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BDNF is modified
| 1058
BDNF is methylated. 10 / 1058
| 1058
sparser
"Regarding question (1) we found significantly increased methylation rates in the alcohol-dependent patients in the beginning of alcohol withdrawal (day 1 and day 7) as well as a significant decrease i[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"In a recent paper, Roth and colleagues demonstrated that Bdnf methylation patterns in the hippocampus were altered following a task requiring remapping of place cells (neurons that provide a “map” by firing when the animal occupies a specific location), a change that did not endure in rats given the DNMT inhibitor zebularine ( xref )."
sparser
"In a study recently discussed [ xref ], reduced BDNF mRNA expression in the PFC of adult rats exposed to maternal abuse during childhood was explained by the fact that in maltreated rats, BDNF DNA methylation (specifically, increases in BDNF exons IX and IV) lasted from infancy into adulthood."
sparser
"This study has several limitations that may, in part, explain the striking results showing no correlation between BDNF protein levels and BDNF DNA methylation."
sparser
"Previously reported data showed increased BDNF DNA methylation in Wernicke׳s area of the brain in subjects, who committed suicide."
sparser
"A significantly higher level of BDNF promoter methylation was observed in AD cases than in controls in a previous study ( Chang et al., 2014 )."
sparser
"There are several possible explanations for the significant association between BDNF methylation status and depression in patients with breast cancer."
sparser
"In response to a learning experience methyl supplementation with Met significantly increased hippocampal Bdnf DNA methylation and reduced chronic overexpression of Bdnf mRNA levels observed in the hippocampus of epileptic animals during memory consolidation."
sparser
"Furthermore, this work provides support for the speculative notion that altered hippocampal Bdnf DNA methylation is a cellular mechanism underlying the persistent cognitive deficits which are prominent features of the pathophysiology of PTSD."
sparser
"It is possible that BDNF methylation is a prerequisite for specific MeCP2 binding and that an antidepressant’s action on BDNF may be more active in people with higher methylation status."
CXXC1 affects BDNF
| 26
CXXC1 methylates BDNF. 10 / 26
| 26
sparser
"Exposure to a neglectful caretaker decreased Bdnf mRNA expression in the PFC, accompanied by increased Bdnf DNA methylation at multiple CpG sites within the promoter region, in adult animals of both sexes."
sparser
"After applying Bonferroni corrections, the prevalence of suicidal ideation at baseline was significantly associated with higher BDNF promoter methylation at CpG sites 5, 7, 8, and 9 and with a highe[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"The increased methylation of CpG sites in the genes CXCL1 and BDNF were associated with PTSD and comorbid total life stress."
sparser
"Analyses of Nr3c1 and Bdnf (IV and IX) CpG methylation indicated increased hippocampal Nr3c1 methylation in maternally separated C57BL/6J males and increased hippocampal Bdnf IX methylation in male and female maternally separated Balb/c mice."
sparser
"BDNF DNA methylation at 4 CpG sites of the promoter region was also measured."
sparser
"We found no significant effect of race on CpG methylation of BDNF (p = 0.75), FKBP5 (p = 0.83), CRHBP (p = 0.39), CRHR1 (p = 0.90) or NR3C1 (p = 0.79) (G) gene."
sparser
"After applying Bonferroni correction, both any depressive disorder and major depressive disorder were significantly associated with higher BDNF methylation at CpG sites 1, 5, 8, 9, and a higher aver[MISSING/INVALID API KEY: limited to 200 char for Elsevier]"
sparser
"Individually, BDNF gene CpG methylation was significantly upregulated in MDD patients compared with healthy controls (p = 0.038; Cohen’s d = 0.63)."
sparser
"This study examined associations of prenatal exposure to maternal stress and BDNF methylation at CpG sites across the BDNF gene."
sparser
"Increased CpG methylation in promoter regions of the Bdnf gene is reportedly correlated with the decreased synthesis of BDNF protein in neurons xref ."
Histone affects BDNF
| 2 4
Histone methylates BDNF. 6 / 6
| 2 4
sparser
"Other studies reported that the levels of mRNA ( xref ) and histone methylation ( xref ) of brain BDNF were decreased by 7 days of withdrawal from chronic morphine."
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"Mice that have been provided with environmental enrichment for 4 weeks (8 mice housed per cage, containing tunnels and a running wheel) show increased mRNA levels and altered histone trimethylation of the neurotrophic factor Bdnf compared with control mice (4 housed per cage without tunnels or running wheel)."
sparser
"Higher histone and DNA methylation of the BDNF gene and consecutive downregulation of BDNF mRNA and decreased levels of BDNF have been demonstrated in animal models of maltreatment. xref , xref Tsankova et al. xref showed that chronic defeat stress in mice induced downregulation of the expression of BDNF promoter/exon IV and was associated with increases in histone H3 lysine 27 methylation (H3K27) at the corresponding promoter."
