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"Additionally, USP32 promotes GC cell growth, metastasis, and chemoresistance by upregulating SMAD2, an important protein in the TGF-β signaling pathway [55]."
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"So far, it has been reported that USP32 was over-expressed in lung and breast cancers, enhancing cellular proliferation and tissue metastasis (9)."
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"USP32 downregulation inhibited cell growth and metastasis in vitro ."
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"Similarly, USP32 knockdown by shRNA significantly impaired peritoneal metastasis in a xenograft assay ( Fig. S1C , Fig. 2 D), confirming that USP32 inhibition exerted antitumor effects in vitro and in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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