IndraLab

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Ethanol leads to the methylation of BDNF. 4 / 4
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"Finally, we identified an EtOH induced change to DNA methylation of the Bdnf promoter in motile sperm that persists in the brain of offspring."
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"Prenatal ethanol exposure has been shown to increase the methylation of the BDNF gene and decrease BDNF expression in the postnatal olfactory bulb, but whether adult ethanol exposure yields similar changes is unknown."
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"We also identified changes in expression of Bdnf in the ventral tegmental area (VTA), and maintenance of ethanol induced DNA hypomethylation of the Bdnf promoter in sires ' sperm and offsprings ' VTA."
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"Similarly, chronic EtOH exposure in fetal rats reportedly induced hypermethylation of Bdnf and subsequent reduction in BDNF protein expression within the olfactory bulb, suggesting yet again a role of alcohol induced epigenetic mechanisms in regulation of synaptic plasticity."
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