1

➶

sparser

"Because OTUD6B is associated with autosomal recessive ID, with characteristic phenotypes that matched our patient’s manifestations, we believed that there could be another OTUD6B mutation in compound with the 8q21.3 microdeletion that is responsible for the patient’s phenotypes."

| PMC

OTUD6B affects Hand

| 1

OTUD6B inhibits Hand. 1 / 1

| 1

➶

eidos

32323143

OTUD6B affects HDDC2

1 |

HDDC2 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

OTUD6B affects GST

| 1

GST binds OTUD6B. 1 / 1

| 1

➶

sparser

"Bacterial‐expressed GST and GST‐OTUD6B protein bound to glutathione‐sepharose 4B beads (from GE) was incubated with pVHL expressed in HEK293T cells for overnight at 4 °C. Then the beads were washed with PBS four times, followed by western blotting."

32328410

OTUD6B affects First Spanish case

| 1

OTUD6B activates First Spanish case. 1 / 1

| 1

➶

reach

"[First Spanish case of syndromic intellectual disability with dysmorphic facies, seizures, and distal limb anomalies caused by balletic mutations in the OTUD6B gene]."

31147255

OTUD6B affects ELAVL1

1 |

OTUD6B binds ELAVL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19322201

OTUD6B affects Delta-actitoxin-Avd1c

| 1

OTUD6B binds CTBP1, Delta-actitoxin-Avd1c, and AS. 1 / 1

| 1

➶

sparser

"In addition, the differential expression levels of lncRNAs included TSIX, NRIR, ncRNA00201, OTUD6B-AS, CTBP1-AS2, AGAP2-AS1, and HIFA-AS1, which can target mRNAs and might also involve pathogenesis and pathological changes in patients with SSc."

| PMC

OTUD6B affects Delta-actitoxin-Avd1a

| 1

OTUD6B binds Delta-actitoxin-Avd1a and linC. 1 / 1

| 1

➶

sparser

35282059

OTUD6B affects Cyclin

| 1

OTUD6B activates Cyclin. 1 / 1

| 1

➶

reach

"Nevertheless, OTUD-6B probably could directly affect either the synthesis or the degradation process of cyclin D2 as overexpressing OTUD-6B in Hela cells could also cause cyclin D2 expression level down-regulation even without affecting cell cycle (XREF_SUPPLEMENTARY)."

21267069

OTUD6B affects Cullin 2VHL E3 ligase complex

| 1

OTUD6B activates Cullin 2VHL E3 ligase complex. 1 / 1

| 1

➶

eidos

"OTUD6B enhances the formation of stable Cullin 2VHL E3 ligase complex , which protects pVHL from proteasomal degradation ."

32323143

OTUD6B affects CTNNB1

| 1

OTUD6B activates CTNNB1. 1 / 1

| 1

➶

reach

"Further, lncRNA OTUD6B can inhibit ccRCC cell proliferation by suppressing the Wnt and beta-catenin pathway and the expressions of epithelial-to-mesenchymal transition related proteins."

33692953

OTUD6B affects CTBP1

| 1

OTUD6B binds CTBP1, Delta-actitoxin-Avd1c, and AS. 1 / 1

| 1

➶

sparser

| PMC

OTUD6B affects CRMP1

1 |

CRMP1 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects CORO1B

1 |

CORO1B binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

OTUD6B affects CHD3

1 |

CHD3 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

OTUD6B affects CD3

| 1

OTUD6B inhibits CD3. 1 / 1

| 1

➶

reach

"For mice vaccinated with Pdhx, Stk39, and Otud6B depletion of CD3 + T cells increased tumor growth (p < 0.0001 compared to empty vector control for all targets)."

31126858

OTUD6B affects BASP1

1 |

OTUD6B binds BASP1. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

OTUD6B affects ASCC3

1 |

ASCC3 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

OTUD6B affects AS

| 1

OTUD6B binds CTBP1, Delta-actitoxin-Avd1c, and AS. 1 / 1

| 1

➶

sparser

| PMC

OTUD6B affects APEX1

1 |

OTUD6B binds APEX1. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

OTUD6B affects AP2M1

1 |

OTUD6B binds AP2M1. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

OTUD6B affects AKAP5

1 |

OTUD6B binds AKAP5. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

OTUD4 affects OTUD6B

| 1

OTUD6B binds OTUD4. 1 / 1

| 1

➶

reach

"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."

