IndraLab

Statements

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"First, we found that mRNA level of OTUD6B in ESCC cells treated with ATRA did not change (Figure 6J), suggesting that ATRA may upregulate OTUD6B protein via regulating its translation."
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"Since RARα has been reported to repress the translation of specific mRNAs through binding with the untranslated region (UTR) of target mRNA, and this repression can be relieved by ATRA, 18 we tested whether ATRA promoted the translation of OTUD6B by relieving the binding of RARα to the UTR of OTUD6B mRNA."
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"Using a luciferase reporter containing 5’ UTR and 3’ UTR of OTUD6B (Figure 6M), we found that ATRA promotes the luciferase translation in a RARα‐dependent manner, confirming it recognizes OTUD6B mRNA and thus regulates its translation (Figure 6N)."
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"Importantly, all-trans retinoic acid (ATRA) is found to promote OTUD6B translation and thus suppress ESCC tumor growth and enhance the response of ESCC tumors to anti-PD-1 immunotherapies."
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"Importantly, all‐trans retinoic acid (ATRA) was found to promote the OTUD6B translation, suppress the tumorigenesis and metastasis of ESCC, and enhance the response of established ESCC tumors to anti‐PD‐1 immunotherapy."
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