IndraLab

Statements

USP32 affects RAB7A

| 7

USP32 deubiquitinates RAB7A.

| 4

USP32 deubiquitinates RAB7A. 3 / 3

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"This suggested that deubiquitylation of Rab7 by USP32 promotes release of Rab7 from the membrane to the cytosol, where a new functional cycle of this Rab can commence (Fig. 5i)."

30926795

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"Taken together with the observations on endosomal transport (Fig. 6), these findings support a model wherein deubiquitylation of Rab7 by USP32 exerts multifaceted control over membrane dynamics at the LE/MVB by promoting their intracellular motility as well as enabling efficient recycling from these organelles (Fig. 9)."

30926795

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reach

"Having established that USP32 can deubiquitylate Rab7 in vitro and in situ, we sought to understand the interplay between USP32 and Rab7 in endosome biology."

30926795

USP32 deubiquitinates RAB7A on K191. 1 / 1

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"Cellular ubiquitome profiling revealed deubiquitylation of Rab7 by USP32 on K191, located in the solvent-exposed flexible C-terminal region of the molecule."

30926795

USP32 activates RAB7A.

| 2

USP32 activates RAB7A. 2 / 2

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"Indeed, USP32 depletion sequesters Rab7 in abnormally enlarged endosomal structures, and the accumulation of ubiquitinylated Rab7 promotes interactions with the retromer and inhibits interactions with RILP [29]."

32033485

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"Using proteome-wide ubiquitin remnant profiling, we reveal Rab7 to be a key substrate of USP32 and go on to show that USP32 supports Rab7 functions in transport and recycling from the MVB by two different mechanisms."

30926795

USP32 increases the amount of RAB7A.

| 1

USP32 increases the amount of RAB7A. 1 / 1

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"This suggested that deubiquitylation of Rab7 by USP32 promotes release of Rab7 from the membrane to the cytosol, where a new functional cycle of this Rab can commence (Fig. 5i)."

30926795

USP32 is modified

7 |

USP32 is phosphorylated on S1372. 2 / 2

2 |

➶

hprd

No evidence text available

19651622

➶

hprd

No evidence text available

17081983

USP32 is phosphorylated on S1361. 2 / 2

2 |

➶

hprd

No evidence text available

19651622

➶

hprd

No evidence text available

17081983

USP32 is phosphorylated on S1366. 1 / 1

1 |

➶

hprd

No evidence text available

19651622

USP32 is phosphorylated on S1423. 1 / 1

1 |

➶

hprd

No evidence text available

19664995

USP32 is phosphorylated on Y1173. 1 / 1

1 |

➶

hprd

No evidence text available

18669648

Aflatoxin B1 affects USP32

3 |

Aflatoxin B1 methylates USP32.

2 |

Aflatoxin B1 methylates USP32. 2 / 2

2 |

➶

ctd

No evidence text available

27153756

➶

ctd

No evidence text available

30157460

Aflatoxin B1 increases the amount of USP32.

1 |

Aflatoxin B1 increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

19770486

USP32 affects transport

| 3

USP32 activates transport.

| 2

USP32 activates transport. 2 / 2

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30926795

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"Loss of USP32 inhibits late endosome (LE) transport and recycling of LE cargos, resulting in dispersion and swelling of the late compartment."

30926795

USP32 inhibits transport.

| 1

USP32 inhibits transport. 1 / 1

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"Loss of USP32 inhibits late endosome (LE) transport and recycling of LE cargos, resulting in dispersion and swelling of the late compartment."

30926795

USP32 affects RAP1B

1 | 2

USP32 ubiquitinates RAP1B.

| 1

USP32 leads to the ubiquitination of RAP1B. 1 / 1

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"At the molecular level, we find that silencing of USP32 increases ubiquitinated Rap1b."

36951484

USP32 binds RAP1B.

1 |

USP32 binds RAP1B. 1 / 1

1 |

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biogrid

No evidence text available

26496610

USP32 activates RAP1B.

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USP32 activates RAP1B. 1 / 1

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reach

"Given the deubiquitination function of USP32, we further hypothesize that USP32 may mediate the malignant behaviors of AML cells by regulating the stability of Ras-related protein (Rap1b)."

