IndraLab

Statements


BDNF is modified
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BDNF is methylated. 10 / 1551
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"In a recent paper, Roth and colleagues demonstrated that Bdnf methylation patterns in the hippocampus were altered following a task requiring remapping of place cells (neurons that provide a “map” by firing when the animal occupies a specific location), a change that did not endure in rats given the DNMT inhibitor zebularine ( xref )."

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"Furthermore, this work provides support for the speculative notion that altered hippocampal Bdnf DNA methylation is a cellular mechanism underlying the persistent cognitive deficits which are prominent features of the pathophysiology of PTSD."

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"Interestingly, we found that BDNF methylation was significantly different between healthy Xinjiang Han Chinese individuals (Northwestern China) and healthy Ningbo Han Chinese individuals (Southeaste[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Associations between BDNF methylation levels and psychiatric medications were reported."

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"No effect of sertraline monotherapy on BDNF methylation was found in subjects with depression."

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"In sum, our results demonstrate a remarkable robustness to the experience-driven changes in BDNF DNA methylation by early-life adverse experiences."

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"BDNF methylation led to a down-regulating of the corresponding mRNA [ xref ]."

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"For example, increased DNA methylation in the brain-derived neurotrophic factor ( Bdnf ) gene has been associated with early-life environmental toxins in the brain and blood of mice, and in human cord blood (Kundakovic et al., xref )."

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"The present study suggests that high neuroticism is related to increased methylation of the BDNF gene."

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"For Bdnf DNA methylation sequencing analysis, we selected a region that has been well characterized to be sensitive to activity-dependent neuronal responses ( xref , xref , xref )."
CXXC1 affects BDNF
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CXXC1 methylates BDNF. 10 / 30
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"Increased CpG methylation in promoter regions of the Bdnf gene is reportedly correlated with the decreased synthesis of BDNF protein in neurons xref ."

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"After applying Bonferroni correction, any depressive disorder was significantly associated with higher BDNF methylation at CpG sites 1, 5, 8, 9, and a higher average methylation percentage; and majo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"An increased CpG methylation in the region of BDNF gene was correlated with decreased BDNF synthesis ( Martinowich et al., 2003 )."

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"The increased methylation of CpG sites in the genes CXCL1 and BDNF were associated with PTSD and comorbid total life stress."

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"Analyses of Nr3c1 and Bdnf (IV and IX) CpG methylation indicated increased hippocampal Nr3c1 methylation in maternally separated C57BL/6J males and increased hippocampal Bdnf IX methylation in male and female maternally separated Balb/c mice."

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"Thus, although we statistically demonstrated there was no association between duration of illness and BDNF methylation at CpG sites, we could not clearly confirm how early these changes in BDNF methylation and cortical thickness among patients with MDD appear."

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"The incidence of suicidal ideation was independently associated with higher BDNF promoter methylation at CpG site 9 and with a higher average percentage."

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"xref (in the online-only Data Supplement) presents the analysis of average BDNF promoter methylation and methylation at each CpG site by BDNF genotype."

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"There were no correlations between BDNF promoter methylation at any CpG sites and cortical thickness among healthy controls ( xref )."

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"Our observations of the increased levels of DNMTs and fear conditioning-associated regulation of exon-specific Bdnf transcripts led us to speculate that CpG island sites methylation of the Bdnf gene might be a mechanism mediating Bdnf gene expression in the mPFC and HIP during fear erasure."
CXXC1 methylates BDNF. 5 / 5
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"Increased methylation of a CpG site in BDNF and peripheral blood of adults with PTSD have been reported ( xref )."

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"Results: After 100 days of selective serotonin-reuptake inhibitor treatment, methylation of promoter CpG sites of BDNF , NR3C1 , FKBP5 and SLC6A4 was significantly reduced."

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"Absence of methylation at one particular CpG site in exon 4 of BDNF has been associated with reduced response to antidepressant drugs ( xref )."