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"Other studies reported that the levels of mRNA and histone methylation of brain BDNF were decreased by 7 days of withdrawal from chronic morphine."
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"Maternal separation decreased repressive histone methylation of the Bdnf exon IV promoter and enhanced BDNF levels 42."
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"Stress induced down-regulation of BDNF splice variant mRNAs in hippocampus was found to be associated with increased histone methylation of the respective BDNF promoters [XREF_BIBR]."
GNAS affects BDNF
| 5
GNAS methylates BDNF. 5 / 5
| 5
sparser
"In support of this, methylation specific real-time PCR revealed that bdnf exon VI DNA methylation increased after fear conditioning."
sparser
"Another study comparing methylation between brain and blood in humans found blood to be a poor predictor of brain, and in contrast to the previously mentioned study found that the majority of the few sites exhibiting correlation with brain tissue were located in gene bodies. xref A 2014 study revealed that though overall positively correlated, methylation within CpG islands is highly dissimilar between saliva and blood in humans, with saliva being a closer match to methylation patterns found in the brain. xref Blood is also a poor predictor of human brain BDNF exon I methylation, though muscle tissue methylation at this locus exhibits a high correlation to brain. xref Interestingly, methylation in brain and blood have been found similar in an animal model."
sparser
"Interestingly, in Balb/cJ mice that were exposed to this same manipulation, Bdnf expression was enhanced within the PFC and increased levels of Bdnf exon IX methylation within the hippocampus were found [ xref ]."
sparser
"However, in the whole prefrontal cortex, Bdnf exon IX methylation was increased 24 hours after the final day of maltreatment exposure (i.e. PD8) and this increase persisted into adulthood."
sparser
"Of note, one study found no differences in BDNF exon 1 methylation between BD patients and controls, which suggests that this marker is sample-specific and might not be generalizable to all populations ( xref )."
DNMT1 affects BDNF
| 5
DNMT1 methylates BDNF. 5 / 5
| 5
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"Dnmt mRNA alterations, increased Bdnf DNA methylation, and altered methylation patterns of numerous genes that play a role in neuronal growth, development, and plasticity have been found in the brains (within the frontal cortex, amygdala, and PVN) of individuals who committed suicide and/or had been diagnosed with major depression."
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"Third, we found that DNMT inhibition causes bdnf DNA demethylation and that demethylation is sufficient to lead to increased bdnf mRNA levels in hippocampus in vivo."
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"Nonetheless, these results confirmed that DNMT inhibition with Zebularine decreased basal bdnf DNA methylation in hippocampus at bdnf exons I, IV, and VI."
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"Dnmt mRNA alterations, increased Bdnf DNA methylation, and altered methylation patterns of numerous genes that play a role in neuronal growth, development, and cholinergic transmission have been found in the brains (within the frontal cortex, amygdala, and PVN) of individuals who committed suicide and/or had been diagnosed with major depression."
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"It has been suggested that IL-6 activated protein kinase B and then it can phosphorylate the nuclear localization signal on DNA methyltransferase-1 (DNMT1) which hypermethylates BDNF promoter and further reduces BDNF level [XREF_BIBR, XREF_BIBR]."
ethanol affects BDNF
| 4
Ethanol leads to the methylation of BDNF. 4 / 4
| 4
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"Similarly, chronic EtOH exposure in fetal rats reportedly induced hypermethylation of Bdnf and subsequent reduction in BDNF protein expression within the olfactory bulb, suggesting yet again a role of alcohol induced epigenetic mechanisms in regulation of synaptic plasticity."
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"Prenatal ethanol exposure has been shown to increase the methylation of the BDNF gene and decrease BDNF expression in the postnatal olfactory bulb, but whether adult ethanol exposure yields similar changes is unknown."
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"We also identified changes in expression of Bdnf in the ventral tegmental area (VTA), and maintenance of ethanol induced DNA hypomethylation of the Bdnf promoter in sires ' sperm and offsprings ' VTA."
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"Finally, we identified an EtOH induced change to DNA methylation of the Bdnf promoter in motile sperm that persists in the brain of offspring."
BDNF affects BDNF
| 2 2
BDNF leads to the methylation of BDNF. 4 / 4
| 2 2
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"The underlying mechanisms concerning BDNF signaling and DNA methylation of Bdnf were also explored."
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"Analyses of Nr3c1and Bdnf (IV and IX) CpG methylation indicated increased hippocampal Nr3c1 methylation in maternally separated C57BL/6J males and increased hippocampal Bdnf IX methylation in male and female maternally separated Balb/c mice."
sparser
"We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b , and greater DNA methylation of Bdnf ."
sparser
"The 5-AzaD treatments also elevated BDNF at the mRNA (p<0.01) and protein (Low-n-3/WD/5-AzaD Vs Low-n-3/WD/VEH, p<0.05; xref ) levels, which corroborates the repressive action of Bdnf methylation on BDNF."
lithium(1+) affects BDNF
| 2
Lithium(1+) methylates BDNF. 2 / 2
| 2
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"Lithium and valproate both decreased BDNF methylation levels, but not to a degree of statistical significance."