36951484

MEIS1 affects USP32

3 |

MEIS1 decreases the amount of USP32. 3 / 3

3 |

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

MiR-19b-3p affects USP32

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MiR-19b-3p increases the amount of USP32.

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MiR-19b-3p increases the amount of USP32. 1 / 1

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"Furthermore, by qRT-PCR, we detected these targeted genes and found that miR-19b-3p could up-regulate the expression of USP32 and RAB18 and down-regulated the expression of Dusp6, while there was no s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

27138803

MiR-19b-3p decreases the amount of USP32.

| 1

Modified miR-19b-3p decreases the amount of USP32. 1 / 1

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"On the other hand, the over expression of miR-19b-3p was reported to repress the expression of USP32, RAB18 and Dusp6 involved in cell differentiation process and contribute to the inhibited proliferation and slow downed cycle of SH-SY5Y cells 35."

29330490

Hsa-miR-93-5p affects USP32

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Hsa-miR-93-5p decreases the amount of USP32. 2 / 2

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biopax:mirtarbase

No evidence text available

23824327

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-519d-3p affects USP32

2 |

Hsa-miR-519d-3p decreases the amount of USP32. 2 / 2

2 |

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biopax:mirtarbase

No evidence text available

23824327

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-20b-5p affects USP32

2 |

Hsa-miR-20b-5p decreases the amount of USP32. 2 / 2

2 |

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biopax:mirtarbase

No evidence text available

23824327

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-20a-5p affects USP32

2 |

Hsa-miR-20a-5p decreases the amount of USP32. 2 / 2

2 |

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biopax:mirtarbase

No evidence text available

23824327

➶

biopax:mirtarbase

No evidence text available

22473208

Hsa-miR-17-5p affects USP32

2 |

Hsa-miR-17-5p decreases the amount of USP32. 2 / 2

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biopax:mirtarbase

No evidence text available

22473208

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-106b-5p affects USP32

2 |

Hsa-miR-106b-5p decreases the amount of USP32. 2 / 2

2 |

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biopax:mirtarbase

No evidence text available

23824327

➶

biopax:mirtarbase

No evidence text available

22473208

ZDHHC17 affects USP32

2 |

ZDHHC17 binds USP32. 2 / 2

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biogrid

No evidence text available

24705354

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biogrid

No evidence text available

24705354

USP32 affects cell population proliferation

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USP32 activates cell population proliferation. 2 / 2

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"In the present study, we reported that knockdown or depletion of USP32 significantly inhibited GC cell proliferation and migration in vitro and in vivo, indicating that USP32 functions as an oncogene in GC."

32226309

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"Further, stable silencing of USP32 expression reduced proliferation and migration in the ERalpha positive MCF-7 cell line [XREF_BIBR]."

33535487

USP32 affects cell growth

| 1 1

USP32 inhibits cell growth.

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USP32 inhibits cell growth. 1 / 1

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"USP32 downregulation inhibited cell growth and metastasis in vitro."

35440702

USP32 activates cell growth.

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USP32 activates cell growth. 1 / 1

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eidos

"USP32 downregulation inhibited cell growth and metastasis in vitro ."

35440702

USP32 affects ZDHHC17

2 |

ZDHHC17 binds USP32. 2 / 2

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biogrid

No evidence text available

24705354

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biogrid

No evidence text available

24705354

USP32 affects SMAD2

| 1 1

USP32 increases the amount of SMAD2.

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USP32 increases the amount of SMAD2. 1 / 1

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"Mechanistically, USP32 silencing caused a decrease in the expression of SMAD2, which resulted in the inhibitory effects of GC cells on growth, motility, and chemoresistance to cisplatin."

32226309

USP32 activates SMAD2.

| 1

USP32 activates SMAD2. 1 / 1

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"Next , we provide evidence that knockdown of USP32 decreased the expression of SMAD2 ."

32226309

USP32 affects Neoplasm Metastasis

| 1 1

USP32 inhibits Neoplasm Metastasis.

| 1

USP32 inhibits Neoplasm Metastasis. 1 / 1

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"USP32 downregulation inhibited cell growth and metastasis in vitro."

