IndraLab

Statements


OTUD6B leads to the deubiquitination of VHL. 2 / 2
| 2

reach
"Surprisingly, OTUD6B limits the ubiquitylation of pVHL independent of its deubiquitylase activity."

reach
"Moreover, mutant forms of OTUD6B with deletion of OTU domain or mutating the putative catalytic active sites could still suppress the ubiquitination of pVHL, which is consistent with previous report showing that OTUD6B is incapable of cutting any di-ubiquitin in vitro (Mevissen et al., 2013)."