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"Another study comparing methylation between brain and blood in humans found blood to be a poor predictor of brain, and in contrast to the previously mentioned study found that the majority of the few sites exhibiting correlation with brain tissue were located in gene bodies. xref A 2014 study revealed that though overall positively correlated, methylation within CpG islands is highly dissimilar between saliva and blood in humans, with saliva being a closer match to methylation patterns found in the brain. xref Blood is also a poor predictor of human brain BDNF exon I methylation, though muscle tissue methylation at this locus exhibits a high correlation to brain. xref Interestingly, methylation in brain and blood have been found similar in an animal model."