35440702

USP32 activates Neoplasm Metastasis.

| 1

USP32 activates Neoplasm Metastasis. 1 / 1

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eidos

"USP32 downregulation inhibited cell growth and metastasis in vitro ."

35440702

USP32 affects FUT3

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USP32 inhibits FUT3.

| 1

USP32 inhibits FUT3. 1 / 1

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"Loss of USP32 inhibits late endosome (LE) transport and recycling of LE cargos, resulting in dispersion and swelling of the late compartment."

30926795

USP32 activates FUT3.

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USP32 activates FUT3. 1 / 1

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"Loss of USP32 inhibits late endosome (LE) transport and recycling of LE cargos, resulting in dispersion and swelling of the late compartment."

30926795

USP32 affects Carcinogenesis

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USP32 activates Carcinogenesis. 2 / 2

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"Furthermore , USP32 knockdown inhibited tumorigenesis in vivo ."

35440702

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"Furthermore, USP32 knockdown inhibited tumorigenesis in vivo."

35440702

RAP1B affects USP32

1 | 1

RAP1B inhibits USP32.

| 1

RAP1B inhibits USP32. 1 / 1

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"Overexpression of Rap1b restores the effects of USP32 knockdown, which further verifies our hypothesis."

36951484

RAP1B binds USP32.

1 |

USP32 binds RAP1B. 1 / 1

1 |

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biogrid

No evidence text available

26496610

ELK1 affects USP32

2 |

ELK1 decreases the amount of USP32. 2 / 2

2 |

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biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

Valproic acid affects USP32

1 |

Valproic acid demethylates USP32. 1 / 1

1 |

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ctd

No evidence text available

29154799

Tungsten affects USP32

1 |

Tungsten decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

30912803

Tris(1,3-dichloro-2-propyl)phosphate affects USP32

1 |

Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

26743178

Topotecan affects USP32

1 |

Topotecan decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

25729387

SiUSP32-386 affects USP32

| 1

SiUSP32-386 inhibits USP32. 1 / 1

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eidos

"Results Silencing of USP32 inhibits GC cell growth and migration in vitro USP32 expression was knocked down in MGC803 and SGC7901 cells by transient transfection with siRNAs against USP32 , and result of western blot analysis indicated that siUSP32-386 and siUSP32-3029 markedly decreased USP32 expression ( Figure 1A ) ."

32226309

SiUSP32-3029 affects USP32

| 1

SiUSP32-3029 inhibits USP32. 1 / 1

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eidos

32226309

Raloxifene hydrochloride affects USP32

1 |

Raloxifene hydrochloride decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

16514628

Progesterone affects USP32

1 |

Progesterone increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

23012394

Potassium chromate affects USP32

1 |

Potassium chromate decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

22079256

Phorbol 13-acetate 12-myristate affects USP32

1 |

Phorbol 13-acetate 12-myristate decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Paracetamol affects USP32

1 |

Paracetamol decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

21420995

Oxaliplatin affects USP32

1 |

Oxaliplatin decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

25729387

Methamphetamine affects USP32

1 |

Methamphetamine decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

29802913

Lead atom affects USP32

1 |

Lead atom increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

19921347

Ionomycin affects USP32

1 |

Ionomycin decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

25613284

Hsa_circ_0013880 affects USP32

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Hsa_circ_0013880 increases the amount of USP32. 1 / 1

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"Mechanistically, hsa_circ_0013880 could elevate the expression of USP32, a deubiquitinating enzyme that is highly expressed in the BMNCs of AML patients."

