IndraLab

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GNAS methylates BDNF. 7 / 7
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sparser
"Another study comparing methylation between brain and blood in humans found blood to be a poor predictor of brain, and in contrast to the previously mentioned study found that the majority of the few sites exhibiting correlation with brain tissue were located in gene bodies. xref A 2014 study revealed that though overall positively correlated, methylation within CpG islands is highly dissimilar between saliva and blood in humans, with saliva being a closer match to methylation patterns found in the brain. xref Blood is also a poor predictor of human brain BDNF exon I methylation, though muscle tissue methylation at this locus exhibits a high correlation to brain. xref Interestingly, methylation in brain and blood have been found similar in an animal model."

sparser
"Interestingly, in Balb/cJ mice that were exposed to this same manipulation, Bdnf expression was enhanced within the PFC and increased levels of Bdnf exon IX methylation within the hippocampus were found [ xref ]."

sparser
"In support of this, methylation specific real-time PCR revealed that bdnf exon VI DNA methylation increased after fear conditioning."

sparser
"There was no strong evidence that blood or buccal BDNF exon 1 promoter DNA methylation is associated with prevalent or incident dementia, and reported associations would not remain after adjustment for multiple testing."

sparser
"BDNF exon 1 promoter methylation was measured in blood at baseline (n = 769) and buccal samples during follow-up (n = 1062)."

sparser
"However, in the whole prefrontal cortex, Bdnf exon IX methylation was increased 24 hours after the final day of maltreatment exposure (i.e. PD8) and this increase persisted into adulthood."

sparser
"Of note, one study found no differences in BDNF exon 1 methylation between BD patients and controls, which suggests that this marker is sample-specific and might not be generalizable to all populations ( xref )."