IndraLab

Statements

OTUD6B inhibits cell migration. 6 / 6
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"Functionally, we revealed that OTUD6B depletion enhanced cell migration and HIF-2α level in ccRCC cells in a pVHL dependent manner."
35110537
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"Correction to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma."
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"For instance, OTUD6B depletion also enhances cell migration and HIF-2α levels in a pVHL (Von Hippel-Lindau protein with missense point mutations)-dependent manner in clear cell renal cell carcinoma (ccRCC) [52]."
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"Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma."
35110537
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"The deubiquitinase OTUD6B inhibits cell migration in clear cell renal cell carcinoma and hepatocellular carcinoma by stabilizing mutated pVHL [16]."
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"Consistent with this mechanism, over-expression of pVHL could antagonize OTUD6B depletion-induced effects in HCC cell migration and metastasis."
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