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"Peripheral blood collected at baseline revealed that any depressive diagnosis was associated with higher BDNF methylation at CpG sites -1, -5, -8, and -9, and a higher average BDNF promoter methylation percentage."

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"Januar et al. have revealed that late-life depression is associated with elevated BDNF methylation of specific CpG sites within promoters I and IV, with all associations remaining after adjustment for a range of covariates [ xref ]."
GNAS affects BDNF
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GNAS methylates BDNF. 7 / 7
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"Another study comparing methylation between brain and blood in humans found blood to be a poor predictor of brain, and in contrast to the previously mentioned study found that the majority of the few sites exhibiting correlation with brain tissue were located in gene bodies. xref A 2014 study revealed that though overall positively correlated, methylation within CpG islands is highly dissimilar between saliva and blood in humans, with saliva being a closer match to methylation patterns found in the brain. xref Blood is also a poor predictor of human brain BDNF exon I methylation, though muscle tissue methylation at this locus exhibits a high correlation to brain. xref Interestingly, methylation in brain and blood have been found similar in an animal model."

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"Interestingly, in Balb/cJ mice that were exposed to this same manipulation, Bdnf expression was enhanced within the PFC and increased levels of Bdnf exon IX methylation within the hippocampus were found [ xref ]."

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"In support of this, methylation specific real-time PCR revealed that bdnf exon VI DNA methylation increased after fear conditioning."

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"There was no strong evidence that blood or buccal BDNF exon 1 promoter DNA methylation is associated with prevalent or incident dementia, and reported associations would not remain after adjustment for multiple testing."

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"BDNF exon 1 promoter methylation was measured in blood at baseline (n = 769) and buccal samples during follow-up (n = 1062)."

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"However, in the whole prefrontal cortex, Bdnf exon IX methylation was increased 24 hours after the final day of maltreatment exposure (i.e. PD8) and this increase persisted into adulthood."

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"Of note, one study found no differences in BDNF exon 1 methylation between BD patients and controls, which suggests that this marker is sample-specific and might not be generalizable to all populations ( xref )."
Histone affects BDNF
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Histone methylates BDNF. 6 / 6
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"Mice that have been provided with environmental enrichment for 4 weeks (8 mice housed per cage, containing tunnels and a running wheel) show increased mRNA levels and altered histone trimethylation of the neurotrophic factor Bdnf compared with control mice (4 housed per cage without tunnels or running wheel)."

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"Other studies reported that the levels of mRNA and histone methylation of brain BDNF were decreased by 7 days of withdrawal from chronic morphine."

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"Other studies reported that the levels of mRNA ( xref ) and histone methylation ( xref ) of brain BDNF were decreased by 7 days of withdrawal from chronic morphine."

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"Higher histone and DNA methylation of the BDNF gene and consecutive downregulation of BDNF mRNA and decreased levels of BDNF have been demonstrated in animal models of maltreatment. xref , xref Tsankova et al. xref showed that chronic defeat stress in mice induced downregulation of the expression of BDNF promoter/exon IV and was associated with increases in histone H3 lysine 27 methylation (H3K27) at the corresponding promoter."

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"Maternal separation decreased repressive histone methylation of the Bdnf exon IV promoter and enhanced BDNF levels 42."

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"Stress induced down-regulation of BDNF splice variant mRNAs in hippocampus was found to be associated with increased histone methylation of the respective BDNF promoters [XREF_BIBR]."
DNMT1 affects BDNF
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DNMT1 methylates BDNF. 5 / 5
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"Dnmt mRNA alterations, increased Bdnf DNA methylation, and altered methylation patterns of numerous genes that play a role in neuronal growth, development, and plasticity have been found in the brains (within the frontal cortex, amygdala, and PVN) of individuals who committed suicide and/or had been diagnosed with major depression."

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"Third, we found that DNMT inhibition causes bdnf DNA demethylation and that demethylation is sufficient to lead to increased bdnf mRNA levels in hippocampus in vivo."