36951484

Hsa-miR-7156-5p affects USP32

1 |

Hsa-miR-7156-5p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-7110-3p affects USP32

1 |

Hsa-miR-7110-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6873-3p affects USP32

1 |

Hsa-miR-6873-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6833-3p affects USP32

1 |

Hsa-miR-6833-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6817-3p affects USP32

1 |

Hsa-miR-6817-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-548ah-5p affects USP32

1 |

Hsa-miR-548ah-5p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-526b-3p affects USP32

1 |

Hsa-miR-526b-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-519c-3p affects USP32

1 |

Hsa-miR-519c-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-519b-3p affects USP32

1 |

Hsa-miR-519b-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-519a-3p affects USP32

1 |

Hsa-miR-519a-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4796-3p affects USP32

1 |

Hsa-miR-4796-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4768-5p affects USP32

1 |

Hsa-miR-4768-5p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4753-3p affects USP32

1 |

Hsa-miR-4753-3p decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4696 affects USP32

1 |

Hsa-miR-4696 decreases the amount of USP32. 1 / 1

1 |

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biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-454-3p affects USP32

1 |

Hsa-miR-454-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4295 affects USP32

1 |

Hsa-miR-4295 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4273 affects USP32

1 |

Hsa-miR-4273 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-3666 affects USP32

1 |

Hsa-miR-3666 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-3609 affects USP32

1 |

Hsa-miR-3609 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-301b-3p affects USP32

1 |

Hsa-miR-301b-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-301a-3p affects USP32

1 |

Hsa-miR-301a-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-2117 affects USP32

1 |

Hsa-miR-2117 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-18a-3p affects USP32

1 |

Hsa-miR-18a-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23622248

Hsa-miR-130b-5p affects USP32

1 |

Hsa-miR-130b-5p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-130b-3p affects USP32

1 |

Hsa-miR-130b-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-130a-3p affects USP32

1 |

Hsa-miR-130a-3p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-124-5p affects USP32

1 |

Hsa-miR-124-5p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-106a-5p affects USP32

1 |

Hsa-miR-106a-5p decreases the amount of USP32. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hexabromocyclododecane affects USP32

1 |

Hexabromocyclododecane decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

29177809

Furan affects USP32

1 |

Furan methylates USP32. 1 / 1

1 |

➶

ctd

No evidence text available

22079235

Fulvestrant affects USP32

1 |

Fulvestrant decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

16514628

Dibutyl phthalate affects USP32

1 |

Dibutyl phthalate increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

21266533

Cyclosporin A affects USP32

1 |

Cyclosporin A increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

25562108

Cupric oxide affects USP32

1 |

Cupric oxide increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

22077320

Copper(II) sulfate affects USP32

1 |

Copper(II) sulfate decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

19549813

Cisplatin affects USP32

1 |

Cisplatin decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

19561079

Cadmium dichloride affects USP32

1 |

Cadmium dichloride decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

24982889

Bta-miR-19b-3p affects USP32

| 1

Bta-miR-19b-3p decreases the amount of USP32. 1 / 1

| 1

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reach

"Therefore, inhibited expression of USP32, RAB18 and Dusp6 caused by bta-miR-19b-3p may be conducive to the maintaining of undifferentiated SSCs in cattleyak, while downregulation of FOXO3 by bta-miR-592 could contribute to the transition of SSCs to a differentiating state, which was consistent with the conclusions from our previous study that spermatogenic arrest of cattleyak started at the stage of spermatogonial differentiation and get aggravated during meiosis 3."

29330490

Benzo[a]pyrene diol epoxide I affects USP32

1 |

Benzo[a]pyrene diol epoxide I decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

19150397

Aluminium atom affects USP32

1 |

Aluminium atom decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

21298039

Afimoxifene affects USP32

1 |

Afimoxifene decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

16514628

Acrylamide affects USP32

1 |

Acrylamide decreases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

28959563

YWHAB affects USP32

1 |

YWHAB binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

WDR20 affects USP32

| 1

WDR20 activates USP32. 1 / 1

| 1

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reach

"Neither was differentially methylated in our study, but several DMR genes mediate AR or its effects in various contexts in other species: hey2 (Fig. 1c), pkn1(102295574) and ncoa2, usp12, usp32 (Fig. 1b), and zmiz1(102310819) [84–88]."

31506062

VPS35 affects USP32

1 |

VPS35 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP6 affects USP32

1 |

USP6 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP4 affects USP32

1 |

USP4 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32P2 affects USP32

1 |

USP32 binds USP32P2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects tumorigenesis chemoresistance carcinoma

| 1

USP32 activates tumorigenesis chemoresistance carcinoma. 1 / 1

| 1

➶

eidos

"USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2 USP32 , a member of the ubiquitin-specific proteases family , has been implicated in the development of breast cancer and small lung cancer ."