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"DNA methylation of BDNF gene promoters by lithium."
Trp-Asp affects BDNF
| 1 1
Trp-Asp leads to the methylation of BDNF. 2 / 2
| 1 1
sparser
"The WD increased Bdnf methylation specific to exon IV in animals previously reared with a diet low in n-3 fatty acids."
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"Our results show that WD promoted hypermethylation of the Bdnf gene at promoter region IV."
TET1 affects BDNF
| 2
TET1 leads to the methylation of BDNF. 2 / 2
| 2
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"5hmC is abundant in the hippocampal dentate gyrus and manipulations of TET1 in the dentate gyrus regulate 5hmC levels and prevent stimulation induced demethylation of Bdnf and Fgf1B (fibroblast growth factor 1B) promoters."
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"Although mRNAs of all three Tet genes are detected in the mouse hippocampus, specific knock-down of Tet1 abolished neuronal activity induced promoter demethylation of Bdnf IX and Fgf1B, suggesting non redundant roles of different TET proteins in DNA demethylation."
CAT affects BDNF
| 1 1
CAT leads to the methylation of BDNF. 2 / 2
| 1 1
sparser
"Cat exposure increases methylation of the BDNF gene in the dorsal hippocampus in rats although this stressor decreases methylation of the BDNF gene in the ventral hippocampus, with no change in the basolateral amygdala or the prefrontal cortex ( xref )."
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"Cat exposure increases methylation of the BDNF gene in the dorsal hippocampus in rats although this stressor decreases methylation of the BDNF gene in the ventral hippocampus, with no change in the basolateral amygdala or the prefrontal cortex."
valproic acid affects BDNF
| 1
Valproic acid leads to the methylation of BDNF. 1 / 1
| 1
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"Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment."
tag SNP affects BDNF
| 1
Tag SNP methylates BDNF. 1 / 1
| 1
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"The interactions between DNA methylation (CpG5) of the BDNF gene promoter and the tag SNP (rs6265) play important roles in the etiology of aMCI and its conversion to AD."
perfluorooctane-1-sulfonic acid affects BDNF
| 1
Perfluorooctane-1-sulfonic acid leads to the methylation of BDNF. 1 / 1
| 1
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"Therefore, we assume that PFOS could lead to the CpG methylation of BDNF mediated by DNMTs and decrease the expression of BDNF."
methyl affects BDNF
| 1
Methyl leads to the methylation of BDNF. 1 / 1
| 1
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"In response to a learning experience methyl supplementation with Met significantly increased hippocampal Bdnf DNA methylation and reduced chronic overexpression of Bdnf mRNA levels observed in the hippocampus of epileptic animals during memory consolidation."
hypo affects BDNF
| 1
Hypo methylates BDNF. 1 / 1
| 1
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"CT resulted associated : in FEP subjects, with global DNA hypo methylation and reduced BDNF gene expression; in healthy subjects, with hyper-methylation of SLC6A4, NR3C1, KITLG, and OXTR; hypo methylation of FKBP5, IL-6, and BDNF; increased IL1B, IL8, and PTGS gene expression; and decreased SLC6A4 gene expression."
cpg-2 affects BDNF
| 1
Cpg-2 methylates BDNF. 1 / 1
| 1
sparser
"In the subgroup analyses by gender, our results showed that BDNF CpG2 and CpG4 methylation was significantly higher in male and female AD cases, respectively, and that a trend towards a significant result was found in females for average methylation and CpG2."
clec-87 affects BDNF
| 1
Clec-87 methylates BDNF. 1 / 1
| 1
sparser
"Compared with healthy controls, BDNF CpG5 methylation levels were significantly lower in both heroin and METH addicts."
aldosterone affects BDNF
| 1
Aldosterone leads to the methylation of BDNF. 1 / 1
| 1
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"Brain derived neurotrophic factor expression and DNA methylation in response to subchronic valproic acid and/or aldosterone treatment."
SNP affects BDNF
| 1
SNP methylates BDNF. 1 / 1
| 1
sparser
"In line with this suggestion, increased volume in the DLPFC may reflect similar findings of increased BDNF SNP rs6265 methylation in ValVal subjects and improved WM ( xref )."
PT affects BDNF
| 1
PT methylates BDNF. 1 / 1
| 1
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"While SE decreased the percentage methylation of specific CpGs of BDNF gene 's promoter, PT did not yield any significant difference in methylation of BDNF CpGs as compared to non exercised SE mice."
