IndraLab
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"Mice that have been provided with environmental enrichment for 4 weeks (8 mice housed per cage, containing tunnels and a running wheel) show increased mRNA levels and altered histone trimethylation of the neurotrophic factor Bdnf compared with control mice (4 housed per cage without tunnels or running wheel)."
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"Higher histone and DNA methylation of the BDNF gene and consecutive downregulation of BDNF mRNA and decreased levels of BDNF have been demonstrated in animal models of maltreatment. xref , xref Tsankova et al. xref showed that chronic defeat stress in mice induced downregulation of the expression of BDNF promoter/exon IV and was associated with increases in histone H3 lysine 27 methylation (H3K27) at the corresponding promoter."