32226309

USP32 affects resistance GC cells cisplatin

| 1

USP32 activates resistance GC cells cisplatin. 1 / 1

| 1

➶

eidos

"Furthermore , knockdown of USP32 attenuated the resistance of GC cells to cisplatin in CCK8 assays , whereas overexpression of SMAD2 partially rescued the defect of USP32 silenced GC cells in cisplatin resistance ( Figure 6B ) , suggesting that USP32 may confer chemoresistance in GC ."

32226309

USP32 affects process

| 1

USP32 activates process. 1 / 1

| 1

➶

eidos

"Considering USP32 regulates SMAD2 expression , we attempted to elucidate whether USP32 could mediate this process ."

32226309

USP32 affects mouse model

| 1

USP32 activates mouse model. 1 / 1

| 1

➶

eidos

"Our data firstly demonstrate that USP32 downregulation significantly inhibited GC cell proliferation and migration in vitro , as well as in a mouse model ."

32226309

USP32 affects migration

| 1

USP32 activates migration. 1 / 1

| 1

➶

eidos

"Our data firstly demonstrate that USP32 downregulation significantly inhibited GC cell proliferation and migration in vitro , as well as in a mouse model ."

32226309

USP32 affects migrated cells

| 1

USP32 activates migrated cells. 1 / 1

| 1

➶

eidos

"Similarly , Transwell chamber assays also proved that knockdown of USP32 decreased the number of migrated cells while overexpression of SMAD2 compensated this phenotype ( Figure 5C ) ."

32226309

USP32 affects miR-19b-3p

| 1

USP32 activates miR-19b-3p. 1 / 1

| 1

➶

reach

"To further determine if the changed expression of those genes resulted from the increased miRNAs, we carried out Western blot to validate and found that the results were consistent with qRT-PCR, sugge[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

27138803

USP32 affects metastatic foci lung surfaces

| 1

USP32 activates metastatic foci lung surfaces. 1 / 1

| 1

➶

eidos

"Moreover , pulmonary metastasis assays were performed and the results showed that downregulation of USP32 markedly decreased metastatic foci on lung surfaces ( Figure 2B ) ."

32226309

USP32 affects localization

| 1

USP32 activates localization. 1 / 1

| 1

➶

reach

"In turn, the DUB enzyme ubiquitin-specific protease 32 (USP32) removes the ubiquitin chains from Lys191, and then restores the late endosome motility and the perinuclear localization of the late compartment mediated by Rab7 (Sapmaz et al., 2019)."

34277632

USP32 affects growth migration defects investigate functional relevance USP32 SMAD2

| 1

USP32 inhibits growth migration defects investigate functional relevance USP32 SMAD2. 1 / 1

| 1

➶

eidos

"SMAD2 restores USP32 knockdown induced growth and migration defects To investigate the functional relevance of USP32 and SMAD2 , we overexpressed SMAD2 together with knockdown of USP32 in MGC803 cells ( Figure 5A ) ."

32226309

USP32 affects endosomal transport

| 1

USP32 activates endosomal transport. 1 / 1

| 1

➶

reach

"USP32 promotes endosomal transport via the Rab7/RILP axis."

30926795

USP32 affects colony cells

| 1

USP32 inhibits colony cells. 1 / 1

| 1

➶

eidos

"Consistently , downregulation of USP32 also led to an inhibitory effect on colony formation of those stable cells ( Figure 1C ) ."

32226309

USP32 affects cisplatin-resistance cells

| 1

USP32 activates cisplatin-resistance cells. 1 / 1

| 1

➶

eidos

"In this regard , we also observed that USP32 downregulation could decrease the cisplatin-resistance in GC cells , suggesting the involvement of USP32 in drug resistance ."

32226309

USP32 affects cell cycle

| 1

USP32 activates cell cycle. 1 / 1

| 1

➶

reach

"Furthermore, USP32 silencing arrested cell cycle progression at G0/G1 phase via decreasing CDK4 and Cyclin D1 complex and elevating p21."

