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Statements


OTUD6B inhibits ubiquitination pVHL. 1 / 1
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eidos
"More interestingly , OTU deubiquitinase 6B ( OTUD6B ) as the first reported deubiquitination enzyme is capable of inhibiting pVHL ubiquitination , and the deubiquitination regulation of OTUD6B on pVHL did not depend on its enzyme activity , but via interaction with pVHL to enhance the stability of CBCVHL ubiquitin ligase complex , and reduce the ubiquitination degradation of pVHL by Trp-Asp repeat and suppressors of cytokine signaling box-containing protein 1 ( WSB1 ) and E2-EPF ubiquitin carrier protein ( UCP ) ."