IndraLab

Statements

CXXC1 methylates BDNF. 5 / 5
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"Increased methylation of a CpG site in BDNF and peripheral blood of adults with PTSD have been reported ( xref )."
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"Results: After 100 days of selective serotonin-reuptake inhibitor treatment, methylation of promoter CpG sites of BDNF , NR3C1 , FKBP5 and SLC6A4 was significantly reduced."
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"Absence of methylation at one particular CpG site in exon 4 of BDNF has been associated with reduced response to antidepressant drugs ( xref )."
31019524
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"Peripheral blood collected at baseline revealed that any depressive diagnosis was associated with higher BDNF methylation at CpG sites -1, -5, -8, and -9, and a higher average BDNF promoter methylation percentage."
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"Januar et al. have revealed that late-life depression is associated with elevated BDNF methylation of specific CpG sites within promoters I and IV, with all associations remaining after adjustment for a range of covariates [ xref ]."
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