28597490

USP32 affects apoptotic process

| 1

USP32 activates apoptotic process. 1 / 1

| 1

➶

reach

"In addition, downregulation of USP32 significantly induced cell apoptosis by activating cleaved caspase-3 and cleaved PARP, as well as inhibiting cell invasiveness via altering epithelial mesenchymal transition expression."

28597490

USP32 affects YWHAB

1 |

YWHAB binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects VPS35

1 |

VPS35 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects Ubiquitination

| 1

USP32 inhibits Ubiquitination. 1 / 1

| 1

➶

eidos

"Loss of USP32 promotes ubiquitination within the unstructured N-terminal region of LAMTOR1 and prevents its efficient interaction with the vacuolar-type H + - ATPase , a prerequisite for full activation of MTORC1 at lysosomes ."

36847417

USP32 affects USP6

1 |

USP6 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects USP4

1 |

USP4 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects USP32P2

1 |

USP32 binds USP32P2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects UBXN1

1 |

UBXN1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects UBC

1 |

UBC binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

28190767

USP32 affects TUBA1A

1 |

USP32 binds TUBA1A. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects TRIP13

1 |

TRIP13 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects TRIM74

1 |

TRIM74 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

USP32 affects TRIM46

1 |

TRIM46 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

USP32 affects TRIM25

1 |

TRIM25 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

29117863

USP32 affects TPCN2

1 |

USP32 binds TPCN2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects TG

| 1

USP32 inhibits TG. 1 / 1

| 1

➶

reach

"While in normal cells frequent transient interactions between these compartments were readily observed (Supplementary Movie 3 and 4), loss of USP32 caused TGN-derived membranes to remain stuck on enlarged acidified endosomes (Supplementary Movie 5, 6)."

30926795

USP32 affects Smad2 Protein

| 1

USP32 activates Smad2 Protein. 1 / 1

| 1

➶

eidos

"Results from western blots indicated that downregulation of USP32 dramatically decreased the SMAD2 protein level after protein synthesis was inhibited ( Figure 4E ) ."

32226309

USP32 affects SYNCRIP

1 |

SYNCRIP binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP32 affects SORT1

1 |

SORT1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP32 affects SMC1A

1 |

SMC1A binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects RRAS

| 1

USP32 activates RRAS. 1 / 1

| 1

➶

reach

"Given the deubiquitination function of USP32, we further hypothesize that USP32 may mediate the malignant behaviors of AML cells by regulating the stability of Ras-related protein (Rap1b)."

36951484

USP32 affects RP23-33N15.1

1 |

USP32 binds RP23-33N15.1. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP32 affects RNF144A

1 |

USP32 binds RNF144A. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

USP32 affects RBCK1

1 |

RBCK1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

USP32 affects RAB6B

1 |

RAB6B binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects RAB5A

| 1

USP32 deubiquitinates RAB5A. 1 / 1

| 1

➶

reach

"In contrast to Rab7 (and in agreement with the proteomic analysis above), no deubiquitylation of GFP-Rab5 by USP32 was observed under the same reaction conditions (Fig. 4d; Supplementary Fig. 5e)."

30926795

USP32 affects RAB35

| 1

USP32 deubiquitinates RAB35. 1 / 1

| 1

➶

reach

"Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours."

36725886

USP32 affects PARP1

| 1

USP32 activates PARP1. 1 / 1

| 1

➶

reach

28597490

USP32 affects Neoplasm Invasiveness

| 1

USP32 inhibits Neoplasm Invasiveness. 1 / 1

| 1

➶

reach

28597490

USP32 affects NME4

1 |

USP32 binds NME4. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects MicroRNAs

| 1

USP32 inhibits MicroRNAs. 1 / 1

| 1

➶

reach

"However, overexpression of USP32 could reverse the effect of miR let-7a on MCF-7 cells proliferation."

35116927

USP32 affects MTNR1A

1 |

USP32 binds MTNR1A. 1 / 1

1 |

➶

biogrid

No evidence text available

26514267

USP32 affects MRPL39

1 |

MRPL39 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects MANSC1

1 |

USP32 binds MANSC1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects LRRC47

1 |

USP32 binds LRRC47. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects LAMTOR1

| 1

USP32 inhibits LAMTOR1. 1 / 1

| 1

➶

reach

"Recently, we identified a non-proteolytic ubiquitin signal at the Ragulator complex subunit LAMTOR1 that is reversed by the deubiquitinase USP32."