34060252

OTUD3 affects OTUD6B

| 1

OTUD6B binds OTUD3. 1 / 1

| 1

➶

reach

"We found that OTUD3, OTUD4, OTUD6B, and OTUD7A bound to EWS–FLI1 in cells (Figure 3B)."

34060252

NRF1 affects OTUD6B

1 |

NRF1 decreases the amount of OTUD6B. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MYH9 affects OTUD6B

1 |

OTUD6B binds MYH9. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

MYH14 affects OTUD6B

1 |

MYH14 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

22863883

MTDH affects OTUD6B

1 |

OTUD6B binds MTDH. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

MT19c compound affects OTUD6B

1 |

MT19c compound increases the amount of OTUD6B. 1 / 1

1 |

➶

ctd

No evidence text available

21781307

METAP2 affects OTUD6B

1 |

METAP2 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26186194

MCTS1 affects OTUD6B

1 |

MCTS1 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

LIN28B affects OTUD6B

| 1

OTUD6B binds LIN28B. 1 / 1

| 1

➶

sparser

36059274

K63 affects OTUD6B

| 1

OTUD6B binds IRF7 and K63. 1 / 1

| 1

➶

reach

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6 mediated K63 linked polyubiquitination of irf3 and irf7."

34183367

IRF7 affects IRF3

| 1

OTUD6B binds IRF3 and IRF7. 1 / 1

| 1

➶

sparser

"Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7."

34183367

IL4 affects OTUD6B

| 1

IL4 activates OTUD6B. 1 / 1

| 1

➶

reach

"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."

21267069

IL3 affects OTUD6B

| 1

IL3 activates OTUD6B. 1 / 1

| 1

➶

reach

"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."

21267069

IL2 affects OTUD6B

| 1

IL2 increases the amount of OTUD6B. 1 / 1

| 1

➶

reach

"On the other hand, IL-2 could not induce Otud-6b expression in Ba/F3 cells (XREF_SUPPLEMENTARY)."

21267069

IL13 affects OTUD6B

| 1

IL13 activates OTUD6B. 1 / 1

| 1

➶

reach

"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."

21267069

ID1 affects OTUD6B

| 1

OTUD6B binds ID1. 1 / 1

| 1

➶

sparser

| PMC

HDDC2 affects OTUD6B

1 |

HDDC2 binds OTUD6B. 1 / 1

1 |

➶

biogrid

No evidence text available

26344197

GST affects OTUD6B

| 1

GST binds OTUD6B. 1 / 1

| 1

➶

sparser

32328410

ELAVL1 affects OTUD6B

1 |

OTUD6B binds ELAVL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19322201

Delta-actitoxin-Avd1c affects OTUD6B

| 1

OTUD6B binds CTBP1, Delta-actitoxin-Avd1c, and AS. 1 / 1

| 1

➶

sparser

| PMC

Delta-actitoxin-Avd1a affects linC

| 1

OTUD6B binds Delta-actitoxin-Avd1a and linC. 1 / 1

| 1

➶

sparser

35282059

CTBP1 affects OTUD6B

| 1

OTUD6B binds CTBP1, Delta-actitoxin-Avd1c, and AS. 1 / 1

| 1

➶

sparser

| PMC

CSF3 affects OTUD6B

| 1

CSF3 decreases the amount of OTUD6B. 1 / 1

| 1

➶

reach

"However, granulocyte colony stimulating factor (G-CSF) could effectively down-regulate OTUD-6B expression when human leukocytes were stimulated for 16 hours XREF_BIBR."

21267069

CSF2 affects OTUD6B

| 1

CSF2 activates OTUD6B. 1 / 1

| 1

➶

reach

"Here we report that Otud-6b, a functional DUB of the OTU family, can be induced by IL-3, IL-4, IL-13 and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulation in B lymphocytes."

21267069