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"Dnmt mRNA alterations, increased Bdnf DNA methylation, and altered methylation patterns of numerous genes that play a role in neuronal growth, development, and cholinergic transmission have been found in the brains (within the frontal cortex, amygdala, and PVN) of individuals who committed suicide and/or had been diagnosed with major depression."

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"Nonetheless, these results confirmed that DNMT inhibition with Zebularine decreased basal bdnf DNA methylation in hippocampus at bdnf exons I, IV, and VI."

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"It has been suggested that IL-6 activated protein kinase B and then it can phosphorylate the nuclear localization signal on DNA methyltransferase-1 (DNMT1) which hypermethylates BDNF promoter and further reduces BDNF level [XREF_BIBR, XREF_BIBR]."
BDNF affects BDNF
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BDNF methylates BDNF. 5 / 5
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"The underlying mechanisms concerning BDNF signaling and DNA methylation of Bdnf were also explored."

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"We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b , and greater DNA methylation of Bdnf ."

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"Increased Methylation of Brain-Derived Neurotrophic Factor (BDNF) Is Related to Emotionally Unstable Personality Disorder and Severity of Suicide Attempt in Women."

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"Analyses of Nr3c1and Bdnf (IV and IX) CpG methylation indicated increased hippocampal Nr3c1 methylation in maternally separated C57BL/6J males and increased hippocampal Bdnf IX methylation in male and female maternally separated Balb/c mice."

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"The 5-AzaD treatments also elevated BDNF at the mRNA (p<0.01) and protein (Low-n-3/WD/5-AzaD Vs Low-n-3/WD/VEH, p<0.05; xref ) levels, which corroborates the repressive action of Bdnf methylation on BDNF."
Ethanol affects BDNF
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Ethanol leads to the methylation of BDNF. 4 / 4
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"Finally, we identified an EtOH induced change to DNA methylation of the Bdnf promoter in motile sperm that persists in the brain of offspring."

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"Prenatal ethanol exposure has been shown to increase the methylation of the BDNF gene and decrease BDNF expression in the postnatal olfactory bulb, but whether adult ethanol exposure yields similar changes is unknown."

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"We also identified changes in expression of Bdnf in the ventral tegmental area (VTA), and maintenance of ethanol induced DNA hypomethylation of the Bdnf promoter in sires ' sperm and offsprings ' VTA."

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"Similarly, chronic EtOH exposure in fetal rats reportedly induced hypermethylation of Bdnf and subsequent reduction in BDNF protein expression within the olfactory bulb, suggesting yet again a role of alcohol induced epigenetic mechanisms in regulation of synaptic plasticity."
Methyl affects BDNF
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Methyl leads to the methylation of BDNF. 2 / 2
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"A recent study has reported that methyl supplementation via methionine is able to increase BDNF DNA methylation and reduce BDNF mRNA levels in the hippocampus of epileptic rats during memory consolida[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In response to a learning experience methyl supplementation with Met significantly increased hippocampal Bdnf DNA methylation and reduced chronic overexpression of Bdnf mRNA levels observed in the hippocampus of epileptic animals during memory consolidation."
Lithium(1+) affects BDNF
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"DNA methylation of BDNF gene promoters by lithium."

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"Lithium and valproate both decreased BDNF methylation levels, but not to a degree of statistical significance."
Bisphenol A affects BDNF
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No evidence text available

No evidence text available
Trp-Asp affects BDNF
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Trp-Asp leads to the methylation of BDNF. 2 / 2
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"Our results show that WD promoted hypermethylation of the Bdnf gene at promoter region IV."

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"The WD increased Bdnf methylation specific to exon IV in animals previously reared with a diet low in n-3 fatty acids."
TET1 affects BDNF
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TET1 leads to the methylation of BDNF. 2 / 2
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"Although mRNAs of all three Tet genes are detected in the mouse hippocampus, specific knock-down of Tet1 abolished neuronal activity induced promoter demethylation of Bdnf IX and Fgf1B, suggesting non redundant roles of different TET proteins in DNA demethylation."