36847417

USP32 affects KRT8

1 |

USP32 binds KRT8. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects KRT19

1 |

USP32 binds KRT19. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects KRT18

1 |

USP32 binds KRT18. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects HSPA12A

1 |

HSPA12A binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects GC cell

| 1

USP32 activates GC cell. 1 / 1

| 1

➶

eidos

"Our data firstly demonstrate that USP32 downregulation significantly inhibited GC cell proliferation and migration in vitro , as well as in a mouse model ."

32226309

USP32 affects FDFT1

1 |

USP32 binds FDFT1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects FARSA

1 |

USP32 binds FARSA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects ERP44

1 |

ERP44 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects ENTPD7

1 |

USP32 binds ENTPD7. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects CUL3

1 |

USP32 binds CUL3. 1 / 1

1 |

➶

biogrid

No evidence text available

21145461

USP32 affects CDK1

1 |

CDK1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP32 affects CD83

1 |

CD83 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects CASP3

| 1

USP32 activates CASP3. 1 / 1

| 1

➶

reach

28597490

USP32 affects CAND1

1 |

USP32 binds CAND1. 1 / 1

1 |

➶

biogrid

No evidence text available

21145461

USP32 affects BAG6

1 |

BAG6 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

USP32 affects ALDH3B1

1 |

USP32 binds ALDH3B1. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

USP32 affects ABCD3

1 |

USP32 binds ABCD3. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

UBXN1 affects USP32

1 |

UBXN1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

UBC affects USP32

1 |

UBC binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

28190767

TUBA1A affects USP32

1 |

USP32 binds TUBA1A. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

TRIP13 affects USP32

1 |

TRIP13 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

TRIM74 affects USP32

1 |

TRIM74 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

TRIM46 affects USP32

1 |

TRIM46 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

TRIM25 affects USP32

1 |

TRIM25 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

29117863

TPCN2 affects USP32

1 |

USP32 binds TPCN2. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

TCF3 affects USP32

1 |

TCF3 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SYNCRIP affects USP32

1 |

SYNCRIP binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

SRY affects USP32

1 |

SRY decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SP1 affects USP32

1 |

SP1 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SOX5 affects USP32

1 |

SOX5 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

SORT1 affects USP32

1 |

SORT1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

SMC1A affects USP32

1 |

SMC1A binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RREB1 affects USP32

1 |

RREB1 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

RP23-33N15.1 affects USP32

1 |

USP32 binds RP23-33N15.1. 1 / 1

1 |

➶

biogrid

No evidence text available

26496610

RNF144A affects USP32

1 |

USP32 binds RNF144A. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

RNAi affects USP32

| 1

RNAi inhibits USP32. 1 / 1

| 1

➶

reach

"Although RNAi mediated knockdown of USP28, USP32 and USP36 showed that their depletion resulted in the increase of ub-K119-H2A, only USP28 depleted cells showed increased cell proliferation."

30910399

REPIN1 affects USP32

1 |

REPIN1 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

RBCK1 affects USP32

1 |

RBCK1 binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

RAB6B affects USP32

1 |

RAB6B binds USP32. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

Plant Extracts affects USP32

1 |

Plant Extracts increases the amount of USP32. 1 / 1

1 |

➶

ctd

No evidence text available

23557933

POU3F2 affects USP32

1 |

POU3F2 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

PAX4 affects USP32

1 |

PAX4 decreases the amount of USP32. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

NME4 affects USP32

1 |

USP32 binds NME4. 1 / 1

1 |

➶

biogrid

No evidence text available

28514442

MicroRNAs affects USP32

| 1

MicroRNAs decreases the amount of USP32. 1 / 1

| 1

➶

reach

"Western blot analysis revealed that miR let-7a mimics dramatically decreased the USP32 protein expression, whereas miR let-7a inhibitors increased the protein expression of USP32 compared with their controls in the MCF-7 cells."

35116927