PN8 affects BDNF
| 1
PN8 methylates BDNF. 1 / 1
| 1
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"Indeed, PN8 offspring (both males and females) derived from maltreated-females had significantly greater methylated BDNF DNA in their prefrontal cortex and hippocampus than offspring derived from normal treated females (XREF_FIG, XREF_SUPPLEMENTARY - XREF_SUPPLEMENTARY)."
NMDA receptor affects BDNF
| 1
NMDA receptor leads to the methylation of BDNF. 1 / 1
| 1
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"These effects are activity dependent, as the NMDA receptor antagonist AP5 prevented BDNF promoter demethylation."
METTL3 affects BDNF
| 1
METTL3 methylates BDNF. 1 / 1
| 1
sparser
"Recent reports have suggested that post-translational modifications can modulate lncRNA expression xref so we utilized N 6-methyladenosine (M6A) RIP assay to determine if there were changes in RNA methylation at predicted M6A sites in BDNF-AS ."
LSM-4015 affects BDNF
| 1
LSM-4015 leads to the methylation of BDNF. 1 / 1
| 1
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"We propose the following putative pathway for scopolamine mediated memory impairment; scopolamine up-regulates hippocampal DNMT1 and HDAC2 expression, induces methylation and deacetylation of BDNF and Arc promoter, represses gene expression and eventually impairs memory consolidation."
H3K9 affects BDNF
| 1
H3K9 methylates BDNF. 1 / 1
| 1
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"XREF_BIBR, XREF_BIBR In a mouse Alzheimer disease model, aberrantly increased H3K9 methylation levels in the BDNF (brain derived neurotrophic factor) gene leads to downregulation of BDNF expression in neurons."
GRIN2B affects BDNF
| 1
GRIN2B methylates BDNF. 1 / 1
| 1
sparser
"We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b , and greater DNA methylation of Bdnf ."
FSCN1 affects BDNF
| 1
FSCN1 leads to the methylation of BDNF. 1 / 1
| 1
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"Similarly, our present study found that SNL increased the binding of DNMT1, DNMT3a, and DNMT3b to the bdnf promoter after operation, implying that SNL increased the spinal DNA methylation of the bdnf promoter in rats."
EXOSC10 affects BDNF
| 1
EXOSC10 methylates BDNF. 1 / 1
| 1
sparser
"Also Bdnf p1 and p9 methylation levels differed only in the cortex, while Bdnf p4 methylation did not vary in either area."
EAF2 affects BDNF
| 1
EAF2 methylates BDNF. 1 / 1
| 1
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"In the present study, the relationship between methylation of the BDNF gene and personality traits including neuroticism was examined."
DNMT inhibitors affects BDNF
| 1
DNMT inhibitors leads to the methylation of BDNF. 1 / 1
| 1
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"This occurs despite the fact that in experimentally naive animals, DNMT inhibitors decrease BDNF methylation at all gene exons examined."
DNMT affects BDNF
| 1
DNMT methylates BDNF. 1 / 1
| 1
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"However, both active and rapid methylation of the memory suppressor gene protein phosphatase 1 (PP1) by the DNMT family of proteins and demethylation of the synaptic plasticity gene reelin and brain derived neurotrophic factor (BDNF) occurred during contextual fear conditioning suggesting that both processes are essential for memory formation."
DNA methyltransferase-1 affects BDNF
| 1
DNA methyltransferase-1 methylates BDNF. 1 / 1
| 1
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"It has been suggested that IL-6 activated protein kinase B and then it can phosphorylate the nuclear localization signal on DNA methyltransferase-1 (DNMT1) which hypermethylates BDNF promoter and further reduces BDNF level [XREF_BIBR, XREF_BIBR]."
DNA methyltransferase affects BDNF
| 1
DNA methyltransferase leads to the methylation of BDNF. 1 / 1
| 1
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"DNA methyltransferase may contribute to the methylation of BDNF, which is involved in neuroprotection in AD."
DNA methylation affects BDNF
| 1
DNA methylation methylates BDNF. 1 / 1
| 1
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"Recent studies suggest that DNA methylation of brain derived neurotrophic factor (BDNF) may serve as a biomarker for multiple psychiatric traits [XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR; XREF_BIBR]."
CENPJ affects BDNF
| 1
CENPJ methylates BDNF. 1 / 1
| 1
sparser
"Also Bdnf p1 and p9 methylation levels differed only in the cortex, while Bdnf p4 methylation did not vary in either area."
Asp-Gly affects BDNF
| 1
Asp-Gly leads to the methylation of BDNF. 1 / 1
| 1
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"TET1 is thought to be involved in neuronal activity induced DNA demethylation and gene expression changes since shRNA mediated knockdown of endogenous Tet1 in the dentate gyrus (DG) abolishes electroconvulsive stimulation (ECS)-induced demethylation of a Bdnf promoter [XREF_BIBR]."