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"5hmC is abundant in the hippocampal dentate gyrus and manipulations of TET1 in the dentate gyrus regulate 5hmC levels and prevent stimulation induced demethylation of Bdnf and Fgf1B (fibroblast growth factor 1B) promoters."
H3K27 affects BDNF
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H3K27 methylates BDNF. 2 / 2
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"Lopez et al. 2013 also investigated H3K27 trimethylation of BDNF exon IV in a prospective study of twenty-five treatment-naïve MDD patients treated with citalopram for eight weeks [59]."

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"Studies of H3K27 methylation of the BDNF exon IV promoter highlight the consistency of methylation changes across PBMC and postmortem prefrontal cortex samples."
CGI affects BDNF
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CGI methylates BDNF. 2 / 2
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"Here we demonstrated that CGI hypermethylation of FIGN, HTRA3, BDNF, HCN4 and STAC2 in colorectal cancer is associated with patient progression to metastasis, identifying them as putative future biomarkers for CRC progression."

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"Furthermore, survival analysis showed that CGI hypermethylation of the genes FIGN, HTRA3, BDNF, HCN4 and STAC2 is related to poor patient survival, making them potential markers for progression of CRC."
CAT affects BDNF
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CAT leads to the methylation of BDNF. 2 / 2
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"Cat exposure increases methylation of the BDNF gene in the dorsal hippocampus in rats although this stressor decreases methylation of the BDNF gene in the ventral hippocampus, with no change in the basolateral amygdala or the prefrontal cortex ( xref )."

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"Cat exposure increases methylation of the BDNF gene in the dorsal hippocampus in rats although this stressor decreases methylation of the BDNF gene in the ventral hippocampus, with no change in the basolateral amygdala or the prefrontal cortex."
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Valproic acid leads to the methylation of BDNF. 1 / 1
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"Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment."
Tag SNP affects BDNF
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Tag SNP methylates BDNF. 1 / 1
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"The interactions between DNA methylation (CpG5) of the BDNF gene promoter and the tag SNP (rs6265) play important roles in the etiology of aMCI and its conversion to AD."
Rs6265 affects BDNF
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Rs6265 leads to the methylation of BDNF. 1 / 1
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"BDNF DNA methylation was mediated by the Val66Met (rs6265) polymorphism."
Perfluorooctane-1-sulfonic acid leads to the methylation of BDNF. 1 / 1
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"Therefore, we assume that PFOS could lead to the CpG methylation of BDNF mediated by DNMTs and decrease the expression of BDNF."

