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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TET1 leads to the methylation of BDNF. 2 / 2

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"Although mRNAs of all three Tet genes are detected in the mouse hippocampus, specific knock-down of Tet1 abolished neuronal activity induced promoter demethylation of Bdnf IX and Fgf1B, suggesting non redundant roles of different TET proteins in DNA demethylation."

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"5hmC is abundant in the hippocampal dentate gyrus and manipulations of TET1 in the dentate gyrus regulate 5hmC levels and prevent stimulation induced demethylation of Bdnf and Fgf1B (fibroblast growth factor 1B) promoters."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...