IndraLab

Statements

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"Further in vitro cell experiments revealed that hsa_circ_0013880-mediated elevation of USP32 promoted cell proliferation and migration and reduced cell apoptosis."
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"Namely, we found that USP32 knockdown effectively inhibited HL-60 and U937 cell proliferation, arrested the cell cycle at G1 phase, and induced cell apoptosis."
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"USP32 promotes NSCLC cell proliferation and migration."
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"USP32 depletion dramatically decreased the proliferation of A549 and H1299 cells, according to the results of the Cell Counting Kit-8 (CCK8) experiment (Fig. 2C)."
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"All of these findings demonstrate that USP32 increases the proliferation and migration process of NSCLC cells."
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"We carried out a number of rescue studies to look into the possibility that BAG3 is involved in USP32-mediated NSCLC cell proliferation, migration, and EMT."
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"Further, stable silencing of USP32 expression reduced proliferation and migration in the ERalpha positive MCF-7 cell line [XREF_BIBR]."
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"USP32 overexpression significantly increased the cell proliferation/survival capacity ( Fig. 3 B, C, and D)."
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"Results of CCK-8 and plate cloning experiments showed that USP32 depletion inhibited NSCLC cell lines growth and single cell clone formation, while further overexpression of BAG3 reversed NSCLC cell lines proliferation inhibition by USP32 knockdown (Fig. 5C, D)."
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"In the present study, we reported that knockdown or depletion of USP32 significantly inhibited GC cell proliferation and migration in vitro and in vivo, indicating that USP32 functions as an oncogene in GC."
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"On the other hand, downregulation of USP32 in vitro caused reduced migration and proliferation rates of SCLC cells."
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"siRNA-directed USP32 inhibition significantly decreased cell proliferation/survival in vitro ( Fig. S1A, B , Fig. 2 A, B, and C)."
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"10 Silencing of USP32 reduced cancer cell proliferation and migration in these studies and suggested USP32 as potential target for future therapy, although the tumor-promoting effects of USP32 are not[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As a highly conserved gene, USP32 was significantly upregulated in BCa cell lines and breast tissue, and silencing of USP32 causes lower proliferation and migration abilities compared to control (33), and in estrogen receptor-positive tumours, DNA copy number and gene expression of USP32 were increased (34)."
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"Moreover, USP32 was found to be overexpressed in human small cell lung cancer tissues, and USP32 silencing significantly suppressed small cell lung cancer cells proliferation and migration, cell cycle progression arrested and cell apoptosis (35)."
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"Wet experiments confirmed that knockdown of USP32 could repress the proliferation, colony formation and migration of HCC cells in vitro and inhibit tumor growth in vivo."
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"In the present study, we discovered that NF‐κB signalling is activated by USP32 overexpression and that the inhibition of the USP32–NF‐κB axis could reverse the proliferation, colony formation, anti‐apoptosis and migration abilities of CRC cells.To further verify USP32's oncogenic roles, we also performed in vivo studies."
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"Due to the fact that Huh7 and HCC-LM3 cells carry different TP53 mutants, further studies could use HCC cell lines expressing wild-type p53 to eliminate the potential effect of TP53 status on USP32 overexpression-induced cell proliferation."
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"So far, it has been reported that USP32 was over-expressed in lung and breast cancers, enhancing cellular proliferation and tissue metastasis (9)."
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"Moreover, USP32 could promote proliferation and epithelial mesenchymal transition abilities of EOC cells via stabilizing farnesyl-diphosphate farnesyltransferase 1 (FDFT1) and regulating mevalonate pathway [40]."
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"Knockdown of USP32 inhibited the proliferation of AML cells ."
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"Hence, we demonstrated that knockdown of USP32 could inhibit the proliferation of HL-60 and U937 cells, which might be related to cell cycle arrest in the G1 phase."
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