No evidence text available
Ketamine affects BDNF
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Ketamine leads to the methylation of BDNF. 1 / 1
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"A long-term ketamine treatment led to less methylation of the BDNF gene in the PFC, which increased its translation and BDNF protein levels."
Hypo affects BDNF
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Hypo methylates BDNF. 1 / 1
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"CT resulted associated : in FEP subjects, with global DNA hypo methylation and reduced BDNF gene expression; in healthy subjects, with hyper-methylation of SLC6A4, NR3C1, KITLG, and OXTR; hypo methylation of FKBP5, IL-6, and BDNF; increased IL1B, IL8, and PTGS gene expression; and decreased SLC6A4 gene expression."
Cytokine affects BDNF
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Cytokine methylates BDNF. 1 / 1
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"Neuroinflammation could be the key factor for the decrease of Bdnf gene expression in schizophrenic patients, as pro-inflammatory cytokines increase methylation of Bdnf gene, leading to a decrease of CREB binding to the specific Bdnf site."
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No evidence text available
Cpg-2 affects BDNF
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Cpg-2 methylates BDNF. 1 / 1
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"In the subgroup analyses by gender, our results showed that BDNF CpG2 and CpG4 methylation was significantly higher in male and female AD cases, respectively, and that a trend towards a significant result was found in females for average methylation and CpG2."
Clec-88 affects BDNF
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Clec-88 methylates BDNF. 1 / 1
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"Moreover, a complete mediation by the BDNF CpG6 methylation emerged between pandemic-related stress during pregnancy and postnatal maternal anxiety, ACME = 0.66, p < 0.05."
Clec-87 affects BDNF
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Clec-87 methylates BDNF. 1 / 1
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"Compared with healthy controls, BDNF CpG5 methylation levels were significantly lower in both heroin and METH addicts."
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No evidence text available
Arsenite(3-) affects BDNF
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No evidence text available
Aldosterone affects BDNF
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Aldosterone leads to the methylation of BDNF. 1 / 1
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"Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment."
Acetylsalicylic acid leads to the methylation of BDNF. 1 / 1
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"Aspirin co-treatment rescued DNMTs activation and BDNF IV hypermethylation, and mitigated the recession in BDNF mRNA and protein induced by B[a]P treatment."
SNP affects BDNF
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SNP methylates BDNF. 1 / 1
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"In line with this suggestion, increased volume in the DLPFC may reflect similar findings of increased BDNF SNP rs6265 methylation in ValVal subjects and improved WM ( xref )."
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No evidence text available
PT affects BDNF
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PT methylates BDNF. 1 / 1
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"While SE decreased the percentage methylation of specific CpGs of BDNF gene 's promoter, PT did not yield any significant difference in methylation of BDNF CpGs as compared to non exercised SE mice."
PN8 affects BDNF
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PN8 methylates BDNF. 1 / 1
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"Indeed, PN8 offspring (both males and females) derived from maltreated-females had significantly greater methylated BDNF DNA in their prefrontal cortex and hippocampus than offspring derived from normal treated females (XREF_FIG, XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
NMDA receptor affects BDNF
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NMDA receptor leads to the methylation of BDNF. 1 / 1
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"These effects are activity dependent, as the NMDA receptor antagonist AP5 prevented BDNF promoter demethylation."
Mindy1 affects BDNF
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Mindy1 leads to the methylation of BDNF. 1 / 1
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"* Molecular and biochemical analyses showed that -NI induces DNA hypomethylation of BDNF and GFAP, increased oxidative stress markers, and neuroinflammation -All of these changes were reversed by daily folic acid supplementation."
Mice affects BDNF
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Mice leads to the methylation of BDNF. 1 / 1
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"More harmful effects of BPA have been elucidated in BALB/c mice where in utero exposure to BPA induces a prominent change in DNA methylation of the Brain Derived Neurotrophic Factor (Bdnf) gene in the hippocampus and blood of F1 progeny [49]."
METTL3 affects BDNF
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METTL3 methylates BDNF. 1 / 1
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"Recent reports have suggested that post-translational modifications can modulate lncRNA expression xref so we utilized N 6-methyladenosine (M6A) RIP assay to determine if there were changes in RNA methylation at predicted M6A sites in BDNF-AS ."
MET3 affects BDNF
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MET3 methylates BDNF. 1 / 1
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"Consequently, increased BDNF promoter methylation by its inhibitor DNMT3 possibly leads to downregulated protein expression."
LSM-4015 affects BDNF
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LSM-4015 leads to the methylation of BDNF. 1 / 1
