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CXXC1 methylates BDNF. 30 / 30
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"Increased CpG methylation in promoter regions of the Bdnf gene is reportedly correlated with the decreased synthesis of BDNF protein in neurons xref ."
29097744
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"After applying Bonferroni correction, any depressive disorder was significantly associated with higher BDNF methylation at CpG sites 1, 5, 8, 9, and a higher average methylation percentage; and majo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26313133
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"An increased CpG methylation in the region of BDNF gene was correlated with decreased BDNF synthesis ( Martinowich et al., 2003 )."
26313133
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"The increased methylation of CpG sites in the genes CXCL1 and BDNF were associated with PTSD and comorbid total life stress."
30781888
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"Analyses of Nr3c1 and Bdnf (IV and IX) CpG methylation indicated increased hippocampal Nr3c1 methylation in maternally separated C57BL/6J males and increased hippocampal Bdnf IX methylation in male and female maternally separated Balb/c mice."
23914177
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"Thus, although we statistically demonstrated there was no association between duration of illness and BDNF methylation at CpG sites, we could not clearly confirm how early these changes in BDNF methylation and cortical thickness among patients with MDD appear."
26876488
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"The incidence of suicidal ideation was independently associated with higher BDNF promoter methylation at CpG site 9 and with a higher average percentage."
24731781
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"xref (in the online-only Data Supplement) presents the analysis of average BDNF promoter methylation and methylation at each CpG site by BDNF genotype."
26508964
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"There were no correlations between BDNF promoter methylation at any CpG sites and cortical thickness among healthy controls ( xref )."
26876488
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"Our observations of the increased levels of DNMTs and fear conditioning-associated regulation of exon-specific Bdnf transcripts led us to speculate that CpG island sites methylation of the Bdnf gene might be a mechanism mediating Bdnf gene expression in the mPFC and HIP during fear erasure."
28473755
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"An increase in CpG methylation at promoter regions on the BDNF gene have been found to be correlated with decreased neuronal synthesis of BDNF xref and with an increased risk of bipolar disorder xref ."
23240009
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"DNA methylation of one CpG site in the BDNF gene and one CpG site in the NR3C1 gene accounts for about 11% (95% CI: 1.3% - 24.4%) and 10% (95% CI: 0.8% - 23.6%), respectively, of the association between childhood trauma and depressive symptoms."
29781947
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"Exposure to a neglectful caretaker decreased Bdnf mRNA expression in the PFC, accompanied by increased Bdnf DNA methylation at multiple CpG sites within the promoter region, in adult animals of both sexes."
27189589
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"For instance, reduced response to antidepressants has been associated with the absence of methylation at a specific CpG site in exon 4 of BDNF in MDD patients ( xref )."
32499729
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"Individually, BDNF gene CpG methylation was significantly upregulated in MDD patients compared with healthy controls (p = 0.038; Cohen’s d = 0.63)."
28246044
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"Both in schizophrenia and in depression at the promoter I of BDNF DNA methylation at a specific CpG site is increased resulting in reduced BDNF gene transcription (Fuchikami et al. xref ; Ikegame et al. xref )."
30767081
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"The incidence of suicidal ideation at the 2-year follow-up was significantly associated with higher BDNF promoter methylation at CpG site 9 and with a higher average percentage."
24731781
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"In addition to increased expression of DNMT3A/B, the rats neonatally exposed to sevoflurane had downregulated methyl CpG binding protein 2, hypermethylated the Bdnf gene, downregulated BDNF levels, and exhibited behavioral deficiencies [XREF_BIBR]."
32477904
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"For example, Roth and colleagues reported that early maltreatment of rat pups produced increased methylation of BDNF that resulted in persistent decreases in gene expression in the adult prefrontal cortex ( xref ) while Smith and colleagues reported increased methylation of a CpG site in BDNF and peripheral blood of adults with PTSD ( xref )."
24103155
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"After applying Bonferroni corrections, the prevalence of suicidal ideation at baseline was significantly associated with higher BDNF promoter methylation at CpG sites 5, 7, 8, and 9 and with a highe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24731781
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"BDNF DNA methylation at 4 CpG sites of the promoter region was also measured."
25451398
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"We found no significant effect of race on CpG methylation of BDNF (p = 0.75), FKBP5 (p = 0.83), CRHBP (p = 0.39), CRHR1 (p = 0.90) or NR3C1 (p = 0.79) (G) gene."
28246044
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"After applying Bonferroni correction, both any depressive disorder and major depressive disorder were significantly associated with higher BDNF methylation at CpG sites 1, 5, 8, 9, and a higher aver[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26313133
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"Finally, higher methylation of CpG sites in the promoter region of the BDNF gene, which translates into lower BDNF mRNA and protein levels, was observed among individuals who died by suicide compared to individuals who died by other causes ( xref )."
28960421
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"This study examined associations of prenatal exposure to maternal stress and BDNF methylation at CpG sites across the BDNF gene."
28680507
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"We have shown that late-life depression is associated with elevated BDNF methylation of specific CpG sites within promoters I and IV, with all associations remaining after adjustment for a range of covariates."
26285129
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"Therefore, we assume that PFOS could lead to the CpG methylation of BDNF mediated by DNMTs and decrease the expression of BDNF."
28441774
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"It was reported that an increase in CpG methylation at promoter regions on the BDNF gene was correlated with decreased synthesis of BDNF in the neurons ( Martinowich et al., 2003 )."
23992681
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"We found no significant effect of race on CpG methylation of BDNF (p = 0.75), FKBP5 (p = 0.83), CRHBP (p = 0.39), CRHR1 (p = 0.90) or NR3C1 (p = 0.79) ( xref ) gene."
28246044
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"Furthermore, chronic depression was also significantly associated with BDNF methylation at the same CpG sites ( xref ), with associations being even stronger than with baseline depression."
26285129