IndraLab

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DNMT1 methylates BDNF. 5 / 5
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"Dnmt mRNA alterations, increased Bdnf DNA methylation, and altered methylation patterns of numerous genes that play a role in neuronal growth, development, and plasticity have been found in the brains (within the frontal cortex, amygdala, and PVN) of individuals who committed suicide and/or had been diagnosed with major depression."
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"Third, we found that DNMT inhibition causes bdnf DNA demethylation and that demethylation is sufficient to lead to increased bdnf mRNA levels in hippocampus in vivo."
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"Dnmt mRNA alterations, increased Bdnf DNA methylation, and altered methylation patterns of numerous genes that play a role in neuronal growth, development, and cholinergic transmission have been found in the brains (within the frontal cortex, amygdala, and PVN) of individuals who committed suicide and/or had been diagnosed with major depression."
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"Nonetheless, these results confirmed that DNMT inhibition with Zebularine decreased basal bdnf DNA methylation in hippocampus at bdnf exons I, IV, and VI."
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"It has been suggested that IL-6 activated protein kinase B and then it can phosphorylate the nuclear localization signal on DNA methyltransferase-1 (DNMT1) which hypermethylates BDNF promoter and further reduces BDNF level [XREF_BIBR, XREF_BIBR]."
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