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"We propose the following putative pathway for scopolamine mediated memory impairment; scopolamine up-regulates hippocampal DNMT1 and HDAC2 expression, induces methylation and deacetylation of BDNF and Arc promoter, represses gene expression and eventually impairs memory consolidation."
LOG affects BDNF
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LOG methylates BDNF. 1 / 1
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"There was only a weak correlation between blood and buccal BDNF log-methylation at two sites (both r=-0.11)."
LEP affects BDNF
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LEP leads to the methylation of BDNF. 1 / 1
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"Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie exon specific transcription of the Bdnf gene induced by leptin."
HPC affects BDNF
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HPC leads to the methylation of BDNF. 1 / 1
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"Thus, we suggest that HPC may upregulate BDNF by inhibiting DNMTs and decreasing DNA methylation of the BDNF gene and then activate BDNF/TrkB signaling to improve learning and memory in mice."
H3K9 affects BDNF
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H3K9 methylates BDNF. 1 / 1
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"XREF_BIBR, XREF_BIBR In a mouse Alzheimer disease model, aberrantly increased H3K9 methylation levels in the BDNF (brain derived neurotrophic factor) gene leads to downregulation of BDNF expression in neurons."
GRIN2B affects BDNF
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GRIN2B methylates BDNF. 1 / 1
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"We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b , and greater DNA methylation of Bdnf ."
FSCN1 affects BDNF
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FSCN1 leads to the methylation of BDNF. 1 / 1
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"Similarly, our present study found that SNL increased the binding of DNMT1, DNMT3a, and DNMT3b to the bdnf promoter after operation, implying that SNL increased the spinal DNA methylation of the bdnf promoter in rats."
EXOSC10 affects BDNF
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EXOSC10 methylates BDNF. 1 / 1
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"Also Bdnf p1 and p9 methylation levels differed only in the cortex, while Bdnf p4 methylation did not vary in either area."
EAF2 affects BDNF
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EAF2 methylates BDNF. 1 / 1
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"In the present study, the relationship between methylation of the BDNF gene and personality traits including neuroticism was examined."
DNMT3 affects BDNF
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DNMT3 methylates BDNF. 1 / 1
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"Consequently, increased BDNF promoter methylation by its inhibitor DNMT3 possibly leads to downregulated protein expression."
DNMT affects BDNF
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DNMT methylates BDNF. 1 / 1
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"However, both active and rapid methylation of the memory suppressor gene protein phosphatase 1 (PP1) by the DNMT family of proteins and demethylation of the synaptic plasticity gene reelin and brain derived neurotrophic factor (BDNF) occurred during contextual fear conditioning suggesting that both processes are essential for memory formation."
DNMT inhibitors affects BDNF
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DNMT inhibitors leads to the methylation of BDNF. 1 / 1
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"This occurs despite the fact that in experimentally naive animals, DNMT inhibitors decrease BDNF methylation at all gene exons examined."
DNA methyltransferase-1 affects BDNF
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DNA methyltransferase-1 methylates BDNF. 1 / 1
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"It has been suggested that IL-6 activated protein kinase B and then it can phosphorylate the nuclear localization signal on DNA methyltransferase-1 (DNMT1) which hypermethylates BDNF promoter and further reduces BDNF level [XREF_BIBR, XREF_BIBR]."
DNA methyltransferase affects BDNF
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DNA methyltransferase leads to the methylation of BDNF. 1 / 1
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"DNA methyltransferase may contribute to the methylation of BDNF, which is involved in neuroprotection in AD."
DNA methylation affects BDNF
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DNA methylation methylates BDNF. 1 / 1
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"Recent studies suggest that DNA methylation of brain derived neurotrophic factor (BDNF) may serve as a biomarker for multiple psychiatric traits [XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR]."
CSF2 affects BDNF
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CSF2 methylates BDNF. 1 / 1
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"Results suggest that higher acute CSF BDNF DNA methylation may promote recovery following severe TBI in adults, and this effect may be more robust with higher age."
CENPJ affects BDNF
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CENPJ methylates BDNF. 1 / 1
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"Also Bdnf p1 and p9 methylation levels differed only in the cortex, while Bdnf p4 methylation did not vary in either area."
Asp-Gly affects BDNF
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Asp-Gly leads to the methylation of BDNF. 1 / 1
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"TET1 is thought to be involved in neuronal activity induced DNA demethylation and gene expression changes since shRNA mediated knockdown of endogenous Tet1 in the dentate gyrus (DG) abolishes electroconvulsive stimulation (ECS)-induced demethylation of a Bdnf promoter [XREF_BIBR]."
AIE affects BDNF
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AIE leads to the methylation of BDNF. 1 / 1
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"22 Recently, it was reported that AIE increased histone 3 acetyl 9 dimethylation (H3K9me2) of Bdnf gene in the amygdala during adulthood."